Capreomycin Injection is a broad-spectrum antibiotic prescribed with other drugs to treat drug-resistant tuberculosis infections.

Generic Capastat




Macleods Pharma


500 mg, 750 mg, 1000 mg




The story of Capreomycin started with its evolution and finding, which marked a notable achievement in medicine. Initially recognized as an antimicrobial substance, it quickly became an essential component in numerous therapeutic applications.

Historical development and discovery of Capreomycin

Throughout history, the discovery of Capreomycin proved a significant milestone in combating stubborn bacterial infections. This compound was found through research efforts to tackle the rise of antibiotic-resistant strains resistant to conventional treatment methods.

Importance in medical treatments

Cornerstone plays a role in the treatment of multi-drug resistant tuberculosis especially when the initial treatments prove to be ineffective. It is a component in the field of interventions against mycobacterial infections.

Uses of Capreomycin

Capreomycin has gained recognition in the field of therapy due to its range of uses going beyond its original intended purpose. Its remarkable advantages and unmatched efficacy have been extensively documented.

Primary indications in medical practice

Capreomycin is a medication that is primarily used as an adjunct drug in tuberculosis treatment. It is a second-line treatment used for active drug-resistant tuberculosis 1Capreomycin is a member of the aminoglycoside family of antibiotics, which have the ability to kill a wide variety of bacteria, including bacteria responsible for causing tuberculosis (TB) 2Capreomycin has gained recognition for its crucial role in fighting against tuberculosis strains that are resistant to multiple drugs 34.

Here are the HTML links to the references:

3Multidrug-Resistant Tuberculosis (MDR TB) | CDC 4TB Drug Resistance in the U.S. - CDC Fact Sheet 2Capreomycin: Uses, Interactions, Mechanism of Action | DrugBank Online 1Capreomycin - Uses, Side Effects, Substitutes, Composition … - Lybrate

Benefits and effectiveness

Capreomycin offers a range of benefits. It has proven to be highly effective in targeting strains of bacteria. Additionally, it allows for treatment durations compared to other regimens, contributing to improved patient compliance thanks to its potency.

How Capreomycin Works

Capreomycin's effectiveness can be credited to its method of operation, which carefully focuses on bacteria and effectively eliminates harmful pathogens with great precision.

Mechanism of action in the body

Capreomycin works by attaching to the RNA in bacteria, which prevents the production of proteins. This interference with the machinery is highly detrimental, to harmful microorganisms, ultimately resulting in their destruction.

Targeted bacteria and pathogens

Capreomycin is effective against strains of Mycobacterium tuberculosis and various other types of mycobacteria.

Off-label Use of Capreomycin

Apart from its uses, Capreomycin has proven effective in treating a wide range of conditions, showcasing its versatility.

Conditions treated outside of primary indications

Capreomycin is a medication that is primarily used as an adjunct drug in tuberculosis treatment. It is a second-line treatment used for active drug-resistant tuberculosis 1Capreomycin is a member of the aminoglycoside family of antibiotics, which have the ability to kill a wide variety of bacteria, including bacteria responsible for causing tuberculosis (TB) 2Although Capreomycin has not been officially approved for treating diseases other than TB, research studies have investigated its potential in treating infections caused by bacteria related to tuberculosis (TB), such as nontuberculous mycobacterial infections 3Capreomycin has also been studied for its potential in treating gram-positive bacterial infections 4.

Here are the HTML links to the references:

3Infections Caused by Bacteria Related to Tuberculosis (TB) - Infections - Merck Manuals Consumer Version 4Biofilm-Related Infections in Gram-Positive Bacteria and … 2Capreomycin: Uses, Interactions, Mechanism of Action | DrugBank Online 1Capreomycin - Wikipedia

Research and evidence supporting off-label usage

Although the use of medications for off-label purposes is increasing, it is crucial to emphasize that each of these applications must be supported by research to prioritize patient safety above all else.

Dosage and Administration

The effectiveness of Capreomycin as a therapy depends on the dosage and careful administration customized to meet the specific needs of each patient.

In the case of tuberculosis, resistant to multiple drugs, the treatment usually requires a carefully adjusted dosage. This adjustment is often based on factors such as the severity of the infection and the patient's physiological condition.

Methods of administration

In some cases, Capreomycin is given through an injection into the muscle to allow for quick absorption and optimal effectiveness.

Dosage adjustments based on patient factors

Sometimes, the dosage may need to be adjusted based on factors like kidney function, age, and other medical conditions to achieve the therapeutic level.

Composition of Capreomycin

Delving deeply into the composition of Capreomycin reveals its chemical structure and the distinctive way it is formulated.

Chemical structure and properties

Capreomycin is a type of antibiotic with a structure consisting of cyclic peptides, allowing it to inhibit bacteria growth.

Formulation details

Primarily found in the form of a salt, its composition guarantees stability, solubility, and effective therapeutic results.

Side Effects of Capreomycin

Like any medication, Capreomycin can have side effects. It is essential to be aware of these side effects to ensure patient care.

Overview of potential side effects

Side effects can range from mild to severe. There are various manifestations to consider. Notable mentions include toxicity, auditory disturbances, and imbalances in electrolytes.

Risk factors and incidence

Certain groups of people, due to their physical characteristics or existing health conditions, may be more prone, to experiencing a higher frequency of these side effects.

Common Side Effects

Among the possible side effects, more reported adverse reactions have been reported.

Most frequently reported adverse reactions

Nephrotoxicity, ototoxicity, and electrolyte imbalances are the prevalent side effects that require careful monitoring.

Managing and mitigating common side effects

Recognizing the prompt, making adjustments to the dosage, and providing necessary support are the three key elements in effectively managing these prevalent side effects, all while prioritizing the patient's well-being.

Interactions with Other Medications

In pharmacology, it is essential to be aware of how Capreomycin interacts with medications to avoid any potential challenges in treatment.

Drugs that may potentiate or diminish Capreomycin’s effects

When Capreomycin is taken together with drugs, like loop diuretics or other nephrotoxic agents, there's a chance of experiencing kidney problems.

Recommendations for co-administration

To ensure the effective use of medications, it is essential to review the patient's medication regimen thoroughly and regularly monitor their progress. This helps ensure that different drugs are working together harmoniously.

Warning and Contraindications

Administering Capreomycin comes with caveats that need to be considered. It is crucial to understand the conditions and situations in which this drug may not be recommended to prioritize safety.

Conditions and situations where Capreomycin should not be used

People who have a documented sensitivity to Capreomycin. Those with kidney problems. Individuals who have experienced hearing problems in the past due to aminoglycosides.

Recognizing and mitigating potential risks

Thoroughly observing and monitoring patients while knowing their medical history and any possible contradictions can help prevent adverse reactions. Moreover, conducting kidney and hearing evaluations can further minimize potential risks.

Careful Administration Recommendations

Capreomycin, while potent, requires astute consideration, especially in unique patient demographics.

Special populations and conditions requiring dose adjustments

Patients who have kidney problems or are taking medications that can harm the kidneys may require adjustments to their doses in order to prevent any adverse effects.

Monitoring parameters for therapy

Tests to assess kidney function. Evaluations to measure hearing ability. Analysis of levels with a focus on potassium and magnesium.

Important Precautions

Before starting Capreomycin there are essential factors that need to be considered to ensure the success of the treatment.

Considerations before starting therapy

Evaluating the kidney function. Examining interactions between drugs. Making sure patients are informed about side effects.

Factors that may affect Capreomycin's safety and efficacy

Other factors, such as the medications being taken alongside Capreomycin, any existing conditions, and how well the patient follows instructions, can significantly impact the safety and effectiveness of this medication. It is crucial to assess these factors and provide proper education to patients.

Administration to Special Populations

In situations, it is crucial to customize the administration of Capreomycin based on the unique needs of different groups of people. This involves tailoring the treatment to meet requirements and circumstances.

Elderly: Adjustments and considerations for geriatric patients

Elderly patients, due, to their reduced kidney function and the possibility of taking medications, may need lower doses and close monitoring.

Pregnant Women and Nursing Mothers: Safety, potential risks, and recommendations

Considering the harmful effects Capreomycin may have on fetal development, it is vital to approach its use during pregnancy with caution. Similarly, nursing mothers should be mindful that we're uncertain how this drug may be excreted through breast milk.

Children: Dosage, safety, and efficacy in pediatric populations

When giving medications to children, it is important to adjust the dosage according to their weight. Close attention should be paid to any signs of toxicity and monitored regularly.


An excessive amount of Capreomycin, while uncommon, is an emergency that requires immediate action.

Recognizing signs and symptoms of overdose

Symptoms of an overdose may appear as increased damage to the ears, kidney problems, and significant imbalances in electrolytes.

Management and treatment guidelines

Stopping the medication away, along, with receiving support and possibly undergoing dialysis, can help alleviate the effects of an overdose.

Storage Guidelines

It is crucial to store Capreomycin to preserve its effectiveness, treatment, and shelf life.

Ideal conditions for storing Capreomycin

The medication must be kept in a place away from direct sunlight and at room temperature.

Expiry and disposal recommendations

Capreomycin should not be used after it has expired. It is essential to follow disposal practices according to pharmaceutical guidelines.

Handling Precautions

Ensuring the safety of patients and healthcare providers is crucial when preparing and administering Capreomycin.

Safety measures during preparation and administration

It is essential to wear gloves avoid touching the skin or eyes, and maintain a sterile environment while preparing for injections. These precautions are necessary. Should not be overlooked.

Recommendations for healthcare providers and caregivers

Strictly adhering to practices, ensuring patients are well informed about potential side effects, and scheduling regular follow-up appointments after administering Capreomycin can significantly enhance the safety measures associated with this therapy.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Lucia on Jul 13, 2017 Verified Purchase

Generic Capastat, Capreomycin Injection

Great product and great service!

Note: does not imply any medical claims from this review.

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