Mefenamic Acid

Mefenamic Acid is a nonsteroidal anti-inflammatory drug that is prescribed to help provide short-term relief from mild to moderate pain, such as dental pain, menstrual pain, muscle or joint pain, etc.

Generic Meftal, Ponstan, Ponstel

Mefenamic acid

Meftal, Meftal-P


Blue Cross Laboratories

Tablet, Dispersible Tablet

100mg, 250 mg, 500 mg


Mefenamic Acid

I. Introduction to Mefenamic Acid

Mefenamic Acid, a type of anti-inflammatory drug (NSAID), is well known for its effectiveness in relieving pain and reducing inflammation. It has earned a reputation in the world of medicine for its ability to alleviate conditions. Since receiving approval from the FDA in the 1960s, Mefenamic Acid has played a role in pain management, particularly for issues like menstrual cramps and arthritis. Its importance in medicine cannot be understated, as it serves as a valuable tool in treating pain and inflammatory conditions.

II. Composition and Properties of Mefenamic Acid

Mefenamic Acid belongs to the fenamate group of NSAIDs, which is known for its chemical makeup that influences its pharmacological characteristics. In terms of attributes, this medication demonstrates favorable properties in terms of how it is absorbed, distributed, metabolized, and excreted, all of which highlight its effectiveness and safety in therapy.

III. How Mefenamic Acid Works

Mefenamic acid works by blocking the enzyme cyclooxygenase, which stops the production of prostaglandins. Prostaglandins are substances that contribute to pain and inflammation. In managing pain and inflammation, this process is essential for alleviating symptoms linked to inflammatory conditions and providing significant comfort to patients.

IV. Uses of Mefenamic Acid

V. Off-Label Uses of Mefenamic Acid

VI. Dosage and Administration

  • Dosage Recommendations for Various Health Conditions; The amount of Mefenamic Acid to take can vary depending on the condition usually falling between 250 mg to 500 mg to be taken thrice daily.
  • Method of Use and Types of Dosage; Mefenamic Acid is available in the form of capsules and it is recommended to consume it with food to reduce potential gastrointestinal side effects.
  • Special Considerations for Specific Groups: Adjustments in dosage might be needed for individuals with kidney issues or for adults, highlighting the significance of personalized care for each patient.

VII. Common Side Effects of Mefenamic Acid

Adverse Reactions Summary; Although Mefenamic Acid is generally well received by individuals it may lead to issues like stomach discomfort, headaches and lightheadedness in certain patients.

Dealing with Minor to Side Effects: The majority of these effects can be effectively controlled and usually diminish with ongoing usage or adjustments in dosage, underscoring the importance of educating patients and keeping a close watch on their progress.

VIII. Serious Side Effects and Complications

Dealing with Severe Reactions: Although uncommon, severe side effects such as bleeding, cardiovascular problems, and kidney issues need urgent medical care.

Ensuring Drug Safety in the Long Run: Using Mefenamic Acid for a period like other NSAIDs should be done cautiously due to the higher chances of heart and stomach issues.

IX. Interactions of Mefenamic Acid with Other Medications

Common Interactions Between Drugs: Mefenamic Acid may interact with medications, such as blood thinners, other pain relievers, and certain blood pressure medications, which could impact how they work. Understanding these interaction mechanisms and taking measures to reduce negative effects is crucial for healthcare professionals to improve treatment results.

X. Contraindications and Precautions

Absolute and Relative Restrictions: Mefenamic Acid, to other NSAIDs, should not be used in patients who have shown sensitivity to the medication or its ingredients. It is advisable to use it in individuals with a background of ulcerative colitis, Crohn's disease, or gastrointestinal bleeding. Conditions that may warrant caution include issues and kidney impairment.

Special Caution for High Risk Groups; Extra care is needed when prescribing this medication to patients with a history of heart disease or high blood pressure. It is important to weigh the risks and benefits due to the potential, for worsening existing conditions or causing new ones.

XI. Important Precautions

  • It is recommended to check blood pressure, kidney function, and liver function tests to quickly identify any potential side effects.
  • To ensure safety it is advised to use the effective dose, for the shortest period needed to manage symptoms.
  • Patients should be informed about the significance of the following dosages.

XII. Special Considerations in Administration

  • When it comes to caring for the elderly, it's important to be aware that they may face a risk of experiencing side effects like gastrointestinal bleeding and kidney issues. It's advisable to use doses and keep a close eye on them.
  • For women and nursing mothers, it's crucial to note that Mefenamic Acid should not be taken during the final trimester of pregnancy because it could lead to premature closure of the ductus arteriosus in the fetus. The safety of using acid while nursing has not been confirmed, so a decision should be made based on whether to stop nursing or discontinue the medication after considering its importance.
  • As for children, using Mefenamic Acid in those under 14 years old is not recommended due to data on its safety and effectiveness.

XIII. Overdose and Management

Signs and Symptoms of Taking Much: If someone takes too much, they might experience nausea, vomiting, stomach pain, bleeding in the digestive system, and, in rare cases, kidney problems and seizures. Severe cases could lead to kidney failure and liver issues.

Immediate Steps and How to Treat: If an overdose happens, it's essential to wash out the stomach and provide supportive care. Giving activated charcoal can help reduce the amount of the drug absorbed by the body.

Supportive treatment should be given based on symptoms as needed.

XIV. Storage and Handling Precautions

Storage Recommendations: It is advisable to store Mefenamic Acid at room temperature in a place shielded from light and moisture to uphold its effectiveness and prevent deterioration.

Guidelines for Disposal and Safety Precautions: It is crucial to discard expired or unused medications correctly to prevent pollution and accidental ingestion by children or pets. Patients should be educated on the significance of disposal methods.

XV. Careful Administration Practices

Healthcare providers must conduct an assessment of patients to identify any factors that may prevent the use of Mefenamic Acid. It is crucial to educate patients on how to take the medication. Regular checkups are necessary to track progress and make dose adjustments as needed. Improving compliance and treatment outcomes can be achieved through clear communication about potential side effects, stressing the importance of following prescribed doses and emphasizing the need for regular monitoring.

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