Atopica Soft Capsule

Atopica Soft Capsule is an advanced veterinary medication designed to manage chronic allergic and autoimmune conditions in companion animals. The primary active ingredient, cyclosporine, is a potent immunosuppressant that modulates immune responses, alleviating symptoms of inflammatory diseases. Veterinarians often prescribe Atopica as a long-term solution for conditions that traditional antihistamines and corticosteroids fail to control.

The U.S. Food and Drug Administration (FDA) has given its approval for the use of Atopica Soft Capsule in treating atopic dermatitis in dogs in the field because of its practical nature. Various regulatory bodies worldwide have assessed its properties to make sure it meets veterinary requirements. Though Atopica's sometimes used off label, for other purposes it is still considered a prescription drug that needs professional supervision.

• Canine atopic dermatitis: Chronic skin inflammation driven by environmental allergens.
• Autoimmune disorders: Conditions where the immune system mistakenly attacks normal tissues.
• Organ transplantation: Used in veterinary medicine to prevent organ rejection.

Atopica is primarily prescribed for dogs but has shown effectiveness in cats and other small animals for off-label conditions.

The primary component of Atopica Soft Capsule is cyclosporine, a lipophilic cyclic polypeptide derived from the fungus Beauveria nivea. It selectively inhibits T-cell activation, reducing inflammation and allergic responses while preserving broader immune function.

• Medium-chain triglycerides (MCTs): Enhance bioavailability and absorption.
• Gelatin capsule: Protects the active ingredient from premature degradation.
• Glycerol: Helps maintain capsule integrity and stability.

Atopica's soft capsule formulation ensures optimal gastrointestinal absorption. The lipid-soluble nature of cyclosporine enables rapid uptake into the bloodstream, where it is transported via lipoproteins to target immune cells.

Cyclosporine works by blocking calcineurin activity – an enzyme, in the T cell activation process. Unlike corticosteroids that broadly suppress the systems functions, it targets immune reactions to keep them in check.

By blocking interleukin-2 (IL-2) synthesis, cyclosporine prevents T-cell proliferation, thereby reducing inflammatory mediators responsible for itching, swelling, and tissue damage.

The suppression of T cell activation results in decreased cytokine release and less infiltration of cells, which helps reduce attacks on tissues.

Atopica is commonly prescribed for dogs with atopic dermatitis, a skin issue marked by itching and redness along with secondary infections as a nonsteroidal choice for extended treatment purposes.

Veterinarians prescribe Atopica for autoimmune conditions such as:

• Pemphigus foliaceus: An autoimmune skin disease causing blistering.
• Immune-mediated hemolytic anemia (IMHA): A disorder where red blood cells are prematurely destroyed.

After kidney or liver transplants, Atopica is occasionally administered to animals to prevent rejection of the organ.

Cyclosporine has shown effectiveness in treating fistulas—a painful inflammatory condition that affects the tissue surrounding the anus.

While Atopica is not officially approved by the FDA for use, cats with feline allergic dermatitis symptoms, such as itching and skin lesions, often find relief through its administration.

• Inflammatory bowel disease (IBD): Helps regulate immune-mediated intestinal inflammation.
• Systemic lupus erythematosus (SLE): Used to modulate aberrant immune activity.

While mainly used in medicine,  research is being conducted on cyclosporine to explore its benefits in treating uncommon inflammatory conditions in humans.

The usual recommended amount is 5 milligrams per kilogram per day. May be changed depending on how the patient responds.

Once the symptoms are under control successfully, it might be possible to reduce the dosage and take it every day instead.

Take it before eating to get the effect on your body. It's best not to combine it with dairy items since they might affect how well your body absorbs it.

Regular visits to the vet are important to keep an eye out for any changes in blood cyclosporine levels and the overall health of your pet's organs.

Remember to keep the item in a spot between 15 and 30 degrees Celsius (59 to 86 degrees Fahrenheit) away from direct sunlight.

Make sure to dispose of expired medication according to guidelines to avoid contaminating the environment.

• Wear gloves when handling.
• Keep out of reach of children and pets.

• Ketoconazole: Increases cyclosporine blood levels.
• Rifampin: Decreases cyclosporine concentration.

When cyclosporine is paired with NSAIDs or corticosteroids, it could increase the effects. It heighten the chances of infections occurring.

Cyclosporine undergoes hepatic metabolism via the cytochrome P450 system, necessitating dose adjustments in patients with liver impairment.

Atopica Soft Capsule is strictly contraindicated in animals exhibiting hypersensitivity to cyclosporine or any of its excipients. Hypersensitivity reactions may manifest as:

• Severe pruritus
• Urticaria (hives) or facial swelling
• Anaphylactic shock in extreme cases

Immediate discontinuation and emergency veterinary intervention are imperative in cases of acute allergic response.

Cyclosporine undergoes hepatic metabolism and renal excretion, necessitating caution in patients with hepatic dysfunction or renal impairment. Prolonged exposure may exacerbate:

• Hepatic enzyme elevation (ALT, AST)
• Nephrotoxicity due to compromised renal clearance

Routine blood chemistry panels are essential to detect early signs of toxicity.

Due to its immunosuppressive properties, Atopica increases susceptibility to bacterial, viral, and fungal infections. Administration should be withheld in cases of:

• Systemic bacterial infections (e.g., pyoderma, pneumonia)
• Chronic viral diseases (e.g., FeLV, FIV in cats)
• Fungal infections (e.g., histoplasmosis, cryptococcosis)

Prolonged cyclosporine therapy may predispose animals to neoplastic transformation due to chronic immunosuppression. Potential risks include:

• Increased incidence of cutaneous papillomas
• Heightened susceptibility to lymphoma
• Accelerated progression of latent oncogenic conditions

Periodic hematological and biochemical assessments are indispensable in animals receiving long-term cyclosporine therapy. Key parameters include:

• Complete Blood Count (CBC) to assess leukocyte suppression
• Serum biochemistry to monitor hepatic and renal function
• Cyclosporine trough levels for therapeutic drug monitoring

Abrupt cessation of Atopica may trigger a rebound effect, leading to exacerbation of inflammatory conditions. A gradual tapering strategy is advised:

• Reduce dosage incrementally over several weeks
• Monitor for clinical deterioration during tapering
• Adjust discontinuation plan based on veterinary assessment

Cyclosporine bioavailability is influenced by food intake. Best practices include:

• Administering Atopica on an empty stomach for optimal absorption
• Avoiding concurrent administration with dairy products or high-fat meals
• Ensuring consistent timing of dosing relative to meals

Long-term immunosuppression requires proactive infection surveillance. Strategies include:

• Routine antimicrobial prophylaxis for high-risk patients
• Early intervention in minor infections to prevent systemic spread
• Regular physical examinations to detect emerging health issues

Geriatric patients exhibit slower metabolic clearance, necessitating dosage adjustments. Veterinary oversight ensures:

• Lower initial doses to reduce toxicity risk
• Extended dosing intervals if renal or hepatic impairment is present

Aging animals are predisposed to organ dysfunction. Cyclosporine therapy in elderly patients should be accompanied by:

• Frequent kidney and liver function tests
• Close monitoring for gastrointestinal and neurological side effects

Cyclosporine is classified as teratogenic in some species, posing risks such as:

• Congenital malformations
• Fetal growth retardation

Cyclosporine is excreted in breast milk, raising concerns for neonatal immunosuppression. Veterinary discretion is advised when prescribing to lactating animals.

Animals in stages of growth need dosage calculations based on their weight to avoid giving them much or too little medication.

Using cyclosporine for extended periods could disrupt the development of the system, in young animals and requires thorough assessment.

• Gastrointestinal disturbances: Vomiting, diarrhea, reduced appetite
• Lethargy and behavioral changes: Mild sedation or hyperactivity
• Increased susceptibility to infections: Recurring skin infections, respiratory issues
• Gingival hyperplasia: Overgrowth of gum tissue

• Nephrotoxicity and hepatotoxicity: Elevated creatinine and liver enzymes
• Hypertension and cardiovascular effects: Increased blood pressure
• Neurological effects: Tremors, seizures, abnormal gait
• Increased risk of neoplasia: Prolonged immunosuppression-related tumorigenesis

• Severe vomiting and diarrhea
• Excessive drooling and lethargy
• Neurological distress (disorientation, tremors)

• Induced emesis if ingestion occurred within the past hour
• Activated charcoal administration to limit absorption
• Intravenous fluid therapy for systemic stabilization

Hospitalization may be required for severe toxicity cases. Supportive care includes:

• Electrolyte and hydration balance correction
• Symptomatic management of tremors and gastrointestinal distress

• Wear gloves when administering capsules
• Wash hands thoroughly after handling

Accidental dermal exposure may lead to localized irritation. Inhalation of cyclosporine powder can cause respiratory discomfort.

Make sure to follow the guidelines when getting rid of any leftover Atopica to avoid harming the environment with contamination.

What is Atopica used for?

Medications are commonly used to relieve itching and skin issues stemming from conditions like atopic dermatitis inflammatory bowel disease or other skin related ailments.

How long should my dog take Atopica?

4-6 weeks

Can Atopica capsules be opened?

Capsules should not be broken or opened.

Does Atopica help with itching?

Atopica is a medication for dogs and cats that can be administered daily to help prevent itching or ease the response of the system to allergens and prevent overreactions in the body.

How effective is Atopica?

Results from studies have indicated that Atopica demonstrates promising effectiveness in reducing the skin's immune system response in pets, particularly dogs, leading to a visible decrease in skin irritation and itching for many furry companions prescribed with Atopica.

What is the warning for Atopica?

Taking Atopica could lead to increased levels of blood sugar.

Is Atopica safe for dogs?

Yes

How fast does Atopica work?

Administer on a stomach (one hour before or two hours post-meal). If your pet shows signs of vomiting or discomfort when given this medication on a stomach consider providing the dose with food or a small snack. If vomiting persists, reach out to your vet for advice. It may take up to two weeks to observe the effectiveness of the medication.

Is cyclosporine an antibiotic?

It's a calcineurin inhibitor

Should Atopica be refrigerated?

Make sure to keep Atopica for Cats in its container at room temperature between 59 and 77°F.

Does Atopica expire?

Yes

What is the indication of Atopica?

Recommended for managing atopic dermatitis in dogs weighing a minimum of 4 pounds at 6 months old.

What can I use instead of Atopica for dogs?

Topical steroids, like Cortavance spray or Isadermm Gel, are approved for use in dogs only, while Cytopoint is also licensed exclusively for dogs. Prednisolone, methylprednisolone and dexamethasone're used steroids. Atopica, Cyclavance and Sporimune are medications that may be prescribed in cases.

Does Atopica affect the liver?

Taking much Atopica® could lead to symptoms like throwing up and diarrhea, as well as reduced hunger and possible harm to the kidneys and liver.

Is Atopica better than prednisone?

It has fewer side effects than prednisone

Is Atopica a steroid?

No, Atopica for cats doesn't contain steroids in its medication ingredients.

Does Atopica suppress the immune system?

Yes

Can humans take Atopica?

Not for human use.

Can dogs have Atopica on an empty stomach?

Make sure to give dogs the capsules when their stomachs are empty.

Can you put Atopica in food?

It can be given with food. Taken directly after eating.

How long can a dog be on cyclosporine?

Lifelong treatment to manage

How long has Atopica been around?

2022

Does Atopica stop itching?

Yes

What are the benefits of Atopica for dogs?

Help manage the itching and skin sores linked to atopic dermatitis such as inflammatory bowel disease and other skin-related issues.