Cycloserine is often prescribed with other drugs to treat tuberculosis. It may also be prescribed to manage urinary tract infections.

Generic Seromycin


Coxerin, Pamserine, Cyclorin

6, 10

Samarth Life Sciences, United Biotech, Macleods Pharma, Lupin


250 mg


Out of Stock.


I. Introduction

Cycloserine plays a role in pharmaceuticals, especially when effectively treating challenging cases of Tuberculosis. Additionally, it shows adaptability as a supplementary treatment in psychotherapy. This article aims to provide an understanding of cycloserine, covering its applications, potential side effects, recommended dosage guidelines, and various other aspects.

II. What is Cycloserine?

Cycloserine, an antibiotic with a chemical structure, contains a rigid isoxazolidone ring. Its breakthrough discovery in 1955 revolutionized the field of antibiotics. Due to regulations, it has gained the approval of the Food and Drug Administration (FDA) for treating specific medical conditions.

III. Uses of Cycloserine

Cycloserine is an antibiotic used to treat tuberculosis for many years. It is effective against Mycobacterium tuberculosis, the bacteria that causes tuberculosis. When other conventional drugs fail, it can be used as a last resort for treating drug-resistant tuberculosis (MDR TB) 12In addition to its properties, it shows potential in psychotherapy for anxiety disorders 3. Overall, cycloserine’s ability to treat conditions is precious in managing infectious diseases and mental health concerns.

1. en.wikipedia.org2. niaid.nih.gov3. psychiatrictimes.com4. who.int5. webmd.com6. apps.who.int7. biolmoodanxietydisord.biomedcentral.com8. academia.edu9. link.springer.com10. academic.oup.com11. journals.plos.org12.

IV. Off-Label Uses of Cycloserine

Cycloserine is an antibiotic used to treat tuberculosis for many years. It is effective against Mycobacterium tuberculosis, the bacteria that causes tuberculosis. When other conventional drugs fail, it can be used as a last resort option for treating drug-resistant tuberculosis (MDR TB) 1. In addition to its properties, it shows potential in psychotherapy for anxiety disorders. Initial studies suggest that it could be useful in treating depression. Researchers have been exploring its effects on the nervous system to see if it can enhance cognitive abilities. However, it is essential to note that these uses are not fully supported or endorsed. Ongoing research is exploring their potential benefits.

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V. How Cycloserine Works

VI. Dosage and Administration

Dosage recommendations for conditions may vary. In the case of Tuberculosis, doctors typically prescribe doses ranging from 250 to 500 mg. However, when it comes to anxiety disorders, lower doses are usually recommended. Oral capsules are the most commonly used form of administration, although injectable solutions are also an option. The frequency and timing of administration generally involve taking the medication twice a day. The specific timing depends on the ailment being treated.

VII. Administration to Specific Populations

Extra care should be taken when giving the medication to groups of people. Giving it to older individuals, The dosage might need to be adjusted considering any changes in their metabolism. Giving it to women and breastfeeding mothers: Due to its potential for causing birth defects, it should be used cautiously during pregnancy and while breastfeeding. Giving it to children: Lower doses should be. They should be closely monitored.

VIII. Composition

Each capsule of cycloserine contains inactive components, usually lactose monohydrate, magnesium stearate, and the actual active substance. This medication is offered in tablets, capsules, and injectable solutions.

IX. Common Side Effects

Although cycloserine is generally well tolerated, it can cause various side effects. Some individuals may experience issues such as nausea, vomiting, and diarrhea. There have also been reports of nervous system effects like dizziness, headaches, and drowsiness. In some cases, skin reactions such as rashes and hives may occur, leading to the discontinuation of the medication. This review aims to enhance your understanding of cycloserine so that healthcare providers and patients can make informed decisions about its use.

X. Rare but Serious Side Effects

Although most side effects of cycloserine can be easily handled, there are rare but serious complications that should be addressed immediately. In some cases, severe allergic reactions may require medical attention. It's essential to monitor for potential neuropsychiatric effects such as delirium, psychosis, and suicidal thoughts, as they can significantly impact the central nervous system. Additionally, reports of elevated liver enzymes and even liver failure have been associated with this medication.

XI. Interactions

When cycloserine is used together with substances, it can lead to a complex network of interactions: Interactions with Other Drugs. Taking cycloserine and antiepileptic medications can increase the effects on the central nervous system. Interactions with Food: Certain foods containing tyramine levels may worsen the neurological effects. Interactions with Alcohol: Drinking alcohol raises the chances of experiencing neurological outcomes.

XII. Warnings and Contraindications

There are situations where the use of cycloserine is limited. It is essential to be cautious in individuals with existing medical conditions such as liver disease or a history of seizures. Before starting cycloserine, a thorough evaluation should be conducted. Additionally, if there is an allergic reaction to cycloserine, its use should be avoided altogether.

XIII. Important Precautions

It is crucial to be extremely careful and attentive when undergoing cycloserine therapy. It is important to monitor liver function and mental state throughout the treatment. Any onset of rash changes in mental state or jaundice should be immediately reported to a healthcare professional for prompt medical attention.

XIV. Careful Administration and Special Cases

Patients who have risk factors require personalized treatment plans. It is essential for patients with kidney problems to adjust the dosage and regularly monitor their function. Individuals with a history of conditions may experience intensified neurological effects, so a thorough analysis of the risks and benefits is necessary.

XV. Overdosage

In cases of taking much medication, it is essential to take immediate and accurate medical actions. Some signs of taking an amount include severe effects on the central nervous system, difficulty breathing, and low blood pressure. Following emergency treatment procedures such as washing out the stomach, providing care, and promptly admitting the individual to a hospital is vital.

XVI. Storage

It is crucial to store cycloserine to ensure its effectiveness. The best storage conditions would be in a dry place away from direct sunlight. When stored correctly, the drug usually remains potent for two years. If you have any unused medication, it is essential to dispose of it following the regulations in your local area.

XVII. Handling Precautions

Safety precautions are crucial when it comes to dealing with cycloserine. To handle the drug safely, it is recommended to wear gloves and a mask. Additionally, it's crucial to keep cycloserine out of reach of children and avoid any contact with your eyes.

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