Terbinafine HCl

Generic Lamisil

Terbinafine HCl

Terbicip, Daskil, Fungotek, Texifen


Cipla, FDC, Novartis India, Leeford Healthcare and others


1% w/w


Terbinafine HCl

I. Introduction to Terbinafine Cream

A. Overview: What is Terbinafine Cream?

Terbinafine cream is a prescribed medication for treating and getting rid of various fungal infections affecting the skin. These infections mainly include athletes' foot, jock itch, and ringworm. It is recognized for its ability to kill fungi, especially dermatophytes, while well tolerated by the body.



B. Common Brands and Manufacturers

Terbinafine, used to treat skin infections, is produced by several pharmaceutical companies and sold under different brand names. Notable among these brands are 'Lamisil' by Novartis and 'Terbinafine Actavis.' These brands have remained popular in the market because of their effectiveness in treating skin infections.

C. Role in Medical Treatments: An Antifungal Medication

Terbinafine cream plays a role in medical treatments due, to its powerful antifungal properties. It is applied externally to effectively treat infections. Its range of usage includes addressing the following conditions;

  • Nail infections (Onychomycosis)
  • Scalp ringworm (Tinea capitis)
  • Skin candidiasis
  • Yeast infections of the skin (Pityriasis versicolor).

II. Understanding How Terbinafine Cream Works

A. Antifungal Mechanism of Action

The effectiveness of terbinafine cream relies on how it works with other treatments. As a type of antifungal called an allylamine, it disrupts the production of ergosterol, an element in the membrane of fungus cells, by blocking the enzyme squalene epoxidase. Doing this leads to an increase in squalene (a substance that helps create sterols) within the fungus cell, which ultimately causes cell death and decreases the number of fungus cells.

B. Time Frame: When Does Terbinafine Start Working?

The time it takes for terbinafine cream to start working can differ from person to person. Depend on the severity of the fungal infection. Typically symptoms begin to improve during the week of treatment. However, completely getting rid of the infection may require treatment, sometimes lasting several weeks.

III. Composition of Terbinafine Cream

A. Active Ingredient: Terbinafine Hydrochloride

Terbinafine cream contains terbinafine hydrochloride as its component, which is an antifungal compound. This synthetic allylamine derivative has the formula C21H26ClN. It has a range of effectiveness, in fighting various fungal pathogens displaying fungicidal properties.

B. Inactive Ingredients and their Roles

Apart from terbinafine hydrochloride, the terbinafine cream consists of additional substances that contribute to its effectiveness and make it easier for patients to use. These substances include;

  • Sodium Hydroxide; is used to regulate the formula's pH level.
  • Benzyl Alcohol; acts as a preservative and also adds a scent to the product.
  • Sorbitan Monostearate; an emulsifier that helps maintain the consistency of the cream.
  • Cetyl Palmitate; is a skin conditioning agent that gives the cream a smooth texture.

All these inactive ingredients play roles in ensuring that the cream remains stable and user friendly and ultimately satisfies the patient's needs.

IV. Uses of Terbinafine Cream

A. Approved Uses: Treating Fungal Skin Infections

The approved uses for terbinafine cream primarily include a range of skin fungal infections, effectively getting rid of the infection and the discomfort that comes with it. It is especially useful against dermatophytes, making it a valuable treatment for the following conditions;.(1) 

1. Athletes Foot (Tinea Pedis); This fungal infection commonly occurs between the toes. Regularly applying terbinafine cream can provide relief from symptoms. Eliminate the fungal infection.(2


Athlete's foot

2. Jock Itch (Tinea Cruris). Ringworm (Tinea Corporis); Terbinafine cream is a proven treatment for these conditions. It helps get rid of the fungi causing the infection and relieves symptoms such as itching and redness(3)

3. Cutaneous Candidiasis; Although Candida is not a dermatophyte, terbinafine cream has effects against this yeast and effectively treats cutaneous candidiasis.

Terbinafine cream is a trusted option for treating skin fungal infections offering both relief from discomfort and eradication of the underlying pathogens. 

1. MayoClinic - Terbinafine cream

2. Cleaveland Clinic - Terbinafine cream

3. WebMD - Terbinafine Cream 

Jock Itch

Example of Jock Itch

B. Off-label Uses: Other Potential Benefits

Terbinafine cream, besides its approved uses, has found applications in situations where it is not officially endorsed. However, it's essential to be cautious and seek guidance when considering these uses.

Some potential benefits include treating Pityrosporum Folliculitis, a condition caused by yeast affecting hair follicles. Although terbinafine cream is not a first-line treatment, some dermatologists recommend it due to its spectrum antifungal properties.

Another condition where terbinafine cream may be helpful is Seborrheic Dermatitis, a skin condition believed to involve fungi. Its potent antifungal activity may aid in managing the symptoms.

Nonetheless, it's crucial to remember that before considering these off-label uses, medical consultation should not be ignored, and traditional treatment methods should still be prioritized.

V. Dosage and Administration of Terbinafine Cream

A. Standard Dosage Guidelines

Terbinafine cream is usually used twice a day, depending on the type and seriousness of the fungal infection. The application involves putting a layer of cream on the affected area and the skin around it. However, it is important to customize the treatment plan based on the guidance of a healthcare provider.

B. How to Apply Terbinafine Cream Correctly

To ensure the effectiveness of terbinafine cream it is important to not consider its strong antifungal properties but also its proper application. Here are the general guidelines for applying the cream

1. Thoroughly, Dry the affected area.

2. Apply a layer of the cream on and, around the infected area.

3. Gently massage the cream into the skin until it is completely absorbed.

4. Wash your hands after applying the cream to prevent the spreading of the infection.

5. Unless specifically advised by a healthcare professional, avoid covering the treated area with bandages or any occlusive dressings.

Following these steps will help ensure results when using terbinafine cream.

C. Varied Dosages: Adjustments Based on Condition

The dosage may need to be adjusted depending on the type and seriousness of the fungal infection. Typically if the infection is mild to moderate, it may be necessary to apply the medication a day. However, if the infection is severe or covers an area, it may be required to use the medication twice a day. It's important to note that the duration of treatment can also vary, ranging from one week for conditions like tinea cruris and tinea corporis up to four weeks for tinea pedis and onychomycosis.

VI. Interactions with Terbinafine Cream

A. Common Drug Interactions

Although terbinafine is primarily a medication with minimal systemic absorption it is important to be aware of certain drug interactions. Specifically the presence of substances that alter the pH of the skin such, as salicylic acid may impact the absorption of terbinafine. If you are currently using any medications, particularly other topical treatments it is advisable to consult your healthcare provider to ensure there are no potential interactions.

B. How Food and Lifestyle Can Influence Effectiveness

While the effectiveness of terbinafine cream is not directly influenced by what you eat, certain lifestyle practices can help enhance its effectiveness. For example, practicing hygiene, ensuring the infected areas are clean and dry, and wearing breathable clothes can all contribute to the treatment process and limit the spread of the infection.

C. Interaction with Other Topical Medications

It's important to be cautious when using topical medications at the same time. Some other topical agents can affect how terbinafine is absorbed weaken its concentration or make skin irritation worse. Remember to seek advice, from a healthcare professional before using terbinafine cream alongside other topical medications.

VII. Side Effects and Risks Associated with Terbinafine Cream

A. Common Side Effects

Although terbinafine cream is typically well tolerated, there are some side effects that may occur. These can include skin irritation, itching, a burning sensation, or redness at the site where the cream is applied(1). Fortunately, these side effects are usually mild and temporary. They generally go away without requiring one to stop using the medication.(2)

1. NHS - Terbinafine cream

2. Mayo Clinic - Terbinafine Cream

B. Rare, But Serious Side Effects

On occasion, certain people might encounter more severe adverse effects like intense skin rash, itchiness, swelling, pronounced dizziness or difficulty in breathing. If any of these indications arise, seeking medical assistance is crucial.

C. Understanding the Risk-Benefit Ratio

When considering the use of terbinafine cream it is important to weigh the benefits, against any risks involved. Although the cream is known to have antifungal properties and usually has minimal side effects, it is essential to be aware of rare but serious side effects. Nonetheless when used correctly and with the guidance of a healthcare professional the advantages of using terbinafine cream generally outweigh the risks when treating fungal skin infections.

VIII. Special Precautions and Contraindications

A. When Terbinafine Cream Should Be Avoided

It is important to be cautious when using terbinafine cream in situations. If you have a known sensitivity to terbinafine or any of its ingredients, it is best to avoid using this product. Additionally, it is wise to refrain from applying the cream on wounds or inflamed skin unless specifically instructed by a healthcare professional. Remember, it is always necessary to consult with a healthcare provider before starting any treatment.

B. Important Precactions Before Starting Therapy

Before beginning any treatment, it is essential to have a discussion about your complete medical background with your healthcare provider. It is important to assess any prior or current skin issues, allergies, or other systemic diseases. Additionally, it is crucial to verify that the infection in question can be effectively treated with terbinafine cream, as not all skin conditions are suitable for this medication.

C. Careful Administration: Mitigating Risks

It is not recommended to apply terbinafine cream on the face or sensitive areas like the mouth, eyes, or vagina unless specifically advised by a healthcare professional. It is essential to be careful when applying it near these areas to avoid any irritation or unintended effects on the body. Moreover, following the treatment plan diligently can help minimize the chances of experiencing any side effects and ensure the best possible results.

IX. Administration of Terbinafine Cream to Special Populations

A. Administration to Elderly Patients

Elderly individuals are advised to follow their healthcare providers' instructions regarding the use of terbinafine cream. Generally, age alone does not require any changes or precautions. However, it is important to take into account interactions with other medications and overall health conditions as is the case with any medication.

B. Use in Pregnant Women and Nursing Mothers

Although terbinafine cream is not anticipated to cause harm to babies, it is advisable to use it during pregnancy only if absolutely necessary and if the advantages outweigh any potential risks. Additionally, the extent to which terbinafine passes into breast milk remains uncertain. Hence it is recommended that nursing mothers consult their healthcare provider to thoroughly discuss the risks and benefits prior to using this medication.

C. Administration to Children: Safety and Guidelines

Terbinafine cream can be utilized for treating fungal infections in children who are at least 12 years old. However, it is important to consult a pediatrician or healthcare before commencing the treatment in younger children since its safety and efficacy in that age group have not been established.

X. Handling Overdoses and Accidental Ingestion of Terbinafine Cream

A. Identifying Signs of Overdose

Since terbinafine is used on the skin, the chance of overdosing is minimal. However, if there is ingestion or improper use, you might experience symptoms such as a headache feeling nauseous, stomach discomfort, dizziness, or having to urinate more frequently. If any of these symptoms arise due to ingestion or misuse, it's important to seek immediate medical assistance.

B. What to Do in Case of Overdose or Accidental Ingestion

If you accidentally take much or consume this substance, make sure to contact your healthcare provider right away or seek emergency medical assistance. In these situations, it's important to start treatment that addresses the symptoms and offers support.

C. Prevention Strategies for Overdose

It is important to keep it out of their reach to ensure that children do not accidentally consume or misuse terbinafine cream. It is also advisable to store the cream in its packaging, which should be clearly labeled, and use it strictly according to the instructions provided by your healthcare provider. Additionally, it is crucial to educate everyone in the household about the usage and potential risks of using this medication.

XI. Proper Storage and Handling of Terbinafine Cream

A. Ideal Storage Conditions for Terbinafine Cream

The ideal storage condition for terbinafine cream is at room temperature, between 20° to 25°C (68° to 77°F). To ensure its quality, keeping it from light and moisture is recommended. It is best to store it in a cupboard or a medicine cabinet, avoiding storage in a bathroom or any other humid area that could affect its effectiveness.

B. Shelf Life and Expiration: What You Need to Know

Terbinafine cream usually remains effective for around 2 to 3 years after it is manufactured. However, it is advisable to confirm this by checking the expiration date mentioned on the packaging. If the cream is used beyond its expiration date, it may not be as effective. It should be avoided. Disposing of expired medications is essential instead of flushing them down the toilet or drain.

C. Precautions for Handling and Disposing Terbinafine Cream

When using terbinafine cream, make sure your hands are clean and avoid getting it in your eyes. If, by chance, it does come into contact with your eyes, rinse them thoroughly with water. When you need to dispose of any expired cream, please follow the disposal instructions mentioned on the package or seek guidance from your pharmacist or a local waste disposal company. It's important not to dispose of medications in household trash, sinks, or toilets unless specifically instructed to do.

XII. Warnings and Additional Information

A. Important Warnings for Users of Terbinafine Cream

Please note that terbinafine cream is intended for use only. It's important to avoid any contact with the eyes, nose, mouth, or other areas, with membranes. If you accidentally ingest the cream, it is crucial to seek medical assistance. Additionally, if you experience burning, itching, redness, blistering, swelling, or oozing at the site of application, it is advisable to discontinue use and consult your healthcare provider, as these symptoms could indicate a severe allergic reaction.

B. Staying Informed: The Importance of Regular Doctor Consultations

It is essential to consult with your healthcare provider while using terbinafine cream. They will keep track of how you're doing, make any adjustments to your treatment if required and address any concerns or side effects you might have. Remember it is not advisable to self-medicate. Make changes to your treatment without proper guidance from a professional. It is always better to stay well informed, maintain contact with your healthcare provider, and prioritize your safety throughout the treatment process.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Lois on Apr 21, 2017 Verified Purchase

Works great!

This is the generic Lamisil Cream. It works great to clear up nail fungus!

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by Lois on Jul 9, 2015 Verified Purchase

Works good

Works good and a good price!

Note: buy-pharma.md does not imply any medical claims from this review.

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