Amiodarone is prescribed to treat certain types of acute ventricular arrhythmias and atrial fibrillation when other medications are ineffective or could not be tolerated. It relaxes overactive heart muscles.

Generic Cordarone, Pacerone, Nexterone


Cordarone x, Amiodar, Tachyra


Cipla, Micro Labs, Sanofi India


100 mg, 200 mg



I. Introduction to Amiodarone

A. What is Amiodarone?

Amiodarone, an flexible medication for heart rhythm disorders, has firmly established itself within the medical field due, to its wide-ranging effectiveness. This remarkable pharmaceutical is primarily utilized to treat forms of irregular heartbeat showing success where other drugs may struggle.

B. History and Development of Amiodarone

First developed during the 1960s, Amiodarone was created by researchers at Laboratoires Labaz. Initially intended for treating angina, this medication showed promising results in regulating heart rhythm disorders. As a result, it received approval from the U.S. Food and Drug Administration (FDA) in 1985. Over time its usage has expanded, playing a role in the care of cardiac patients, across the globe.

II. Composition of Amiodarone

A. Chemical Properties and Structure

Amiodarone belongs to the derivative family. Its intricate chemical structure has a di-iodinated benzofuran ring and a phenoxy group. What sets Amiodarone apart is its iodine content making up around 37% of its overall molecular weight. This distinct structure is responsible for both its antiarrhythmic effects and the various side effects it can cause.


B. Pharmacological Characteristics

Amiodarone possesses fascinating pharmacological properties. It is known for its lipid solubility, contributing to its extensive distribution throughout the body. Additionally, it has a prolonged elimination life that can span several weeks, supporting its long-lasting effects. The drug undergoes liver metabolism, leading to the formation of its active metabolite, desethylamiodarone.

III. How Amiodarone Works

A. Mechanism of Action

The way Amiodarone works is quite complex, but its primary goal is to restore the heart's rhythm. It achieves this by blocking alpha and beta-adrenergic receptors, which reduces stimulation. At the time, it alters the flow of ions across cell membranes causing the action potential duration and refractory period in heart tissue to increase. By targeting channels like potassium, calcium, and sodium, Amiodarone falls into a category that combines elements from all four classes of antiarrhythmic medications, as defined by Vaughan Williams.

B. The Impact on the Cardiac System

The impact of Amiodarone on the heart is significant. It has ways of working to achieve this; It helps prevent dangerous heart rhythm disturbances by suppressing abnormal electrical activity. By reducing excitability and slowing down the spread of electrical signals, it helps maintain a normal heart rhythm. It also stabilizes the heart muscle cells' cell membrane, preventing electrical currents from arising. In the end, all these actions work together to restore a rhythmic heartbeat, which is crucial for maintaining overall health.

Approved Uses of Amiodarone

Treating Arrhythmias

Amiodarone is an antiarrhythmic medication used to treat irregular heart rhythms, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.

Here is a reference that you can check out for more information about Amiodarone:

Use in Heart Failure Management

Amiodarone is also used for the treatment of heart failure. Its mechanism involves decreasing the incidence of cardiac arrest and enhancing cardiac performance.

Here is a reference that you can check out for more information about Amiodarone:

Other Cardiac Conditions and Their Treatment

Amiodarone is also prescribed for treating heart conditions such as hypertrophic cardiomyopathy, long QT syndrome, and Wolff Parkinson White syndrome.

Here is a reference that you can check out for more information about Amiodarone:

Off-label Uses of Amiodarone

In the Management of Atrial Fibrillation

Amiodarone is sometimes prescribed for atrial fibrillation even though it is not approved for this specific use.

Here is a reference that you can check out for more information about Amiodarone:

Role in Non-cardiac Diseases

Amiodarone is an antiarrhythmic drug that blocks specific electrical signals in the heart that can cause an irregular heartbeat. It is used to treat and prevent serious, life-threatening types of abnormal heart rhythm, such as ventricular arrhythmias, when other medications do not work or cannot be tolerated. It relaxes overactive heart muscles and controls muscle contractions in the heart. It may not be effective in cardiac arrest1.

Amiodarone is not officially approved by authorities for treating cancer, lung disease, thyroid disease and autoimmune diseases1.

Here are some references for you to check out:

VI. Dosage and Administration

A. Standard Dosage Guidelines

Finding the balance between achieving therapeutic benefits and minimizing potential side effects is crucial when prescribing Amiodarone. In the case of ventricular arrhythmias, the initial recommended dosage typically ranges from 800 to 1600mg per day for one to three weeks. Afterward, the dose is gradually reduced to 600 to 800mg daily for a month. Eventually, a maintenance dose of 400mg per day is generally recommended. It's essential to follow the guidelines provided by the prescriber for medical conditions when using Amiodarone.

B. Adjustments for Specific Patient Populations

Particular groups of patients require the use of Amiodarone. In individuals with liver problems, it may be necessary to use doses or take longer breaks between doses because the way their bodies process the drug is different. For people with thyroid issues, whether it's an underactive thyroid, it's essential to monitor them closely and consider adjusting the dose if needed because Amiodarone contains a high amount of iodine.

C. Mode of Administration and Timing

Usually, Amiodarone is taken by mouth. In emergencies, doctors may use the intravenous form. It's recommended to take the tablet with food to help with absorption. Also, it's essential to take it at the time every day to keep the medication levels in your bloodstream stable.

VII. Side Effects of Amiodarone

A. Common Side Effects and Their Management

Although Amiodarone is generally well tolerated, it has some side effects that patients may experience. These can include feelings of nausea and vomiting which can often be managed by taking the medication with food. It's also important to note that Amiodarone can make the skin more sensitive to sunlight. It's necessary to take precautions and protect yourself from the sun when using this medication. Additionally, constipation may be a side effect, but it can usually be managed through dietary adjustments and increasing fluid intake.

B. Serious Side Effects and Warning Signs

Amiodarone may have some side effects that need to be taken seriously. These can include lung disease, characterized by cough and shortness of breath requiring immediate medical attention. It's essential to undergo thyroid function tests to detect and manage any potential dysfunction. Additionally, liver function tests should be performed on a basis while undergoing treatment, with Amiodarone to monitor for any hepatic dysfunction.

VIII. Interactions with Other Drugs and Substances

A. Potential Drug Interactions

Amiodarone requires monitoring due to its potential for numerous drug interactions. There is a risk of increased bleeding when combined with anticoagulants. It may also require dosage adjustments alongside antiarrhythmics, beta-blockers, or certain antibiotics.

B. Dietary Considerations and Interactions

The way we eat can have an impact on how Amiodarone works in our bodies. Eating high-fat meals can make Amiodarone absorb better while having grapefruit juice can increase the levels of Amiodarone in our blood, making its effects and side effects even more vital. It's important to avoid taking Amiodarone at the time as certain herbal supplements, like St. Johns Wort, as they could potentially interact with each other.

IX. Warnings and Contraindications

A. Patient Categories at Risk

Although Amiodarone benefits many patients, it is essential to exercise caution when prescribing this medication to specific groups. Individuals with existing thyroid, liver, or lung conditions should be monitored closely, as the drug may worsen these conditions. Additionally, individuals with genetic variations that affect the metabolism of Amiodarone may have increased drug levels and experience undesirable reactions as a result.

B. Situations Where Amiodarone is Contraindicated

There are situations where Amiodarone should not be used. These include; Patients who have a hypersensitivity to Amiodarone or iodine. Patients who have sinus node dysfunction that causes severe bradycardia. Individuals who have second or third-degree atrioventricular block but do not have a pacemaker. It is crucial to evaluate the patient before starting Amiodarone therapy, as these contraindications highlight the importance of a comprehensive assessment.

X. Careful Administration of Amiodarone

A. Monitoring Parameters During Treatment

Regular monitoring is essential when undergoing Amiodarone therapy to ensure effective treatment minimizes any side effects. It is necessary to assess liver and thyroid function due to the medication's potential to cause liver and thyroid issues. In addition, it might be necessary to conduct electrocardiograms, chest X-rays, and pulmonary function tests to evaluate the impact of the drug on the respiratory systems.

B. Special Administration Instructions

When using Amiodarone, it's essential to follow guidelines. For example, make sure to take the medication with meals to absorb it properly. Also, avoid stopping the medication due to Amiodarone's long half-life and the possible rebound effects on the heart.

XI. Special Considerations for Administration

A. Administration to Elderly Patients

When dealing with patients, it is essential to consider the potential decline in renal, hepatic, and cardiac function that may come with age. This can have an impact on how Amiodarone's processed in the body. To ensure safety and effectiveness, starting with doses and closely monitoring these patients is recommended.

B. Use in Pregnant Women and Nursing Mothers

Amiodarone falls under pregnancy category D, suggesting some risks to the fetus. It should be considered for use during pregnancy only if the potential advantages outweigh the risks. Since Amiodarone can be passed through breast milk, the decision to administer this medication to breastfeeding mothers should consider the impact on the baby's well-being.

C. Administration to Children

Although not officially approved for use in children, Amiodarone may be considered when other treatments have been unsuccessful, and a child's life is at risk. However, it is crucial to approach its usage due to the drug's long-lasting effects and potential for adverse consequences. Regular monitoring is necessary to ensure the well-being of patients being treated with Amiodarone.

XII. Handling an Overdose of Amiodarone

A. Symptoms of Overdose

Taking an amount of Amiodarone can lead to different symptoms mainly caused by its effects on the heart. These symptoms may include slowed heart rate problems with heart conduction and low blood pressure. In addition, it is possible to experience cardiac effects like nausea, tremors, and liver damage. It is crucial to identify and acknowledge these indications as it plays a role in enabling prompt medical intervention.

B. Medical Intervention and Treatment

If someone experiences an overdose of Amiodarone, it is crucial to seek medical help. The treatment mainly focuses on providing support and addressing symptoms and complications as they occur. In situations with bradycardia or heart block, it might be necessary to insert a pacemaker. Although Amiodarone cannot be removed through dialysis, there is a possibility of considering elimination techniques under the guidance of an expert.

XIII. Storage and Handling Precactions for Amiodarone

A. Ideal Storage Conditions

Amiodarone should be stored in a controlled environment to ensure its effectiveness and safety. It is best to keep it at room temperature, between 20 and 25 degrees Celsius, away from extreme heat and moisture. This precaution helps maintain the quality of the ingredient, ensuring its efficacy.

B. Safety Measures for Handling

Ensuring safety when dealing with Amiodarone is crucial. It is essential to keep the medication from children and pets and to avoid direct contact with the tablets to prevent any contamination. Moreover, it is essential to dispose of any leftover medication or waste properly, following the regulations set by your authorities.

XIV. Important Precautions While Using Amiodarone

A. Lifestyle and Dietary Considerations

When taking Amiodarone, changing your lifestyle and diet might be essential. Remember to protect yourself from the sun since this medication can make your skin more sensitive. It's also an idea to have a balanced and nutritious diet, possibly with lower iodine levels, to prevent any issues with your thyroid. Lastly, its recommended to drink alcohol in moderation as the medication can impact your liver.

B. Adherence to Dosage and Administration Guidelines

It is crucial to follow Amiodarone's recommended dosage and administration instructions to ensure treatment. Remember, if you miss a dose, do not try to make up for it by taking it at the next scheduled time. Also, it is not advisable to stop taking Amiodarone as it can lead to rebound cardiac effects. Stay consistent with your medication schedule and regularly consult your physician for possible treatment results.

Amiodarone side effects?

One must exercise caution when using amiodarone due to the possible side effects it presents. These include common complaints such as nausea or constipation alongside feeling shaky or fatigued. On a more concerning note are the serious risks of pulmonary toxicity or hepatic insufficiency as well as thyroid dysfunction and visual disturbances that cannot be overlooked.

Amiodarone is used for?

Ventricular arrhythmias and atrial fibrillation or flutter pose significant health risks that require immediate professional medical intervention. One of the medications medical experts commonly prescribe for these situations is amiodarone. Its a potent medication that plays an essential role in treating these severe cardiac concerns while improving general well-being.

Amiodarone uses?

A reliable remedy in the face of critical ventricular arrhythmias Amiodarone serves as a key medicinal asset. It can treat not only such grave conditions but also help manage ones like atrial fibrillation or atrial flutter.

Amiodarone mechanism of action?

To stabilize the heartbeat of individuals with cardiac problems, Amiodarone functions by obstructing specific electrical signals present in their hearts. It impacts crucial sodium, potassium, and calcium channels alongside having beneficial beta-blocking properties.

Amiodarone 200 mg?

When administering Amiodarone, healthcare professionals often prescribe a common dose form of 200 mg to be taken once daily. Nevertheless, its crucial to assess the individual requirements and adjust the dosage accordingly for each patient.

Amiodarone dosage?

Amiodarone dosing varies case-by-case taking into account factors like patient condition, medication response and general health status.Thus typically speaking a loading dose precedes ongoing maintenance doses to ensure successful treatment regimens are in place under professional guidance.

Amiodarone dose?

To initiate treatment with Amiodarone, healthcare providers often begin by prescribing a higher loading dosage before determining a lower maintenance dosage based on patient response and tolerance.

Amiodarone class?

Antiarrhythmics are drugs used to regulate heart rhythms and Amiodarone is specifically classified as a Class III type among them.

What Amiodarone used for?

For individuals suffering from ventricular arrhythmias, atrial fibrillation or atrial flutter like heartbeat issues amiodarone is typically prescribed as a medication to treat the condition or prevent its occurrence.

Amiodarone drug class?

Class III antiarrhythmic drugs encompass Amiodarone, which is often prescribed to treat various heart conditions.

Amiodarone for afib?

Amiodarone is a medication frequently employed to address and avoid recurrence of atrial fibrillation (afib) an irregular heart rhythm commonly observed in individuals.

Amiodarone afib?

When dealing with atrial fibrillation (afib) one commonly relied upon solution is amiodarone. Its mechanism of action restores normal cardiac rhythm and provides lasting protection against arrhythmic episodes.

Amiodarone side effects elderly?

When administering Amiodarone treatment to elderly patients healthcare professionals should take caution as they might encounter heightened side effects. These can range from episodes of lightheadedness and fainting to the deterioration of pre-existing heart problems. It's important to remember that increased systemic toxicity, such as lung and liver complications, could also arise.

Amiodarone half life?

The longevity of Amiodarones half-life spanning over 40 to 55 days implies that post cessation of administration it remains present in the system for an extended period. Hence one should be mindful when using this medication.

Amiodarone drip?

The intravenous administration of Amiodarone through an Amidorane drip is a common emergency procedure used to manage critical heart arrhythmias and save lives.

Amiodarone toxicity?

The adverse effects of amiodarone toxicity are diverse and potentially severe since this antiarrhythmic agent affects multiple organs through various mechanisms of action. To illustrate those risks further: pulmonary toxicity results from direct cytotoxicity or immune-mediated lung injury triggered by phospholipidosis; liver damage stems from mitochondrial injury caused by amiodarones accumulation in hepatocytes; thyroid dysfunction arises from iodine load and inhibition of thyroid hormone synthesis; optic neuropathy and retinopathy occur due to intracellular lipid deposit formation in ocular tissues. These complications may require discontinuation of amiodarone treatment or prompt intervention, depending on their severity and progression. Therefore clinicians should inform their patients about the possibility of developing adverse effects from amiodarone and monitor them regularly during therapy.

Amiodarone moa?

Amiodarone operates as an effective agent for rectifying abnormal heartbeat patterns by blockading numerous ion channels within the cardiac cells. Its mechanism of action results in a slower heart rate and puts it back into its natural rhythm, ultimately restoring regularity.

Amiodarone brand name?

In regards to Amiodarone within the United States, it is important to recognize that available brand names include Cordarone and Pacerone.

What is the lowest dose of Amiodarone?

For appropriate treatment and upkeep with Amiodarone, standard practice dictates taking a daily maintenance dose ranging from as little as 100 up to a maximum of 200 mg daily. However, doctors could modify the amount as necessary in accordance with patients' varying conditions.

Amiodarone hcl?

When purchasing medication for Amiodarone you'll typically come across its hydrochloride salt form, also referred to as Amiodarone HCl.

Amiodarone interactions?

It's essential to exercise caution when taking Amiodarone alongside other medications since it can cause interactions with medicines such as Warfarin, Statins, Beta-blockers and specific antiarrhythmic drugs. These interactions may interfere with medication effectiveness or contribute to more severe side effects.

Amiodarone indications?

When other measures prove inadequate in treating and preventing ventricular arrhythmias, atrial fibrillation, or atrial flutter in individuals, the use of Amiodarone may be worth considering as a potential solution.

Amiodarone generic name?

When discussing the medication Cordarone or Pacerone, it's worth noting that its underlying generic name is Amiodarone.

Amiodarone dose for afib?

In cases of atrial fibrillation (afib) physicians may advise an initial loading dosage of Amiodarone ranging from 800 1600 mg per day for a period lasting between one and two weeks. For ongoing management and treatment, a safe and common maintenance dosage of approximately 100 200 mg is administered daily.

Amiodarone medication?

Medical experts may prescribe amiodarone to protect against or manage certain life-threatening heart disorders, including ventricular tachycardia and ventricular fibrillation. The drug has crucial properties that help address these specific types of arrhythmias.

Amiodarone vs Adenosine?

When there is an abnormality in one's heart rhythm which needs treatment, medical professionals may suggest two particular drugs - namely Amiodarone and Adenosine. However dissimilar in their methodology towards normalizing such rhythms: while Amiodarone stabilizes it by adjustment of numerous ion channel pathways within our system, Adenosine operates via its capability to impede progression and decrease the pace at which spasmodic beats occur.

Amiodarone warnings?

Amiodarone merits careful consideration due to its potential to cause grave side effects such as lung toxicity, liver damage, thyroid dysfunction, and ocular complications. Healthcare experts need to use this medication with discretion following their assessment of all available treatment choices and confirming that it is indispensable in treating the presented case.

Amiodarone nursing considerations?

For safe administration of Amiodarone medication by nurses on a patient, they must regularly monitor critical health indicators like heart rate, rhythm, and blood pressure readings. Also important is keeping an eye out for warning signs that may suggest harmful reactions from the drug use, like respiratory complications, might be a sign of lung damage resulting from its use, or other related symptoms indicate that the patient might have developed liver malfunctioning attributable to this medication.

Amiodarone loading dose?

In order to rapidly establish effective levels of Amiodarone in the body when initiating treatment, healthcare providers usually prescribe high-loading doses. A typical dosage regimen would consist of daily oral administration ranging from 800 to 1600mg over one or two weeks.

Amiodarone ACLS?

In the case of life-threatening occurrences of ventricular arrhythmias or pulseless VT, medical professionals may consider utilizing Amiodarone as an option within their protocol for Advanced Cardiac Life Support (ACLS).

Amiodarone adverse effects?

When considering treatment options for cardiac arrhythmias involving Amiodarone usage, it's crucial to take into consideration possible side effects, which can be serious. These adverse effects include pulmonary toxicity complications; harm to the liver; thyroid problems; vision impairment, and an unusual blue-gray tinge in skin pigmentation as an outcome of medication intake.

Amiodarone dose ACLS?

In the context of emergency cardiac care, when dealing with scenarios involving either pulseless ventricular tachycardia or ventricular fibrillation during Advanced Cardiac Life Support interventions, physicians will usually administer an initial dosage of Amiodarone through IV push at a rate of 300 mg. As needed and determined by attending clinicians, a second dose amounting to 150 mg will be dispensed to patients undergoing such treatment.

Amiodarone for SVT?

Normally Amiodarone is administered for ventricular arrhythmias and atrial fibrillation or flutter. Yet healthcare providers may also use this drug off-label for supraventricular tachycardia (SVT).

Amiodarone for blood pressure?

Amiodarone typically isn't prescribed to alleviate high blood pressure symptoms. Rather its generally reserved for treating potentially life-threatening complications related to abnormal heart rhythms. Nevertheless the capacity of this drug to impact cardiac rhythms may produce a secondary outcome of stabilizing blood pressure in certain situations.

Amiodarone pulmonary toxicity?

There are certain side effects of Amiodarone that require close attention and one of them is pulmonary toxicity. The consequences of this condition can be dire and might result in serious illnesses like pulmonary fibrosis or interstitial lung disease. These situations warrant immediate attention from medical professionals.

Amiodarone lung toxicity?

The adverse effect of Amiodarone, known as lung toxicity carries significant risk to ones life. This ailment could emerge as either prolonged interstitial pneumonitis, pulmonary fibrosis, or acute respiratory distress syndrome.

Amiodarone drip rate?

The Amiodarone drips administration pace can differ and might depend on various factors. One customary approach is to have it infused at a speed of 1 mg/minute for the first six hours before lowering to a routine dose of 0.5mg/minute.

Amiodarone IV?

When medical professionals administer amiodarone via intravenous delivery they are employing the therapy commonly called Amiodarone IV. This treatment option is typically reserved for critical scenarios where time is of the essence in managing life threatening arrythmias and preventing potential fatalities.

Amiodarone infiltration?

Intravenous injection of Amiodarone carries a risk of inadvertent infiltration, which occurs when the drug escapes into nearby tissue instead of entering veins properly. When this happens it can lead to damage in surrounding tissue that requires prompt intervention for effective control and resolution.

Amiodarone infusion protocol?

To administer Amiodarone via infusion medical practitioners typically follow a specific protocol that entails an initial loading dose infused at a rate of one milligram per minute over six hours' time. Following this first phase administering continues steadily at a maintenance level equivalent to 0.5 milligrams per minute. The medication dosage may need adjustment based on how well patients respond and handle treatment.

Amiodarone blood pressure?

Though primarily intended for other purposes besides controlling blood pressure, Amiodarone's impact on heart rhythm brings about consequential effects that may indirectly affect this particular vital sign. A significant instance would be how rapid intravenous administration can lead to hypotension.

Amiodarone bolus?

An effective approach utilized in emergency contexts involves administering Amiodarone rapidly via the intravenous route in the form of a bolus. This tactic permits quick establishment of desirable drug levels.

Amiodarone blue skin?

Although rare taking Amiodarone could result in blue skin syndrome or Amiodarone skin. This side effect is marked by a noticeable bluish gray coloration of the skin and usually affects areas that are exposed to direct sunlight.

Amiodarone beta blocker?

While Amiodarone does not fall under the umbrella of beta blockers it does exhibit traits common among that category of drugs. These particular attributes include slowing down heartbeat and lessening the force exerted by myocardial contractions within the heart muscle itself.

Amiodarone vs Dronedarone?

As a Class III antiarrhythmic medication for managing atrial fibrillation and flutter symptoms, clinicians may offer either Amiodarone or its derivative option: Dronedarone. The distinguishing factor lies in the latter's creation with reduced instances of medical complications revolving around pulmonary- and thyroid-related toxicities in mind.

Amiodarone vs Cardizem?

Heart arrhythmias present a health concern where treatment options include Amiodarone or Cardizem (Diltiazem). However these drugs have variances in classification and function. For instance while Amiodarone operates on Class III antiarrhythmic medications Cardizem falls under calcium channel blockers' category.

Amiodarone and Warfarin?

Caution is crucial when prescribing Amiodarone alongside Warfarin since a potential side effect includes an increase in anticoagulation due to drug interactions. This results in heightened blood loss susceptibility thus prompting careful supervision, constant monitoring, and possible dose adjustments.

Customers also bought

Popular Products

Similar Product