Actonel is used for the prevention of osteoporosis, Actonel works by altering the cycle of bone formation and breakdown in the body, Actonel works to slow down the loss of bone in the body preventing bone fractures.


Risedronate sodium



Sanofi Aventis, Sanofi India


5 mg, 35 mg, 75 mg

India, Turkey


I. Introduction

What is Actonel? Actonel is a medication known for its remarkable contribution to pharmaceuticals. It belongs to a class of drugs called bisphosphonates. It is specifically designed to combat and prevent osteoporosis. This condition affects the system, causing bones to become fragile and susceptible to fractures. The development of Actonel involved research spanning several decades, with scientists tirelessly working towards finding a solution for the debilitating effects of osteoporosis. Their efforts made Risedronate sodium a game changer in this therapeutic area. Today, Actonel stands at the forefront as a treatment option in the battle against bone degenerative diseases.

II. Uses of Actonel

Actonel is a bisphosphonate medicine that alters bone formation and breakdown in the body. It is used for the following primary purposes:

  1. Osteoporosis and similar conditions: Actonel is used to treat or prevent osteoporosis caused by menopause, steroid use, or gonadal failure1.
  2. Osteoporosis in women after menopause: Actonel is used to treat or prevent osteoporosis caused by menopause1.
  3. Preventing osteoporosis in individuals at risk: Actonel is used to treat or prevent osteoporosis caused by menopause, steroid use, or gonadal failure1.
  4. Treating osteoporosis caused by use: Actonel is used to treat or prevent osteoporosis caused by menopause, steroid use, or gonadal failure1.

In addition to these primary uses, Actonel is also prescribed for patients with Paget’s disease of the bone, a condition characterized by irregular bone remodeling that weakens bone strength1.

You can find more information about Actonel on the website.

1Actonel: Uses, Dosage & Side Effects Guide -

III. How Actonel Works

How Actonel works in the body by stopping the breakdown of bones caused by osteoclasts. In other words, it maintains a balance between bone breakdown and formation, ensuring healthy bone mass. Actonel protects bone health by regulating activity, resulting in better bone density and a lower risk of fractures.

IV. Dosage and Administration

To start with adults usually begin with a dose of 5 mg or a once-weekly dose of 35 mg, depending on their specific conditions and indications. However, this may vary for individuals, especially the elderly or those with kidney problems, as their doses might need adjustments to optimize effectiveness while minimizing potential side effects. Monitoring the response to Actonel and any adverse reactions is essential to make necessary dosage adjustments. Actonel is taken orally. It's crucial to follow guidelines like taking the tablet with a full glass of water and avoiding lying down immediately after taking it to maximize absorption and benefit from the medication.

V. Composition of Actonel

Active ingredient: Risedronate sodium. This compound, known as Risedronate sodium, is the component that makes Actonel effective. It belongs to a group of medications called bisphosphonates, which are well known for their ability to protect bones. Other than Risedronate sodium, Actonel tablets contain inactive ingredients necessary for the drug's stability, appearance, and how well the body absorbs it. These inactive ingredients can include binders, fillers, coatings, and others. Actonel is available in strengths, typically ranging from 5 to 35 mg. There is also a strength option of 150 mg for monthly dosing. The primary form of Actonel is in tablet form. It is designed to be taken orally.

VI. Common Side Effects

Issues: Some patients may experience digestive discomfort, such as mild nausea or occasional episodes of heartburn. However, these side effects are usually temporary. It can be managed with proper care. Musculoskeletal discomfort: Although it may seem contradictory for a medication meant to support bone health, there have been reports of pain, particularly in the back and limbs. However, this is relatively uncommon. Typically, it resolves over time. Headaches: A small number of users may encounter headaches when using this medication. However, these headaches are generally not severe. It tends to fade away with continued use.

VII. Side Effects

Side effects can be classified based on how they occur. Common side effects may affect 1 in 10 users, while rarer side effects may only impact 1 in 10,000 individuals. There are adverse reactions that, although infrequent, can be more severe. These include conditions like osteonecrosis of the jaw and femoral fractures. You must seek medical attention if you experience these rare but severe side effects. When using Actonel for some time, it is recommended to closely monitor bone health due to the potential risk of excessive suppression of bone turnover.

VIII. Off-label Use of Actonel

In addition to these primary uses, Actonel is also prescribed for patients with Paget’s disease of the bone, a condition characterized by irregular bone remodeling that weakens bone strength1.

You can find more information about Actonel on the website.

Please note that the information provided here is not exhaustive, and it is always best to consult a healthcare professional for accurate and personalized medical advice.

1Actonel: Uses, Dosage & Side Effects Guide -

Regarding the use of Actonel for conditions not officially approved, while there is increasing interest in using Actonel for preserving bone health in conditions such as osteoarthritis and certain types of bone metastatic cancers, extensive clinical trials are required to determine its effectiveness in these specific areas234.

2Actonel - Medical News Today 3Actonel: 7 things you should know - 4Overview of Metastatic Cancer in Bones - WebMD

IX. Interaction with Other Medications

Drug interactions concern Actonel as it can interact with other medications. Some examples of drugs that may have interactions with Actonel include antacids, specific diuretics, and certain anti-inflammatory drugs. Healthcare providers must understand a patient's medication regimen to avoid potential interactions. It's important to note that taking calcium or vitamin D supplements at the time, as Actonel, can affect how well your body absorbs the medication. To optimize Actonel's absorption, taking these supplements at times is generally recommended. Certain medications can also impact the absorption or elimination of Actonel. For example, drugs that alter the stomach's pH levels, such as proton pump inhibitors, may influence how much of Actonel is available in your body. Additionally, specific diuretics could affect how quickly the kidneys excrete Actonel's active ingredient.

X. Warnings and Precautions

a. Prolonged use warning: Using Actonel for a time may excessively suppress bone turnover, which can affect the natural healing processes of bones. Risk of injury: If Actonel is not taken correctly, there is a slight chance of injuring the esophagus. So, following guidelines like staying after taking the medication is essential. b. Conditions that prevent using Actonel: Individuals with abnormalities, low blood calcium levels, severe renal impairment, or hypersensitivity to the drug are generally advised against using Actonel. c. Caution in administration: Certain populations and conditions, like Barrett's atrophic gastritis or certain vitamin deficiencies, might require modified dosing or additional monitoring when taking Actonel. d. Essential precautions to consider: oral health: Informing your dentist about using Actonel before dental procedures due to a rare risk of jawbone damage called osteonecrosis. Monitoring bone density and turnover markers: Regular assessments are necessary to ensure effective treatment and minimize potential risks associated with long-term use. e. Administration in individuals; Dose adjustments and considerations; Organ function changes with age may require dosage adjustments. Evaluating risk versus benefit: It's essential to weigh the therapeutic benefits against potential side effects in this demographic. f. Administration in women and nursing mothers: Safety profile and data during pregnancy is limited for Actonel. As a result, it is usually used in situations where the potential benefits outweigh the potential risks. Healthcare providers may suggest treatments or advise stopping medication during pregnancy and breastfeeding. When it comes to children, Actonel is not commonly prescribed; if deemed necessary, dosing and monitoring would need to be tailored. However, there is research on its use in pediatric patients, so a cautious approach is recommended.

XI. Overdosage

Signs of an overdose of Actonel When Actonel is taken in amounts, it can cause disruptions in bone metabolism, low calcium levels (hypocalcemia), or gastrointestinal symptoms. It is essential to seek medical attention in such cases. The recommended approach for management and treatment may involve providing relief, ensuring proper hydration, and closely monitoring the situation. In certain circumstances, specific interventions such as calcium infusions may be necessary.

XII. Storage Recommendations

To ensure the effectiveness and safety of Actonel, it is essential to store it. Keep Actonel in a dry place away from direct sunlight and at temperatures, below 30°C. Remember that, like all medications, Actonel has an expiration date. Not consuming Actonel after its expiration date is crucial, as doing so may decrease its effectiveness and safety. Always follow the expiration dates provided.

XIII. Handling Precautions

It's crucial to store Actonel where children cannot access it to ensure safety. When disposing of Actonel, following the guidelines for pharmaceutical disposal is recommended to prevent any potential environmental contamination. If you happen to miss a dose of Actonel, it is generally recommended to take the missed dose as soon as you remember. However, it is not advisable to double up on doses. If there has been ingestion of Actonel, immediate medical consultation should be sought.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Ostrowski on Jan 8, 2018 Verified Purchase

Actonel 35 mg

Product works great.

Note: does not imply any medical claims from this review.
Posted by William on Jul 24, 2017 Verified Purchase

Actonel - 35 mg

Works great, and was delivered in a timely manner.

Note: does not imply any medical claims from this review.

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