Dipyridamole is used in the treatment of stroke prevention. Dipyridamole is also used to prevent blood clots after heart valve replacement surgery.
How it Works
Dipyridamole helps to prevent platelets in the blood from sticking together and forming a blood clot. Dipyridamole helps to prevent a thrombus forming in an artery, which will reduce the risk of a heart attack or a stroke.
Common Side effects
Some of the potential side effects of Dipyridamole can include the symptoms below; Headache, Flushing of face, Chest pain Gallstones Tightness or swelling of neck Yellow eyes or skin Dizziness, Nausea, Diarrhoea, Decreased blood pressure.
Dipyridamole tablet acts as adhesion of platelet inhibitor chemically helps in platelet treatment but the contrivance of action was not yet known for its significance. It acts on the red blood cell to take up adenosine which considers itself working as an inhibitor on reactivation of platelet, inhibition of phosphodiesterase contributing to increase the 5'-adenosine monophosphate, within platelets, thromboxane A2 formation inhibition- a potent stimulator of platelet activation and cyclic-3'. In scientific studies, platelet reactivity is believe with good interface on cardiac valve prosthetic surfaces that results to lessen the platelet time of survival. This is the important element which plays an important role in thromboembolic complications that exists in connection of the prosthetic heart valve replacement and the Dipyridamole was also discovered as the length of abnormal shortening of the platelet life span in the survival of the dose medicine in a manner of introducing it to the patient. The three random control clinical trials involve the 854 patients who have undergo the surgical operation in replacement of their prosthetic heart valve, it's there that dipyridamole is combined with warfarin medication alone. The occurrence of such thromboembolic tendencies among patients who receive the combination of warfarin and dipyridamole ranges from 1.2% to 1.8% base on the result. There it revealed that 392 patients using coumarin-like anticoagulants, and dipyridamole also shown that thromboembolic occurrence is ranging from 2.3 %to 6.9%.
Dipyridamole tablet with a generic Persantine is greatly characterized with powder colored yellow crystalline powder. It is dissolvable in alcohol, methanol and even in chloroform. This medicine is moderately soluble in water and a little bit soluble in ethyl acetate and acetone. Every dipyridamole tablet is intended for the oral treatment on which each has 25 mg or 50 mg or 75 mg of this dipyridamole. Moreover, each tablet also contains several inactive ingredients which are magnesium stearate, corn starch, hypromellose, lactose monohydrate, polyethylene glycol, iron oxide yellow, titanium dioxide and povidone.
Dipyridamole tablets are used as an indication like an accompany medicine to coumarin which is an anticoagulants to prevent the postoperative thromboembolic impediments on replacement of cardiac valve.
Dosage and administration
The standard dose for patient is 75 mg to 100 mg required for 4 times day together with the normal medication of warfarin therapy. Do not use to administer aspirin for coumarin anticoagulants concomitant.
Strong hypersensitivity to this drug is greatly disallowed for patients who have chronic conditions and allergies on the active contents of this product as well as to its other related components.
Proper precautions must be done with patients who have hepatic insufficiency, coronary artery disease, and hypotension.
Some side effects which can be experienced by patients such as dizziness, abdominal distress, rash, urticaria, headache, and angioedema, larynx edema, severe bronchospasm, malaise, fatigue, myalgia, nausea, arthritis, dyspepsia, hepatitis, paresthesia, alopecia, thrombocytopenia, hypotension, cholelithiasis, tachycardia and palpitation.
Make sure that medicine is inside the controlled room storage temperature which must need a 68