What is Sirolimus and Rapamycin?
Sirolimus (Generic Rapamycin) is a macrolide compound that helps prevent organ transplant rejection. It has macrolide immunosuppressant functions in humans. It's used to coat coronary stents, treat rare lung disease, lymphangioleiomyomatosis, and also after kidney transplant surgery.
Rapamycin was originally developed as a drug immunosuppressant for organ transplant patients where it works to help prevent organ rejection by suppressing the immunity in the recipient's body, however, it has had a new lease on life as a potential anti-aging drug.
Rapamycin is a member of a larger family of drugs called macrolides and safe for humans. Rapamycin has been shown in lab tests to decrease inflammation throughout the body. Rapamycin is an anticancer drug or rapamycin inhibits mTOR, a protein kinase, s6 kinase, fk506 binding protein, proline rotamase, with a wide variety of downstream signaling pathways. Rapamycin was isolated in 1972 from a bacterium found on Easter Island, aka Rapa Nui – hence the name. For many years it was an obscure transplant drug but in the early 2000s was found to significantly extend the lifespan of worms, yeast, flies and mice
Rapamycin works through the inhibitor of mTOR signaling, which induces autophagy, induces cell and inhibits cell proliferation. The drug was first isolated from streptomyces hygroscopicus by hatae ishii at tanabe seiyaku corporation in 1976. In 1989 it became the first-ever example of an antibiotic being successfully applied clinically on cancer patients without producing any measurable resistance.
What is Rapamycin used for
To use this drug: patients should take only one dose per day before or after any food that they might eat with; side effects may include sepsis, septic shock, gastrointestinal bleeding among other things.
Rapamycin is used in combination with other antibiotics to prevent organ transplant rejection, or as a coating on coronary stents for people who are at high risk of complications after surgery. Most recent research has found this drug to be useful as an anti-ageing drug as well. Rapamycin has been found to work by exerting its life-extending properties by mimicking the effect of caloric restriction, one of the most reliable ways to extend lifespan in non-human animals as most of the research so far has been done only on animals. It targets a signaling molecule called mTOR which is important in human body nutrient-sensing pathways. Lack of food switches mTOR off and activates emergency systems that enable us to survive periods of starvation.These pathways include autophagy, the process by which cells scavenge dysfunctional organelles and molecules for energy. This reduces the accumulation of the detritus that normally clog up our tissues as we get older, and hence slows or even reverses the aging process.
Sirolimus (Generic Rapamycin) is also used after kidney transplant surgery to prevent the body from rejecting the transplanted organ. Sirolimus can be used to slow stem cells tumor growth by stopping cells proliferation from dividing so quickly (a process called angiogenesis).The drug has been found useful for treating renal cancer cell carcinoma; breast cancer; prostate cancer; melanomas; lung cancers; cervical and ovarian cancers; esophageal, stomach, pancreatic, and head/neck cancers.
Rapamycin (Sirolimus) for Anti-aging
Rapamycin (Sirolimus) slows aging, extends life span, and prevents age-related diseases, including diabetic complications such as retinopathy. Rapamycin may also induce insulin resistance or glucose intolerance without insulin resistance. This mirrors the effect of fasting and very low calorie diets, which improve insulin sensitivity and reverse type 2 diabetes, but also can cause a form of glucose intolerance known as benevolent pseudo-diabetes. In transplant patients, a weak association between rapamycin use and hyperglycemia is mostly due to a drug interaction with calcineurin inhibitors. When it occurs in cancer patients, the hyperglycemia is mild and reversible. No hyperglycemic effects of rapamycin/everolimus have been detected in healthy people. For antiaging purposes, rapamycin/everolimus can be administrated intermittently (e.g., once a week) in combination with intermittent carbohydrate restriction, physical exercise, and metformin.
Can Rapamycin cause depression
Rapamycin can cause depression but this is rare. Rapamycin has been found to reduce symptoms of some types of cancer by slowing the growth and spread. It does not cure these cancers, just helps them progress more slowly than usual.
How do i buy Sirolimus online?
Rapamycin (sirolimus) works by weakening the body's immune system which allows it to accept an organ such as a kidney. As mentioned earlier sirolimus works by suppressing immune response which means it can be prescribed for many different types of conditions.
In solid organ transplantation, it is given to prevent the immune system from attacking a transplanted kidney or liver. It also prevents rejection in bone and tissue grafts as well as skin allografts.
The drug works by inhibiting an enzyme called calcineurin which signals t-cells and b cells cycle. That tell them when they should attack foreign substances like viruses, bacteria, or transplanted organs.
How do i get or buy Sirolimus online?
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