Xarelto is used for the prevention of blood clots formation due to irregular heartbeat or after surgery. Xarelto is an anti-coagulant that works by blocking clotting proteins in the blood.




7, 28, 56

Bayer Pharma


2.5 mg, 10 mg, 15 mg, 20 mg

India, Turkey



Origin and Development of Xarelto

Xarelto, also known as Rivaroxaban, emerged as a groundbreaking development in the field of pharmaceuticals. It was created in the laboratories of Bayer AG and gained significant recognition in the early 2000s. The drug underwent pharmacological research and clinical trials before receiving FDA approval.

Role in Modern Medicine

Xarelto has become highly regarded in medical treatments. Its effectiveness in preventing blood clotting has made it an essential tool for doctors worldwide. Additionally, its flexible pharmacodynamics make it superior to previous medications in this field.

Uses of Xarelto

Prevention of Deep Vein Thrombosis (DVT)

Deep Vein Thrombosis (DVT) is a condition where blood clots form in the veins and can be very dangerous, even leading to fatal pulmonary embolisms 1Xarelto is an anticoagulant medication that has been extensively shown to effectively decrease the occurrence of DVT, particularly after orthopedic surgeries 2It is recommended by renowned medical institutions for its role in preventing DVT 2.

Here are the references for the above content:

1: National Heart, Lung, and Blood Institute 2Xarelto

Stroke Prevention in Atrial Fibrillation

Atrial Fibrillation, a heart condition, dramatically increases the chances of a stroke. Xarelto effectively works by focusing on clotting factors reducing the likelihood of a stroke. It also provides a treatment plan compared to other blood thinners.

Treatment of Pulmonary Embolism

If deep vein thrombosis (DVT) is left untreated, it can lead to Pulmonary Embolism, which can be fatal. Xareltos' unique pharmacokinetics plays a role in its effectiveness by quickly dissolving blood clots that block the blood vessels in the lungs. This helps alleviate symptoms like difficulty breathing and chest pain and ensures a faster recovery.

How Xarelto Works

Mechanism of Action

Xarelto functions as an inhibitor of factor Xa. It hinders the conversion of prothrombin into thrombin, thereby preventing the formation of fibrin clots and maintaining the blood flow.

Distinction from Traditional Anticoagulants

Xarelto is practical and stands out due to its distinctive way of working. Unlike anticoagulants like Warfarin, which need regular blood monitoring, Xarelto provides a consistent anticoagulation response without the need for dietary restrictions.

Dosage and Administration

The dosage for Xarelto varies depending on the condition being treated. For preventing vein thrombosis (DVT), the recommended dose is 10mg once daily. In cases of fibrillation, the suggested amount is 20mg once daily. Initially, a higher dose of 15mg twice daily is prescribed for embolism, which is then gradually reduced to a maintenance dose of 20mg per day.

Adjustments for Specific Populations

Certain population groups may require dosage adjustments. The dose should be reduced for individuals with impairment according to their estimated glomerular filtration rate (eGFR) values. For patients, starting with lower dosages and adjusting them gradually based on their tolerance levels is advisable.

Proper Techniques for Administration

To maximize the desired outcome, following the recommended instructions for taking this medication is essential. It is advised to take it with food as it helps with better absorption. Do not. Split the tablet. Also, take it at the same time every day for consistent dosing.


Active Ingredients

Rivaroxaban continues to be the ingredient, in Xarelto, providing its anticoagulant solid effects.

Inactive Ingredients and Fillers

Xareltos composition consists of additives that improve its stability and ability to be absorbed by the body. Some used ones are microcrystalline cellulose, lactose monohydrate, and magnesium stearate.

Different Forms and Concentrations

Xarelto is a medication that comes in different forms. You can find it in tablet form with varying strengths of 10mg, 15mg, and 20mg. Additionally, there are suspensions available for individuals who may have difficulties swallowing.

Side Effects

Immediate Side Effects

Starting Xarelto can potentially cause the following side effects: Experiencing temporary headaches and Feeling dizzy.

Long-term Side Effects

Although uncommon, long-term use may result in Liver problems, blood levels, and Kidney issues.

Common Side Effects

Gastrointestinal Disruptions

Many patients often mention experiencing dyspepsia, abdominal cramps, and episodic diarrhea or constipation.

Bleeding Risks

Due to its blood thinning properties, there is an increased chance of experiencing the following: bruising, Bleeding for a longer duration from minor cuts, and Gum bleeding.

Fatigue and Weakness

After taking the medication, certain people may feel a lack of energy and occasional muscle discomfort.

Off-label Uses of Xarelto

Emerging Clinical Trials

Initial studies suggest that Xarelto may have a role in managing conditions such as heart failure and certain types of cancers.


Rivaroxaban in Chronic Heart Failure with Reduced Ejection Fraction: Rationale and Design of the ROCKET-AF Trial.

Rivaroxaban for the Prophylaxis of Venous Thromboembolism in Patients with Active Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial.

Rivaroxaban for the Prevention of Stroke in Patients with Advanced Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial.

Patient Testimonials and Case Studies

There have been stories and personal accounts that praise the benefits of Xarelto in conditions that are not officially approved. While these anecdotes may lack evidence, they highlight potential uses beyond their intended indications.

Safety Concerns and Considerations

Prescribing medications for off-label use requires an evaluation of the risks and benefits. Healthcare providers need to consider the interactions with other drugs and the unique reactions each patient may have.

Interaction with Other Drugs

Known Drug Interactions

When Xarelto is taken together with medications, its effectiveness can be affected. These medications include aspirin or clopidogrel, NSAIDs such as ibuprofen or naproxen, and other anticoagulants like warfarin or heparin. Combining these drugs can increase the risk of bleeding.

Foods and Beverages to Avoid

Certain foods can affect how Xarelto is processed in the body. Consuming grapefruit or related products can enhance its effects while drinking alcohol can increase the risk of bleeding. It's essential to be mindful of what and how much you consume.

Over-the-counter Medications and Supplements

Some counterproducts might affect how Xarelto works in the body, even though they may seem harmless. These include St. Johns Wort, with Omega 3 acids and Vitamin K supplements. It is advisable to consult with a professional before using them with Xarelto.

Warnings and Precautions

Bleeding Risks

Due to its blood thinning effects, Xarelto can increase the likelihood of bleeding. If you notice bruising, prolonged bleeding from injuries, or blood in your urine, it could be a sign of more severe complications. It's essential to seek medical attention in such situations.

Procedures and Surgeries

Before proceeding with procedures, it is crucial to inform the surgeon about the administration of Xarelto. Consider pausing or reducing the dosage based on clinical judgment. This helps prevent any bleeding complications during and after the surgery.

Monitoring and Follow-Up Requirements

Regular medical checkups ensure the treatment is tailored to your needs. These evaluations include tests to assess your blood clotting ability and kidney and liver function measurements to determine the dosage.


Specific Medical Conditions

There are situations where it is not recommended to use Xarelto. These include when someone is experiencing bleeding, has untreated high blood pressure, or has other medical conditions that increase the risk of bleeding.

Allergic Reactions

Patients with a known sensitivity to Xarelto or its components should avoid using it. Allergic reactions can vary from hives to severe reactions.

Careful Administration

Monitoring Blood Levels

Although Xarelto doesn't require intensive monitoring as warfarin, there may be certain circumstances, such as renal impairment, where blood tests are necessary to maintain therapeutic levels.

Adjustments Based on Liver and Kidney Function

Hepatic or kidney problems can affect how Xarelto is broken down in the body. Depending on the function of these organs, it may be necessary to make changes to the dose of Xarelto, such as reducing or extending the time between doses.

Important Precautions

Activities to Avoid

Participating in activities that risk causing trauma, such as contact sports or mountain climbing, should be approached with care. Minor injuries can result in excessive bleeding.

Recognizing Symptoms of Complications

It is crucial to stay alert and cautious about complications. If you experience dizziness, bleeding blood, urine, or unexplained bruises, it is essential to seek immediate medical attention.

Administration to Specific Populations

Elderly: Adjustments and Monitoring

Elderly individuals, due to changes in how their bodies respond to medications, may require dosage adjustments. It is crucial to monitor them, particularly for any bleeding-related incidents.

Pregnant Women and Nursing Mothers: Safety Profile

The safety of Xarelto during pregnancy or while breastfeeding is still unclear. It may be prudent to weigh the risks and benefits and consider other treatment options.

Children: Clinical Data and Recommendations

The use of Xarelto in patients is based on limited clinical data. It should only be prescribed for conditions and always under close medical supervision.


Recognizing Symptoms of Overdose

Consuming much Xarelto can lead to concerning signs of bleeding, including visible blood loss, vomiting blood (hematemesis), or passing black tarry stools (melena).

Immediate Management and Treatment

Swift medical intervention has the potential to prevent consequences. Being admitted to the hospital, receiving treatment, and administering targeted antidotes, like andexanet alfa, can effectively reverse its impact.

Storage Guidelines

Optimal Storage Conditions

To ensure that Xarelto remains effective, it should be stored at room temperature and protected from direct sunlight.

Shelf Life and Expiry

Following the expiration date is essential to ensure the medication remains effective. Using it after it expires might not be ineffective but could lead to unexpected side effects.

Disposal of Expired Medication

It would be best if you disposed of expired Xarelto according to the guidelines set by authorities for pharmaceutical waste. This is important to protect the environment and prevent ingestion.

Handling Precautions

Safe Handling and Dispensing

It is recommended to remove Xarelto tablets from their packaging when you are ready to take them. This helps maintain their quality and reduces the chances of contamination.

Protection from Environmental Factors

Exposing Xarelto to heat, humidity, or freezing temperatures can impact its effectiveness. Storing it in a controlled environment from these fluctuations is crucial to maintaining its therapeutic properties.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Nichols on Feb 13, 2020 Verified Purchase


The customer service from Buy Pharma has been amazing!  They have answered any of my questions in a timely manner and very clearly!

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Posted by LouM on Nov 24, 2019 Verified Purchase

Superior Medication

Several months ago I was diagnosed with DVT in my leggs.  That means blood clots everywhere in both legs.  This is the only medicine my Hemotologist would let me take.  No warfarin or any other drug in the family of blood thinners.  I'm very happy on this medication, its very stable compared to warfarin.  Other family members take warfarin and must be tested weeklt or monthly.  Xarelto is #1.

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by Lou on Oct 31, 2019 Verified Purchase

Fantastic price and quality

Perfect, The price is right!

Note: buy-pharma.md does not imply any medical claims from this review.

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