Eflornithine HCl Cream is prescribed for the reduction of unwanted facial hair in women. It can also be used to minimize unwanted hair under the chin.


Eflornithine Hcl

Eflora Cream

15 g

Sun Pharma


13.9% w/w



I. Introduction

Eflornithine is an example of pharmaceutical advancement rooted in a fascinating history of medical progress. This exceptional compound, first discovered in the mid-20th century, has become a treatment option for various conditions. By delving into its structure, one can uncover a complex blend of molecules carefully arranged to highlight its unique chemical composition and special characteristics.

Brief history of Eflornithine

The story of Eflornithine began in the 1970s when experts first discovered its potential. Originally developed as a treatment for cancer, it unexpectedly showed effectiveness in fighting against the Trypanosoma parasite leading to a direction in its use for medical purposes.

Chemical composition and properties

Chemical Formula; C6H12F2N2O2 Molecular Mass; 182.17 grams per mole Characteristics; Eflornithine, commonly known by its brand names such as Vaniqa, appears as a powdery substance with a slightly off-white color. It dissolves in water and has limited solubility in methanol. Its chemical composition is carefully designed to ensure absorption and effectiveness.

II. Uses of Eflornithine

From enhancements to life-saving treatments Eflornithine's uses in medicine are diverse. Its range of applications demonstrates its versatility and significant impact.

Primary indications: hirsutism and African trypanosomiasis

Eflornithine has shown effectiveness in managing hirsutism, which can cause distress due to unwanted facial hair in women. It works by inhibiting the enzyme ornithine decarboxylase, which helps reduce hair growth and brings a sense of normalcy to those affected. Additionally, it plays a role in fighting African trypanosomiasis, also known as sleeping sickness. Preventing the growth of Trypanosoma brucei gambiense offers hope to those who suffer from this disease.


1Eflornithine: Mechanism of Action, Uses, Side effects, and Contraindications 2Eflornithine: Uses, Interactions, Mechanism of Action - DrugBank Online 3Eflornithine - Wikipedia 4Eflornithine: MedlinePlus Drug Information

Benefits in dermatological care

Apart from hair growth, dermatologists have praised the benefits of Eflornithine in treating other skin conditions. While it may not be its use, its ability to inhibit cell proliferation has shown promise in addressing specific dermatological concerns making it a valuable tool in skincare treatments.


1Eflornithine topical Uses, Side Effects & Warnings - Drugs.com 2Eflornithine Cream | Vaniqa Australia - Skin Plus Compounding Pharmacy 3Topical Eflornithine Facial Hair Inhibitor Cream - OKDERMO Skin Care 4Eflornithine (Vaniqa) Skin Cream: Uses & Side Effects - Cleveland Clinic 5Eflornithine: A Novel Therapeutic Option for Actinic Keratosis - PubMed : Eflornithine: A New Treatment for Photoaging - PubMed

The role in parasitic disease management

Eflornithine's effectiveness in combating the Trypanosoma parasite is genuinely exceptional. It does not serve as a treatment but also plays a vital role in preventing potential infections, making it a crucial component in managing parasitic diseases.


1Eflornithine | drug | Britannica 2Eflornithine - Wikipedia 3CDC - African Trypanosomiasis - Resources for Health Professionals 4Human African trypanosomiasis: Treatment and prevention 5African trypanosomiasis - Data From: Focus Medica. 6Safety and effectiveness of first line eflornithine for Trypanosoma …

III. How Eflornithine Works

Eflornithine plays a role, in the complex dance of biochemistry, showcasing its unique ways of working and highlighting its diverse range of uses.

Mechanism of action in hirsutism

By blocking the actions of the enzyme ornithine decarboxylase in hair follicles, Eflornithine slows down hair growth on a cellular level. This focused method ensures that there is absorption into the bloodstream resulting in improved outcomes while minimizing any unwanted side effects.

Anti-parasitic action: Inhibiting enzyme activity in parasites

When dealing with the Trypanosoma parasite, Eflornithine takes an approach. This drug disrupts the polyamine biosynthetic pathway that is essential for the survival of the parasite, ultimately causing its downfall.

IV. Dosage and Administration

Administering Eflornithine calls for a balance between accuracy and flexibility, depending on the specific use and characteristics of the patient.

Hirsutism treatment usually involves the application of a cream twice a day. For trypanosomiasis, the recommended approach is an intravenous infusion. The dosage may vary depending on the severity of the condition and the patient's weight.

Forms available: cream, injectable, etc.

Eflornithine offers a range of treatments designed for medical purposes. Whether it's a cream for hirsutism or a solution, for sleeping sickness there are various formulations available to address specific clinical needs.

Instructions for application and intake

To achieve the outcome, it is crucial to follow the given instructions carefully. When applying the cream make sure your skin is clean and dry and avoid getting it near your eyes or any mucous membranes. On the hand when using the injectable form it's essential to have a healthcare professional administer it, with great care and attention.

V. Composition

When you delve into Eflornithine, you uncover a combination of ingredients that work together to provide outstanding therapeutic benefits.

Active and inactive ingredients

While Eflornithine is the component responsible for its effectiveness, it is supported by other inactive ingredients such as ceteareth 20 and glycerin. These additional constituents play a role in improving the stability and application process of the medication.

Pharmaceutical form and characteristics

Whether it's the texture of its topical version or the apparent clarity of its injectable variation, Eflornithine's different forms, as medication, are designed to maximize how well it is absorbed by the body and to make it easier for patients to use as instructed.

VI. Storage

It is important to follow strict storage protocols to ensure that Eflornithine remains effective as a treatment. These protocols not protect its potency but also prevent any potential degradation.

Ideal storage conditions for potency

Eflornithine prefers to be kept in a dry place away from direct sunlight. The best temperature range for it is 15 25°C. It's important to make sure that the environment is not humid, as this can affect its composition and quality.

Shelf life and expiration

Eflornithines stability is evident in its ability to remain effective for years. However, conducting inventory checks and utilizing the medication promptly after it expires is crucial, as its therapeutic benefits may decrease over time.

VII. Interaction with Other Drugs

Like planets in a vast galaxy, drugs tend to attract each other, resulting in either beneficial effects or disastrous interactions. Eflornithine is not an exception to this rule, as certain medications can impact its effectiveness and safety characteristics.

Common drugs that may interact with Eflornithine

When using Eflornithine creams with retinoids, it is possible to experience stronger skin reactions in the treated area. Similarly, antiparasitics may require dosage adjustments due to interactions with other medications.

Implications of concurrent administration

When Eflornithine interacts with medications, it can change how it works as a treatment. While some combinations enhance its effectiveness, others may cause effects highlighting the importance of careful monitoring.

It's always better to be prepared than caught off guard. To avoid any issues with drug interactions, you must have a comprehensive review of your medications and regular checkups with your healthcare provider. Additionally, share all your medicines, including any over-the-counter products or supplements. It's crucial for your well-being.

VIII. Side Effects

Every therapeutic intervention comes with the potential for both adverse outcomes. Despite being a source of hope for many, Eflornithine is not immune to this reality. It is essential to pay attention and stay vigilant, about its side effects even though they are mostly harmless.

Overview of potential adverse reactions

From skin reactions to more systemic severe symptoms, Eflornithine can cause various adverse effects. Patients may commonly experience redness, a stinging sensation, or tingling when using topical forms of the medication. However, although uncommon, it's essential to acknowledge that severe reactions are still possible.

Distinction between common and rare side effects

Although most people may experience side effects, like skin irritation or a rash a very small number may face more uncommon symptoms. These could involve allergic reactions or systemic effects, mainly if the medication is used in ways that go beyond its intended use. These differences highlight the significance of educating patients and seeking medical attention when necessary.

IX. Common Side Effects

The journey of using Eflornithine for purposes is generally smooth though it may occasionally come with some common side effects. While most of these reactions are harmless, they still deserve attention.

List of frequent side effects

Erythema; When the skin temporarily turns red and feels warm. Burning; Sometimes, there could be discomfort after applying the product, especially if it's topical. Rash; In some cases, the skin may become itchy. Have a raised texture. Dryness; The area where the product is applied might experience dryness.

Management and mitigation strategies

A balanced combination of proactive measures and after-the-fact handling can alleviate these side effects. This involves using moisturizers for the skin or temporarily stopping the use of the product until symptoms improve. Additionally, conducting a patch test before applying it entirely could be a move to prevent possible reactions.

X. Off-label Use

Eflornithine flexibility has sometimes extended beyond its approved uses leading to its application in, off label circumstances.

Emerging research and potential benefits

The world of science is full of studies exploring the potential of Eflornithine in new areas. Early research suggests that it could be helpful for more than treating excessive hair growth and sleeping sickness. Even though they are still in their early stages, these promising directions indicate that the drug may have a wide range of therapeutic uses.


1Eflornithine: MedlinePlus Drug Information 2eflornithine: Uses, Taking, Side Effects, Warnings - Medicine.com 3Eflornithine hydrochloride | DermNet 4Eflornithine: Indications, Side Effects, Warnings - Drugs.com 5Eflornithine - Wikipedia

Risks and considerations

Venturing down the road requires careful consideration. While there may be advantages, there are also risks to consider. Due to the availability of solid evidence in these specific areas, both healthcare professionals and patients should approach such utilization cautiously and equipped with thorough evaluations of the potential risks and benefits involved.


110 Facts about road safety - World Health Organization (WHO) 2The Health Costs and Benefits of Living Near Roads, Highways, and Light Rail - PRB 3How Does Transportation Affect Public Health? | FHWA

XI. Warnings

Although Eflornithine has proven to be a treatment option, it is essential to consider a few caveats. When used in prolonged situations there are precautions that need to be taken into account.

Potential risks associated with prolonged use

Extended usage could increase the likelihood of skin reactions. In more uncommon cases, systemic side effects. Additionally, the possibility of developing resistance, especially when dealing with infections, cannot be ignored entirely.

Situations where Eflornithine should be used with caution

Patients who already have skin conditions, weakened systems, or are taking specific medications may require a more cautious approach when administering Eflornithine. In these situations, it becomes essential to monitor their condition.

XII. Contraindications

The realm of pharmacology is full of complexities. Eflornithine is not exempt from that. Although it can cure many, some circumstances and characteristics define its limitations.

Please refrain from using Eflornithine or its components if you have a history of hypersensitivity or allergic reactions. Additionally, avoid applying the medication to open wounds or infected areas. It is also essential to consult with healthcare before using Eflornithine if you have severe liver or kidney problems.

Patient profiles to consider

Children, pregnant women or breastfeeding, and individuals taking multiple medications simultaneously require a careful approach, often leaning towards being more cautious or avoiding specific actions.

XIII. Careful Administration

Administering Eflornithine may appear simple. It requires careful attention to prevent any unexpected incidents.

Ensuring correct dosage and monitoring

It is essential to follow the recommended dosages and regularly have checkups to avoid any potential problems. Additionally educating patients so that they can identify and promptly report any unusual symptoms is crucial.

Recognizing signs of misuse or overdose

Sometimes if someone experiences worsening of side effects or develops new and unusual symptoms, it could indicate that they have been misusing or taking too much of something. In these situations, it's essential to seek medical help.

XIV. Important Precautions

With precautions in place, the use of Eflornithine for therapeutic purposes can be effective and safe.

Necessary patient monitoring during treatment

Regular appointments with your healthcare provider are crucial, particularly when starting treatment. These visits help assess the effectiveness of the therapy and ensure any possible side effects are identified and addressed promptly.

Adjustments based on patient response

Being too rigid in therapy can often lead to less than results. Sometimes it's necessary to adjust the dosage based on how individuals respond or if new side effects arise. These adjustments help ensure that therapy is optimized for outcomes.

XV. Administration to Special Populations

The therapeutic landscape of Eflornithine is quite diverse. When it comes to administering it to different populations, customized considerations are necessary.

Elderly: Adjustments and concerns specific to older adults

The elderly population, with their physiological characteristics, may experience increased sensitivity to Eflornithine. It is crucial to reduce the dosage and closely monitor their response. Additionally, considering the possibility of medications in this age group, it is essential to be vigilant about potential drug interactions.

Pregnant Women and Nursing Mothers: Potential risks, benefits, and considerations

When considering using Eflornithine during pregnancy or breastfeeding, assessing the potential risks and benefits is essential. Although no evidence of it causing birth defects, we cannot assume it is entirely safe. Therefore, its use in this group should be limited to situations where there are medical reasons and when safer alternatives are unavailable.

Children: Safety profile and dosage adjustments

The field of pediatrics, with its changing drug absorption and metabolism rates, requires individualized approaches to dosing. Although generally safe, it is essential to remain vigilant for side effects and regularly reassess the appropriate dosage.

XVI. Overdosage

Although it is uncommon, it is possible to overdose on Eflornithine. Recognizing the warning signs and taking action can prevent serious consequences.

Recognizing signs of Eflornithine overdose

Apart from intensifying the recognized adverse effects taking too much of a medication can lead to broader symptoms such as feeling lightheaded, experiencing digestive issues, or even having changes, in awareness.

Immediate actions and antidotes

If someone overdoses, they should seek medical help. Although there isn't an antidote available specific supportive measures, like gastric lavage or activated charcoal, can be helpful especially if the overdose happened recently.

XVII. Handling Precautions

Eflornithine involves more than administering it; how we handle and dispose of it are also important, sometimes overlooked aspects.

Safe handling and disposal of Eflornithine

It is crucial to keep the medication from children, avoid using it after it has expired, and dispose of it according to local regulations. Additionally, please refrain from flushing or pouring any topical product down the drain.

Minimizing environmental impact

Disposing drugs responsibly and following the guidelines in our area not only keeps us safe but also reduces the environmental impact. It reminds us that we are responsible for taking care of our surroundings beyond just our health.

Rated: 4.5 / 5 based on 4.5 customer reviews.

Posted by Jade on Feb 5, 2024 Verified Purchase


So I know that this product was was discontinued because people said it didn't work. I beg to differ, it has actually slowed down the growth of the hair on my face pretty significantly. I would say I see about a 70% improvement.  The smell is bad, but it's worth it. I will continue to use this product.

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by trent on Feb 19, 2018 Verified Purchase


Ive only used it for a week but i can say it doesnt smell or irritate my skin.

Note: buy-pharma.md does not imply any medical claims from this review.

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