Clemastine Fumarate

Clemastine Fumarate is prescribed for the treatment of allergic reactions such as sneezing, runny nose, watery eyes, itching and other symptoms. Clemastine Fumarate is an antihistamine which blocks or reduces the effects of natural histamine in the body which leads to the reduction of the symptoms of allergic reactions.

Generic Tavist


Clemastine Fumarate


Novartis Biochemie


1.34 mg


Out of Stock.

Clemastine Fumarate

1. Introduction

Overview of Clemastine Fumarate

Clemastine Fumarate, known for its effectiveness in relieving symptoms, is categorized as a first-generation antihistamine.This medication is adept, at easing the discomforts associated with allergies, including rhinitis and hives.

Historical development and FDA approval

Clemastine Fumarate was created in the 1960s and received FDA approval in 1977. This milestone represented a progression in treatment choices for individuals with allergies, providing a fresh approach to alleviating enduring and distressing symptoms.

2. Composition and Properties

Chemical structure and characteristics of Clemastine Fumarate

Clemastine Fumarate is known for its dichlorobenzene ring, which gives it its antihistamine properties. This specific structure plays a role in allowing it to cross the blood brain barrier leading to sedation in addition, to its main anti allergy effects.

Clemastine Fumarate

Formulations available (tablets, syrup, etc.)

The medication comes in forms;

  • Tablets are easy for adults usually taken twice a day.
  • Syrup is good for kids or those who like medicine.

3. Uses of Clemastine Fumarate

Approved therapeutic uses

Clemastine Fumarate is mainly used to treat symptoms related to rhinitis and hives. It works effectively in easing nasal congestion, itching and sneezing.

Mechanism of action in allergy relief

4. Off-Label Uses of Clemastine Fumarate

Exploration of additional therapeutic areas

Case studies and research supporting off-label uses

Based on real-life examples, it seems that Clemastine Fumarate could be helpful in managing issues like preventing migraines and treating asthma. However, these applications are not official. Need more testing, in clinical trials for validation.

5. How Clemastine Fumarate Works

Pharmacodynamics: Interaction with histamine receptors

Clemastine Fumarate mainly works by blocking H1 receptors, which helps relieve allergy symptoms and may cause sedative effects, in certain individuals.

Pharmacokinetics: Absorption, metabolism, and excretion details

Clemastine Fumarate is easily absorbed in the stomach, reaching levels in the bloodstream two to four hours after intake. It goes through processing in the liver and is mostly removed through the kidneys, with a minor portion being expelled through feces.

6. Dosage and Administration

The amount of Clemastine Fumarate prescribed usually depends on factors such as the patient's age, the seriousness of symptoms, and the particular allergic issue being addressed. Adults might be advised to take 1.34 mg twice a day. Adjustments to the dosage are suggested for children and older individuals.

Clemastine fumarate for dogs

Clemastine, which is an antihistamine is typically deemed safe for dogs when administered as instructed by a vet.

Clemastine and MS 

In a phase II clinical study, researchers found that the oral antihistamine clemastine had a slight positive effect on enhancing the conduction of electrical signals along the optic nerve in individuals with MS who experienced optic nerve impairment.

Methods of administration and timing

To get the most out of Clemastine Fumarate and reduce side effects, it's best to take it with meals. Keeping a schedule can help keep your blood levels steady, which can improve the medication's effectiveness.

7. Side Effects of Clemastine Fumarate

Common side effects and their management

  • Typically well received, some usual effects may involve feeling sleepy, which could lessen over time.
  • Additionally, experiencing a mouth can be relieved by drinking more water or using saliva substitutes.

Serious side effects and actions to take

8. Important Precautions

Precautions for patients with existing health conditions

Lifestyle and dietary considerations

9. Interactions with Other Medications

Common drug interactions and their implications

Clemastine Fumarate could have effects when taken with certain medications. Some key interactions to watch out for include:

  • Combining it with nervous system depressants like alcohol, benzodiazepines, or opioids may increase sedative effects.
  • Taking it with Anticholinergic agents might raise the risk of experiencing side effects such as dry mouth, urinary retention, and constipation.

How to manage potential interactions

To effectively handle these interactions healthcare providers need to review medications. They may need to modify dosages or replace medications as needed. It's important for patients to seek advice from their healthcare provider before initiating any medication, including, over the counter drugs and herbal supplements.

10. Contraindications and Warnings

Conditions and scenarios where use is advised against

Clemastine Fumarate should not be used in patients with narrow-angle glaucoma, urinary retention, or a known hypersensitivity to antihistamines.

Warnings for specific populations

Please use care when giving this to:

  • Elderly individuals: There is a possibility of heightened anticholinergic effects and drowsiness.
  • Pregnant women: use if the benefits outweigh the risks to the fetus.

11. Special Considerations

Administration to elderly: Adjustments and monitoring

Elderly individuals might require reduced doses of Clemastine Fumarate because their metabolism and excretion rates tend to decrease. Monitoring them for any potential adverse effects, like confusion or excessive sedation, is advisable.

Administration to pregnant women and nursing mothers: Safety profile

There is not information available about the usage of Clemastine Fumarate during pregnancy and breastfeeding. It is recommended to use it while pregnant only if absolutely necessary after evaluating both the risks and benefits. If given to nursing mothers caution is advised as there may be a risk of effects, on the baby.

Administration to children: Dosage accuracy and precautions

When giving medicine to kids it's important to calculate the amount based on their weight. Using the formula is key to getting the dosage right and watching out for signs of taking too much, like being overly excited or easily irritated.

12. Managing Overdosage

Symptoms of overdosage and immediate actions

Signs of taking too much medication can lead to feeling very sleepy, being confused, and experiencing a fast heartbeat.

  • Steps you should take away involve getting help from emergency services and providing care, such as ensuring proper breathing and keeping an eye on important health indicators.

Long-term management and treatment options

13. Storage and Handling Precautions

Proper storage conditions to maintain efficacy

It's best to keep Clemastine Fumarate in a dry place at room temperature to maintain its effectiveness and prevent deterioration.

Handling precautions to prevent accidental exposure

Proper handling involves:

  • Keeping the medicine from children.
  • Refraining from touching the medicine if you are pregnant especially when the tablets are crushed or broken.

14. Careful Administration Practices

Guidelines for healthcare providers

Healthcare professionals need to make sure that patients are well informed about how to use Clemastine Fumarate and its potential risks. They should also regularly check the patients medication plan to avoid any interactions and handle side effects effectively.

Patient education and adherence strategies

Some helpful tactics involve:

  • Offering instructions regarding when to take medication and managing any potential side effects.
  • Establish reminders and schedule follow-up visits to evaluate effectiveness and ensure compliance.

Rated: 4.8 / 5 based on 4.8 customer reviews.

Posted by Cook on Aug 29, 2019 Verified Purchase

clemastine fumarate

It's all good!

Note: does not imply any medical claims from this review.
Posted by kohler on Oct 28, 2018 Verified Purchase

clemastine fumerate

great price , great product , fast shipping , great people !

Note: does not imply any medical claims from this review.
Posted by Altieri on Aug 16, 2018 Verified Purchase


Hi, I received the product to day. Thanks you. I can't rate it. Stars are only for Buy Pharma

Note: does not imply any medical claims from this review.
Posted by Hay on Jul 13, 2018 Verified Purchase

Excellent product

Product came on time and the quantity was correct.

Note: does not imply any medical claims from this review.
Posted by Trautt on Jun 21, 2018 Verified Purchase

Good service

I received the product within the quoted time span. It was exactly what I had ordered. The tabs were individually packed in foil. I was completely satisfied with my order.

Note: does not imply any medical claims from this review.

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