Know the History of Nolvadex Tamoxifen Medication

Title: Know the History of Nolvadex Tamoxifen Medication


The National Cancer Institute has termed Nolvadex (Tamoxifen) as a medication that creates impediments in the activities of estrogen, a female sex hormone released by the ovary. The need of this US FDA approved drug is felt when men and women are diagnosed with carcinoma or cancer of the breast. Presently marketed under the brand name Nolvadex, Tamoxifen treats as well as prevents breast cancer in persons at greater risk for this dreaded ailment. We’ll now throw light on the history of generic Nolvadex for the benefit of its admirers.

It all began when ICI Pharmaceuticals (currently recognized as Zeneca) carried out research work in the 1950s to lay the foundation for the evolution of Tamoxifen. During the initial studies, scientists found out that oral contraceptive pills suppressed the quantity of estrogen generated by the body. This led to the introduction of a collection of medications called triphenylethylenes.

Although the objective of the research was to make use of triphenylethylenes as an effective birth control medium in the beginning, new findings by groups of cancer research workers showed that these medications might also come in handy as antagonists for estrogen to bottle up the development of cancer cells, particularly cancer cells of the breast. In the 1970s, another lab trialing at ICI Pharmaceuticals confirmed the assistance of estrogen in the growth of new cancer cells. An estrogen receptor called alpha ligant (a protein) was discovered to bind to estrogen and estrogendiol to produce new cells. Tamoxifen curbed this binding action and decelerated the production of cancer cells.

A clinical trial on the prevention of breast cancer was taken place in 1999 under the watchful eyes of a renowned scientist. The five-year trial was one of a kind with 13,000 participants. The results of the clinical test reaffirmed the effectiveness of Nolvadex (Tamoxifen) in preventing breast cancer as invasive breast cancer was brought down by 66 percent in females receiving this medication. Moreover, women volunteers having lobular carcinoma in situ (detection of breast cancer in the milk-producing cells) and untypical hyperplasia (abnormal increase in the number of cells) experienced a reduction almost by 86 percent. In the end, the outcomes of the trial indicated that physicians should earnestly look at the preventative treatment option with generic Nolvadex (Tamoxifen) for women with both kinds of breast cancers.

Generic Nolvadex is presently recommended to females more than 35 years of age who come under a high risk group as determined by the boundaries of the Gail Model Risk Assessment. According to experts, Tamoxifen is at present the most sought-after hormonal therapy for all phases of breast cancer and is the paragon for anti-estrogen treatment.

However, the detractors of generic Nolvadex use remark that the participants of the famous prevention trial for breast cancer did not boast an augmented endurance rate, and that the medication simply elongated lifespan. There are also certain side effects that even out its advantages as happened with any medication. These include bigger occurrence of blood clots in lungs, uterine cancer and cataracts (eye diseases). Higher happenings of strokes were also reported by trial volunteers.

Back to Tamoxifen

Related Products