Calcium Dobesilate

Calcium Dobesilate which is a vasoprotective is classified in the group of medicines called venotonics . Calcium Dobesilate is administered in the treatment of piles and also varicose veins in which it improves blood flow by decreasing viscosity and thickness of blood.

Doxium, Cabisyl

Calcium Dobesilate



Wallace Pharma


500 mg


Calcium Dobesilate

I. Introduction to Calcium Dobesilate

Overview of Calcium Dobesilate

Calcium Dobesilate is a medication that helps improve the symptoms of venous insufficiency, such as varicose veins and hemorrhoids. It works by strengthening capillaries and decreasing their permeability, which helps reduce swelling and inflammation.

Historical Background and Development

Calcium Dobesilate was first found in the mid-1900s as a solution to the increasing demand for treatments for vascular issues. Its significant health benefits have established it as a key component in vascular treatments within different medical fields.

II. Composition of Calcium Dobesilate

Chemical Structure and Properties

Calcium Dobesilates' molecular structure allows it to regulate pathways related to vascular health. This synthetic compound possesses anti-inflammatory and anti-blood clotting characteristics.

 Calcium Dobesilate

Available Forms and Variants

Calcium Dobesilate comes in types, like capsules, tablets and topical creams catering to various treatment requirements and patient choices.

III. Mechanism of Action: How Calcium Dobesilate Works


Calcium Dobesilate functions by regulating the permeability of blood vessels, strengthening the endurance of endothelial cells against harmful elements, and preventing abnormal blood vessel growth. These effects are achieved by influencing the activity of substances like histamine and serotonin.

Impact on Vascular Health and Microcirculation

The medicine has an impact on the flow of blood in small blood vessels, which is crucial in conditions such as diabetic eye disease, where damage, to small blood vessels is common. By enhancing the movement of blood in these vessels, Calcium Dobesilate helps prevent and control additional issues linked to vein and diabetes-related small blood vessel problems.

IV. Uses of Calcium Dobesilate

Primary Indications: Venous Disease and Hemorrhoids

Secondary Applications in Diabetic Retinopathy and Varicose Veins

  1. Chronic Venous Insufficiency (CVI):
    • Calcium Dobesilate is primarily used to treat symptoms associated with chronic venous insufficiency (CVI). These symptoms include:
      • Swelling
      • Pain
      • Hemorrhoids in the legs16.

2. Diabetic Retinopathy:

    • Calcium Dobesilate has also proven effective in the treatment of diabetic retinopathy.
    • Diabetic retinopathy is characterized by retina damage caused by inadequate blood sugar management in individuals with diabetes25.

3. Varicose Veins:

    • Additionally, Calcium Dobesilate is utilized to alleviate symptoms associated with varicose veins, such as discomfort and skin sores16.

V. Off-Label Uses of Calcium Dobesilate

Exploration of Non-Approved Therapeutic Areas


    • Kidney Disease: Researchers are investigating the potential use of Calcium Dobesilate in treating certain types of kidney disease.
    • Eye Conditions Not Related to Diabetes: Ongoing studies explore its efficacy in managing eye conditions beyond diabetic retinopathy.
    • Varicose Veins: Calcium Dobesilate also alleviates symptoms associated with varicose veins, such as discomfort and skin sores1145.

Recent research has been looking into how Calcium Dobesilate can protect the brain and potentially be used in cancer treatment by studying its ability to block abnormal blood vessel growth, a key feature in cancer development.

VI. Dosage and Administration

Dosage Guidelines for Adults and Specific Conditions

  • For venous insufficiency, take 500 mg twice daily.
  • During hemorrhoidal attacks, the initial week requires 1500 mg daily, followed by a maintenance dose of 1000 mg daily.

 Calcium Dobesilate

Methods of Administration and Duration of Treatment

Calcium Dobesilate is best taken by mouth along with food to improve absorption and minimize stomach discomfort. The length of treatment depends on how serious the condition is, usually lasting anywhere from a couple of weeks to a few months.

VII. Side Effects of Calcium Dobesilate

Common Side Effects: Gastrointestinal Discomfort, Headaches

While most people can handle it well, a few might encounter stomach problems like feeling queasy or having diarrhea, as well as occasional headaches. These reactions usually go away with usage or tweaking the dosage.

Rare and Serious Adverse Reactions

In some cases, individuals may experience serious reactions such as agranulocytosis, a dangerous decrease in white blood cells, which requires prompt medical care and stopping the medication.

VIII. Important Precautions and Warnings

Contraindications: When to Avoid Calcium Dobesilate

Its recommended to avoid using Calcium Dobesilate in patients who have known allergies to the drug or any of its ingredients. Moreover, individuals with an experience of agranulocytosis or severe kidney problems should steer clear of its usage as it may worsen their conditions.

Important Precautions: Monitoring and Risk Management

For Calcium Dobesilate to work safely and effectively, it's important to check hemoglobin levels, kidney function, and overall blood counts. Patients need to be informed about how to spot signs of blood disorders and should seek medical help if they experience symptoms like sudden fever, throat pain, or unusual bruising.

IX. Interactions with Other Medications

Potential Drug Interactions and Consequences

Calcium Dobesilate might interact with blood thinners like warfarin and drugs that prevent platelet aggregation, such as aspirin, which could boost their impact and elevate the possibility of bleeding. Using it together with medications that protect blood vessels may also enhance vascular effects, necessitating modifications in dosage.

Recommendations for Avoiding Adverse Interactions

Make sure to keep track of all the medications you take, check drug levels as needed, and adjust doses with guidance from a healthcare provider.

X. Special Considerations in Administration

a. Administration to Elderly Patients

Elderly individuals might need reduced amounts of Calcium Dobesilate as their kidney function declines with age. It's crucial to monitor the effectiveness and potential side effects, in this group of patients.

b. Administration to Pregnant Women and Nursing Mothers

It's important to consider the safety of using Calcium Dobesilate during pregnancy and weigh the benefits against any risks, to the fetus. When it comes to nursing mothers, caution should be taken as it's unclear whether this medication passes into milk.

c. Administration to Children

Dosage and safety information for Calcium Dobesilate may vary based on age. It is important to note that the safety and effectiveness of this medication in children have not been fully determined. Therefore, any decision to use Calcium Dobesilate in patients should be made after a thorough evaluation of the risks and benefits by a healthcare professional.

XI. Handling and Storage of Calcium Dobesilate

Storage Conditions and Shelf Life

Store Calcium Dobesilate in a dry place shielded from light and moisture to maintain its medicinal effectiveness. When stored correctly, it typically remains potent for 2 to 3 years from the manufacturing date.

Handling Precautions for Safety

Remember to handle it by keeping it away from very hot or cold environments and direct sunlight. Additionally, make sure the packaging is secure to avoid any risk of contamination.

XII. Overdose and Management

Symptoms of Overdosage

Taking too much Calcium Dobesilate could lead to issues like low blood pressure, dizziness, and severe stomach problems. Additionally, there may be abnormalities in blood counts.

Steps for Immediate Management and Antidotes

In the event of an overdose, prompt medical attention is crucial. Treatment involves providing support and addressing symptoms. Calcium Dobesilate does not have an antidote, so early detection and supportive care are essential in managing an overdose.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by emma on Feb 15, 2017 Verified Purchase

Thank you, prompt delivery

Good product, thank you

Our response:
Dear Emma, Thank you for your feedback we greatly appreciate it,Please continue supporting us as we value your business with us. thank you
Note: does not imply any medical claims from this review.

Customers also bought

Popular Products