SSDee Cream, Silver Sulfadiazine

SSDee Cream is used in the treatment of burn wound infections. SSDee Cream works to stop the growth of bacteria which infects the open wounds

Silvadene 1%

Silver Sulfadiazine

Burnheal, SSDee

Universal Twin Land

15gm, 25gm, 250gm, 500gm



SSDee Cream, Silver Sulfadiazine


To truly grasp the significance of SSDee Cream in wound care, it is essential to delve into its history, unique composition, and the mechanisms that drive its remarkable effectiveness. In this article, we will explore these aspects in detail.(1)

1. WebMD - Silver Sulfadiazine Topical 

Brief Overview of SSDee Cream

SSDee Cream, a trusted name in the field of wound treatment, has become a component of contemporary healthcare. Its origin can be traced back to a commitment to finding innovative solutions that effectively tackle the challenges associated with wound care.

Skin burn

History and Development of Silver Sulfadiazine

The origins of Silver Sulfadiazine (SSD) can be traced back to when it was discovered and subsequently developed. By delving into the background, we can gain a deeper understanding of how it has evolved as a crucial element in strategies for healing wounds.

How it Works

Mechanism of Action

SSDee Cream works in ways to achieve its therapeutic benefits;

1. Hindering Bacterial Growth: Its main purpose is to slow down the growth of bacteria by creating an environment for their survival.

2. Alleviating Inflammation: SSD possesses inflammatory properties, which help reduce the body's inflammatory response and support a healing-friendly environment.

3. Enhancing Wound Healing: Apart from inhibiting bacteria, SSDee Cream actively stimulates and speeds up the natural processes involved in tissue repair and regeneration.


Active Ingredients

The effectiveness of SSDee Cream depends on choosing the right active ingredients.

  • One crucial ingredient is silver sulfadiazine, which plays a role in fighting against harmful bacteria.
  • In addition to that, there are components in the formulation that work together to improve overall effectiveness, creating a synergistic approach to managing wounds.

Formulation Considerations

To create the SSDee Cream, it's essential to pay close attention to the specific details of its formulation.

  • The cream base is especially important as it determines not only the texture of the product but also how well it absorbs into the skin and how easy it is to apply.
  • Additionally, even though they may be called "inactive," the other ingredients in the cream play a role in ensuring its stability, shelf life, and compatibility with other components.

These factors are all vital for achieving an overall formulation.



SSDee Cream, a formulation with versatile applications, has found its place in various clinical settings. Each application is supported by its mechanism of action and effectiveness.

Primary Use in Burn Wound Management

SSDee Cream(1) plays a role in managing burn wounds with its applications focused on two main aspects;

1. Treating Burns: The cream's effectiveness lies in its ability to inhibit the growth of microbes while creating an environment that promotes healing.(2)

2. Preventing Infections: Acting as a shield, the cream acts as a guard against opportunistic pathogens, preventing infections from entering burn wounds.(3)

1. NCBI - Silver Sulfadiazine

2. MayoClinic.Org - Silver Sulfadiazine (Topical Route)

3. PubMed - Silver Sulfadiazine 

Applying SSDee cream


Applying SSDee cream

Secondary Uses

Apart from its use, SSDee Cream has a wide range of secondary applications.

  • It proves beneficial in the field of wound management as its antimicrobial properties create an environment that supports healing.
  • Additionally, it is effective in preventing operative infections in surgical wounds due to its antimicrobial capabilities.
  • SSDee Cream also serves as a solution for various dermatological conditions by leveraging its anti-inflammatory and wound-healing qualities.

Off-label Use

Venturing into territory, the unconventional usage of SSDee Cream reveals a wide range of alternative uses that go beyond its typical medical purposes. This article explores the areas, shedding light on the fascinating aspects of using it off-label.

Exploring Alternative Applications

Apart from its established uses, SSDee Cream has gained attention for its applications beyond what it was originally intended for. It offers a range of possibilities;

1. Podiatric Applications: In the field of podiatry, the antimicrobial properties of SSDee Cream have proven beneficial in addressing foot conditions. This unique feature complements the treatment.

2. Acne Management: The cream's anti-inflammatory properties have caught the interest of dermatologists as a solution for managing acne. It presents an approach to conventional methods.

3. Scar Reduction: Some medical professionals are exploring the use of SSDee Cream to reduce scarring post-injury. By harnessing its wound-healing abilities, they hope to minimize the appearance of scars.

These off-label applications demonstrate the versatility and potential benefits that SSDee Cream can offer beyond its intended purposes.

Research and Studies Supporting Off-label Use

The changing field of medical research has shed light on the use of SSDee Cream beyond its intended purpose, with studies revealing its effectiveness in various areas.

  • For instance, preliminary research suggests that SSDee Cream may be a tool for addressing certain foot ailments in podiatric applications.
  • Additionally, there have been discussions about its potential as a traditional solution for managing acne in dermatological practices.
  • Moreover, investigations into the impact of SSDee Cream on formation and reduction have sparked interest among professionals looking for innovative approaches.

These findings open up possibilities and avenues for further exploration in the medical community.

Considerations and Risks

While the appeal of using medications for purposes other than their approved indications may be tempting, it is crucial to approach this practice with a thorough understanding of the factors and risks involved.

  • Considering Individual Patient Factors: It is important to carefully consider each patient's unique characteristics, such as allergies and sensitivities in order to minimize the potential for any adverse reactions.
  • Absence of Regulatory Approval: Since off-label applications do not have endorsement from regulatory bodies, it is necessary to proceed cautiously and acknowledge that these practices are experimental in nature.
  • Ethical Considerations: Healthcare providers who engage in off-label use must navigate deliberations by striking a balance between innovation and prioritizing the well-being of their patients while ensuring informed consent.

Dosage and Administration

It is crucial to ensure that the administration of SSDee Cream is done in the best possible way to maximize its therapeutic effectiveness. This section provides information on the recommended dosage for different conditions techniques for application and also discusses common side effects and potential interactions.

The appropriate dosage of SSDee Cream depends on the particular medical condition being treated.

  • For burn wounds, it is recommended to apply a layer of SSDee Cream with a silver sulfadiazine concentration typically ranging from 1% to 2% for optimal antimicrobial activity.
  • When it comes to chronic wound healing, a personalized approach is often taken with input from healthcare professionals. The application frequency and dosage are adjusted based on the characteristics of the wound.
  • How it responds to treatment. In cases where SSDee Cream is used off-label, the recommended dosage may be. It should be tailored to the specific condition and response to treatment.

Application Techniques

Topical Application Guidelines

The key to getting the most out of SSDee Creams benefits lies in how it is applied topically. Here's a step-by-step guide to help you make the most of it;

1. Start with a cleansing of the affected area making sure it's completely dry before you apply the cream.

2. Apply a thin layer of SSDee Cream ensuring that you cover the wound or affected skin area evenly.

3. Depending on your condition, healthcare professionals might suggest covering the treated area with sterile dressings to enhance the effectiveness of the cream.

Remember, the proper application plays a role in maximizing SSDee Cream's therapeutic impact.

Frequency of Application

The frequency of applying SSDee Cream depends on the nature and severity of the condition.

  • For burn wounds, it is usually recommended to apply the cream twice a day, but this can be adjusted based on how well the wound is healing and the advice of your healthcare provider.
  • When it comes to wounds, the application frequency may vary, and adjustments should be made in consultation with healthcare professionals while carefully monitoring how the wound responds.
  • In cases where SSDee Cream is used for off-label purposes, clinicians will determine the frequency based on the specific condition and how it affects each patient individually.

Common Side Effects

While SSDee Cream is celebrated for its advantages, it is crucial to have a comprehensive understanding of the potential drawbacks to ensure holistic patient care.

Overview of Common Adverse Reactions

Some of the effects linked to using SSDee Cream are as follows:

1. Skin Irritation: It's quite common to experience irritation, redness, or a burning sensation in the area where the cream is applied.

2. Allergic Reactions: In instances, individuals may show allergic responses that can vary from a rash to more severe symptoms.

3. Absorption: If SSDee Cream is used excessively or for a long duration, there's a possibility of silver sulfadiazine being absorbed into the body, which might result in adverse effects.

Skin-related Side Effects

Itching and Irritation

It is not uncommon for individuals to experience itching and irritation as side effects of the treatment. These symptoms are usually temporary and mild in nature.

  • Mild itching may occur at the beginning of the treatment. It is generally harmless.
  • If there is any redness or irritation at the site of application, it is typically. It tends to improve with regular use of the treatment.
  • However, if itching persists or becomes severe, it is advisable to consult a healthcare professional. They will assess the situation and make any necessary adjustments to the treatment plan if needed.

Allergic Reactions

Allergies reactions, although not common, need to be watched;

  • Rash and hives: Some people might experience a skin rash or hives, which could indicate an allergic reaction to SSDee Cream.
  • Swelling or trouble breathing: Although rare, if you notice swelling or have difficulty breathing after using the cream, it's crucial to seek immediate medical attention and stop using the product.
  • Patch testing: In situations where allergy is suspected, patch testing may be done to confirm hypersensitivity before continuing use.

Monitoring and Managing Side Effects

Systematic monitoring and proactive management play a role in handling side effects effectively;

1. Regular Evaluation: It is crucial for healthcare providers to regularly assess patients who are using SSDee Cream, promptly addressing any side effects that may arise.

2. Modification of Treatment Plan: If the side effects persist or become severe, the healthcare team may consider adjusting the treatment plan, such as altering the dosage or frequency of application.

3. Patient Education: Providing education to patients is vital as it empowers them to recognize and report any side effects they experience, ensuring timely intervention when needed.


It is crucial to have an understanding of possible interactions in order to guarantee the safe and efficient utilization of SSDee Cream alongside other medications or treatments.

Potential Drug Interactions

SSDee Cream has the potential to interact with medications, so it's important to consider and consult with your healthcare provider.

  • If you have known allergies to sulfa drugs, there is a possibility of hypersensitivity to SSDee Cream, which means you should use it cautiously and be closely monitored.
  • If you are using topical antibiotics at the same time, there may be an increased antimicrobial effect, but healthcare providers should assess the risk of any adverse reactions.
  • When using wound healing agents along with SSDee Cream, it might be necessary to adjust the frequency and dosage of application for optimal results.

Interactions with Other Topical Medications

When it comes to the combination of SSDee Cream and other topical medications, it is crucial to conduct an evaluation.

Warning and Contraindications

To ensure safety and achieve the best possible treatment results it is crucial to have a thorough understanding of the warning signs and contraindications related to SSDee Cream. This section provides information on the groups that may be at risk as well as contraindications and precautions for allergic reactions.

Patient Groups at Risk

While SSDee Cream is generally effective for wound care, it is important to exercise caution when using it with patient groups.

  • Pregnant and breastfeeding women should consult healthcare professionals who can conduct a risk-benefit analysis before deciding to use SSDee Cream.
  • Individuals who have a known allergy to sulfa drugs should also be careful as they may have a risk of experiencing adverse reactions when applying SSDee Cream.
  • Additionally, special precautions should be taken when using the cream in pediatric and geriatric patients, considering the unique physiological factors that could affect its safety and effectiveness.

Contraindications for SSDee Cream

There are situations where it is not recommended to use SSDee Cream;

1. Allergic Reaction or Sensitivity: If you have experienced any sensitivity or allergic reactions to sulfadiazine or any of the ingredients in the cream, it is best to avoid using it.

2. Pre-existing Blood Disorders: If you have any pre-existing blood disorders or conditions that affect blood cell formation, SSDee Cream may not be suitable for you due to potential systemic effects.

3. Infants Under Two Months: It is important to note that the safety of SSDee Cream has not been established for infants under two months old. Therefore, it is not recommended for use in this age group.

Please consult with a healthcare professional for guidance and advice regarding the appropriate use of SSDee Cream.

Allergy Precautions

To ensure safety and minimize the risk of reactions, it is crucial to take careful precautions. Before applying SSDee Cream, consider conducting a patch test on a small area, especially if you have a history of allergies or heightened sensitivity. If any signs of a reaction occur, such as rash or swelling, it is essential to immediately stop using SSDee Cream and seek prompt consultation from healthcare professionals. For patients with known allergies, healthcare professionals may explore wound care formulations as appropriate.

Handling Precautions

The use of SSDee Cream goes beyond considering the patients. It also involves handling it, ensuring the safety of healthcare professionals, and following appropriate storage guidelines.

Safe Application Techniques

To properly apply SSDee Cream, it is important to follow the following techniques;

1. Use Gloves; Healthcare professionals should wear gloves while applying the cream to avoid contact with the skin and reduce the risk of any potential adverse reactions.

2. Maintain Aseptic Technique: It is essential to maintain technique during the application process. This means ensuring that the cream is applied to clean and dry skin surfaces, which helps maximize its effects.

3. Apply Evenly and Thinly: A careful application involves spreading the cream thinly across the skin. This promotes coverage without using excessive amounts. By following these techniques, you can ensure the utilization of SSDee Cream for optimal results.

Protection Measures for Healthcare Professionals

Healthcare providers should take precautions to protect themselves from occupational hazards associated with SSDee Cream.

  • This can be done by wearing attire such as gloves and, if necessary, masks, which help shield healthcare professionals from accidental exposure during patient care activities.
  • It is also important to ensure ventilation in treatment areas to reduce the risk of inhaling any volatile components released during the application of SSDee Cream.
  • Additionally, providing training and awareness programs can help healthcare professionals become more skilled in safely and responsibly handling SSDee Cream.

Storage Guidelines

To maintain the quality of SSDee Cream, it is important to follow storage recommendations;

1. Keep it in a dry place; Store SSDee Cream in a cool and dry area to prevent any changes in its composition that could affect its effectiveness for therapeutic purposes.

2. Protect it from sunlight; Avoid exposing the cream to direct sunlight as it can cause alterations in its chemical structure.

3. Use secure packaging: Ensure that the cream is stored in securely packaged containers to prevent contamination and maintain its sterility for the entire duration of its shelf life.

Important Precautions

To ensure the safety of patients, it is important to take precautions when using SSDee Cream for an extended period. This includes monitoring for any absorption into the body and adjusting its application accordingly for pediatric and geriatric patients.

Precautions for Prolonged Use

It is important to take precautions when using SSDee Cream for an extended period of time;

1. Regular Assessments: Healthcare providers should regularly assess and monitor for any signs of the cream being absorbed into the body, especially when it is used for a duration.

2. Monitoring Renal Function: It is advisable to monitor the function in cases where the cream is used for an extended period. This is because silver sulfadiazine, which is present in the cream, can potentially be absorbed into the body and affect kidney health in individuals.

3. Considering Alternatives: When anticipating prolonged use of SSDee Cream, it may be worth exploring wound care formulations while considering both their effectiveness and potential systemic effects.

Monitoring for Systemic Absorption

It is crucial to monitor the potential effects of SSDee Cream on the body to ensure safety. Regular blood cell count checks are necessary for patients with existing blood disorders. These checks help identify any impacts that may occur. Additionally, periodic laboratory assessments, including blood tests and evaluations of kidney function, provide an understanding of the risks associated with systemic absorption. Healthcare professionals should emphasize the importance of reporting any symptoms or side effects promptly.

Considerations for Pediatric and Geriatric Patients

Adapting the use of SSDee Cream for geriatric patients requires careful considerations;

1. Adjusting Dosage for Pediatric Patients: Dosage adjustments may be necessary for patients, taking into account factors such as age, weight, and the specific condition being treated. This ensures that the treatment achieves therapeutic outcomes.

2. Addressing Skin Sensitivity in the Geriatric Population: The geriatric population has more sensitive skin, which means it is important to closely monitor any potential skin reactions. If needed, adjustments in application frequency can be made to ensure their comfort.

3. Collaborating with Healthcare Providers: Close collaboration with healthcare providers is crucial when applying SSDee Cream to geriatric patients. This collaboration helps customize the treatment to suit their physiological characteristics.

By considering these nuanced factors, we can provide effective. Tailored SSDee Cream application for both pediatric and geriatric patients.

Administration to Special Populations

Administering SSDee Cream to populations requires careful consideration and attention to detail. It involves adjusting dosage, monitoring for reactions, and being aware of specific needs. This article explores the complexities of administering SSDee Cream to groups, including elderly pregnant women, nursing mothers, and children.

Administration to Elderly

To ensure that the elderly can safely and effectively use SSDee Cream, it is important to customize the dosage and carefully monitor for any negative reactions. Adjusting the dosage based on the changes that occur with aging will help achieve the best therapeutic results without putting them at unnecessary risk. Additionally, due to changes in skin health and sensitivity, it is crucial to closely observe and monitor for any adverse reactions, including irritation or allergic responses, particularly in older individuals.

Administration to Pregnant Women and Nursing Mothers

To ensure the use of SSDee Cream during pregnancy and lactation, it is important to assess both its therapeutic benefits and potential risks carefully. Healthcare professionals should be involved in conducting an evaluation to determine if using SSDee Cream is appropriate in these situations. Additionally, clear guidelines need to be established regarding its use during pregnancy and lactation, taking into account any effects on fetal development and the transfer of components into breast milk.

Administration to Children

When it comes to using SSDee Cream in patients, it's important to carefully consider the dosage and be aware of potential side effects that may be specific to children. Here are a couple of points to keep in mind;

  • Dosage for Children: It's crucial to adjust the dosage based on the child's age, weight, and specific condition. This helps ensure that they receive the right amount of medication and achieve optimal therapeutic results without over or under-dosage.
  • Side Effects in Children: Children may experience side effects, so it's important to be extra vigilant about monitoring their skin reactions, allergies, or any other adverse events that might be more common among this group.

By considering these factors, we can provide patients with appropriate treatment using SSDee Cream while minimizing any potential risks.


SSDee Cream is indeed a tool for wound care, but it's crucial to be aware of the potential risks of overdosage. Understanding the symptoms, having emergency response procedures in place, and conducting follow-up and monitoring are all essential aspects to consider.

Symptoms of Overdosage

It is crucial to be able to recognize the signs of taking medication as it allows for timely intervention.

  • If you apply an amount, you may experience heightened irritation in the specific area, leading to symptoms like redness, swelling, or increased discomfort at the site of application.
  • Overdosing can also worsen reactions, resulting in more noticeable symptoms such as a rash, itching, or even affecting your entire body.
  • Additionally, using much medication for an extended period can increase the risk of it being absorbed into your bloodstream and potentially impacting kidney function and blood cell counts.

Emergency Response Procedures

It is crucial to respond effectively if you suspect an overdose of SSDee Cream. Here are the steps to follow;

1. Stop using SSDee Cream as soon as you suspect an overdose to avoid any further complications or negative effects.

2. Thoroughly wash the area with water and mild soap to remove any excess cream and minimize its absorption into the body.

3. It is important to seek medical help for a thorough evaluation and appropriate treatment, especially if severe symptoms or systemic involvement occur.

Remember, taking these actions quickly can make a difference in managing the situation effectively.

Follow-up and Monitoring After Overdosage

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Art on Apr 16, 2017 Verified Purchase

Great product

This is commonly used for burns and we have used it for that purpose but recently I had an open wound which some people call bed sores and the doctor told me to use this on it. Very effective in helping to heal the wound

Our response:
Dear Art , Thank you for your feedback we greatly appreciate it,We are glad to hear that you are happy with your purchase and the product works perfectly with you. Please continue supporting us as we value your business with us. thank you
Note: does not imply any medical claims from this review.

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