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Chloramphenicol

Chloramphenicol is prescribed to manage typhoid fever and other severe bacterial infections.
US Brand Name Chloromycetin
Generic Name Chloramphenicol
Other Brand Name Ranphenicol
Packing 10
Manufacturer Cipla
Form Capsule
Strength 250 mg, 500 mg

  • 30 tabs 250 mg $10.20
  • 30 tabs 500 mg $17.70
Available online
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Details

Chloramphenicol

Uses

Chloramphenicol is used in the treatment of bacterial infections, and bacterial eye infections.

How it Works

Chloramphenicol is an antibiotic. Chloramphenicol works by inhibiting synthesis of essential proteins, which are required by bacteria to carry out vital functions.

Common Side effects

Patients who take Chloramphenicol may suffer from such side effects;

Nausea,
Vomiting,
Tiredness or weakness,
Nausea,
Sore throat,
Diarrhea,
Pale skin,
Vomiting,
Abnormal bleeding or bruising,
Diarrhoea,
Altered taste

Introduction

Chloramphenicol is an antibiotic used in the treatment of serious bacterial infections. It is only indicated when the other antibiotics do not work. It is not given in the cases of cold, flu, or other viral infections as it is not effective for viral infection treatment. It is only available on a doctor’s prescription and you can discuss its side effects with your doctor.

Use

Chloramphenicol has a broad spectrum of activities and has been effective in treating infections caused by a number of bacteria, including staphylococcus aureus, streptococcus pneumoniae, and escherichia coli. It was initially indicated in the treatment of typhoid fever, however, presently, it is given to treat tetracycline resistant cholera. Due to its excellent blood-brain penetration, it is used to treat brain abscess and meningitis. It is also used to treat several ocular infections. The mechanism of action is by inhibiting the protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. By preventing the protein synthesis, it makes the bacterial cell undergo cell lysis.

Dosage and administration

This drug is available as capsules in the strengths of 250 mg and 500 mg. The route of administration is oral. It is to be taken with a glass of water. It can also be taken as suspensions or intravenously when available and required. Your dose of the medicine depends on your general medical condition, the particular health problem you are facing, and your body's response to the drug.

The recommended oral dose in adults and children whose age is more than 2 weeks, is 12.5 mg/kg body weight to be given every 6 hours. The recommended oral dose in infants up to 2 weeks of age is 6.25 mg/kg body weight, given every 6 hours. It is important to maintain the drug concentration at equal levels throughout the day. Do not stop taking the drug once you start feeling better, otherwise there are chances that the symptoms may return and be more severe. Complete the full prescribed drug course.

Warning

  • It is necessary that you inform your doctor about the allergies, medical history, and the drugs you have been kept on before starting this medicine.
  • Use of this medicine in an infant has been associated with a condition called Gray baby syndrome. The symptoms are pale or blue skin color, swelling of the abdomen, vomiting, difficulty breathing, diarrhea, and severe weight loss. Consult the doctor immediately and withdraw the drug completely.
  • This medicine may reduce your body’s immunity, therefore, it is advised to avoid contact with people who are possible source of infections. Also, avoid getting bruised and wounded since the drug reduces the body’s clot forming potential.
  • It is advised to regularly monitor your blood sugar levels while using this medicine.
  • Side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Headaches
  • Fever with chills
  • Sore throat
  • Confusion
  • Delirium
  • Itch
  • Rashes