Bupropion Hydrochloride SR is an antidepressant or mood elevator that is prescribed to manage depression or seasonal affective disorder. It can also help individuals stop smoking.

Generic Zyban, Wellbutrin

Bupropion Hydrochloride SR

Smoquit, Bupron, Zupion



Extended Release Tablet

150 mg, 300 mg





What is Bupropion?

Bupropion, which is sold as Wellbutrin and Zyban, is a type of antidepressant that is prescribed for treating depression and assisting with quitting smoking. It falls under the category of antidepressants, which function differently compared to other antidepressants like selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants. This distinctive medication was initially approved by the U.S. Food and Drug Administration (FDA) in 1985 for the treatment of depressive disorder (MDD). It also received approval as a smoking cessation aid named Zyban in 1997. Bupropion has been used off-label to address conditions such as ADHD, anxiety disorders, and weight management. Different subtypes of ADHD exist.


Subtypes of ADHD

How Does Bupropion Work?

Bupropion stands out from commonly used antidepressants due to its unique mechanism of action. Unlike traditional medications that primarily aim to boost serotonin levels in the brain, bupropion works by inhibiting the reuptake of two neurotransmitters: norepinephrine and dopamine. This action leads to an increase in their concentration within nerve synapses, ultimately resulting in the regulation of mood and a reduction in symptoms related to depression or nicotine withdrawal.

The Benefits of Using Bupropion

  • Treatment for Depression: Bupropion, as a type of antidepressant, can be particularly beneficial for individuals who have not responded well to other antidepressants. It can also be an option for those who experience unwanted side effects from medications like SSRIs or tricyclics, such as weight gain or sexual dysfunction.
  • Smoking Cessation: Bupropion has been proven effective in aiding individuals in quitting smoking by reducing cravings and withdrawal symptoms. This can significantly improve the chances of quitting and maintaining long-term abstinence from nicotine use.

Off-Label Uses: Although not officially approved for these purposes, bupropion has shown promise in treating conditions such as ADHD anxiety disorders and promoting weight loss. Its unique mechanism of action may benefit individuals who have not found relief with medications or treatments.

In summary, bupropion is a medication that offers various treatment options for individuals struggling with depression, nicotine addiction, and other mental health conditions. Understanding its effects and potential benefits can help people make decisions about whether this medication is right, for them. Bupropion is prescribed to address depression and other psychological health issues. Before considering its use, it's important to understand what bupropion is and how it works.

One important point to remember is that Bupropion, known as Wellbutrin and Zyban is a prescription drug that is commonly prescribed for depression and to aid in smoking cessation. What sets it apart from antidepressants is its ability to block the reuptake of norepinephrine and dopamine which helps with regulating mood. This medication can be particularly helpful for individuals who have not had success with types of antidepressants or have experienced undesirable side effects.


A woman Smoking 

What is Bupropion used for?

Bupropion is a medication prescribed primarily for the treatment of depressive disorder and to aid smoking cessation. It falls under the category of antidepressants called norepinephrine dopamine reuptake inhibitors (NDRIs), which work by increasing the levels of brain chemicals like dopamine and norepinephrine. These chemicals play a role in regulating mood, motivation, and reward systems.

Along with its uses, Bupropion has also shown effectiveness in treating other conditions off-label. Some common off-label uses include;

  • Attention Deficit Hyperactivity Disorder (ADHD): Studies indicate that Bupropion can be a treatment option for adults with ADHD who may not respond well to or tolerate traditional stimulant medications like methylphenidate or amphetamines (source).
  • Anxiety Disorders: While not officially approved by the FDA for anxiety disorders, some research suggests that Bupropion might help alleviate symptoms of anxiety disorder (GAD) when used alongside other treatments (source). However, further studies are required to validate these findings.
  • Bipolar Depression: In cases where healthcare providers may prescribe Bupropion in conjunction with mood stabilizers or antipsychotic medications for individuals diagnosed with bipolar depression (source). It's important to note that Bupropion should not be used as the treatment for bipolar disorder as it could potentially increase the risk of triggering manic episodes.
  • Weight Loss: Studies have discovered that Bupropion, when combined with naltrexone, an antagonist (source), can assist in promoting weight loss for certain individuals. This combination is available as Contrave, a branded medication. The FDA has approved Contrave for weight management in adults who are overweight or obese and have at least one weight-related health condition.

It is crucial to consult a healthcare provider for supervision before taking Bupropion. Always seek advice from your doctor before starting or changing your medication. Bupropion is a pharmaceutical used to address depression and SAD (Seasonal Affective Disorder). Aid in smoking cessation. Before determining if Bupropion is the medication for you, it's important to consider its potential side effects.

Bupropion is a prescription medication used to treat depressive disorder and help individuals quit smoking. It falls under the category of antidepressants called norepinephrine dopamine reuptake inhibitors (NDRIs), which increase neurotransmitters in the brain. While Bupropion has also shown effectiveness in treating conditions off label, it should only be done under the close supervision of a healthcare provider.


A person suffering with Anxiety

Understanding Bupropion's Mechanism of Action

Bupropion is an antidepressant medication that stands out for its mode of action, differing from other commonly prescribed options. It falls under the category of drugs known as norepinephrine dopamine reuptake inhibitors (NDRIs). Unlike SSRIs and SNRIs that primarily target serotonin and/or norepinephrine, bupropion focuses on blocking the reuptake of dopamine and norepinephrine. Acting on both neurotransmitters, it helps improve mood, boost energy levels, and alleviate symptoms associated with depression. Notably, bupropion has been observed to have an impact on sexual function compared to SSRIs or SNRIs, which makes it an appealing choice for patients concerned about this specific side effect (1).

1. NCBI - SSRI Antidepressant Medications: Adverse Effects and Tolerability

Differences from Other Antidepressants

Bupropion works differently from other antidepressants by targeting dopamine and norepinephrine instead of just serotonin. This unique mechanism of action may result in sexual side effects compared to SSRIs or SNRIs. However, in some individuals, it might lead to insomnia or agitation. In cases where initial antidepressant treatment does not yield results, bupropion is sometimes prescribed as an additional therapy. This combination approach can enhance the effectiveness of depression treatment.  

It's important to consult with a professional to determine if bupropion is a suitable option for you. Understanding how bupropion functions can help individuals make decisions about their treatment and potentially benefit from its unique advantages. Improved mood and reduced sexual side effects by targeting dopamine and norepinephrine. Discover an approach to treating depression with bupropion. Focusing on dopamine and norepinephrine for better emotional well-being while minimizing sexual side effects. 

Bupropion as an Antidepressant

Bupropion is a prescribed medication for treating depression, helping to enhance mood and alleviate symptoms. It is frequently used to address Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). In this section, we will explore the utilization of Bupropion and the potential advantages it offers to patients.

How to Take Bupropion

To ensure that Bupropion is effective, it's crucial to follow the instructions provided by your healthcare provider. This medication is available in forms, such as immediate sustained or extended-release tablets. Your doctor will determine the type and dosage based on your specific needs.

  • For immediate-release tablets, its usually recommended to take them two or three times a day with at least six hours between each dose.
  • Sustained-release tablets are typically taken twice a day with at least eight hours between doses.
  • As for extended-release tablets, they are generally taken once a day in the morning.

Remember to swallow these tablets whole without crushing or chewing them. Breaking them apart can release all the medication at once. Increase the risk of experiencing side effects.

Potential Benefits for Patients

In addition to being used as a treatment option for depression and seasonal affective disorder (SAD), Bupropion offers advantages over traditional antidepressants like fluoxetine (Prozac) and sertraline (Zoloft). These benefits include;

1. Reduced likelihood of sexual side effects; Bupropion is less likely to cause dysfunction, which is a common issue with other antidepressants.

2. Dual action mechanism: Unlike SSRIs that primarily target levels, Bupropion affects both norepinephrine and dopamine neurotransmitters. This dual action may provide comprehensive relief for some patients.

3. No weight gain: While many antidepressants are associated with weight gain, Bupropion has an impact on body weight or even promotes modest weight loss in some cases.

Research suggests that combining Bupropion with an SSRI may enhance effectiveness for individuals who have not responded adequately to either drug. It's important to consult your healthcare provider before making any changes to your treatment plan. Bupropion has proven to be a medication for treating depression and has helped many individuals manage their symptoms successfully. Furthermore, it can also be used for purposes such as smoking cessation. 

Bupropion is widely used as an antidepressant medication that effectively alleviates symptoms of depression. There are advantages to using Bupropion instead of traditional SSRIs. These include an occurrence of sexual side effects, a dual action mechanism, and the absence of weight gain. It is crucial for patients to diligently follow the instructions provided by their healthcare provider in order to maximize the effectiveness of Bupropion.

Bupropion for Smoking Cessation

Bupropion can be an aid for individuals who want to quit smoking. This versatile medication has shown its effectiveness in helping people overcome their addiction to nicotine. In this section, we will explore how Bupropion functions as a tool for smoking cessation, its success rates, and the potential advantages of combining it with approaches.

How Bupropion Helps with Quitting Smoking

The way Bupropion works to help people quit smoking is different from how it functions as an antidepressant. It targets neurotransmitters in the brain, such as dopamine and norepinephrine, to decrease cravings and alleviate withdrawal symptoms that occur when someone stops smoking. This approach makes it easier for individuals who want to overcome their addiction to nicotine.

Success Rates and Studies

Clinical trials have shown that the use of Bupropion can significantly increase the chances of quitting smoking compared to taking a placebo or receiving no treatment. Based on a study that analyzed research findings, it was found that smokers who used Bupropion were approximately twice as likely to quit compared to those who did not receive any pharmacological assistance.

  • In terms of short-term success, research indicates that 44% of participants who took Bupropion were able to abstain from smoking after seven weeks, whereas only 19% in the placebo group managed to do the same.
  • When considering long-term success, it was observed that after one year, 23% of individuals who used Bupropion remained smoke-free, whereas only 12% in the placebo group achieved this outcome.

Combining Bupropion with Other Smoking Cessation Aids

To improve your chances of quitting smoking, it is often suggested to combine Bupropion with methods for quitting. One popular approach is using nicotine replacement therapy (NRT) like patches or gum. This combination has shown to be more effective than using either method in helping people quit smoking for good.

Additionally, receiving support such as counseling or joining a support group can further enhance the effectiveness of Bupropion treatment. By combining the psychological aspects of quitting smoking, you significantly increase your odds of achieving long-lasting abstinence. Bupropion has been found to be helpful in aiding those who are trying to quit smoking. It may also reduce the likelihood of a relapse. It is worth mentioning that Bupropion is also commonly used for treating Attention Deficit Hyperactivity Disorder (ADHD).

Bupropion is a medication proven to be effective for quitting smoking by reducing cravings and withdrawal symptoms associated with cessation. Clinical studies have demonstrated that combining Bupropion with cessation methods, like nicotine replacement therapy (NRT) or behavioral support, can greatly improve the chances of successfully quitting smoking both in the short term and long term.

Bupropion for ADHD Treatment

While Bupropion is commonly prescribed as an antidepressant, it has also shown results in treating Attention Deficit Hyperactivity Disorder (ADHD) in adults. Its use for this condition, even though not officially approved, presents advantages when compared to conventional ADHD medications.

Off-Label Use and Effectiveness

Research has indicated that Bupropion has the potential to enhance concentration, attention, and self-control in adults with ADHD. Numerous individuals have reported improvements in their symptoms upon commencing treatment with Bupropion, although its effectiveness may vary from person to person.

Comparison to Traditional ADHD Medications

The medications frequently prescribed for ADHD are stimulants like Ritalin (methylphenidate) and Adderall (amphetamine). While these drugs can be quite effective, they do carry some side effects, such as increased heart rate, elevated blood pressure, and a risk of addiction. On the other hand, Bupropion is a nonstimulant medication that offers relief from symptoms with fewer associated risks. This makes it an appealing choice for individuals who may have difficulty tolerating or prefer not to take medications.

Potential Benefits for Adults with ADHD

Bupropion, an antidepressant primarily used to treat ADHD in adults, offers advantages compared to traditional stimulant medications. One major benefit is its occurrence of side effects. Unlike stimulants, Bupropion carries a risk of addiction and is not classified as a controlled substance. Additionally, for adults with ADHD who also experience depression or anxiety, Bupropion can provide relief for both conditions simultaneously.

Another advantage is the ease of access to Bupropion as it does not require the level of complexity in obtaining a prescription compared to stimulant medications. This makes the treatment process more accessible and convenient for patients. If you believe that Bupropion may help manage your ADHD symptoms, it's important to consult your healthcare provider to discuss benefits and risks specific to your circumstances. Your doctor can guide you in using Bupropion after considering any potential side effects and reviewing safety data associated with the medication.

In summary, Bupropion proves more effective in treating ADHD among adults while offering side effects than traditional stimulant medications. Using Bupropion for purposes other than those approved by the FDA may have some advantages, including fewer adverse effects and a lower risk of addiction compared to conventional stimulant drugs used for treating ADHD. However, it's important to consult with healthcare to evaluate whether Bupropion is suitable for your individual requirements.

Important Safety Information

Before embarking on your journey with Bupropion, it is vital to familiarize yourself with the side effects, potential risks, contraindications, and drug interactions that may be associated with this medication. Being aware of the benefits and hazards linked to Bupropion is crucial for creating a safe and effective treatment plan.

Common Side Effects

Bupropion can sometimes lead to side effects that typically lessen as your body gets used to the medication. These may include a mouth, headaches, feelings of nausea or vomiting, dizziness or lightheadedness as well as sweating or experiencing hot flashes. You can find a comprehensive list of potential side effects of Bupropion here.

Serious Side Effects and Risks

In instances, Bupropion can sometimes cause more serious side effects that require immediate medical attention. Some examples of these effects include seizures ( in patients who have a history of seizures) allergic reactions such as rash or swelling and changes in mood that may include thoughts of self-harm. If you'd like to learn more about the risks associated with using Bupropion you can visit the following link, for a comprehensive list.

Contraindications and Drug Interactions

Not everyone may be suitable for taking Bupropion as certain medical conditions or medications could increase the chances of complications. Some factors to consider include a history of seizures or eating disorders allergies to Bupropion or its ingredients, and other contraindications that can be found in detail elsewhere. It's crucial to inform your healthcare provider about medications you're currently using, as Bupropion may interact with them. For instance, combining Bupropion with monoamine oxidase inhibitors (MAOIs) can result in side effects. Before starting treatment with Bupropion, it's important to keep in mind the safety information associated with it. 

Bupropion Dosage and Administration

When beginning the Bupropion medication, it is essential to adhere to the prescribed dosages and guidelines given by your healthcare provider. This ensures that you obtain the advantages of the medication while also minimizing any possible adverse effects. In this section, we will discuss the recommended dosages for situations, provide tips, on safely taking Bupropion, and explain how to adjust your dosage over time.

For treating Major Depressive Disorder, it is recommended to take 150 mg daily in the morning. Your doctor may adjust this dosage based on how you respond to the treatment and your tolerance level. The maximum daily dose should not exceed 450 mg. When it comes to quitting smoking, patients usually start with a dose of 150 mg once daily for three days before increasing it to twice daily (totaling 300 mg). However, please remember that these are guidelines. It's always important to consult with your healthcare provider about dosing instructions that suit your specific needs.

Tips for Taking Bupropion Safely

It's important to take Bupropion at the time each day, ideally in the morning or as instructed by your doctor. This helps ensure that the medication remains at a level in your body. While using Bupropion, it's advisable to avoid consuming alcohol as it can potentially increase feelings of drowsiness or dizziness. If you happen to miss a dose, take it promptly unless it's close to bedtime or almost time for your scheduled dose. In some cases, skip the missed dose and continue with your regular dosage routine.

Adjusting Dosage Over Time

It is crucial to note that your healthcare provider may make adjustments to your Bupropion dosage over time, considering factors such as side effects, effectiveness, and any changes in other medications you may be taking. It is important to adhere to their instructions and never alter the dosage without consulting them first. If you experience side effects or notice no improvement after a few weeks of treatment, it is imperative to discuss potential adjustments in dosage or alternative medications with your doctor. They may suggest modifying the dosage or trying a medicine if necessary. Please remember that the information provided here is for purposes only and should not replace professional medical advice from a qualified healthcare provider.

Always consult your doctor before starting any medication or making changes to existing prescriptions if you are interested in purchasing Bupropion hydrochloride (Wellbutrin XL). Before proceeding with the purchase of Bupropion, it is crucial to consult your healthcare provider for dosage instructions and administration guidelines. To ensure dosing, here's a guide on obtaining Bupropion through authorized means. 

How to Buy Bupropion Safely and Legally

If you're thinking about using Bupropion hydrochloride to treat depression quit smoking or manage ADHD it's important to ensure that you obtain the medication in a legal manner. This article will provide guidance on how to receive a prescription for Bupropion from your healthcare provider. The first step in acquiring Bupropion is to obtain a prescription from your doctor. Schedule an appointment with your physician to discuss your symptoms and determine if Bupropion is the choice, for you. Your doctor will carefully review your history and current medications before prescribing the appropriate dosage.

Verifying the Authenticity of the Medication

It is important to ensure that the Bupropion medication you purchase is genuine, as counterfeit drugs can be harmful to your health. Here are some tips to help you verify the authenticity of your Bupropion purchase:

1. Check the packaging; Look for any signs of tampering or counterfeit products, such as misspelled labels or unusual colors and textures.

2. Research the manufacturer; Go and find information about the drug manufacturer. Compare their contact details with the information provided on your medication package.

3. Consult your healthcare provider. If you have any concerns about a medication, it's always best to consult with your doctor before taking it.

By following these steps and consulting with your healthcare provider, you can ensure that you safely and legally acquire Bupropion for treating depression, smoking cessation, or ADHD symptoms. It is essential to adhere to procedures and obtain a valid prescription from a reputable pharmacy accredited by organizations like NABP before taking any medication.

What are the side effects of Bupropion usage?

Bupropion, similar to any medication, has the potential to cause various side effects. It is crucial to be informed about these side effects and have a discussion, with your healthcare provider before starting the treatment. In this section, we will address both more severe side effects that can occur with the use of Bupropion.

Common Side Effects

Reported side effects of Bupropion include dry mouth, difficulty sleeping or insomnia, nausea or vomiting, headaches, dizziness or feeling lightheaded, an increase in heart rate (tachycardia), muscle pain (myalgia), and excessive sweating (hyperhidrosis). If you happen to experience any of these symptoms while taking Bupropion, it is crucial to inform your healthcare provider. They may need to consider adjusting your dosage or suggesting treatments.

Serious Side Effects and Risks

In some instances, some patients may experience more severe reactions to Bupropion. These reactions can include responses such as hives, rash, itching, and swelling in the face tongue, throat, lips, eyes, hands, feet, ankles, or lower legs. If any of these symptoms arise along with hoarseness or difficulty breathing or swallowing it is crucial to seek medical attention. If you are considering taking Bupropion medication it is important to have a discussion with your healthcare provider about the risks and benefits associated with it. Bupropion hydrochloride is the component found in Wellbutrin XL medication which is commonly prescribed for treating depression and seasonal affective disorder.

FAQs in Relation to Buy Bupropion

Can I Buy Bupropion Online?

Certainly, it is possible to buy Bupropion from a reputable pharmacy. 

Why Was Bupropion Taken Off the Market?

In 1986 there were worries about seizures at doses, which led to a temporary withdrawal of Bupropion from the market. However, after conducting research and making necessary dosage adjustments it was reintroduced in 1989 with safer guidelines for usage. Today Bupropion is still accessible as a treatment option, for depression, smoking cessation and ADHD when properly supervised by medical professionals.

Can I Buy Bupropion Over the Counter?

No, you cannot purchase Bupropion without a prescription. It is a medication that can only be obtained with a prescription from your healthcare provider. It is important to consult with your doctor to ensure that it is safe and effective for your condition. Always follow the recommendations provided by your doctor when using this medication.

Is Wellbutrin Going to Be Discontinued?

Currently, there are no plans or signs of Wellbutrin (Bupropion) being discontinued. Doctors worldwide still prescribe it as a medication for treating depression. If there are any changes in its availability or production status in the future, regulatory agencies, like the FDA, will likely provide updates.

Buy Bupropion with Buy Pharma Today!

Bupropion is a medication that is commonly used to treat depression, aid in smoking cessation, and manage ADHD. It functions by increasing the levels of dopamine and norepinephrine in the brain. Although it may have some side effects like mouth and difficulty sleeping, it is generally well tolerated. It is crucial to consult your doctor before starting Bupropion to ensure its suitability for you. Your doctor will also provide guidance on dosage and administration instructions. If you're interested in purchasing Bupropion legally online, you can visit Buy Pharma. They offer a range of medications at reasonable prices with fast shipping options. Don't let cost or convenience hinder you from obtaining the treatment – consider buying Bupropion today!

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Dr J on Feb 12, 2016 Verified Purchase

Bupriopion is 5 star

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Note: buy-pharma.md does not imply any medical claims from this review.

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