Tolnaftate cream is used as an anti-fungal treatment. Tolnaftate cream is used in the treatment of jock's itch, athlete's foot and ringworm.

Aftate; Blis-To-Sol; Dr Scholl's Athlete's Foot; Genaspor; Podactin; Quinsana Plus; Tinactin;





Cream, Soln

10 mg/20 mL

Out of Stock.


I. Introduction

Brief History of Tolnaftate

Tolnaftate, first developed in the 1960s, marked a significant breakthrough in treating dermatophytic infections. Its effectiveness was quick. It has remained a vital component of antifungal therapy ever since.

General Description: What is Tolnaftate?

Tolnaftate is a type of medication that is mainly used to treat skin infections. It comes in creams, powders, and sprays, effectively treating various dermatological conditions.

Scope of the Article

This article offers an overview of Tolnaftate, exploring its various applications, potential side effects, instructions for administration, and other relevant details. Both medical experts and the general public will find this information extremely valuable.

II. Uses of Tolnaftate

Treating Athlete's Foot (Tinea Pedis)

Tolnaftate is an antifungal medication that fights infections caused by fungus. It is used to treat infections such as athlete’s foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis) 1Tolnaftate topical is available in various forms such as cream, powder, solution, and spray 1.

The Mayo Clinic provides information on the symptoms and causes of athlete’s foot, a fungal skin infection that usually begins between the toes. It commonly occurs in people with sweaty feet while confined in tight-fitting shoes. Signs and symptoms of athlete’s foot include an itchy, scaly rash 2.

Treating Jock Itch (Tinea Cruris)

Tolnaftate is just as effective in relieving the symptoms of Jock Itch, which's another type of fungal infection that affects the skin.


Tolnaftate for jock itch

Addressing Ringworm (Tinea Corporis)

For ringworm cases, applying a treatment can help speed up the healing process and resolve the infection more quickly.


Tolnaftate versus clotrimazole for the treatment of tinea cruris

Tolnaftate 1% cream for the treatment of tinea cruris

Efficacy Against Fungal Nail Infections

While it is not commonly used, Tolnaftate has shown some effectiveness in treating onychomycosis.


Tolnaftate for onychomycosis

III. Off-Label Uses of Tolnaftate

Application in Seborrheic Dermatitis

Some medical professionals support tolnaftate utilization for treating dermatitis even though it does not have FDA approval, for this specific purpose.

Experimental Uses in Laboratory Settings

Ongoing research is being conducted to explore how it can effectively combat a variety of fungal pathogens through, in vitro studies.

IV. How Tolnaftate Works

Mechanism of Action Against Fungal Cells

Tolnaftate works by blocking the activity of an enzyme called squalene epoxidase, which disrupts the synthesis of cell membranes.

Rate of Absorption and Effectiveness

When topical treatments are applied, they have limited absorption into the bloodstream, which means they mainly work directly at the area to achieve the best results.

V. Composition of Tolnaftate

Chemical Formula and Structure

The main component of the chemical compound has the molecular formula C_19H_17NOS. It exists in the form of a powder with a white crystalline appearance.

Inactive Ingredients in Commercial Preparations

  • Stabilizers
  • Emollients
  • Propellants (in sprays)

VI. Dosage and Administration

For treating athlete's Foot, it is recommended to apply the medication two times a day for 2 to 4 weeks. In the case of Ringworm, applying the drug daily for 3 weeks is advised.

Different Forms: Cream, Spray, Powder

Each formulation offers customized benefits based on the specific type of infection and its location.

Application Guidelines

a. Careful Administration

The application should be accurate, covering the infected area to prevent the spread of fungi.

b. Administration to Elderly

Elderly individuals might need doses of medication due to their slower metabolism.

c. Administration to Pregnant Women and Nursing Mothers

Tolnaftate is classified as Category C by the FDA, which means it is recommended to exercise caution during pregnancy and while breastfeeding.

d. Administration to Children

It is advisable to seek guidance from a pediatrician regarding the dosages of Tolnaftate as it is generally not recommended for children below the age of 2.

VII. Side Effects of Tolnaftate

Common Side Effects: Itching, Burning

It's common to experience an itching or burning sensation when applying the product, but there's no need to worry as it usually goes away with regular use.

Less Common Side Effects: Rash, Irritation

Cases of skin rash or irritation are uncommon. Requires stopping the medication right away and seeking advice from a healthcare professional.

VIII. Important Precautions

What to Do in Case of Severe Side Effects

It is crucial to seek medical assistance in cases of severe reactions, such as anaphylactic shock.

Interactions with Other Medications

Tolnaftate topical application reduces the chances of any interactions with other medications. However, you should consult a healthcare provider if you use medications simultaneously. The information provided above acts as a guide on Tolnaftate. It is essential to seek advice from a healthcare professional who can provide a diagnosis and personalized treatment based on your medical requirements.

IX. Over Dosage

Signs and Symptoms

Overdosing on Tolnaftate is not an occurrence as it is primarily used topically. However, it is not entirely impossible. If an overdose were to happen, you might experience irritation of the skin, severe redness, or unusual changes in skin coloration.

Emergency Procedures and Antidotes

If an overdose occurs it is essential to seek medical attention. While there is no antidote, for overdosing on Tolnaftate, it is recommended to rinse the affected area with plenty of water as a supportive measure.

X. Storage and Handling Precautions

Optimal Storage Conditions

To maintain the effectiveness and quality of the medication, it is essential to store Tolnaftate in this manner: Keep it at room temperature. Avoid exposing it to sunlight. Store it in a dry environment.

Shelf Life

Typically, Tolnaftate remains effective for around 2 to 3 years. After this time, it is advisable to dispose of it to avoid any reduction in its potency or potential risks.

Disposal Guidelines

Improperly disposing of medication can pose risks to the environment. Therefore, it is essential to refrain from flushing them down toilets. Instead, make use of community take-back disposal programs whenever they are available.

XI. Drug Interactions

Potential Interactions with Prescription Drugs

Although it is not usually significant, Tolnaftate with other antifungal agents may impact its pharmacodynamic profile.

Over-the-Counter Drug Interactions

Using Tolnaftate simultaneously with other over-the-counter antifungal creams might reduce its effectiveness. It's advisable to consult a healthcare professional for a list of potential interactions.

XII. Warnings and Contraindications

When Not to Use Tolnaftate

Tolnaftate should not be used by individuals who have shown hypersensitivity to the ingredient or any of the other substances in it.

Contraindications with Other Medical Conditions

It is essential to exercise caution when using Tolnaftate in situations involving wounds or severe dermatological conditions that require systemic treatment.

XIII. Conclusion

Summary of Key Points

Tolnaftate continues to be a weapon in the fight against skin fungal infections. However, its effectiveness relies on the use and following the recommended guidelines.

Recommendations for Safe and Effective Use

To ensure the results from your therapy, it is essential to consult with healthcare professionals for precise diagnosis and suitable treatment methods. It is crucial to follow the storage guidelines. Exercise caution when dealing with groups such as older individuals, expectant mothers, and children. Implementing these recommended approaches will not only enhance Tolnaftate's effectiveness but also minimize any risks or complications that may arise.

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