Calcitriol Capsule

Calcitriol is a man made form of Vitamin D. Calcitriol is administered to control the parathyroid hormone and the level of minerals in the body that are required for building and maintaining strong bones.

Calcitriol, Calcijex, Rocaltrol.


Bio D3, Rocaltrol


Nicholas Piramal, Macleods Pharma, Abbott


0.25 mg


Calcitriol Capsule

1. Introduction to Calcitriol Capsule

Overview of Calcitriol

Calcitriol, the active form of Vitamin D3, is crucial for maintaining optimal calcium levels in the human body. It plays a role in aiding the absorption of calcium in the intestines, regulating calcium storage in bones, and controlling the excretion of calcium by the kidneys.

Importance in Calcium Regulation

Maintaining the balance of calcium is essential for keeping our bodies functioning properly, such as ensuring our muscles and nerves work well, regulating blood pressure, and controlling hormone release. Calcitriol plays a role in maintaining the correct levels of calcium and phosphate in our blood, which are important, for strong bones and overall cell function.

2. Composition of Calcitriol Capsules

Active Ingredients

The main ingredient found in Calcitriol capsules is calcitriol, which is artificially produced to replicate the hormone that naturally exists in the body.

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Inactive Ingredients and Excipients

Ingredients like lactose monohydrate microcrystalline cellulose and magnesium stearate are commonly used in products.

3. Pharmacological Action: How Calcitriol Works

Mechanism of Action in the Body

Calcitriol attaches to the vitamin D receptor (VDR) found in tissues throughout the body, initiating the transcription and activation of genes that regulate calcium and phosphate uptake. This process boosts calcium absorption from both the gut and kidney tubules, ultimately improving bone mineralization.

Role in Calcium and Phosphate Metabolism

Calcitriol regulates phosphate levels and supports bone health and nerve function. It works hand in hand with calcium to ensure a balanced state. By lowering hormone levels, it plays a key role in keeping serum phosphate levels stable.

4. Uses of Calcitriol Capsules

Primary Indications: Managing Hypocalcemia in Patients with Hypoparathyroidism and Renal Osteodystrophy

5. Off-Label Uses of Calcitriol

6. Dosage and Administration

Standard Dosing Guidelines

The usual doses of Calcitriol vary between 0.25 mcg to 0.5 mcg per day, depending on the levels of serum calcium and how the patient reacts.

Adjustments for Specific Patient Populations

Patients with kidney issues or those taking medications that impact how the body processes vitamin D, may need to have their doses modified.

7. Administration to Specific Groups

Elderly Patients: Dosing and Risks

Elderly individuals might need reduced amounts of Calcitriol because of their declining kidney function and increased risk of developing hypercalcemia.

Pregnant Women and Nursing Mothers: Safety and Recommendations

Calcitriol plays a role in the development of fetal bones, but it should only be administered to pregnant women and nursing mothers under careful medical guidance to prevent potential risks of hypercalcemia.

Pediatric Use: Age-Specific Dosing and Precautions

Children with long-term kidney issues require precisely measured amounts of Calcitriol to avoid stunted growth and promote healthy bone growth.

8. Common Side Effects of Calcitriol Capsules

List of Frequent Adverse Effects

  • Nausea
  • Headache
  • Dizziness
  • Dry mouth
  • Muscle pain

Management of Side Effects

Side effects are usually controllable by adjusting the dosage or providing treatment for symptoms. It is crucial to monitor blood calcium levels to reduce potential risks.

9. Serious Side Effects and Adverse Reactions

Identifying Serious Complications

Calcitriol regulates calcium levels and bone health, but careful monitoring is required to avoid harmful side effects. Adverse reactions like calcium levels in the blood, calcification of blood vessels, and kidney problems can arise if not managed properly. Symptoms to watch out for include nausea, extreme fatigue, sensory issues, and irregular heartbeats.

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When to Seek Medical Attention

Getting help immediately is important if you notice any severe side effects. Make sure to see a doctor if you have ongoing or intense symptoms like heart palpitations, feeling confused, or showing signs of kidney issues such as less urine production.

10. Interactions with Other Medications

Impact of Other Drugs on Calcitriol Efficacy

Taking medications at the same time may affect the effectiveness of calcitriol. For example, corticosteroids can lower calcium absorption, while thiazide diuretics can raise the chances of hypercalcemia by decreasing the amount of calcium excreted in urine.

Calcitriol’s Effect on Other Medicinal Agents

On the side, Calcitriol has the potential to influence how other medications work, especially bisphosphonates, possibly enhancing their impact on bone density.

11. Warnings and Precautions

Contraindications: Conditions and Factors

Patients who have levels of calcium or are sensitive to vitamin D should avoid using calcitriol. It is also not recommended for individuals showing signs of vitamin D overdose or increased levels of calcium in their blood.

parathyroid hormone and calcitriol 1 25 dihydroxyvitamin d


Important Safety Information for All Users

Regularly monitoring all individuals for indications of high calcium levels, kidney function, and blood electrolyte levels is crucial to prevent any harm. It is essential to modify medication doses according to these laboratory findings and the patient's reaction.

12. Special Considerations and Warnings

Hypercalcemia Risk and Management

To effectively manage the risk of hypercalcemia, it's crucial to monitor both dietary and medication-related calcium intake while regularly checking serum calcium levels. Modifying the dosage of Calcitriol should be done according to these measurements to avoid the complications that can arise from hypercalcemia.

Monitoring Requirements for Long-term Use

Regular monitoring of bone strength, kidney function, and electrolyte levels is essential when using Calcitriol over a period. This helps avoid issues, like softening of the bones and excessive calcium buildup in the kidneys, and ensures that the treatment continues to work.

13. Overdosage Information

Signs and Symptoms of Overdose

Excessive intake of Calcitriol may result in high levels of calcium in the body, causing symptoms such as nausea, fatigue, drowsiness, and irregular heartbeats. Prolonged overdosing can trigger the accumulation of calcium in tissues, potentially leading to calcification in blood vessels and organs.

Emergency Procedures and Treatments

In case of an overdose, it's crucial to seek medical assistance. Treatment options may involve administering fluids, diuretics, corticosteroids, or bisphosphonates to address levels of calcium in the blood while closely monitoring heart and kidney functions.

14. Storage and Handling of Calcitriol Capsules

Remember to store calcitriol capsules in a dry place at room temperature and away from sunlight to keep them effective and prevent them from deteriorating. Make sure to seal the containers to shield them from any potential contamination.

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