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Pioglitazone/ Metformin Tablets

Pioglitazone and Metformin Hydrochloride combination medication is prescribed to help regulate blood sugar levels in individuals with type 2 diabetes mellitus.
US Brand Name ACTOplus/ ACTOplus MET
Generic Name Pioglitazone/ XR Metformin
Other Brand Name Biodub-M, Mefomin P, MOPADAY HS
Packing 10
Manufacturer SUN PHARMACEUTICALS, Franco Indian, Macleods, Wockhardt
Form Tablets
Strength 15 mg/ 500 mg, 30 mg/ 500 mg, 15 mg/800mg

  • 30 tabs 15 mg/ 500 mg $12.30
  • 30 tabs 30 mg/ 500 mg $26.70
Available online
More Views
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Details

Metformin

Uses

Metformin is used in the treatment of type 2 diabetes.

How it Works

Metformin helps in allowing the body to make full use of the reduced amount of Insulin that occurs in type 2 diabetes patients. Insulin occurs naturally in the body's pancreas which helps to control the level of glucose(Sugars) in your blood, insufficient or inaffective insulin results in the condition called diabetes mellitus. Metformin helps in treatment of the type 2 diabetes.

Common Side effects

Patients who take Metformin may suffer from such side effects; Headache,
Bloating,
Flushing,
Changes in the nails,
Altered taste,
Abdominal pain,
Diarrhoea,
Loss of appetite,
A metallic taste in the mouth,
Nausea,
Vomiting

Pioglitazone

Uses

Pioglitazone is used in the treatment of type 2 diabetes mellitus.

How it Works

Pioglitazone works by increasing the sensitivity of your body's cells to insulin, it helps the body use Insulin more effectively, so more glucose is taken into cells for the same amount of insulin in the bloodstream. In type 2 diabetes the body produces insufficient amounts of insulin which causes the cells to build a resistance against the insulin(Insulin resistance). Pioglitazone directly helps in reducing this insulin resistance and helping in the treatment of type 2 diabetes.

Common Side effects

Patients who take Pioglitazone may suffer from such side effects;

Blurred vision,
Respiratory tract infection,
Bone fracture,
Numbness,
Putting on weight,
Aches and pains,
Flu-like symptoms,
Chest infections,
Reduced sense of touch (numbness),
A greater risk of broken bones

Introduction

Pioglitazone or also known as pioglitazone hydrochloride, is an oral tablet that acts as antidiabetic agent that reduces insulin resistance in the body. Studies have revealed that this medicine helps to increase insulin sensitivity in the body in patients who have non-insulin-dependent diabetes mellitus because of its active content. One of the manufacturer that produces this drug is, SUN PHARMACEUTICALS.

Composition

ACTOplus is composed of pioglitazone hydrochloride and metformin hydrochloride along with inactive ingredients such as hypromellose 2910 USP, povidone USP, titanium dioxide USP, croscarmellose sodium NF, microcrystalline cellulose NF, polyethylene glycol 8000 NF, magnesium stearate NF and talc USP. Pioglitazone and metformin are both crystalline powder but only metformin is water soluble. Pioglitazone is soluble in dimethylformamide but definitely not in water. This medicine is to be taken orally.

Use

Presently, it is used to lessen the transformation of diabetes from prediabetic stage to type 2 diabetes by almost 72%. There is an approximate rate of 15% to 30% dosage of this drug found in urine upon its oral administration.

Dosage and administration

This drug starts at a dosage of 500 mg two times a day or a total of 850 mg once every day. It can be increased gradually by 500 mg per week or 850 mg every two weeks as medication by the body response on glucose levels. The maximum dose is 2550 mg for three days by dividing the dosage. Begin on 500mg or 1000 mg per day every day after dinner. Dosage can be increased by the doctor to 500 mg per week to a maximum dose of 2000mg or 25000 for Fortamet just once per day or divided into two doses. Pediatric patients aging 10-16 years old can start taking it for 500 mg two times a day.

Contraindication

Patients with hypersensitivity in using pioglitazone cannot use this drug medicine or any other part of its medicinal forms especially thiazolidinediones. There is also a great restriction for those who have heart ailment/s.

Important Precautions

It can also activate the ovulation cycle of female patients who is at big risk for pregnancy for those women who are on oral contraception.

Side effects

This XR Metformin tablets are capable of fluid retention in the body of the patients. Patients can also experience peripheral edema, suffer from anaemia, a mild gaining of weight and increase in the tendency of a headache, experience dental problems, sinusitis, myalgia and acquire upper respiratory tract infection as well.

storage

It usually comes in 10 tablets content per pack, and it must be kept away from children and kept in a safe place, which is away from direct heat and sunlight and also away from moisture.