Aggrenox (Dipyridamole/Acetylsalicylic) is prescribed to lower the risk of stroke in individuals who have had transient ischemic attacks or a previous stroke due to a blood clot.


Dipyridamole/ Acetylsalicylic



Boehringer Ingelheim


Dipyridamole 200 mg / Acetylsalicylic 25 mg



1. Introduction

Aggrenox, a drug used for preventing strokes, combines the antiplatelet medications Aspirin and Dipyridamole. Its development and subsequent approval by the FDA represent an achievement in medical treatment. The primary purpose of this medication is to reduce the risk of stroke, especially in individuals who have previously had transient ischemic attacks or "mini-strokes."

2. Composition of Aggrenox

Active Components: The combination of Aspirin, a known anti-inflammatory agent, and Dipyridamole, a phosphodiesterase inhibitor, comprise the essential elements responsible for Aggrenox's therapeutic effects. Inactive Components and Their Functions: While these ingredients may not have pharmacological effects, they are crucial in optimizing drug absorption and stability. Comparison to Other Antiplatelet Medications: When compared to similar drugs, Aggrenox stands out due to its unique dual action mechanism that provides a distinct advantage in antiplatelet therapy.

3. Mechanism of Action: How Aggrenox Works

4. Uses of Aggrenox

Aggrenox is a combination of aspirin and dipyridamole used to reduce the risk of stroke in people who have had blood clots or a “mini-stroke” (also called a transient ischemic attack or TIA) 1Studies comparing Aggrenox to single drug treatments show that Aggrenox is a more effective choice 1To gain an understanding of how well it works in preventing strokes, it is important to carefully analyze the results of clinical trials conducted on Aggrenox 123.

Here are some references that you can use to learn more about Aggrenox:

  1. Aggrenox: Uses, Dosage & Side Effects -
  2. FDA Label - Aggrenox capsule, extended release
  3. Aggrenox | Boehringer Ingelheim

5. Off-Label Uses of Aggrenox

Aggrenox has a wide range of off-label applications due to its diverse pharmacological effects. It has been observed to have some usefulness in managing symptoms related to anxiety, although in a conventional manner. Additionally, Aggrenox’s positive effects also extend to cardiovascular conditions, demonstrating its versatility as a therapeutic option 2345.

Here are some references that you can use to learn more about Aggrenox:

  1. Aggrenox: Uses, Dosage & Side Effects -
  2. Off-Label Uses of Aggrenox - Healthline
  3. Aggrenox - FDA prescribing information, side effects and uses
  4. Aggrenox (aspirin/dipyridamole) dosing, indications, interactions, adverse effects, and more
  5. Aggrenox - Drug Usage Statistics, ClinCalc DrugStats Database

6. Dosage and Administration

It is crucial to follow the recommended dosage instructions to achieve the results of your treatment. Adjustments may be necessary for specific groups of people depending on factors like age or kidney function. It's essential to have guidelines on what to do if you miss a dose or accidentally take too much medication, as this ensures that your treatment remains effective and safe.

7. Side Effects of Aggrenox

Although Aggrenox is usually well tolerated, it can still have some side effects. The common ones are headaches and gastrointestinal discomfort, which can generally be managed. There are also severe side effects that require immediate medical attention. Compared to antiplatelet agents, the side effect profile is similar, although there may be variations in how often they occur and their severity.

8. Interactions with Other Medications

Interactions with Medications: When taking Aggrenox, awareness of potential interactions with certain medications is essential. These interactions can occur with anticoagulants and anti-inflammatory drugs, among others, which may increase the risk of bleeding. Interactions between Aggrenox and Over-the-counter Medications: Even commonly used over-the-counter remedies like NSAIDs or supplements such as fish oil can impact the effectiveness of Aggrenox or potentially lead to side effects. Interactions with Dietary and Herbal Supplements: It is essential to exercise caution when combining Aggrenox with herbal supplements like ginkgo biloba or St. Johns Wort, as they may have the potential for interactions that require careful monitoring.


9. Contraindications and Warnings

Please note that Aggrenox should not be used by individuals who have had a hypersensitivity reaction to aspirin, dipyridamole, or any of its components. It is also essential to be aware that active gastrointestinal bleeding and certain cardiac conditions may contraindicate the use of this medication, as indicated by the black box warnings. If you have allergies, asthma, or any other pre-existing medical conditions, it is advisable to exercise caution and consult with a healthcare before starting Aggrenox therapy.

10. Special Administration Considerations

Guidelines for the Elderly: When it comes to patients, it is crucial to carefully adjust and monitor the medication dosage due to the changes in how their bodies process drugs. Considerations for Pregnant Women and Nursing Mothers: We do not have information on whether Aggrenox is safe during pregnancy or while breastfeeding, so it's best to approach its use cautiously. Usage in Children: We haven't decided yet whether Aggrenox is effective and safe for patients. Therefore it is generally not recommended for use in this age group.

11. Overdose: Identification and Response

Identifying Signs of Overdose: If someone experiences high blood pressure, a headache, dizziness, or gastrointestinal discomfort, it could be a sign of taking too much Aggrenox. What to Do and Medical Assistance: If an overdose occurs, it is crucial to seek medical help. Treatment may involve providing support and addressing the symptoms. Taking Care of Overdose Patients in the Long Run: It is essential to monitor and provide supportive care to prevent any potential long-term complications resulting from an overdose.

12. Storage and Handling Precautions

It is essential to store Aggrenox in conditions to maintain its effectiveness. Keep it at room temperature, away from moisture and direct sunlight. When handling Aggrenox, be cautious to ensure safety and comply with the therapy. Dispose of any unused medication properly to prevent misuse and environmental contamination.

13. Important Precautions

Preventive Measures: If you are taking Aggrenox, it is essential to follow your doctor’s instructions carefully. Do not stop taking the medication without consulting your doctor first. If you experience any unusual symptoms while taking Aggrenox, such as severe headache, difficulty breathing, or chest pain, seek medical attention immediately 1.

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