Diclofenac Gel

Diclofenac Gel is a topical nonsteroidal anti-inflammatory drug used to alleviate certain joint pain caused by osteoarthritis.

Generic Voltaren


Cofenac, Volini

15 g, 30 g, 50 g

Cipla, Ranbaxy and other generic brand




Diclofenac Gel


Few medications in the field of pharmacology have captured as much attention and praise as Diclofenac. This drug, classified as a steroidal anti-inflammatory (NSAID), has a rich history that dates back to the early 1960s, filled with scientific curiosity and continuous advancements. The significance of Diclofenac in today's landscape cannot be emphasized enough. Its effectiveness is demonstrated through its availability in forms, with the gel formulation being especially notable.


Exploring the composition of Diclofenac Gel reveals a combination of ingredients, each playing a crucial role in the effectiveness of this medication. These key components blend together harmoniously to provide effects sought by countless patients worldwide.

  • Diclofenac Sodium, as the active ingredient, acts as a strong NSAID that inhibits enzymes responsible for producing inflammation-mediating chemicals called prostaglandins within the body.
  • Polysorbate is commonly used as an emulsifier in this gel, ensuring consistency and guaranteeing that each application delivers a dose of Diclofenac Sodium.
  • Carbomers serve as thickening agents giving the gel its viscosity and making it easy to apply and adhere to the skin.
  • Propylene Glycol, known for its moisturizing properties, helps retain moisture and enhances the skins ability to absorb the medication effectively.
  • Alcohol facilitates evaporation upon application, to the skin, leaving behind the essential active ingredients to work their therapeutic magic.

To fully grasp Diclofenac gel potency, it is crucial to recognize the role played by each ingredient. While Diclofenac Sodium takes the stage in tackling inflammation, its supporting cast ensures that the formulation remains homogeneous, consistent, and capable of penetrating effectively. This careful arrangement turns Diclofenac Gel into a tool to combat pain and inflammation.

Uses of Diclofenac Gel

Diclofenac Gel, a variation of the well-known class of non-steroidal anti-inflammatory drugs (NSAIDs), has established its own unique position in the vast field of contemporary medical treatments.(1)

1. Mayo Clinic - Diclofenac Gel 

Gel application

Gel application

Approved indications: Pain and inflammation relief

When discussing the approved uses of Diclofenac Gel, the main focus is on its ability to relieve pain and reduce inflammation. It is highly regarded for its qualities, including; (1)

1. Targeted Relief; By applying the gel to the affected area, it provides precise relief and reduces discomfort.

2. Minimal Systemic Impact: As a treatment, it minimizes the potential side effects that oral medications may cause by limiting exposure to other parts of the body.

3. Quick Action: The gel matrix ensures absorption providing prompt relief to affected areas.

Among the nonsteroidal anti-inflammatory drugs (NSAIDs) types, Diclofenac Gel showcases therapeutic innovation by combining effectiveness with safety.

1. NHS - Diclofenac

Comparison with other forms of Diclofenac

The therapeutic journey of Diclofenac has been marked by formulations, each with its unique qualities when compared to forms; The gel form offers several distinct benefits.

  • Targeted Application: Unlike versions like tablets, the gel provides localized treatment, focusing its effects on the specific area of concern.(1)
  • Reduced Gastrointestinal Concerns: Oral Diclofenac has been linked to issues. However, the gel bypasses this pathway, minimizing potential problems.
  • Flexibility in Treatment: The tactile nature of the gel allows patients to adjust the amount they use based on the severity of their symptoms.

While each form of Diclofenac plays a role in therapy, the exceptional advantages of the gel highlight its growing popularity among both healthcare professionals and patients.

1. Medline Plus - Diclofenac Topical (arthritis pain)

Off-label Use

In the field of pharmaceuticals although there are specific guidelines for using each medication doctors often explore the use of drugs beyond their officially approved purposes.

This unconventional practice involves using a drug for conditions that regulatory agencies haven't officially supported. Diclofenac Gel, known for its effectiveness in managing pain and inflammation has also been subject, to this trend.

Situations where Diclofenac Gel is used outside of official guidelines

Diclofenac gel's versatility extends beyond its uses. It has been explored in scenarios, including;

1. Relieving Muscle Soreness after Exercise: Athletes and fitness enthusiasts have found this gel helpful in easing discomfort following intense physical activity.

2. Managing Osteoarthritis Flare-ups; Although primarily intended for pain, some healthcare professionals recommend it for occasional flare-ups in chronic conditions like osteoarthritis.

3. Addressing Neuropathic Pain; There are reports suggesting its effectiveness in managing neuropathic pain, which is typically treated with antineuropathic medications.

While these applications may differ from the expected uses they highlight the gel's versatility and adaptability.

Evidence supporting these off-label uses

Entering the realm of off-label use is not a decision but is often based on empirical evidence though sometimes it may be preliminary. Regarding Diclofenac Gel;

  • Clinical Observations: Over time, healthcare professionals have recorded cases where patients experienced relief from conditions that are not officially listed as indications for the gel.
  • Small scale Studies; Certain academic explorations, with limited sample sizes have shed light on the potential benefits of using Diclofenac Gel in off label situations.
  • Testimonials; The abundance of stories that praise the gels effectiveness in unconventional circumstances adds another aspect to the growing body of evidence.

Although off-label use is still in its stages and accumulating knowledge, it is precisely this courage to venture into uncharted territories that often leads to groundbreaking discoveries in the field of medicine.

How It Works

Understanding how medications work in the body is crucial for comprehending their effectiveness and the details surrounding them. Diclofenac Gel is no different. Grasping its mode of operation can shed light on its significant role in managing pain and inflammation.

Mechanism of action in the body

Diclofenac Gel works by targeting and inhibiting enzymes in the body, particularly cyclooxygenase (COX). This action helps reduce the production of prostaglandins which are chemical messengers that cause inflammation and pain.

As a result, the gel effectively reduces inflammation in the affected area. Offers relief by modulating pain sensations.

Absorption and effectiveness of gel formulation

The gel matrix used in Diclofenac plays a role in achieving effective absorption. By applying it to the affected area, we can ensure that the medication is delivered precisely where it is needed, maximizing its therapeutic benefits while minimizing any potential side effects throughout the body.

Moreover, the gel formulation contains ingredients that facilitate effective penetration of Diclofenac into the layers of the skin. This ensures that the medication is absorbed efficiently and reaches its target effectively. Overall, this approach strikes a balance between effectiveness and safety, making the gel formulation highly praiseworthy.

Dosage and Administration

To maximize the advantages of using Diclofenac Gel, it is crucial to follow the recommended instructions ensuring both safety and effectiveness, in its use.

For pain, apply a specified quantity, typically about the size of a dime, to the affected area up to 3 to 4 times per day. When experiencing flare-ups of osteoarthritis, the recommended dosage may vary depending on the severity. Intermittent application is often advised.

Proper method of application

To achieve the outcomes, it is recommended to softly massage the gel onto the area that requires treatment making sure to cover it completely. It is advisable to wash your hands after applying the gel unless you are treating your hands themselves.

Duration and frequency of use

Consistency is important. It's crucial to use it as directed. However, if you need to use it for more than the recommended two weeks for conditions, it's advisable to consult a medical professional.

Side Effects

Similar, to any product Diclofenac Gel despite its benefits may have certain side effects. Being aware of these can help individuals make choices and take prompt actions if needed.

Overview of potential side effects

The effects of Diclofenac Gel can range from temporary reactions, to more serious but uncommon complications.

Differentiation between common and rare side effects

Common; These include skin reactions such as redness, itching, or a localized rash. Usually, these reactions go away on their own when you stop using the gel.

Rare: There are uncommon effects that can occur if the gel is absorbed unintentionally. If you experience symptoms like gastrointestinal discomfort, dizziness, or respiratory problems, it's important to seek medical attention.

Although the side effects are generally not harmful, it's crucial to be watchful and promptly address any symptoms.

Common Side Effects

Like any medication, Diclofenac Gel has its own set of side effects despite its impressive therapeutic abilities. Being aware of and identifying these effects is crucial for ensuring the possible outcomes for patients.

List and brief description

  • Skin Reactions: This can include redness (erythema), itching (pruritus), and the appearance of localized hives (urticaria).
  • Sensitivity to Sunlight: Increased sensitivity to sunlight which can make sunburns more likely.
  • Dryness in Specific Areas: This may cause the skin to flake or peel at the location where the product was applied.

Management and mitigation strategies

The key to managing side effects is being proactive and addressing them in a timely manner. Here are some strategies that can help alleviate discomfort;

Take care of your skin. Applying moisturizers or emollients can help with dryness and relieve itching.

Protect yourself from the sun; Make sure to apply sunscreen. Wear protective clothing to prevent photosensitivity reactions.

Adjust your dosage: With a professional's guidance, adjusting the application frequency can often lessen the severity of side effects.


Sometimes when you take medications together, they can unexpectedly affect each other. In the case of Diclofenac Gel some drugs can change how it works or cause reactions.

Medications and substances that may interact with Diclofenac Gel

Using nonsteroidal anti-inflammatory drugs (NSAIDs) at the same time can increase the chances of experiencing gastrointestinal or cardiovascular side effects. Diclofenac may reduce the effectiveness of medications used to manage blood pressure. Drinking alcohol can worsen the risk of developing complications.

Recommendations for concurrent use

In situations that require the coordinated efforts of individuals, being attentive and customizing routines can have a significant impact.

  • Optimizing dosage; With guidance from a healthcare provider, medication doses can be fine tuned to reduce risks.
  • Consistent monitoring; By checking vital signs such as blood pressure, any potential adverse interactions can be detected ahead of time.


Being aware of situations that require caution when using Diclofenac Gel can be crucial, in preventing severe complications. It's always better to be prepared and informed in advance.

Situations where extreme caution is advised

Individuals who have had heart conditions should be cautious when using NSAIDs due to the possible risks to their cardiovascular health. Similarly for those, with a history of ulcers or bleeding it is important to be vigilant as the gel may worsen these issues.

Cases of severe adverse reactions reported

Although uncommon, there have been incidents where individuals experienced serious complications such as Stevens-Johnson syndrome, a severe skin reaction, and anaphylaxis, a potentially life-threatening allergic reaction. It is crucial to seek medical assistance in these situations.


There are situations or circumstances where using Diclofenac Gel is not just unadvisable but potentially dangerous. People who have a known allergy or hypersensitivity to Diclofenac or its components should avoid using it. Additionally, after surgeries, particularly coronary artery bypass graft surgery, it is not recommended to use Diclofenac Gel.

Careful Administration

Within the range of patients, there are certain groups that require additional care and attention when considering the application of Diclofenac Gel.

Precautions to take for specific populations or conditions

During pregnancy, it is important to consider and consult with a medical professional before using Diclofenac Gel, especially in the later stages.

For the population, caution is advised due to the potential for reduced kidney function in older individuals.

If there are existing hepatic conditions, dose adjustments may be necessary as the metabolic pathways could be affected.

Regular monitoring or tests required

Liver and kidney function tests, along with periodic evaluations of the heart, are crucial, for individuals who are undergoing long-term treatments or have additional risk factors.

Important Precautions

To effectively utilize Diclofenac Gel, it is crucial to understand the necessary precautions. This knowledge not only improves the effectiveness of treatment but also skillfully avoids any potential risks or problems.

Environmental factors affecting use (e.g., sun exposure)

Exposing the area where the application is done to sunlight can increase the chances of experiencing sensitivity reactions. Therefore it is advisable for users to take the following precautions; Protect the treated area from radiation for a minimum of 12 hours after applying. If sun exposure is unavoidable, apply sunscreen with a sun protection factor (SPF). Refrain from using tanning booths and other sources of ultraviolet light.

Applying Sunscreen

Applying Sunscreen

Activities to avoid while using the gel

To maximize the effectiveness of the treatment and avoid any issues it is recommended to follow these guidelines;

  • After applying the medication, it is best to wait before swimming or taking a bath to allow for proper absorption.
  • It is advisable to avoid activities that may lead to sweating as it can dilute the medication and reduce its effectiveness.
  • Unless instructed by a healthcare professional it is not recommended to use dressings or bandages on the area where the medication was applied.

These precautions are essential, for ensuring therapeutic benefits and minimizing any complications.

Administration to Specific Groups

Using an approach for everyone is not always the best option. Paying attention to the requirements of different demographics can have a significant impact.

Taking care of the elderly, who often deal with weakened organ function and take medications, requires careful attention. Here are some important things to consider; Start with a dosage since their kidney function may be reduced. Regularly check their kidney and liver function to prevent any complications. Be cautious to avoid worsening any existing conditions they may have, such as hypertension or gastrointestinal issues.

Pregnant Women and Nursing Mothers: Safety profile, risks, and guidelines

The significant changes that occur in a woman's body during pregnancy and breastfeeding require consideration. Here are the important points to keep in mind;

  • It is important to use Diclofenac Gel, especially in the later stages of pregnancy as it may pose risks to the developing fetus.
  • Before using this medication while breastfeeding it is crucial to consult with a healthcare professional due to the possibility of it being excreted into breast milk.
  • Always weigh the benefits of using this treatment against any potential risks with a primary focus on ensuring safety, for both the unborn baby and newborn.

Children: Safety concerns, age restrictions, and dosage recommendations

The pediatric population, with its changing physiology, requires guidelines for dosing and precautions. Make sure to use the appropriate dosage based on the child's age, weight, and the severity of their condition. Avoid using it in children below a certain age unless absolutely necessary and under the supervision of a pediatrician. Keep an eye out for any reactions or side effects because pediatric physiology can be dynamic.

Over Dosage

Taking more than the suggested amount, whether, by accident or not can result in a range of complications.

Symptoms of overdose

The signs that someone may be experiencing an overdose can vary from mild to obvious. These signs may include symptoms of stomach discomfort like feeling sick, throwing up, or having pain. Other signs could involve issues with the system, such as feeling dizzy, having headaches, or feeling disoriented. In some cases, individuals might also experience difficulties with breathing or have a decreased drive to breathe.

Immediate steps to take

When someone appears to have taken much of a substance, it's crucial to act quickly to potentially save their life—first stop using the product. Then seek medical help by either going to the emergency room or contacting a poison control center. It's important to provide care such as keeping them hydrated and monitoring their vital signs. These actions are of importance, in such situations.

Long-term complications

While it is crucial to provide care some complications may persist over a longer period, which could lead to possible damage, to the kidneys or liver. Therefore regular checkups and monitoring are essential.


Proper storage is crucial, for maintaining the quality and effectiveness of Diclofenac Gel.

Proper storage conditions for Diclofenac Gel

To ensure that the gel remains effective for therapy, it should be kept under the following conditions: Store it at room temperature, avoiding excessive heat or cold. Keep it in its container, protecting it from direct light. Place it out of the reach of children and pets to avoid ingestion or application.

Shelf life and signs of expired or compromised product

It is important to avoid using a compromised product as it can reduce the benefits and even be harmful. Always make sure to check the expiration date before applying. Also be cautious of any changes, in consistency, color, or odor as these may indicate that the product has degraded. If you notice that the gel is separated or contains particulate matter, it is best to discard it.

Handling Precautions

Although Diclofenac Gel provides a solution, for ailments it is important to handle it with care and finesse.

Instructions for safe handling and disposal

To prevent exposure or environmental contamination, make sure to wash your hands thoroughly before and after applying the gel. Be careful not to let the gel come into contact with unintended areas. Dispose of tubes or containers according to local regulations making sure they don't end up in regular waste. Also, be cautious around flames or any sources of ignition since certain ingredients in the gel could potentially catch fire.

Washing Hands

Washing Hands

Precautions to avoid contamination or misuse

It is crucial to maintain the integrity of the product. Always make sure to close the tube after using it to avoid any contamination. Avoid sharing the product with family members as this can lead to cross contamination. Keep it out of reach of children. Educate them about its medicinal properties to prevent accidental misuse.

Rated: 4.8 / 5 based on 4.8 customer reviews.

Posted by schmidt on Apr 5, 2020 Verified Purchase

good stuff

great for pain

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by Mack on Dec 19, 2019 Verified Purchase

Helps with joint pain

This ointment is great for joint pain on my hands and elbows, without having to take oral medication.

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by schmidt on Aug 10, 2019 Verified Purchase

voltarn gel

great for any pain

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by schmidt on Oct 22, 2018 Verified Purchase

Diclofenac Gel

great stuff this is 1/4 the price in the usa

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by Dave on Jul 9, 2017 Verified Purchase

Works as well as us product

Works as well as US prescription products. Applies the same, smells the same, gives the same inflammation reduction as US product. at a small fraction of the cost compared to US prescription products

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by kenneth on Apr 25, 2017 Verified Purchase

Relieves the pain

I use it 3-4 times a day on my thumb, and it helps a lot. This product works well on arthritic joints in between cortisone shots, or for those with milder pain who do not take injections.

Note: buy-pharma.md does not imply any medical claims from this review.

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