Plaquenil (Hydroxychloroquine) is prescribed for rheumatoid arthritis, systemic and discoid lupus erythematosus, as well as for the treatment and management of the symptoms of malaria.




30, 100

Sanofi Aventis


200 mg

UK, France



Plaquenil, a medication with a significant history, has firmly established itself in medicine because of its versatile applications. Originally designed to fight against malaria, it underwent testing and clinical trials over several decades before gaining approval. As time passed, its importance expanded to address various medical conditions.


How it Works

The efficacy of Plaquenil is attributable to its complex mechanism of action:

  • Mechanism of action against parasites: Plaquenil impedes the growth of malaria-causing parasites in red blood cells.
  • Immunomodulatory effects: In autoimmune diseases, it modulates the immune response, thereby preventing the body from attacking its tissues.

Once administered, its duration of action in the body is extensive, making it practical for both acute and chronic conditions.

Dosage and Administration

Ensuring the drug's effectiveness and minimizing any effects is crucial by following the correct dosage and administration guidelines. Here are some essential points to consider: dosing recommendations. In most cases, adults with malaria are initially given a higher dose of the medication, followed by smaller maintenance doses. Dosing adjustments: Specific populations, such as those with kidney problems or older individuals, may require adjustments in their dosage. Methods of administration: Plaquenil is typically taken orally in tablet form. Remember to consult your healthcare professional for advice regarding this medication's appropriate dosage and administration.

Side Effects

Like with any medication, Plaquenil also has its share of side effects. While most are mild and temporary, some can be more serious. It's important to distinguish between uncommon side effects so that patients and healthcare providers can effectively monitor and address them.

Common Side Effects

Some common side effects that people may experience include issues such as mild nausea or more severe symptoms like vomiting and diarrhea. Skin reactions like itchiness, rashes, or changes in skin color are also possible. It is recommended to have eye exams for those undergoing long-term treatment to monitor for any retinal toxicity or eye complications. In cases, there might be neuromuscular weakness or specific effects on the heart.

Off-label Use

According to 1, Plaquenil (hydroxychloroquine) is an FDA-approved prescription medication used to treat lupus, rheumatoid arthritis, and prevent or treat malaria. However, it has also been investigated for possible off-label uses. The medical community has engaged in controversies and debates regarding the safety and effectiveness of these applications. Some off-label uses have gained support from clinical trials and anecdotal evidence 2.


Delving into the composition of Plaquenil:

  • The active ingredient responsible for its therapeutic effects is Hydroxychloroquine.
  • There are also various inactive ingredients that contribute to the drug's stability, shelf-life, and bioavailability.
  • Plaquenil comes in multiple formulations and strengths, catering to the diverse needs of patients.


To guarantee the efficacy and safety of Plaquenil, adherence to specific storage protocols is imperative. The fundamental storage aspects to consider are:

  • Recommended storage temperatures: Plaquenil should be stored between 20°C to 25°C (68°F to 77°F), with excursions permitted to 15°C to 30°C (59°F to 86°F).
  • Stability considerations: Prolonged exposure to excessive heat or humidity can degrade the medication, making it ineffectual.
  • Proper disposal: Expired or unused Plaquenil should be disposed of in adherence to local pharmaceutical waste guidelines to ensure environmental safety.


The way we interact with medications can have an impact on their effectiveness and safety. Specifically, when it comes to Plaquenil: 1. Common drugs: Medications such as antacids, cimetidine, and digoxin may interact with Plaquenil, which may require adjustments in dosage or careful monitoring. 2. Lifestyle interactions: It's important to note that consuming alcohol while taking Plaquenil could intensify specific side effects. 3. Impact on lab tests and monitoring: Plaquenil can potentially affect liver enzyme levels, so it is necessary to undergo testing and remain vigilant. These factors should be considered when using Plaquenil to ensure its effectiveness and safety.


Warnings serve as paramount advisories for potential hazards. For Plaquenil:

  • Black box warnings: Plaquenil warns for potential retinal damage, underscoring the need for periodic eye examinations.
  • Potential long-term risks: Chronic use can lead to cardiac complications and certain neurological effects.
  • Safety monitoring recommendations: Regular blood tests, cardiovascular assessments, and ocular screenings are advocated to monitor for adverse effects.



Contraindications highlight circumstances under which a drug should not be utilized. About Plaquenil:

  • Absolute contraindications: Known hypersensitivity to hydroxychloroquine mandates its avoidance.
  • Relative contraindications: Conditions like psoriasis or porphyria, where the drug might exacerbate symptoms.
  • Drug-specific contraindications: Concomitant use with certain medications like specific antiarrhythmics can be hazardous.

Careful Administration

Certain groups of people require attention when it comes to the use of Plaquenil. These special populations include individuals with existing eye conditions or certain genetic predispositions. It is essential to monitor these individuals, and this can be done through regular eye exams liver function tests, and electrocardiograms. In cases with existing liver or kidney diseases, adjustments may be necessary. This could involve modifying the dosage or extending the intervals between doses for those with renal impairments.

Important Precautions

Taking precautions can help prevent any potential adverse effects. It is essential to avoid sun exposure as Plaquenil can make one more prone to sunburns. Therefore, it is recommended to use sunscreens. Regular eye checkups should be conducted to keep track of any changes or visual issues. Additionally, it is crucial to monitor for any symptoms, such as muscle weakness, and seek immediate medical attention if they occur.

Administration to the Elderly

Elderly patients require attention because their bodies undergo physiological changes as they age. When it comes to aging, there are factors to consider: a higher likelihood of experiencing side effects due to changes in how drugs are processed in the body. It may be wise to make adjustments in dosing, such as reducing the amount of medication or extending the time between doses. Additionally, this population is more vulnerable to complications like heart-related issues or effects on health.

Administration to Pregnant Women and Nursing Mothers

Pregnancy and lactation present unique pharmacological challenges.

  • Fetal risks and benefits: While Plaquenil might be beneficial in conditions like lupus during pregnancy, potential fetal risks should be appraised.
  • Levels in breastmilk: Trace amounts of Plaquenil can be found in breastmilk, albeit the clinical implications remain elusive.
  • Recommendations for pregnancy planning: Discussing potential risks and benefits with a healthcare provider is essential before conception.

Administration to Children

Children who need treatment should be given doses and monitored in a specific way. When it comes to dosing, their body weight is usually taken into account. Adjustments are made periodically. In general, children tolerate the medication well. It's important to remain vigilant for any potential side effects. There is evidence that shows the effectiveness of this medication in treating conditions like idiopathic arthritis or other pediatric diseases.


Taking an amount of this substance can lead to severe complications so it is essential to be aware of the signs and how to manage them. If you overdose, you may experience dizziness, headaches, changes in vision, and dangerous effects on your heart. In cases, immediate medical attention is necessary. Treatment options may include lavage and addressing symptoms as they arise. It's also worth noting that there could be long-term consequences, such as lasting changes or irregularities in heart rhythm.

Handling Precautions

To ensure users' safety and maintain the medication's effectiveness of the medication, it is essential to handle it. Follow these guidelines for handling: 1. Store the medicine in its container away from direct sunlight or moisture. 2. In case of a spill, wear gloves. Carefully collect any spilled tablets. Afterwards, sanitize the area to prevent contamination. 3. While patients may not need protective equipment on a regular basis healthcare workers dealing with bulk quantities should consider wearing gloves and masks. By following these instructions we can prioritize user safety and ensure that the medication remains effective.

Rated: 4.9 / 5 based on 4.9 customer reviews.

Posted by Garvey on Sep 22, 2021 Verified Purchase




Note: does not imply any medical claims from this review.
Posted by hill on Jan 15, 2021 Verified Purchase

as described. plus great customer service

I used this product to protect myself against covid. I am more than happy to know a compan that can provide this.

What is best is the wonderful customer service. 

I have been buying from Buy Pharma for years now and have never been dissapointed,

Thank you.

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Posted by hill on Jul 4, 2020 Verified Purchase

received order, Thank you!


My country thinks we cshould not be able to use this drug for an infection that is killing hundreds of thousands of people. 

Thank God for Buy Pharma who thinks otherwise.

Note: does not imply any medical claims from this review.
Posted by Nwogu on May 24, 2020 Verified Purchase


I use it for malaria  and the quality is good.

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Posted by Deppe on May 22, 2020 Verified Purchase

good product

I will this product for treatment of covid-19 if needed

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Posted by hill on May 21, 2020 Verified Purchase

Great customer service!


I have not used the product. I am a prepper and wanted the entire array of drugs for the future if neccessary. Robert is a wonderful person I have dealt with a few times and recommend his site to friends who have used it and are very pleased.

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Posted by Domenico on Apr 21, 2020 Verified Purchase


Excellent cusotmer service. Thank you.

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