Trezav Ped, Lamivudine/ Zidovudine/ Nevirapine

Lamivudine is used together with other anti-retroviral medicines in the treatment of HIV-1 infection and chronic hepatitis b virus (HBV) infection.

Lamivudine is a nucleoside analogue, it works by destroying CD4 helper cells and stopping the HIV virus from spreading.It blocks the action of the Reverse Transcriptase enzyme which helps the virus replicate, this results in destroying the viral HIV chain

Patients who take Lamivudine may suffer from such side effects;

Fatigue,
Headache,
Insomnia,
Dyspepsia,
Nausea,
Cramps and Abdominal pain,
Dizziness,
Ear and/or Nasal infection,
Sore throat,
Skin rash,
Muscle pain,
Fever,
Chills,
Diarrhoea

Zidovudine is an anti-retroviral which is prescribed and used in treatments for human immunodeficiency virus (HIV) infections.

Zidovudine treats HIV infections by inhibiting viral reverse transcriptase and DNA polymerases. The HIV virus needs An enzyme called RT (reverse transcriptase) to replicate its DNA in order to spread and infect more cells. Zidovudine works by blocking the reverse transcriptase, this then helps to terminate the DNA chain and prevent the virus from multiplying. Zidovudine slows down the HIV Infection progress in the body but it is not a cure.

Patients who take Zidovudine may suffer from such side effects;

Diarrhea,
Decreased appetite,
Headaches,
Sleep disruption,
Body fat abnormalities,
Digestive upset or discomfort

Nevirapine is used in the treatment to suppress the HIV virus and preventing it from infecting the immune system in the body

Nevirapine is not recomended to be used on its own, this is because that the virus can become rapidly resistant to treatment if monotherapy is used. Nevirapine as a NNRTI (non-nucleoside reverse transcriptase inhibitor) blocks the activity of the reverse transcriptase (RT) viral enzyme by biding to the NNRTI pocket on the enzyme. this directly interferes with the enzymes ability to replicate the HIV virus DNA material thus slowing down the virus from spreading. Nevirapine helps kepping the level of HIV virus as low as possible which minimizes the chance of developing AIDS in patients

Patients who take Nevirapine may suffer from such side effects;

Rash,
Headache,
Stiff muscles,
Decrease in granulocyte count,
Vomiting,
Allergic reaction,
Nausea,
Abdominal pain,
Fatigue,
Fever,
Increased liver enzymes,
Diarrhoea