Kiwof Plus for Dogs, Praziquantel/ Pyrantel Pamoate/ Febantel

1. Introduction

Kiwof Plus for Dogs is a highly effective broad-spectrum deworming tablet designed to eliminate a wide range of internal parasites in canines. It combines three potent active ingredients—Praziquantel, Pyrantel Pamoate, and Febantel—to ensure comprehensive protection against intestinal worms that threaten a dog’s vitality and wellbeing.

Regular deworming plays a pivotal role in maintaining optimal canine health. Parasite infestations can cause nutrient loss, gastrointestinal distress, anemia, and, in severe cases, life-threatening complications. By eradicating internal worms, Kiwof Plus enhances digestion, nutrient absorption, and overall vitality.

Manufactured by trusted veterinary pharmaceutical companies, Kiwof Plus is widely available in veterinary clinics and online pharmacies. It can be purchased over the counter in many regions, though professional veterinary consultation is always recommended. The formulation exemplifies the power of combination therapy—each component targets specific parasites, collectively delivering broad and sustained protection.

2. Composition and Active Ingredients

Each Kiwof Plus tablet is meticulously formulated to contain three synergistic anthelmintic agents:

• Praziquantel – A potent cestocidal compound effective against tapeworms.
• Pyrantel Pamoate – Targets and paralyzes roundworms and hookworms.
• Febantel – A pro-benzimidazole that disrupts energy metabolism in nematodes.

The pharmacological harmony between these agents ensures comprehensive control of both immature and mature stages of parasitic worms. Tablets are available in varying strengths, typically differentiated by color to suit small, medium, and large dog breeds, ensuring precise weight-based dosing.

3. Mechanism of Action (How Kiwof Plus Works)

Kiwof Plus acts through a multifaceted mechanism:

• Praziquantel alters the permeability of worm membranes, causing paralysis and disintegration of tapeworms within the intestines.
• Pyrantel Pamoate functions as a depolarizing neuromuscular blocker, immobilizing nematodes such as roundworms and hookworms, leading to their expulsion.
• Febantel is metabolized into fenbendazole, disrupting energy production and leading to the death of whipworms and other nematodes.

Together, these mechanisms yield a rapid and thorough anthelmintic effect. Most dogs experience full parasite clearance within 24 to 48 hours, with the protective benefits persisting for weeks when used routinely.

4. Therapeutic Uses

Kiwof Plus provides broad-spectrum treatment and prevention against multiple intestinal parasites, including:

• Roundworms – Toxocara canis, Toxascaris leonina
• Hookworms – Ancylostoma caninum, Uncinaria stenocephala
• Whipworms – Trichuris vulpis
• Tapeworms – Dipylidium caninum, Taenia spp., Echinococcus spp.

It is ideal for routine deworming schedules—commonly every three months in adult dogs and every two weeks in puppies. In multi-dog environments or kennels, Kiwof Plus minimizes cross-infection, helping maintain a parasite-free setting.

5. Off-Label and Additional Uses

While primarily designed for intestinal worms, veterinarians may prescribe Kiwof Plus off-label for complex parasitic infections, including those involving Giardia. It may also complement flea control regimens since fleas act as vectors for certain tapeworms. Integrated Parasite Management (IPM) programs often include Kiwof Plus as a cornerstone product due to its high efficacy and safety profile.

Comparative studies have shown Kiwof Plus to be as effective as leading international brands, offering reliable results at an accessible cost for long-term parasite control.

6. Dosage and Administration

The dosage of Kiwof Plus is determined by body weight:

• Small dogs (up to 10 kg): ½ tablet
• Medium dogs (10–20 kg): 1 tablet
• Large dogs (20–35 kg): 1½ tablets
• Extra-large dogs (35–50 kg): 2 tablets

It can be administered directly or mixed with food. Feeding is not mandatory before or after dosing. Consistent deworming at recommended intervals ensures total elimination and prevents reinfection.

For puppies, administration typically begins at 2–3 weeks of age, repeated every two weeks until 12 weeks, and then every three months thereafter.

7. Possible Side Effects

Kiwof Plus has an excellent safety margin. However, mild and transient reactions may occur in sensitive dogs, such as:

• Vomiting or soft stool
• Excessive salivation
• Lethargy or mild appetite reduction

Rarely, hypersensitivity or allergic reactions may occur, presenting as itching, facial swelling, or breathing difficulties. If these symptoms appear, immediate veterinary evaluation is recommended.

8. Warnings and Precautions

Use this product responsibly and under veterinary supervision when possible:

• Do not administer to weak or severely ill animals without approval.
• Ensure accurate dosing based on the dog’s body weight.
• Keep the tablets out of reach of children and other pets.
• Never exceed the recommended dosage frequency.

Careful adherence to dosing guidelines minimizes side effects and maximizes therapeutic efficacy.

9. Contraindications

Kiwof Plus should not be administered in the following situations:

• Known hypersensitivity to any of the active components.
• Puppies under 3 weeks of age or weighing less than 2 kilograms.
• Dogs with significant hepatic or renal dysfunction should be treated only after veterinary consultation.

10. Drug Interactions

Certain medications may interact with Kiwof Plus and reduce its effectiveness:

• Piperazine-based dewormers should not be co-administered, as they may antagonize Pyrantel’s neuromuscular blocking action.
• Generally compatible with flea and tick preventives such as isoxazolines or selamectin, but always confirm with a veterinarian before combining treatments.
• Drugs influencing hepatic enzyme activity may alter metabolism of active ingredients and require dosing adjustments.

By observing these precautions and following veterinary advice, Kiwof Plus ensures safe, dependable parasite control for dogs of all breeds and sizes.

11. Administration in Special Populations

11.1 Administration to Puppies and Young Dogs

Kiwof Plus can be administered safely to puppies as young as 2 to 3 weeks of age, provided that the correct dosage adjustments are made according to body weight. The developing physiology of young dogs requires cautious dosing to prevent gastrointestinal irritation and ensure complete elimination of intestinal parasites.

Preventive treatment is vital, as puppies are highly susceptible to transplacental and transmammary worm infections. Routine administration is recommended at:

• 2 weeks of age
• 4 weeks of age
• 8 weeks of age
• Every 3 months thereafter

This regimented approach breaks the life cycle of intestinal parasites, promoting strong immunity and healthy growth during the formative months of life.

11.2 Administration to Pregnant and Nursing Dogs

The safety of Kiwof Plus in pregnant and lactating females has been well-documented when administered under veterinary supervision. Deworming pregnant dogs is essential to prevent prenatal and postnatal transmission of parasites such as Toxocara canis to their offspring.

Recommended administration schedule:

• Once before mating to reduce worm burden
• Once during mid-pregnancy (around day 40–45 of gestation)
• Once during lactation, typically 2–3 weeks after whelping

Proper deworming during these periods protects both the mother and her litter, ensuring optimal neonatal health and preventing parasite contamination in the whelping environment.

11.3 Administration to Elderly Dogs

Older dogs often experience reduced hepatic and renal efficiency, which may alter drug metabolism and excretion. Before deworming geriatric dogs, a veterinarian should evaluate their organ function and overall health condition.

In certain cases, a reduced dosage or extended dosing interval may be necessary. Continuous monitoring for signs of intolerance—such as fatigue, decreased appetite, or gastrointestinal upset—ensures the treatment remains both safe and effective.

12. Overdosage

Although Kiwof Plus has a wide safety margin, overdosing may cause transient but concerning symptoms such as:

• Excessive salivation or drooling
• Tremors and muscular weakness
• Vomiting and loose stools
• Uncoordinated movements or general lethargy

In the event of suspected overdose, immediate veterinary assistance is required. Supportive care—such as fluid therapy and symptomatic management—is typically effective. With timely intervention, most dogs recover fully without lasting complications.

13. Handling Precautions

Kiwof Plus tablets should be handled with care, especially around children and other household pets. While the product is non-toxic to humans in normal circumstances, certain precautions should be observed:

• Avoid direct contact with the eyes, mouth, or broken skin.
• Wash hands thoroughly after administering the tablet to your dog.
• Do not eat or drink while handling the medication.
• Store out of reach of children and away from food items.

Following these safety practices ensures that accidental exposure and contamination risks remain minimal.

14. Storage and Stability

To maintain potency and stability, Kiwof Plus should be stored under controlled environmental conditions:

• Temperature: below 25°C (77°F)
• Humidity: low to moderate; store in a dry area
• Protection: keep in original packaging, tightly sealed and away from sunlight

The shelf life typically extends up to 24 months from the manufacturing date. Expired or unused tablets should be disposed of safely, preferably through a veterinary clinic or pharmaceutical disposal facility. Avoid discarding in household waste or waterways to prevent environmental contamination.

15. Important Precautions and Veterinary Guidance

For optimal parasite management, professional supervision is strongly advised. Veterinary guidance ensures proper diagnosis, dosing, and prevention strategies. Key recommendations include:

• Conduct fecal examinations before and after deworming to confirm efficacy.
• Avoid repetitive dosing or unsupervised long-term use without professional oversight.
• Integrate deworming with flea, tick, and environmental control for holistic protection.

This integrated approach not only safeguards individual pets but also minimizes the risk of reinfestation within multi-dog households or breeding facilities.

16. Frequently Asked Questions (FAQ)

How often should I give Kiwof Plus to my dog?

For adult dogs, administration every 3 months is generally sufficient. Puppies require more frequent dosing—starting at 2 weeks of age and continuing at regular intervals until 12 weeks old.

Can Kiwof Plus be used alongside heartworm preventives?

Yes. It is typically compatible with heartworm medications such as ivermectin or milbemycin oxime. Nonetheless, concurrent use should always be verified by a veterinarian to prevent drug overlap or adverse reactions.

Is Kiwof Plus safe for lactating dogs?

When administered as directed, Kiwof Plus is safe for nursing females. It aids in reducing parasitic transmission to suckling puppies through contaminated milk or feces.

What should I do if my dog vomits after taking the tablet?

If vomiting occurs within one hour of ingestion, re-dosing may be required. Consult a veterinarian before repeating the dose to ensure safety and correct timing.

Can humans catch worms from infected dogs?

Yes. Some intestinal parasites, such as Toxocara and Echinococcus species, are zoonotic and can infect humans. Maintaining strict hygiene and routine deworming minimizes this risk.

When will I see results after giving Kiwof Plus?

Most worms are expelled within 24 to 48 hours of dosing. Noticeable improvement in your dog’s appetite, stool quality, and energy levels typically follows within a few days.

17. Summary and Key Takeaways

Kiwof Plus for Dogs offers reliable, comprehensive protection against a spectrum of internal parasites. Its triple-action formulation—comprising Praziquantel, Pyrantel Pamoate, and Febantel—targets multiple worm species at various developmental stages.

• Broad-spectrum efficacy against tapeworms, roundworms, hookworms, and whipworms.
• Proven safety across all canine life stages—puppies, adults, breeding females, and seniors.
• Convenient, easy-to-administer tablet for routine deworming and prevention.

When used responsibly and under veterinary supervision, Kiwof Plus ensures long-term parasite control, improved digestive health, and enhanced quality of life for dogs of all breeds and ages.