Dostinex (Cabergoline) is a dopamine receptor agonist prescribed for the treatment of hyperprolactinemia. In women, it can help treat inconsistent breast milk production, missed periods, etc. In men, it can help treat decreased sexual desire, enlarged breast, etc.







0.5 mg

Italy, Turkey

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What is Dostinex?

Dostinex, or Cabergoline, is a medication that works as an agonist for dopamine receptors. Its primary function is to decrease the production of hormones from the anterior pituitary gland.

Historical background and discovery

Dostinex's story started in the half of the 20th century. It was created as an alternative to medications that inhibit prolactin using ergot derivatives. The aim was to reduce side effects and provide a precise action. Thanks to its effectiveness and safety record, it quickly became well-known in pharmacology.

Importance in the medical field

Due to its ability to inhibit prolactin, Dostinex has a significant role in treating conditions such as hyperprolactinemia, Parkinsons' disease, and specific types of pituitary tumors. Its value is more evident when it proves effective for cases that do not respond to other treatment options.

Uses of Dostinex

Primary indications

Dostinex (cabergoline) is a medication that belongs to the class of dopamine receptor antagonists 1It is used to treat hyperprolactinemic disorders of either idiopathic or pituitary adenoma origin 1Dostinex is indicated for conditions such as hyperprolactinemia and prolactin-secreting adenomas 1It is also used to treat Parkinson’s disease 1.

Please find below the references for Dostinex:

  1. Dostinex (cabergoline) dosing, indications, interactions, adverse effects, and more - Drugs & Diseases - Medscape

Mechanism of action and its role in therapy

Dostinex functions by activating dopamine receptors in the gland resulting in a decrease in prolactin secretion. This distinctive mechanism positions it as a treatment option for hyperprolactinemia and similar conditions.

Benefits for patients

Patients taking Dostinex can enjoy advantages, such as restoring regular menstrual cycles, shrinking tumors, and improving Parkinsonian symptoms. Additionally, its extended half-life allows for frequent administration, making it easier for patients to follow the prescribed dosage.

How Dostinex Works

Pharmacological action

Dostinex functions by acting as a dopamine agonist, imitating the effects of dopamine, a neurotransmitter type. As a result, it hampers the synthesis and release of prolactin from the pituitary gland.

Target receptors in the body

Dostinex mainly focuses on the D2 dopamine receptors found in the gland. Its strong binding to these receptors guarantees a powerful effect.

Physiological impact on the endocrine system

Dostinex has the ability to regulate the release of prolactin, which can help correct imbalances. This in turn can aid in treating conditions such as amenorrhea, galactorrhea, and infertility. The impact of Dostinex on the endocrine system is comprehensive. Contributes to overall health improvement.

Off-label Use

What constitutes off-label use?

Using medications for conditions that have not been officially approved by agencies is known as, off label use. Although this practice may rely on evidence or preliminary research it is crucial to ensure that such usage is supported by reliable clinical judgment.

Common off-label applications of Dostinex

Dostinex (cabergoline) is a medication that belongs to the class of dopamine receptor antagonists 1It is used to treat a hormone imbalance in which there is too much prolactin in the blood (hyperprolactinemia) 2Dostinex is primarily prescribed for hyperprolactinemia, diabetes type 2, acromegaly, and Parkinson’s disease 3It may also be prescribed off-label for tardive dyskinesia 3.

Restless legs syndrome (RLS) management typically involves lifestyle measures such as reducing caffeine and alcohol consumption, stopping smoking (if relevant), and undertaking moderate regular exercise 45Supportive therapy is often given to people with schizophrenia, where typically after a person is established in the care of mental health services, they will receive general support rather than specific talking therapies such as cognitive-behavioral therapy (CBT) 6.

Please find below the references for Dostinex:

  1. Dostinex (cabergoline) dosing, indications, interactions, adverse effects, and more - Drugs & Diseases - Medscape
  2. Dostinex Oral: Uses, Side Effects, Interactions, Pictures … - WebMD

Research and evidence supporting these applications

There have been studies that suggest Dostinex might help treat restless leg syndrome and reduce the negative symptoms of schizophrenia. However, extensive research is needed to confirm these findings. Nonetheless, the initial data shows promising results.

Dosage and Administration

Standard dosage recommendations

Usually, when it comes to hyperprolactinemia, the usual starting dose is 0.25 mg, taken twice a week. The dosage may be adjusted depending on how the patient responds to the treatment.

Variations based on patient profiles

Patients with kidney or liver problems well as elderly individuals, may require adjustments to their dosage.

Administration guidelines: oral intake, timing, and frequency

Dostinex is typically taken by mouth with meals. The frequency of administration may vary depending on the indication, but in most cases, taking it every two weeks is sufficient.


Active ingredients

Cabergoline is the active component found in Dostinex.

Inactive ingredients and fillers

Apart from Cabergoline, Dostinex tablets might include ingredients such, as leucine and lactose to facilitate tablet production.

Pharmaceutical form: tablet strengths and appearance

Dostinex is typically found in tablets, which come in strengths ranging from 0.5 mg to 1 mg. These tablets are oblong. Have a white to, off white color.

Side Effects

Overview of potential side effects

Like any other medication, Dostinex may cause some side effects. These can vary from ones like feeling nauseous to more severe and uncommon effects like experiencing difficulty in breathing.

Differentiating between common and rare side effects

Some of the side effects you might experience are headaches and dizziness. However, there are side effects that require immediate medical attention, such as cardiac changes or pulmonary problems.

Common Side Effects

List of frequently observed side effects

  • Headache
  • Nausea
  • Dizziness
  • Fatigue

Managing and mitigating common side effects

The frequent side effects are usually temporary and will go away by themselves. Nevertheless, you can consider using over-the-counter medicines or adjusting the dosage to help manage them. Drinking water and getting some rest can also assist in relieving specific symptoms.

When to consult a physician

If the side effects continue or get worse or if you experience chest pain trouble breathing, or hallucinations, it is crucial to seek medical help.


Potential drug interactions

Dostinex, similar to other medications, may have interactions with other drugs. Some examples include antipsychotics, antiemetics, and specific antiretrovirals. These interactions can. Enhance or reduce the effectiveness of the medications or increase the likelihood of experiencing adverse reactions.

Interaction with food and beverages

While the absorption of Dostinex is not significantly influenced by food, it is advisable to be cautious with alcohol consumption during treatment as it may worsen side effects such as dizziness. It would be wise to avoid either or limit alcohol intake while undergoing therapy.

Impact on other treatments or underlying conditions

Dostinex can potentially affect the treatment of conditions such as hypertension. It may also interact with medications used for Parkinsons' disease. It is essential for healthcare professionals to carefully consider any consequences that may arise when combining therapies or treating patients with existing medical conditions.


Specific populations at risk

Situations where Dostinex should be avoided or used with caution


Absolute contraindications: When Dostinex should not be used

Relative contraindications: Situations where Dostinex should be used with care

Careful Administration

Monitoring therapy

Adjustments in dosage or administration

Important Precautions

Things to avoid while on Dostinex

Lifestyle considerations and potential interactions

Administration to Specific Populations

Elderly: Special considerations and precautions

Pregnant Women and Nursing Mothers: Safety profile, risks, and guidelines

Children: Usage, safety, and age-related considerations


Recognizing signs of overdose

Immediate actions and interventions

Potential long-term consequences


Proper storage conditions

Shelf life and expiration

Disposal of expired or unused medication

Handling Precautions

Safe handling and storage

Precautions to avoid contamination or degradation

Recommendations for caregivers or those handling medication for others

Rated: 5.0 / 5 based on 5.0 customer reviews.

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Good quality

Note: does not imply any medical claims from this review.
Posted by Ghamgo on Sep 10, 2018 Verified Purchase


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Note: does not imply any medical claims from this review.

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