Nicorandil is prescribed for the treatment of angina pectoris.

Generic Ikorel, Dancor , AV -COR




Sun Pharma


5 mg, 10 mg



I. Introduction to Nicorandil

A. Definition and Basic Understanding

Nicorandil, a type of medication, is recognized for its ability to act as both a nitrate and potassium channel opener. It is commonly prescribed as tablets to alleviate the uncomfortable symptoms of angina pectoris, which causes chest pain resulting from decreased blood flow to the heart.

B. Role in Medical Therapies

Nicorandil plays a role in the field of medical treatments. It is not used to manage stable angina pectoris; clinicians also explore its potential benefits in treating other cardiovascular conditions. The vasodilatory effects of Nicorandil are highly appreciated by healthcare professionals as they help reduce the pressure, on the heart both and after it pumps blood.

II. The Composition of Nicorandil

A. Active Ingredient Profile

Nicorandil, the component of Nicorandil, stands out due to its unique composition. It combines the characteristics of nitrate and a potassium channel opener, serving as a bridge between the two. This unique composition allows it to work in two ways, enhancing blood flow to the heart and alleviating angina symptoms simultaneously.

B. Other Ingredients Involved

Nicorandil formulations often include substances called excipients alongside the main ingredient—these substances, like binders, disintegrants, glidants, and fillers,, help manufacturing. Enhance the effectiveness of the final medicinal product. However, the specific composition of these ingredients can vary depending on the formulation and the manufacturer involved.

III. Understanding How Nicorandil Works

A. Mechanism of Action

Nicorandil has a way of working due to its unique structure. It acts like a nitrate triggering the release of nitric oxide, which then stimulates the production of cyclic guanosine monophosphate (cGMP). This chain reaction causes the muscles to relax and the blood vessels to widen, relieving symptoms. At the time, Nicorandil acts as a potassium channel opener, which makes the blood vessels cell membranes more negative, further widening the blood vessels. These two mechanisms working together help alleviate symptoms associated with angina.

B. Biological Impact

The impact of Nicorandil on the body is quite significant. It helps widen blood vessels, which leads to a decrease in the heart's need for oxygen and an increase in the amount of oxygen delivered to the heart muscle. Additionally, it lowers resistance in the body's blood vessels, ultimately easing the workload on the heart. As a result, individuals undergoing Nicorandil treatment often notice a decrease in angina occurrences, an improvement in their ability to exercise, and an overall enhancement in their quality of life.

Uses of Nicorandil

Approved Medical Applications

Nicorandil is a medication for managing cardiovascular disorders, effectively reducing heart pain and strain. It is specifically prescribed for patients who cannot take beta blockers, another type of medication. Additionally, Nicorandil is recommended for individuals whose pain is not sufficiently controlled by treatments. It falls under the “potassium channel openers” Medications work by widening the arteries by removing potassium from their walls. This results in a reduced workload for the heart—improved blood and oxygen supply to the heart muscle.

References: : Nicorandil - Practo

Off-label Uses and Emerging Research

Nicorandil has been explored for its applications in various conditions, including pulmonary hypertension, peripheral arterial disease, and erectile dysfunction (ED). However, it is essential to note that these applications have not yet received approval from agencies like the US Food and Drug Administration (FDA) or the European Medicines Agency (EMA).

References: : Nicorandil - Wikipedia

V. Dosage and Administration of Nicorandil

A. Standard Dosage Guidelines

Nicorandil is usually prescribed in the form of tablets. Initially, doctors commonly recommend a dosage of 10mg to be taken a day for managing angina pectoris. However, depending on how each patient responds to the treatment, the doctor may adjust the dosage, up to 20mg, taken twice daily at their discretion.


B. Factors Influencing Dosage

Some factors can affect the recommended Nicorandil dosage. These include the patient's age, their specific medical condition, the severity of their symptoms, how they respond to the treatment, and if they have any existing health conditions. Any adjustments to the dosage must be made exclusively by a healthcare professional.

VI. Proper Storage of Nicorandil

A. Optimal Storage Conditions

Nicorandil should be stored in a dry location, usually at room temperature, away from heat and direct sunlight. Keeping the medication out of children's reach is recommended to avoid ingestion.

B. Shelf Life and Expiry Considerations

The durability of Nicorandil depends on how it's manufactured and packaged. However, like most medications, it's essential not to use Nicorandil after it has expired. When the medicine expires, it should be disposed of properly, following the guidelines for managing waste in your local area.

VII. Potential Interactions with Nicorandil

A. Drug-Drug Interactions

Nicorandil can interact with other medications, affecting how effectively it works or leading to unwanted side effects. It's important to note that medications like vasodilators, blood pressure medications, and specific antiarrhythmic types can potentially interact with Nicorandil. To minimize risks, patients must share a detailed list of all the medications they are taking with their physicians.

B. Drug-Food Interactions

While Nicorandil typically doesn't have interactions with food it's advisable to avoid consuming alcohol while undergoing treatment. This is because alcohol can enhance the medication's effects potentially causing excessive drops, in blood pressure.

C. Drug-Health Condition Interactions

Nicorandil effectiveness, as a treatment, may be impacted by health conditions. People with kidney or liver problems, low blood pressure, or a past heart attack should be cautious. It is essential to administer Nicorandil in these situations under the close supervision of a medical professional.

VIII. Warnings and Contraindications of Nicorandil

A. Pre-existing Conditions and Risks

Individuals who have pre-existing medical conditions may encounter higher risks when using Nicorandil. This group comprises individuals with liver or kidney diseases, low blood pressure (hypotension), or those who have recently had a heart attack. Additionally, it is essential for people with an inherited blood disorder called 'glucose six phosphate dehydrogenase deficiency' to be cautious.

B. Contraindications for Specific Populations

There are reasons why Nicorandil should not be used in certain groups;

1. People who have allergies to Nicorandil or any of its components.

2. Patients experiencing shock, a severe and life-threatening condition.

3. Individuals with acute pulmonary edema, a condition involving an accumulation of fluid in the lungs.

Patients need to share their medical history with their healthcare provider to ensure the safe administration of the medication.

IX. Careful Administration of Nicorandil

A. Administration in Elderly Patients

Although Nicorandil is generally well tolerated among individuals, this group may be more vulnerable to experiencing the hypotensive effects of the medication. As a result, it is recommended to commence treatment at a dosage and closely monitor for any potential side effects or adverse reactions.

B. Administration in Pregnant Women and Nursing Mothers

If a pregnant woman needs to take Nicorandil, it should only be done when necessary, considering the potential risks to the developing baby. As for breastfeeding mothers, it is advisable to avoid using Nicorandil if possible, although we are uncertain whether this medication can pass into breast milk.

C. Administration in Children

At present, we do not have evidence to determine the safety and effectiveness of Nicorandil in children. As a result, administering this medication to patients is typically not advised.

X. Overdose and Handling Precautions

A. Symptoms and Treatment of Overdosage

If you take much Nicorandil, you may experience symptoms like feeling sick, throwing up, weakness, low blood pressure, and in severe situations, even losing consciousness. If you suspect an overdose, you must seek help immediately. The usual treatment involves providing care to keep your body functions stable, including receiving IV fluids to address low blood pressure.

B. Safe Handling and Disposal of Nicorandil

When dealing with Nicorandil, handling it with your hands is essential. Store the medication where children or pets cannot reach it. Remember to dispose of Nicorandil according to the guidelines set for waste in your local area. It is best to avoid flushing the medication down the toilet or throwing it in with household waste.

XI. Common Side Effects of Nicorandil

A. Most Common Side Effects and Their Management

Nicorandil is generally well tolerated, like any other medication. However, some cases might lead to some patient side effects. The commonly reported headaches, flushing, dizziness, nausea or vomiting, and weakness. These side effects are usually mild. Tend to improve as the body becomes accustomed to the medication. However, if they persist or worsen, seeking advice is advisable. Healthcare providers may recommend measures such as staying hydrated, resting, and using over-the-counter remedies for symptom relief.

B. Rare but Serious Side Effects

In a few cases, certain patients might encounter significant adverse effects. These could involve low blood pressure allergic reactions, like rash, itching, swelling, intense bouts of nausea, vomiting, diarrhea, and unusual fatigue or weakness. Although these side effects are not usual, they should be taken seriously. If any of these occur, seeking medical attention is crucial.

XII. Important Precautions with Nicorandil

A. Preventive Measures

To ensure the effective use of Nicorandil there are certain preventive measures that should be taken. These measures include;

1. Following the dosage accurately.

2. Monitoring blood pressure and heart rate regularly.

3. Avoid alcohol consumption.

4. Scheduling regular follow-up appointments with your healthcare provider.

By adhering to these guidelines you can enhance the safety and effectiveness of using Nicorandil.

B. Emergency Procedures in Case of Adverse Reactions

If you suspect an adverse reaction to Nicorandil, it is essential to take immediate action;

1. Stop taking the medication.

2. Seek medical assistance.

3. Inform the healthcare professional about the dosage, duration of use, and any observed symptoms.

Acting promptly is crucial to ensure treatment and avoid any potential complications.

Nicorandil FAQ

What is the brand name of Nicorandil?

It is worth noting that the product Nicorandil is sold under the label Ikorel in several areas.

What is the mechanism of action of Nicorandil?

When battling angina symptoms, consider using Nicorandil—a medication known for its ability to relax your heart’s blood vessels. Doing so promotes heightened circulation of necessary nutrients and oxygen to your cardiac muscles and reduces strain felt by your vital organ.

What is a Nicorandil tablet?

For the management of angina pectoris, Nicorandil is an effective medicinal formulation. Activating potassium channels and containing nitrate ester impedes restricted blood flow to the heart muscles.

What are the side effects of Nicorandil?

Nicorandil usage carries the possibility of developing several unwanted symptoms worth mentioning. Amongst these are frequent headaches alongside feelings of dizziness and nausea/vomiting, also leading to an experience of flushing sensations. Notably, while these issues occur frequently reported results from Nicorandil treatment, some rare cases exist where using it led to ulceration across various bodily regions - notably so within both eye and face anatomy structures, including skin lesions found on oral embrasures on occasion too!

What are the alternatives to Nicorandil?

There are other options available as alternatives to Nicorandil in treating angina. These include medications like beta-blockers, calcium channel blockers, and nitrates such as Isosorbide Mononitrate and Nitroglycerin.

What is the drug class of Nicorandil?

The medicinal agent Nicorandil is classified within the group of drugs known to be potassium channel activators.

What is the drug classification of Nicorandil?

To be precise, with drug classification, Nicorandil is classified as a vasodilator and anti-anginal agent.

Why is Nicorandil not available in the US?

At present, Nicorandil is not accessible to residents of the United States as it lacks essential authorization from the FDA. The probable reasons behind this include differences in regulatory standards and clinical data necessities.

What is Nicorandil used for?

A prevalent use of nicorandil is its role in averting and sustaining relief from angina pectoris - discomfort from diminished blood flow to the heart. Prescribed for its efficacy in managing this condition, it serves as an essential component of long-term treatment plans.

What are Nicorandil tablets for?

Angina pectoris sufferers find relief in Nicorandil tablets, which are commonly advised by clinicians not only to control symptoms but also to thwart further episodes.

How does Nicorandil work?

Nicorandil functions by loosening up the heart's blood vessels to minimize strain while broadening peripheral blood vessels to optimize blood circulation and enhance pumping capacity.

Is Nicorandil available in the USA?

Nicorandil hasn't received FDA approval and thus remains unavailable in the United States.

Is Nicorandil a beta blocker?

While sometimes confused with beta-blockers, Nicorandil functions as a potassium channel opener with some nitrate components. Nonetheless, the medication effectively treats symptoms caused by angina pectoris and should be considered an option by those experiencing such symptoms.

Is Nicorandil a blood thinner?

To clarify, Nicorandil does not fall under the classification of blood thinners. Its intended use remains as a vasodilator and anti-anginal medication.

Is Nicorandil a calcium channel blocker?

The notion that Nicorandil falls under the classification of calcium channel blockers is erroneous. On the other hand, its actual role involves stimulating potassium channels and functioning as a nitrate ester.

Is Nicorandil used for hypertension?

Primarily used for treating angina, Nicorandil has vasodilatory effects, which can potentially result in a decline in blood pressure levels. However, despite this possible effect, physicians generally do not suggest Nicorandil as an initial medication choice for hypertension.

What is Nicorandil used for?

The medication Nicorandil serves as a primary option for preventing and treating instances of angina pectoris.

What is the combination of Nicorandil and Isosorbide Mononitrate?

Nicorandil and Isosorbide Mononitrate present two distinct therapies for individuals seeking relief from anginal symptoms. Dually noted for their efficacy in promoting blood flow to the heart, each medication is administered separately in clinical practice rather than as a combined treatment approach. While their ultimate objective aligns, these drugs differ in their respective mechanisms employed towards achieving this purpose.

What is the combination of Nicorandil and Aspirin?

Optimizing the management of heart conditions requires the convergence of tailored medications like Nicorandil and Aspirin. Nicorandil can address Angina symptoms while preventing clot formation with the help of effective antiplatelet medication such as Aspirin.

What is the price of Nicorandil 10 mg?

When it comes to buying medication, there exists a variance in cost dependent on several traits like geographical location, type of health insurance policyholders, and choice between generic or branded pharmaceuticals. The sensible thing would be to acquire accurate price information from a nearby pharma establishment.

What is the difference between Nikoran OD 10 and Nikoran 10?

When comparing Nikoran OD20 against standard medication like Nikoran-10 containing Nicorandil; it's important to note differences in release mechanisms between them. It appears that Nikoran OD might be an extended-release product primarily manufactured for consumption once daily based on its labeling abbreviation (OD). Given the potential impacts of such differences on patient outcomes, seeking counsel from credible sources like healthcare providers remains crucial for optimal treatment.

How does Nicorandil compare to Nitroglycerin?

Treating angina pectoris can involve Nicorandil or Nitroglycerin administration, which can increase blood flow within the heart, albeit through different modes of action. However, their accompanying side effect profiles differ appreciably and necessitate personalized consideration for each patient received.

What are the uses of Nicorandil tablet?

To effectively manage angina pectoris, your healthcare provider may prescribe a Nicorandil tablet. This medication alleviates chest pain by increasing blood flow to the heart.

What is Nicorandil tablets IP 5mg?

Nicorandil IP 5mg tablets contain a fixed amount of the active ingredient, with each tablet specifically comprising 5mg. This particular drug bears the designation 'IP' as confirmation that it meets or exceeds Indian Pharmacopoeia standards for quality of manufacture and effectiveness.

What are Nicorandil tablets 5mg?

Nicorandil tablets 5mg comprise of Nicorandil medication in a dosage form. These tablets contain 5mg active drug in each one. Their primary function is to treat and prevent angina pectoris.

What are the uses of Nicorandil tablet in Tamil?

To treat and prevent angina pectoris, a medical condition known as அங்கீனா பெக்டோரிஸ் in the Tamil language healthcare providers often prescribe Nicorandil tablets.

What are the uses of Nicorandil tablets 5mg?

Nicorandil tablets 5mg offer effective treatment and prevention options for angina pectoris.

What are Nicorandil tablets IP K-Cor 5?

Within the Indian market, one may encounter the name K-Cor in reference to Nicorandil. For those seeking specifically the 5mg variant of this medication under this brand, they would reach for Nicorandil tablets IP K-Cor 5.

What are Nicorandil tablets IP 10mg?

Each Nicorandil IP 10mg tablet has a precise quantity of 10mg of Nicorandil – an active ingredient. The abbreviation “IP” denotes Indian Pharmacopoeia and assures that this medication adheres to the standards set by this body within India.

What is the trade name of Nicorandil?

Depending on the locality, there are various trade names attributed to Nicorandil. To elucidate further, in the United Kingdom it is colloquially referred to as Ikorel.

What is Nicorandil SPC?

The officially recognized legal document containing crucial information about medicines like Nicorandil is a Summary of Product Characteristics (SPC). It outlines how this medication functions, including recommended doses suited for varied scenarios, and highlights likely side effects and instances when one should not use it.

What is the structure of Nicorandil?

The molecule Nicorandil consists of a pyridine core structure that includes a nitrate ester group and a nicotinamide group at opposite ends.

What is Nicorandil storage?

Proper storage can significantly impact the shelf life of Nicorandil. Therefore we advise keeping it in a cool and dry place inaccessible to kids and free from direct sunlight exposure. Please don't forget to refer to the packaging or ask your pharmacist for accurate storage instructions.

What is a substitute for Nicorandil?

In cases of angina treatment where Nicorandil is not an option, other potential alternatives include beta-blockers, calcium channel blockers, and related nitrates. Deciding which medication is best suited for a particular patient will require consideration of their current health record and unique requirements.

What is Nicorandil solubility?

Nicorandil's capacious solubility is notable in water and commonly used organic solvents.

What is Nicorandil synthesis?

The synthesis of Nicorandil encompasses multiple chemical reactions that start by incorporating pyridine as the core structure. Then, nitrate ester and nicotinamide moieties are added through a series of reactions.

What is Nicorandil Rivopharm?

It's worth noting that Rivopharm operates worldwide and is dedicated to producing cost-effective versions of known medicines, along with developing biosimilars. With this in mind, Nicorandil Rivopharm refers explicitly to their interpretation of medication containing nicorandil.

What is Nicorandil Rivopharm 20?

Nicorandil Rivopharm 20 is a medication produced by Rivopharm and comes with a 20mg dosage of Nicorandil.

Is Nicorandil a nitrate?

Nicorandil is classified as a nitrate, more specifically as both a nitrate ester and a potassium channel activator.

What is the action of Nicorandil?

Nicorandil is an effective vasodilator with properties that enhance coronary circulation by reducing resistance in narrow or contracted blood vessels. This has therapeutic effects in relieving angina pectoris by lessening the workload on the heart.

What are the adverse effects of Nicorandil?

Nicorandil use should be cautiously approached due to possible side effects, including head pain and discomforts such as dizziness or nausea, along with complexion changes like flushing. On rare occasions, though typically not expected by most, this medication could foster ulceration development inside various bodily areas, such as on keratinized mucosa's lining within oral cavity tissues (mouth), the epidermis (skin), and cornea (eyes).

Is Nicorandil used for angina?

In medicine, Nicorandil is frequently utilized to prevent and treat episodes of angina pectoris.

What is Nicorandil EMC?

Accessing information about medicines can be accomplished through various resources, including the Electronic Medicines Compendium (EMC). Looking up Nicorandil within this resource will provide an individual with the pertinent listing and corresponding information for this medication.

What are the brands of Nicorandil in India?

In India, Nicorandil can be found available under several brand names. Among them are Nikoran and K-Cor, to name a few.

What are the other names for Nicorandil?

There exist other names for Nicorandil which refer to its brand names, depending on the location. Some of these names include Ikorel, Nikoran, and K-Cor.

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