Mesalamine Suppository

Mesalamine Suppository is an aminosalicylate anti-inflammatory drug that is prescribed to treat active ulcerative proctitis.

Canasa, Rowasa, sfRowasa, Pentasa.

Mesalamine (Mesalazine)

Mesacol Suppository


Sun Pharma


500 mg


Mesalamine Suppository

I. Introduction to Mesalamine Suppository

Using mesalamine suppositories is crucial in treating bowel diseases, especially ulcerative colitis. These suppositories are created to target the affected areas and provide relief from inflammation and its symptoms.

Overview of Mesalamine

Mesalamine, also referred to as mesalazine or 5 aminosalicylic acid, is a medication commonly utilized to alleviate symptoms and control bowel disease (IBD). Its effectiveness in treating a range of patient populations has been extensively studied and recognized.

Importance in Treating Inflammatory Bowel Diseases

The practical application of Mesalamine goes beyond managing symptoms; it plays a crucial role in reducing the inflammatory reactions that are critical characteristics of disorders, like ulcerative colitis.

II. Composition of Mesalamine Suppository

The unique blend of Mesalamine suppositories is designed to optimize the uptake of the component in the rectal region, boosting its effectiveness and health benefits.

Mesalamine Suppository

Active Ingredients

Mesalamine suppositories are mainly composed of mesalazine, an anti-inflammatory compound that works specifically on the colon's lining.

Formulation Specifics

These rectal suppositories contain additives that help the mesalazine dissolve and be delivered effectively to the inflamed tissues.

III. How Mesalamine Works

Mesalamine works by blocking the creation of substances in the body that trigger inflammation, leading to a decrease in swelling and discomfort in the digestive system.

Mechanism of Action in the Body

The medication hinders the function of cyclooxygenase and lipoxygenase, which are essential pathways in the inflammatory process.

Impact on Inflammation and Immune Response

Mesalamine affects the system by focusing on the inflamed epithelium, helping to improve both long-term and immediate inflammation.

IV. Uses of Mesalamine Suppository

Benefits and Effectiveness in Treatment

Mesalamine not only helps manage active disease but also plays a crucial role in sustaining remission, greatly improving the quality of life for patients.

V. Off-Label Uses of Mesalamine

Studies have investigated the use of Mesalamine in treating conditions beyond its intended purposes, frequently resulting in results.

Exploration of Non-Approved Uses

Review of Studies and Research Supporting Off-Label Use

Recent findings indicate that there may be a chance for cancer prevention in groups at high risk through specific methods.

VI. Dosage and Administration

The amount of Mesalamine suppositories needed should be adjusted precisely to suit each patient's condition, as the recommendations differ greatly depending on the seriousness and scope of the inflammation.

Dosages usually vary between 500 mg and 1,000 mg, taken once or twice a day, depending on the treatment guidelines and the patient's response to therapy.

How to use Mesalamine suppository

Administering a mesalamine suppository is quite simple. It's important to follow specific steps for proper application:

  • Make sure the area is clean to help with absorption.
  • Carefully insert the suppository into the rectum pointed end first to ensure it stays in place.
  • Lie down for a few minutes afterward to prevent the suppository from coming out.

Mesalamine suppository hemorrhoids

If you have hemorrhoids, it's advisable to apply a water-based lubricant, like K Y Jelly, on the tip before insertion. Avoid using Vaseline. Afterward, rest on your side for around 30 minutes and retain the medication in your rectum for at least an hour, ideally overnight.

Tips for Self-Administration

It is recommended that patients stay calm and relaxed when receiving the treatment to make it easier to apply and improve the medication's efficacy.

VII. Side Effects of Mesalamine Suppository

Although mesalamine is usually well received, there are instances where patients might encounter controllable side effects.

Overview of Potential Side Effects

The medication can cause stomach issues or, in rare cases, more serious allergic reactions.

Common Side Effects Encountered by Patients

  • Experiencing irritation and discomfort in the area where the medication is applied
  • Feeling pain and cramps in the abdomen
  • Dealing with headaches and feeling dizzy
  • Experiencing gas and slight diarrhea

It's important for patients to keep an eye on any reactions and inform their healthcare provider so that the treatment plan can be adjusted as needed.

VIII. Important Precautions When Using Mesalamine

Who should avoid using Mesalamine

Mesalamine, a component in treating inflammatory bowel conditions may not be suitable for some people. Those who are sensitive to salicylates or related substances are recommended to avoid using it. Additionally individuals with a history of kidney problems should seek advice, from their healthcare provider as it could worsen their kidney issues.

Special precautions for various health conditions

  • Patients with liver issues should have their liver function checked regularly to catch any liver damage early.
  • People with existing lung problems like asthma should be closely watched as mesalamine can trigger worsening.
  • It's also important to keep an eye on blood levels to catch low white blood cell counts or anemia early, both of which mesalamine can sometimes cause.

Mesalamine suppository alternative

Mesalamine enema vs suppository

Mesalamine suppositories help around 90% of patients with to moderate ulcerative proctitis stay in remission after a year whereas mesalamine enemas keep about 72% of patients with mild to moderate ulcerative proctosigmoiditis, in remission when used every other day for a year.

IX. Interactions with Other Medications

Common drug interactions

When Mesalamine is taken together with medications like nonsteroidal anti-inflammatory drugs (NSAIDs) or angiotensin-converting enzyme (ACE) inhibitors, it can increase the chances of kidney problems due to potential interactions.

Mesalamine suppository and alcohol

It's okay to have a drink while on mesalazine. Be mindful that alcohol could potentially aggravate your stomach and possibly worsen your symptoms.

How to manage and prevent harmful interactions

Ensuring that negative drug reactions are avoided requires reviewing medications and potentially changing doses or switching medications. Patients should remember to inform their healthcare provider about any medications they start or stop taking.

X. Warnings and Contraindications

Specific health conditions that contraindicate use

It is absolutely advised against using mesalamine in patients who have a known sensitivity to aspirin or any other salicylates. Moreover, individuals with kidney problems or those currently dealing with active peptic ulcers should avoid using it as it could worsen their conditions.

Safety warnings for users

It's important for people to recognize the signs of acute intolerance syndrome, which can mimic the symptoms of colitis. If you experience cramps, stomach pain, or bloody diarrhea, seek medical help right away.

XI. Special Considerations for Different Populations

Administration to elderly patients

Elderly individuals might experience reduced kidney function, requiring dosage changes and frequent monitoring to reduce the chances of harmful effects throughout the body.

Usage during pregnancy and breastfeeding

During pregnancy, mesalamine is deemed safe (the FDA classified it as category B). It's advisable to use it with the guidance of a healthcare professional. Although mesalamine is excreted in breast milk, it's still recommended to consult with a healthcare provider to guarantee the well-being of the nursing baby.

Considerations for pediatric use

When it comes to treating children it is important to consider the safety and effectiveness of using mesalamine. This is especially crucial, for young kids who might find it hard to communicate their symptoms. The dosage should be based on their weight. Closely monitored to ensure it works well and doesn't cause any negative reactions.

XII. Managing Overdosage

Signs of overdose

Symptoms of taking much mesalamine can show up as intense stomach discomfort like cramps, belly ache, and bloody stools along with rapid heartbeat and high fever.

Immediate actions and treatments

In case of an overdose, the main priority should be to provide support, such as ensuring hydration to prevent dehydration and kidney issues. Activated charcoal could be given after ingestion to limit absorption. It is crucial to monitor the individual in a medical setting.

XIII. Storage and Handling of Mesalamine Suppositories

Proper storage conditions

Remember to store Mesalamine suppositories in a dry place at room temperature, away from direct sunlight, to ensure they work effectively and don't lose their effectiveness.

Disposal and safety handling

To prevent harm to the environment, dispose of any expired or unused mesalamine suppositories correctly. Avoid flushing them down the toilet; instead, take them to a pharmacy or an authorized disposal site.

XIV. Careful Administration Tips

Best practices for efficacy and safety

For the results from mesalamine treatment, it is recommended to take it with a full glass of water and on an empty stomach unless advised otherwise by your doctor. Being consistent in timing with meals can also assist in symptom management.

Monitoring therapy effectiveness and side effects

It's important to keep up with check-ins with your healthcare provider to see how well the treatment is working and watch out for any possible side effects. This involves getting checks on your kidney and liver functions as well as blood tests to make sure you're safe during the course of treatment.

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