Bilastine  is an antihistamine that is used to relieve symptoms of allergic rhinoconjunctivitis and other forms of allergic rhinitis. Bilastine can also be used for the treatment of itchy skin or rashes 

Bilastine Tablet


Bilashine, Billargic, Bilagra, BL, Bilanta, Bilasure, Beltas, Ubil, Bilazo, Byloza and other generic brands


Sun Pharma, Cipla, Lupin, Indiabulls pharma, Ajanta Pharma, Glenmark Pharma, Dr Reddy's Lab, Indiabulls pharma and others


20 mg



I. Introduction

An effective solution for managing allergies, Bilastine represents a major advancement in the field of antihistamines. Its creation, driven by the goal of improving effectiveness while reducing side effects signifies a noteworthy achievement in medical innovation. This summary compares Bilastine to medications in its class, highlighting its distinct qualities and tracing its evolution from initial development to its current esteemed position.

Historical Context and Development

The origin of Bilastine can be traced back to a period of research dedicated to improving allergy treatment methods. Its development was motivated by the need to overcome the challenges presented by antihistamines, especially in terms of drowsiness and heart-related side effects. Following scientific investigation, Bilastine emerged as a symbol of advancement, providing a more effective therapeutic profile.

Comparison with Other Antihistamines

  • Unlike antihistamines, it doesn't cause drowsiness.
  • It's safer for the heart than some versions.
  • Studies show it works well or even better, than them in relieving allergy symptoms.

II. Composition

Active Ingredient Description

Bilastine, being at the core of the formula, is an antihistamine of the second generation. It is carefully crafted to block the histamine H1 receptors effectively reducing reactions, with accuracy and efficiency.

Excipients and Formulation Variants

The selected additives are crucial in maintaining the stability, effectiveness, and taste of Palestine. This medicine comes in forms, like tablets and liquid solutions, to meet the different needs and choices of patients.

III. How It Works

Mechanism of Action

Bilastine works by blocking the histamine 1 (H1) receptors, which stops the pathway that causes allergic symptoms. This action helps to reduce reactions from starting and provides specific relief, for symptoms.

Pharmacodynamics and Pharmacokinetics

The way Bilastine behaves in the body involves uptake and a long-lasting presence, making it suitable for daily use. Its impact on H1 receptors is strong highlighting its effectiveness against allergies.

IV. Uses

Indications for Bilastine

Bilastine is a non-sedating, long-acting antihistamine that provides relief for various allergic conditions. Let’s break down its uses:

  1. Allergic Rhinitis:

    • For symptomatic relief of allergic rhino-conjunctivitis (both seasonal allergic rhinitis and perennial allergic rhinitis), the recommended dosage for adults is 20 mg once daily. Treatment should be limited to the period of allergen exposure. Discontinue treatment after symptoms resolve for seasonal allergic rhinitis, and reinitiate if symptoms reappear for perennial allergic rhinitis
  2. Urticaria (Hives):

    • For urticaria, the adult dosage is 20 mg once daily using conventional tablets. The duration of treatment may vary depending on the type, duration, and course of symptoms.

Evidence-Based Benefits

Clinical trials with evidence support the effectiveness of Bilastine in treating allergic rhinitis and hives. These studies highlight its ability to enhance quality of life and manage symptoms surpassing both placebos and certain antihistamines.

V. Off-Label Use

Exploring Non-Approved Uses

According to studies, Bilastine has shown promise in treating conditions beyond its approved indications, including asthma and atopic dermatitis.

Asthma Management

Preliminary studies suggest that Bilastine may help relieve asthma symptoms, pointing towards a direction for potential future treatments.

Atopic Dermatitis

Initial reports indicate that Bilastine shows promise in alleviating the itching linked to atopic dermatitis, signaling a potential application for this adaptable antihistamine.

VI. Dosage and Administration

The typical amount of Bilastine recommended for grown-ups is 20 mg per day, best taken on a stomach, for better absorption.

Dosage Adjustments for Specific Populations

Changes in dosage might be required due to reasons like kidney issues or the influence of drugs. It's crucial to assess the patient's complete medical situation to determine the best dosage.

VII. Administration to Specific Populations

Administration to Elderly

In individuals, Bilastine is given while considering the possibility of heightened sensitivity or other existing health conditions, with adjustments made to the dosage as needed.

Administration to Pregnant Women and Nursing Mothers

Although Bilastine is considered safe it is important to weigh the risks and benefits before using it during pregnancy or while breastfeeding.

Administration to Children

Bilastine provides an effective solution for allergic symptoms in children aged 12 years and older, with dosages specifically adjusted for kids.

VIII. Common Side Effects

Overview of Frequent Adverse Reactions

Although Bilastine is praised for its side effects, a few people might encounter slightly negative responses, like headaches, feeling sleepy, or stomach discomfort.

Managing Mild Side Effects

Sometimes, these minor side effects tend to go on their own.. If they linger, it's a good idea to talk to a healthcare provider to make sure that using Bilastine is still the right choice for you.

IX. Serious Side Effects and Reactions

Identifying Severe Adverse Effects

Although Bilastine is known for having side effects, it still carries the risk of causing severe adverse reactions such as anaphylaxis, extreme dizziness, and heart irregularities. It is crucial to identify these symptoms.

Immediate Actions and Management

In case of negative responses, it is important to stop taking Bilastine right away and seek urgent medical help. Healthcare providers can take actions from treating symptoms to providing more intensive care based on how severe the reaction is.

X. Interaction

Drug-Drug Interactions

Bilastine could react with drugs, which might change how well it works or increase the risk of negative effects. Specifically, there have been reports of interactions with ketoconazole, erythromycin, and diltiazem requiring modifications to treatment approaches.

Food and Beverage Interactions

The way the body absorbs Bilastine can change based on whether you take it with food fatty meals, which might make it less effective. Drinking alcohol could make its drowsiness effects stronger, though Bilastine is not as sedating as older antihistamines.

Effects on Laboratory Tests

Bilastine could impact the outcomes of skin tests for identifying allergies. It is recommended that patients stop taking Bilastine at a week before undergoing these tests to prevent any inaccuracies in diagnosis.

XI. Warnings and Precautions

Pre-existing Conditions and Bilastine

People who have existing health issues, like kidney problems or heart conditions should be careful when using Bilastine. It's important to provide a medical history and consider adjusting the dosage to minimize any potential risks.

Allergy Warnings

Patients who have a confirmed sensitivity to Bilastine or any of its ingredients should refrain from using it. It is essential to review a patient's history for any drug allergies before recommending the use of Bilastine.

XII. Contraindications

Absolute Contraindications

Bilastine should not be used in individuals with kidney problems or those who have an allergy to the medication. Additionally, it is advised against children under 12 years old due to information on its safety and effectiveness in this age group.

Conditional Risks

During pregnancy and while breastfeeding it is important to weigh the advantages and disadvantages before deciding to use Bilastine.

XIII. Careful Administration

Monitoring for Side Effects

Regularly checking for reactions while on Bilastine treatment helps in promptly spotting and dealing with possible side effects, thus improving patient safety.

Adjustments in Dosage

Changes in the amount of Bilastine needed, might be required depending on the patient's age, kidney function, and other medications they are taking to improve treatment results and reduce risks.

XIV. Important Precautions

Safety Measures and Avoidance of Adverse Effects

Following the doses, taking into account potential drug interactions, and keeping an eye out for any side effects are important steps to reduce the chances of experiencing negative responses to Bilastine.

Precautionary Measures for Long-Term Use

To ensure the effectiveness and safety of using Bilastine over a period it is recommended to consistently evaluate its performance. This involves keeping a check on any alterations in the patient's health status that could require modifying the dosage or stopping the treatment.

XV. Overdosage

Symptoms of Overdose

Signs of taking too much Bilastine may involve feeling sleepy, disoriented, and experiencing a rapid heartbeat. Identifying these symptoms quickly is essential for efficient treatment.

Immediate Management and Treatment

In situations where an individual takes much of a substance, it is crucial to seek urgent medical help. The treatment primarily focuses on providing support for the person's symptoms, which may involve actions like washing out the stomach and giving activated charcoal to stop more of the drug from being absorbed.

XVI. Handling Precautions

Storage Conditions

Make sure to keep Bilastine in a dry place, at room temperature, to maintain its effectiveness and extend its lifespan.

Disposal Guidelines

Ensuring that Bilastine is disposed of correctly following guidelines is crucial to avoid accidental ingestion or environmental pollution. Patients should receive guidance on how to get rid of expired or leftover medication.

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