Proluton Depot Injection, Hydroxyprogesterone Caproate

Proluton Depot Amp. (Hydroxyprogesterone Caproate) is administered to help lower the risk of habitual and threatened abortion.

Proluton Depot Injection

Hydroxyprogesterone Caproate

Proluton Depot Injection

1 ml, 2 ml

German remedies, Zydus Cadila


250 mg, 500 mg



Proluton Depot Injection is used in the prevention of spontaneous abortion in women with a history of recurrent miscarriage or in preterm labor.

How it Works

Proluton Depot Injection is a synthetic hormone similar to the natural female sex hormone progesterone, Proluton Depot Injection is a synthetic form of the female hormone progesterone. Spontaneous abortion occurs when the body`s levels of progesterone drop below the required level to maintain pregnancy. Therefore Proluton Depot Injection is used to maintain these levels and prevent miscarriage.

Common Side effects

Patients who take Proluton Depot Injection may suffer from such side effects;

Adrenal insufficiency,
Vaginal discharge,
Back pain,
Abdominal pain,
Lower abdominal pain,
Breast pain,
Hair loss,
Hot flushes,
Irregular menstrual cycle,
Cushingoid syndrome,
Increased blood pressure,
Increased appetite,
Decreased libido,
Pain in extremity,
Abdominal distension,
Cushing syndrome,
Mood changes,
Increased glucose level in blood,
Breathing difficulty


Hydroxyprogesterone Caproate is a synthetic progestin. It is a clear and sterile solution meant to be injected intramuscularly. It is available under many brand names and is given to women who are at an increased risk of delivering a premature child.


Hydroxyprogesterone Caproate is indicated to reduce the risk of delivering a baby too early from the normal term. It should only be used by women who are pregnant with one baby and have had a preterm baby delivery in the past. This medication is not intended to prevent preterm births in women who are pregnant with more than one baby like twins or triplets. It is also not intended to stop active preterm labor. The mechanism by which it works to reduce the probability of recurrent preterm births is not known.

Dosage and administration

This medication is given as an injection into the gluteal (hip) region by a health care professional, usually once a week. It is advised to start receiving the injections any time between the 16th and 20th week of pregnancy. Continue to receive the injections once a week until the 37th week of pregnancy or when your baby is delivered, whichever happens earlier.

Instructions for administration:

Disinfect the vial top with an alcohol swab.
Draw 1 ml of the drug into a 3 ml syringe.
Change the needle to a 21 gauge, 1 and a half inch needle.
Disinfect the skin and inject the drug into the upper outer quadrant of the gluteus maximus muscle. Since the solution is viscous, it is advised to inject the solution slowly for about a minute.
Apply pressure on the injection site to minimize bruising.

Use this medication as regularly as prescribed to get the maximum benefits.


Before taking the medicine, the patient is advised to consult the doctor if she has any allergy to any of the ingredients of the drug. Also, inform the doctor about all the drugs that have already been prescribed.
It is important that the patient discusses her medical history with the doctor, especially if there is any history of asthma, blood clotting problems, cancer (especially of the breast, uterus, or other female organs), diabetes, severe headaches, heart problems, high blood pressure, etc.
This drug is known to fluctuate the blood sugar levels hence it is advised that a diabetic patient should regularly monitor her sugar levels and in case of any major problems, seek immediate health care.
This drug is not indicated in women who have had menopause or in children who are under 16 years of age.

Side effects

The following side effects may occur at the injection site-


Other than those mentioned above, nausea, vomiting, and diarrhea are also common side effects when using the drug.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Dixon on Feb 26, 2018 Verified Purchase

Will order again

I’ve ordered the product before. Received it in about a week. Will definitely order again soon.

Note: does not imply any medical claims from this review.
Posted by Khismar on May 8, 2017 Verified Purchase

Great product

Bought the product with no hiccup or hassle. My only complaint is the length of time it took to get to me.

Note: does not imply any medical claims from this review.

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