Cefditoren Pivoxil

Cefditoren Pivoxil is a cephalosporin prescribed to help treat bacterial infections, such as infections of the respiratory tract, skin, etc.

Generic Spectracef

Cefditoren Pivoxil


6, 10

Zuventus Healthcare


200 mg


Cefditoren Pivoxil

I. What is Cefditoren Pivoxil

An Overview of Cefditoren Pivoxil: Cefditoren Pivoxil, a third-generation cephalosporin antibiotic, is highly regarded for its effectiveness in treating a wide variety of bacterial infections. When taken orally and converted into its form, cefditoren it effectively fights against pathogens.

Significance in Antibacterial Treatment; This medication plays a role in the field of antibacterial therapy, especially because of its wide-ranging effectiveness and its ability to combat bacteria that produce beta-lactamase. These qualities make it significantly useful in treating infections that are resistant to other antibiotics.

Cefditoren brand name

Cefditoren is a type of third generation cephalosporin that is often sold under the brand name Spectracef, by Cornerstone BioPharma.

II. Composition of Cefditoren Pivoxil

Key Components; Cefditoren pivoxil functions as the prodrug form of cefditoren serving as both a prodrug and an antibacterial medication. It falls under the category of pivaloyloxymethyl esters 1,3 thiazoles, oxime O ethers and cephams. Presentations; Commonly found in tablet formulations making it convenient for patients, from backgrounds to take and adhere to their treatment regimens.

III. Pharmacodynamics: How Cefditoren Pivoxil Works

Mechanism of Action Against Bacteria:

Cefditoren is prescribed for treating infections by either eliminating the bacteria or impeding their growth. Specifically, Cefditoren pivoxil is utilized to address throat and lung infections like bronchitis and tonsillitis, along with some skin infections.

By targeting the penicillin-binding proteins in cell walls, Cefditoren pivoxil triggers lysis, leading to bacterial cell demise and demonstrating a strong bactericidal impact.

Its antimicrobial range covers a spectrum effectively combatting both Gram positive and Gram negative bacteria making it a versatile choice, in clinical scenarios requiring broad antibacterial coverage.

IV. Clinical Uses of Cefditoren Pivoxil

It is mainly used for treating community acquired pneumonia, acute exacerbation of bronchitis and uncomplicated skin and skin structure infections. Research shows that Cefditoren Pivoxil is often more effective than cephalosporins particularly, in cases involving multi resistant strains.

V. Off-Label Uses of Cefditoren Pivoxil

  • In addition to respiratory and skin infections, cefditoren pivoxil has demonstrated good clinical and bacteriological efficacy in treating acute exacerbations of chronic bronchitis (AECB), community-acquired pneumonia (CAP), acute maxillary sinusitis, acute pharyngitis/tonsillitis, and uncomplicated skin and skin structure infections. It is generally well tolerated3.

VI. Dosage and Administration

Dosage Recommendations for Conditions: The amount prescribed can differ, usually falling between 200 mg to 400 mg taken twice a day, depending on the seriousness and nature of the infection.

Adapting Dosages for Kidney Issues: It's important to adjust dosages for patients with kidney problems to avoid buildup and potential harm.

How to Take Cefditoren Pivoxil Properly; It's best to take Cefditoren Pivoxil with meals to improve absorption and effectiveness a factor, in reaching therapeutic levels.

VII. Side Effects of Cefditoren Pivoxil

Common Side Effects: Patients might encounter stomach issues like diarrhea, feeling queasy, and stomach discomfort, which usually doesn't last long.

Possible Serious Adverse Reactions: While uncommon, severe responses such as colitis, hypersensitivity reactions, and Stevens-Johnson syndrome require prompt medical care.

VIII. Drug Interactions

Common and Important Interactions: Cefditoren Pivoxil can interact with substances, affecting how well it works. 

  • taking antacids with magnesium or aluminum, as well as iron supplements, can reduce the absorption of Cefditoren, making it less effective.
  • If you take warfarin at the time, it could increase the blood thinning effects and require closer monitoring of your prothrombin times.

Remember to take antacids and iron supplements from Cefditoren. Keep an eye on your INR levels when using warfarin.

Managing Potential Drug-Drug Interactions: It's crucial to handle interactions by scheduling when you take your medications and checking your drug levels regularly. Healthcare providers should consider adjusting doses or switching to medications if interactions cannot be avoided.

IX. Special Precautions and Warnings

People who are allergic to cephalosporin antibiotics should not use Cefditoren Pivoxil as it can trigger allergic reactions. Additionally, individuals with a deficiency should avoid this medication as it may worsen their condition.

When prescribing Cefditoren, doctors should be cautious with patients who have issues like colitis, as the medication could make these conditions worse. It's important to note that chewable tablets may contain phenylalanine, so individuals with phenylketonuria (PKU) need to be mindful of this.

X. Administration Considerations in Special Populations

Patients; Dosage and Safety Concerns:

  • Before prescribing Cefditoren Pivoxil to elderly patients it is important to evaluate their kidney function. As age related decline in function may occur adjustments in dosage might be necessary to prevent potential buildup and toxicity issues.
  • Pregnant. Nursing Mothers; Risks and Recommendations: Although Cefditoren is classified as a category B drug with no risks in human studies, it should only be used during pregnancy if absolutely necessary. Additionally caution is advised when considering its use in nursing mothers due to the potential for effects on the newborn.
  • Pediatric Usage; Safety and Dosage Guidelines: The safety and effectiveness of Cefditoren in children between six months and 12 years of age have been well established. However, it is not recommended for infants under six months old due to metabolic processes within this age group.

XI. Handling and Storage

Storage Recommendations: It is advisable to store Cefditoren Pivoxil at room temperature, ensuring it is kept away from heat and moisture to maintain its effectiveness.

Regarding shelf life and disposal, this medication usually remains viable for up to two years from the manufacturing date. Patients should be informed about the methods of disposal, such as returning any unused or expired medication to pharmacy collection programs.

XII. Managing Overdose

Signs of taking too much: If you take too much, you might experience more stomach issues like diarrhea, nausea, and stomach pain. You could also have problems with thinking and may have seizures.

How to handle an overdose: If someone takes much, it's important to provide care for the symptoms and offer support. In some cases where the medication was taken recently, washing out the stomach might be considered. Hemodialysis isn't very effective in removing cefditoren from the bloodstream, so focusing on care is key.

XIII. Important Precautions

When using Cefditoren Pivoxil it might impact some lab tests like glucose tests, in urine and Coombs test which could result in results. Although it usually doesn't affect driving or machine operation any medication that can cause dizziness or drowsiness should be used carefully when doing tasks that need attention.

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