Solifenacin is used for the treatment of overactive bladder where people who are suffering with this condition have more frequency urgency for urination. Solifenacin works to relax the muscles in the bladder and allows patients to control urination.

Generic Vesicare


Soliten, Fenopaz, Kinzy


Ranbaxy Limited, Sava Healthcare, Abdi Ibrahim


5 mg, 10 mg

India, Turkey


I. Introduction

Brief Overview of Solifenacin

Solifenacin is a medication primarily used to treat Overactive Bladder (OAB).

Medical Importance

The medication acts as a drug, improving symptoms like the urgent need to urinate, frequent urination, and waking up at night to urinate. This significantly improves the quality of life for individuals experiencing Overactive Bladder (OAB).

Structure of the Article

This article will explore aspects of Solifenacin including its chemical makeup, uses in clinical settings potential side effects, and detailed information, about how it is processed and works in the body.

II. What is Solifenacin?

Chemical Composition and Structure

Solifenacin is a man-made substance called Solifenacin succinate, which has a chemical structure known as quinuclidinyl carbamate.

FDA Approval Status

Solifenacin received approval from the FDA in 2004, which solidified its reputation as a treatment option for Overactive Bladder (OAB).

III. Uses of Solifenacin

Treatment of Overactive Bladder (OAB)

Mechanism of Action

Solifenacin is a medication that works by blocking muscarinic receptors in the detrusor muscle of the bladder1. This mechanism of action helps to achieve its therapeutic effects. For more information about solifenacin, you can visit the DrugBank Online website1.

1Solifenacin: Uses, Interactions, Mechanism of Action | DrugBank Online

Clinical Efficacy

Solifenacin has been studied in various randomized clinical trials, which have corroborated its potency in reducing episodes of urgencyfrequency, and incontinence1. For more information about solifenacin and its use in treating urinary incontinence, you can visit the following references:

  1. A review of solifenacin in the treatment of urinary incontinence
  2. NCT03787654
  3. Electroacupuncture versus solifenacin for women with urgency-predominant mixed urinary incontinence: a protocol for a three-armed non-inferiority randomized controlled trial
  4. Solifenacin Succinate 5mg or 10mg Once Daily in the Treatment of Overactive Bladder (OAB)
  5. A Study to Evaluate Quality of Life in Patients Switched to Solifenacin Succinate 5mg or 10mg Once Daily

Off-label Uses

Urinary Retention

Solifenacin is a medication that is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage) 1. It belongs to a class of medications called anticholinergic medications. It works by relaxing the bladder muscles and preventing spasms of the bladder muscle. This helps to increase the amount of urine that your bladder can hold and control the release of urine 1Although it is not officially approved by the FDA for this use, solifenacin is occasionally used to treat urinary retention 1. For more information about solifenacin, you can visit the following references:

  1. Solifenacin Succinate - Bladder & Bowel Community

Neurogenic Bladder

Solifenacin is a medication that is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage) 1. It belongs to a class of medications called anticholinergic medications. Although some doctors do prescribe Solifenacin for patients with bladder conditions, the evidence supporting this usage is not as strong 2For more information about Solifenacin, you can visit the DrugBank Online website 1.

1Solifenacin: Uses, Interactions, Mechanism of Action | DrugBank Online 2Solifenacin Succinate - Bladder & Bowel Community

Irritable Bowel Syndrome

Recent studies suggest that there could be benefits in using Solifenacin for gastrointestinal applications in conditions such as Irritable Bowel Syndrome (IBS)1

1Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea: Open-label Prospective Pilot Trial

IV. How Solifenacin Works


Action on Muscarinic Receptors

It functions as an antagonist on the M3 muscarinic acetylcholine receptors.

Relaxation of Smooth Muscles

This interaction with receptors results in the relaxation of muscles in the urinary bladder, which helps to alleviate the symptoms of overactive bladder (OAB).



Solifenacin is well-absorbed upon oral administration, reaching peak plasma concentrations within 3 to 8 hours.


The drug spreads throughout the body's tissues, covering an area of distribution.

Metabolism and Excretion

It is mainly broken down by liver enzymes CYP3A4 and eliminated primarily via the kidneys.

V. Dosage and Administration

Standard Dosages

Initial Dosage

Usually, the recommended starting dose is 5 mg, taken once a day. However, adjustments to the dosage may be necessary depending on how the patient responds to the treatment.

Maintenance Dosage

The recommended daily maintenance dosage typically falls within 5 to 10 milligrams.

Forms Available

Tablets come in both 5 mg and 10 mg variations, while oral solutions are commonly utilized but still accessible.

How to Take Solifenacin

With Food or Without Food

Solifenacin can be taken with or without food.

Time of Day

For the results, taking the medication simultaneously every day is recommended to ensure consistent therapeutic effects.

VI. Side Effects of Solifenacin

Common Side Effects

Dry mouth is a side effect that affects around 28% of patients. Constipation has been reported in up to 15% of patients. While blurred vision is not frequently reported, caution is still essential.

Serious Side Effects

Allergic Reactions

Sometimes, people may experience skin rashes, hives, or, in instances, a potentially life threatening condition called anaphylaxis.

Renal Impairment

Although rare, renal function could be compromised.

Reporting Side Effects

How to Report

It would be best if you informed your healthcare providers or relevant medical authorities about any side effects you may experience.

When to Seek Medical Attention

If you experience any serious side effects, it's essential to seek immediate medical attention and assistance.

VII. Drug Interactions with Solifenacin

Interaction with Other Medications

Anticholinergic Drugs

The amalgamation of Solifenacin with other anticholinergic agents can produce an additive effect, intensifying the propensity for anticholinergic side effects such as dry mouth or constipation.

CYP3A4 Inhibitors

It's essential to be cautious when using Solifenacin with CYP3A4 inhibitors such, as ketoconazole because these substances can increase the levels of Solifenacin in the blood.

Alcohol and Substance Interactions

Drinking alcohol at the same time as taking Solifenacin can make you feel even more tired than usual.

Nutritional and Herbal Interactions

There is a possibility that certain herbal supplements, like St. Johns Wort, might affect the way Solifenacin is metabolized. It's challenging to find concrete data on this matter.

VIII. Warnings and Contraindications

Black Box Warnings

Currently, regulatory agencies have not issued a Black Box Warning for Solifenacin.


Severe Renal Impairment

Patients who have recently experienced kidney problems should avoid taking Solifenacin because it can be harmful to the kidneys.

Allergic Reactions

Not recommended for people who have shown a reaction to Solifenacin or similar substances.

Careful Administration

In Patients with Liver Diseases

Patients with liver problems must have their medication dosage adjusted.

In Patients with Cardiovascular Conditions

Patients with preexisting heart conditions should be given Solifenacin while closely monitored by professionals.

IX. Special Populations and Considerations

Administration to Elderly

Adjusted Dosage

Some older patients might require a starting dose to minimize the chances of experiencing any adverse effects.

Monitoring and Risks

It is crucial to monitor kidney function for this specific population.

Administration to Pregnant Women and Nursing Mothers

Pregnancy Category

Solifenacin is classified as Pregnancy Category C, which means there are risks to the fetus.

Risks and Considerations

Lactating mothers are advised to avoid taking Solifenacin because the potential risks of it being excreted into breast milk are still unknown.

Administration to Children

Age Limitations

Solifenacin is generally not recommended for pediatric populations.

Clinical Studies and Efficacy

The evidence for the drug's effectiveness in children is not yet strong enough.

X. Overdosage and Management

Symptoms of Overdose

Overdose symptoms may encompass tachycardia, severe drowsiness, and blurred vision.

Immediate Actions and Antidote

Immediate medical attention is requisite; no specific antidote is available.

Long-term Consequences

Excessive and prolonged use of medication can lead to the development of anticholinergic symptoms.

XI. Storage and Handling Precautions

Optimal Storage Conditions

Store solifenacin at room temperature, away from moisture and heat.

Shelf Life

The drug has a shelf life commensurate with the expiration date imprinted on the packaging.

Handling Precautions

In Case of Spillage

Avoid contact, and make sure to wear gloves when cleaning up.

Disposal Methods

It is essential to dispose of any medication that is unused or expired following the regulations set by your local authorities.

XII. Important Precautions

Monitoring Parameters

Healthcare professionals need to evaluate the functionality of the urinary system and ensure that symptoms are effectively relieved.

Risk Mitigation Strategies

It is important to schedule follow-up appointments and consider adjustments to the dosage as effective strategies.

XIII. Conclusion

Summary of Key Points

Solifenacin is an efficacious pharmacological intervention for OAB but demands cautious administration due to potential drug interactions and side effects.

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