Rasagiline

Rasagiline is used for the treatment of the symptoms of Parkinson's disease such as shakiness and difficulty in moving. Rasagiline is an MAO inhibitor, it works by increasing the levels of neurotransmitters such as serotonin and dopamine in the brain

Generic Azilect

Rasagiline

Rasalect

50

Sun Pharma

Tablet

0.5 mg, 1 mg

India

Rasagiline

I. Introduction

Brief Overview of Rasagiline

Rasagiline is a drug known for its ability to inhibit monoamine oxidase B (MAO B). This remarkable medication is primarily used to help manage the symptoms of Parkinsons' Disease.

FDA-approved Indications

The FDA has approved rasagiline for the treatment of Parkinsons' Disease, either as a therapy or in combination with other medications such, as levodopa.

Importance of Rasagiline in Medical Treatment

The introduction of rasagiline has brought about a change in the way Parkinsons' Disease is managed. It has improved motor control. Helped reduce fluctuations in the condition of patients.

Scope of the Article

This detailed article explores the facets of rasagiline, including its applications, potential side effects, recommended dosages, and contraindications.

II. Uses of Rasagiline

FDA-Approved Uses

Parkinson's Disease Management

Rasagiline is a monoamine oxidase type B (MAO-B) inhibitor that can be used as monotherapy or adjuvant therapy to levodopa in Parkinson’s disease (PD) 1. According to a retrospective case-control study, long-term use of MAO-B inhibitors resulted in a significant reduction in levodopa requirements and a lower frequency of dyskinesias in patients with PD. Selegiline and rasagiline had equal efficacy in controlling motor symptoms in PD patients on optimized therapy 1.

1: Cereda, E., Cilia, R., Canesi, M., Tesei, S., Mariani, C. B., Zecchinelli, A. L., & Pezzoli, G. (2017). Efficacy of rasagiline and selegiline in Parkinson’s disease: a head-to-head 3-year retrospective case–control study. Journal of Neurology, 264(6), 1254-1263. Link

Monoamine Oxidase Inhibitor

Rasagiline is a monoamine oxidase type B (MAO-B) inhibitor 1 that can be used as monotherapy or adjuvant therapy to levodopa in Parkinson’s disease (PD) 2. According to a retrospective case-control study, long-term use of MAO-B inhibitors resulted in a significant reduction in levodopa requirements and a lower frequency of dyskinesias in patients with PD. Selegiline and rasagiline had equal efficacy in controlling motor symptoms in PD patients on optimized therapy 2.

MAO-B is an enzyme that breaks down several chemicals in the brain, including dopamine. An MAO-B inhibitor makes more dopamine available to the brain, which can modestly improve many PD movement symptoms 1. Rasagiline’s MAO-B inhibitory activity causes an increase in extracellular levels of dopamine in the striatum. The elevated dopamine level and subsequent increased dopaminergic activity are likely to mediate rasagiline’s beneficial effects seen in models of dopaminergic motor dysfunction 3.

2: Cereda, E., Cilia, R., Canesi, M., Tesei, S., Mariani, C. B., Zecchinelli, A. L., & Pezzoli, G. (2017). Efficacy of rasagiline and selegiline in Parkinson’s disease: a head-to-head 3-year retrospective case–control study. Journal of Neurology, 264(6), 1254-1263. Link 1: Parkinson’s Foundation. (n.d.). MAO-B Inhibitors. 

Off-Label Uses

Depression Management

According to some doctors, rasagiline can be used as an additional treatment option for patients struggling with resistant depression, although it is not officially approved by the FDA for this purpose1.

1: For more information, please refer to this article on JAMA Network.

Other Neurological Disorders

Research is being conducted to investigate the effectiveness of rasagiline in treating neurological conditions such as restless legs syndrome and multiple system atrophy 12.

1: Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation. Springer. Link 2: In a randomized trial, rasagiline did not alter clinical disease progression in multiple system atrophy. Rasagiline is one of several monoamine oxidase inhibitors that have been proposed as possible disease-modifying therapies for Parkinson disease (PD). NEJM Journal Watch. Link

III. How Rasagiline Works

Mechanism of Action

MOA in Parkinson’s Disease

The primary way that Rasagiline works is by blocking the MAO B enzyme. This causes dopamine levels in the space between nerve cells to increase, which helps with communication, between them.

MOA in Off-Label Uses

The specific processes involved in off-label uses are still unclear, although certain studies indicate a mode of action, through the enhancement of serotonin levels.

Metabolism and Excretion

The liver primarily breaks down Rasagiline. Then eliminated from the body through the kidneys.

IV. Composition of Rasagiline

Active Ingredient

Rasagiline mesylate serves as the component in rasagiline.

Inactive Ingredients

Typically, these ingredients may consist of substances, like mannitol and colloidal silicon dioxide.

Available Formulations

Rasagiline is commonly found in strengths as oral tablets.

V. Dosage and Administration

Standard Dosages

Dosage for Parkinson's Disease

The typical recommended dosage usually falls between 0.5 and 1 milligram, per day.

Dosage for Off-Label Uses

For uses that are not officially approved the recommended dosage may vary depending on the doctors judgment. Is usually lower.

Methods of Administration

Oral Tablet

Rasagiline is mostly given in the form of tablets.

Combined Therapy

In instances rasagiline is employed as part of combination therapy alongside other medications, for the treatment of Parkinsons disease.

Missed Dose Protocols

If you happen to miss a dose it's an idea to take the medication as soon as you can unless its almost time, for your next scheduled dose.

VI. Side Effects of Rasagiline

Common Side Effects

Gastrointestinal Issues

Many patients frequently experience feelings of queasiness and discomfort in the abdomen.

Neuropsychiatric Symptoms

There have been reported instances of sleeplessness and feelings of unease.

Serious Side Effects

Serotonin Syndrome

This is a situation that requires urgent medical attention.

Hypertension

There have been observations of higher blood pressure levels, especially in overdose cases.

Managing Side Effects

Adjusting the dosage and providing treatment for symptoms are management practices.

VII. Interaction with Other Drugs and Substances

Drug-Drug Interactions

Antidepressants

Taking agents can increase the likelihood of developing serotonin syndrome.

Hypertensive Agents

Taking rasagiline together with antihypertensive medications may lead to an increase in blood pressure levels.

Food and Alcohol Interactions

Although there aren't interactions, with food, it's essential to avoid consuming alcohol as it can worsen the potential side effects.

VIII. Warnings and Contraindications

Absolute Contraindications

Allergic Reactions

Patients who have a known allergy or sensitivity to the drug rasagiline should not take it.

Certain Medical Conditions

Patients who have previously experienced medical conditions such, as liver disorders should exercise caution.

Relative Contraindications

Liver Disorders

Patients with liver damage need to be monitored.

Other Neurological Conditions

Individuals with neurological disorders must seek guidance from a healthcare professional.

IX. Careful Administration and Important Precautions

Monitoring Parameters

Blood Pressure

Regularly checking blood pressure is not a good idea but essential as rasagiline has the potential to cause high blood pressure. Using a blood pressure monitor is recommended, especially when starting the medication and adjusting the dosage.

Neurological Status

Regular neurological assessments are necessary to evaluate the effectiveness of the medication and identify any adverse effects, on the nervous system.

Safety Protocols

Periodic Tests

It is essential to conduct thorough laboratory evaluations, which should include tests to assess liver function and complete blood counts.

Consultation with Healthcare Providers

To avoid any consequences or potential issues with drug interactions, it is highly recommended to have regular discussions, with healthcare professionals.

X. Special Populations

Administration to Elderly Patients

Dosage Adjustments

When it comes to adults, it may be necessary to carefully adjust medication doses because their bodies may process and distribute drugs differently due to changes, in their physiology.

Monitoring

Given the increased likelihood of outcomes in this particular group, it is crucial to maintain close monitoring and surveillance.

Administration to Pregnant Women and Nursing Mothers

Risk Category

Rasagiline falls into a pregnancy risk category that is not clearly determined, so it should be used with caution during pregnancy and breastfeeding.

Recommendations

Healthcare providers are responsible for carefully considering the advantages and risks before prescribing rasagiline in these situations.

Administration to Children

Safety and Efficacy

Considering the amount of definitive information available regarding the use of rasagiline, in children, the safety and effectiveness of this medication still remain uncertain.

Dosage Guidelines

If the medication is given, it is essential to adjust and customize the dosages based on the specific requirements of each patient. Typically it is advisable to start with doses, within the recommended range.

XI. Overdose Management

Symptoms of Overdose

Typical signs of an overdose can include high blood pressure, serotonin-related symptoms, and severe disturbances in mental health.

Immediate Steps for Management

It is crucial to stop taking the medication to provide symptom relief and seek urgent medical advice in drug overdose cases.

Long-Term Consequences

The consequences of an overdose can have lasting effects impacting both the neurological and cardiovascular systems, with potential long-term complications.

XII. Storage and Handling Precautions

Optimal Storage Conditions

The medication must be kept in a container at average room temperature and away from sunlight and moisture to ensure its effectiveness, as a medicine.

Disposal Protocols

It is recommended to dispose of any medication that's unused or expired by following the medication disposal guidelines provided by the FDA. The preferable method of disposal is through participation in a take-back program.

Guidelines to Prevent Contamination and Degradation

Always make sure to close the container after administering the medication. Avoid transferring tablets to containers that are not the original ones.

Rated: 4.5 / 5 based on 4.5 customer reviews.

Posted by 建华 on Jun 27, 2018 Verified Purchase

Rasagiline is effective

The disease is controlled.

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by Dingrm on Mar 1, 2018 Verified Purchase

Nice

Fast shipping, nice product

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by 王 on May 16, 2017 Verified Purchase

very well

The product is good,shipping is soon

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by 和 on Apr 21, 2017 Verified Purchase

The curative effect

Have buy many times, curative effect is good!

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by haoping on Apr 12, 2015 Verified Purchase

effective

This tablet is effective for relieve symptom. It would be great if the casing of the tablets be improved for easy to tearing.

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by haoping on Mar 26, 2015 Verified Purchase

helpful

The function of this generic medicine is almost same as the real one. and the price is cheaper than that. so, it is very helpful. It would be great if the packaging could be improved for mor easy to tearing.

Note: buy-pharma.md does not imply any medical claims from this review.

Customers also bought

Popular Products

Similar Product