Sandostatin LAR Injection

Sandostatin LAR Injection is used for the treatment of diarrhea.Sandostatin LAR Injection is a octreotide which works to treat diarrhea caused by certain types of tumors.

Sandostatin LAR

Octreotide acetate

Sandostatin LAR

1

Novartis India

Vial

10 mg, 20 mg, 30 mg

India

Out of Stock.

Sandostatin LAR Injection

Introduction to Sandostatin LAR Injection

Overview of Sandostatin LAR

Sandostatin LAR Injection is a type of medication that helps with hormonal and digestive issues over an extended period by using octrotide acetate which imitates natural hormones to control excessive hormone release more accurately in the body.

Therapeutic Class and Mechanism of Action Summary

Sandostatin LAR is classified under the somatostatin analog category of medications. Its way of functioning includes attaching to receptors to reduce the release of growth hormone and other hormones, like insulin growth factor. 0 (IGi, for short). It also controls secretions to ease symptoms in a range of conditions.

Key Uses and Benefits

- Regulates excessive hormonal activity

- Reduces symptoms of hormone-secreting tumors

- Enhances quality of life in patients with chronic endocrine disorders

Composition and Formulation

Active Ingredient: Octreotide Acetate

The key ingredient, in this medication is octerotide acetate. A man-made peptide that acts similarly to somatostatin but lasts longer and is more potent in its effects.


List of Excipients

- Polylactide-co-glycolide (PLGA) - Mannitol - Carboxymethylcellulose sodium - D-mannitol

Pharmaceutical Form and Strength

Sandostatin LAR comes in prefilled syringes as a powder suspension in strengths from 10 mg to 30 mg.


Uses of Sandostatin LAR

Approved Indications

Off-Label Uses


How Sandostatin LAR Works

Mechanism of Action in Reducing Hormone Secretion

Octreotide acetate attaches to receptors. Helps reduce the release of different hormones such, as growth hormone and insulin.

Effect on Growth Hormone and IGF-1

It directly inhibits growth hormone production in the pituitary gland and reduces IGF-1 synthesis in the liver, essential for managing acromegaly.


Role in Inhibiting Neuroendocrine Tumor Symptoms

Decreasing the release of hormones from tumors, helps relieve signs, such as blushing and discomfort in the stomach and eases diarrhea.

Dosage and Administration Guidelines

Acromegaly treatment involves administering 20 milligrams every four weeks. Take 30 milligrams of NET every four weeks.

Administration Technique for Intramuscular Injection

Inject into the buttock muscle using an injection method for better absorption.

Frequency of Administration

Usually given every month, adjusted depending on how the patient is responding clinically.

Adjustments for Specific Patient Populations

Adjustments to the dosage, might be necessary for individuals with liver or kidney issues.

Storage and Handling Precautions

Ideal Storage Conditions

Remember to keep the medication stored between 2 to 6 degrees Celsius and shielded from light.

Guidelines for Maintaining Stability During Transport

Make sure to keep the temperature controlled during transportation to prevent any decrease in effectiveness.

Proper Disposal Methods

Make sure to follow your regulations when getting rid of any leftover medication you no longer need.

Side Effects of Sandostatin LAR

Common Side Effects

- Gastrointestinal disturbances: Nausea, abdominal pain, diarrhea

- Injection site reactions: Pain, swelling, redness

- Changes in blood glucose levels: Hypoglycemia or hyperglycemia


Serious Side Effects


Interactions with Other Medications

Interaction with Antidiabetic Medications

Sandostatin LAR can affect how the body processes glucose and may lead to high blood sugar levels, in patients using insulin or oral hypoglycemic medications; close monitoring is advised to ensure proper management of blood sugar levels and potential adjustments, in diabetes medication dosages may be required for maintaining stable blood sugar levels.

Potential Effects When Combined with Beta-Blockers

Using Sandostatin LAR along with beta-blockers can increase the chances of bradycardia occurring in individuals with heart issues; hence it is important to keep an eye on heart rate and make adjustments to beta-blocker doses as needed.


Risk of Altered Drug Absorption with Cyclosporine and Other Medications

Sandostatin LAR can affect gastrointestinal motility, leading to decreased absorption of medications such as cyclosporine. Therapeutic levels should be routinely assessed, and alternative formulations or dosages may be required.

Warnings and Contraindications

Conditions Requiring Caution

Gallbladder issues can be exacerbated by Sandostatin LAR because it leads to a decrease in bile flow, potentially raising the risk of developing gallstones. Patients who have existing heart conditions, like arrhythmias or heart disease need to be observed to watch for any worsening of their symptoms related to their health.

Absolute Contraindications

If someone has allergies to octreotide or any of its ingredients they should steer clear of this medication to steer clear of reactions such, as anaphylaxis.

Important Precautions

Monitoring Liver and Kidney Function During Therapy

It is important to check the functioning of the liver and kidneys since Sandostatin LAR can impact metabolic processes in individuals, with existing health issues.

Regular Blood Glucose Monitoring

Regular monitoring of blood sugar levels is advised for individuals with diabetes or those at risk of developing the condition due to its impact on glucose metabolism.

Importance of Periodic Gallbladder Ultrasounds

Gallstones often occur as a consequence. Regular gallbladder ultrasounds can be beneficial in identifying and managing biliary issues before they show symptoms.

Administration in Special Populations

Elderly Patients

Elderly individuals may experience changes in how their bodies process and eliminate medications due to age-related changes. It is recommended to adjust drug doses according to their kidney and liver function to reduce the risk of side effects.


Pregnant Women and Nursing Mothers

Safety information and suggestions are limited due, to a lack of research. It's important to be careful when considering use, especially when the benefits to the unborn child are greater than the potential risks. Animal research indicates dangers to development and breastfeeding due to octreotide use; however, its presence in human breast milk remains uncertain.

Pediatric Use

The effectiveness and safety of Sandostatin LAR in children are not fully known yet. It is advised to make dosage adjustments. Closely monitor its use, for pediatric purposes not approved by the authorities.

Overdosage and Management

Symptoms of Overdose

Excessive intake could lead to stomach issues or heart rate and sugar levels – recognizing these signs promptly is crucial.

Immediate Actions to Take in Case of Overdose

Provide care depending on the symptoms that are observed initially.

Role of Supportive Care

The patient may need treatments, like IV fluids to stabilize their condition and administer nausea medication or glucose as necessary.

Handling and Disposal Precautions

Safe Handling Guidelines for Healthcare Professionals

Healthcare professionals should follow procedures when preparing and giving Sandostatin LAR to uphold cleanliness and ensure well-being.

Disposal of Unused or Expired Medication

Make sure to get rid of any medications that you don't need or that are past their expiration date, following the instructions in your area for disposing of waste to avoid harming the environment or risking misuse.

Environmental Considerations

Improperly disposing of waste can harm the environment significantly, so it's important to adhere to regulations for eco-disposal methods.

Sandostatin LAR Injection FAQ

What is sandostatin lar used for?

Octreotide is a hormone found naturally in the body. It is utilized to manage the syndrome in individuals diagnosed with carcinoid or neuroendocrine tumors.

Is sandostatin lar chemotherapy?

Sandostatin is not classified as a form of chemotherapy; instead, it is a hormone that mimics the functions of somatostatin. A hormone naturally secreted by our hypothalamuses and various tissues like the pancreas and gastrointestinal tract, in our bodies.

What is the difference between Sandostatin and sandostatin lar?

When you receive immediate release Sandostatin, the drug is quickly released into your body upon injection. In contrast extended release Sandostatin LAR Depot releases the drug slowly into your system over time following injection.

What is the purpose of the Sandostatin drip?

Sandostatin Injection is used to lower the levels of growth hormone (GH) and insulin growth factor. That is somatomedin C in those with acromegaly who have not responded well to surgery or other treatments, like irradiation and bromocriptine mesylate, at the doses they can tolerate.

What are the benefits of Sandostatin?

It is used to treat acromegaly and bleeding variceal veins. 

What is a common side effect of Sandostatin?

Some of the side effects noted in individuals using Sandostatin to treat acromegaly consist of issues with the gallbladder, a decreased heart rate, and feelings of nausea.

What foods should I avoid while taking Sandostatin?

Steer clear of anything that could make the symptoms worse, like oily foods and spicy or acidic edibles such as lemons and tomatoes.

How long is the treatment for Sandostatin?

at least 2 weeks

Does Sandostatin shrink tumors?

There are instances where octreotide may cause a reduction in tumors; however, it does not provide a permanent cure for them.

Where is the best place to inject octreotide?

Administering medication can be done by injecting it under the skin or directly into a vein.

What is the success rate of octreotide?

67%

Does Sandostatin need to be refrigerated?

Refrigerate at 2°C to 8°C (36°F to 46°F)

How long can you use octreotide?

You can continue using octreotide as it provides relief from your symptoms without causing any adverse effects.

Does Sandostatin stop bleeding?

Sandostatin (also known as octreotide acetate) has the potential to aid in the treatment of types of gastrointestinal (GI) related bleeding by employing methods such as minimizing blood flow in the GI tract, suppressing stomach acid production, and preventing platelet aggregation.

Where to give a Sandostatin injection?

deep intramuscular injection

What is sandostatin used for?

Sandostatin is prescribed to inhibit the overproduction of growth hormones and works to decrease the levels of chemicals and proteins in your body.

What is the indication of sandostatin LAR injection?

It is prescribed for the management of diarrhea and flushing episodes linked to metastatic carcinoid tumors in patients who have responded well to and can tolerate initial treatment with Sandostatin® Injection.

What is the generic for Sandostatin?

Octreotide acetate

How do you know if octreotide is working?

If you have been diagnosed with a tumor and are undergoing treatment, for it s an octreotide scan can be used to assess the effectiveness of the treatment.

Can Sandostatin be given at home?

No

What are the benefits of sandostatin?

Sandostatin is a protein that resembles a hormone, in the body known as somatostatin. Octreotide reduces substances in the body, including insulin and glucagon (which play roles in blood sugar regulation), growth hormone, and compounds that impact digestion. Sandostatin is prescribed for the treatment of acromegaly.

What is octreotide acetate used for?

Octreotide injection is administered to address diarrhea and additional manifestations associated with intestinal tumors, such as vasoactive intestinal peptide tumors (VIPomas) or metastatic carcinoid tumors that have spread throughout the body.

How does octreotide stop diarrhea?

Octreotide is considered as a medication for helping these individuals because it can slow down movements in the system and reduce pancreatic secretions while also limiting absorption in the intestines.

What is the role of octreotide?

Addressing tumors that produce growth hormone and tumors in the gland.

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