Prochlorperazine Maleate

Prochlorperazine a known phenothiazine is administered for the treatment of nausea and vomitting and can also be used for managing schizophrenia.

Generic Comapazine, Stemetil, Buccastem

Prochlorperazine Maleate

Acuvert, Stemetil MD


Piramal Healthcare


5 mg




Prochlorperazine is used for the treatment and prevention of nausea, vomiting, vertigo, dizziness, agitation, meniere's disease and schizophrenia.

How it Works

Prochlorperazine is known as a phenothiazine. Prochlorperazine works by blocking the action of a chemical called dopamine which acts on the nervous system in the brain. Prochlorperazine works by blocking dopamine receptor in the brain which triggers nausea and vomiting. Prochlorperazine works in schizophrenia by using high doses, it works by blocking dopamine in certain brain regions that affect thoughts and mood.

Common Side effects

Some of the potential side effects of Prochlorperazine can include the symptoms below;

Orthostatic hypotension


Prochlorperazine Maleate belongs to a class of drugs called phenothiazine tranquilizers. It is used to treat nausea and vomiting due to certain conditions like migraine.


Prochlorperazine Maleate is available as tablets of 5 mg concentration. It may be used to treat: -

Nausea and vomiting due to migraine, cancer chemotherapy or radiotherapy
Vertigo due to Labyrinthitis or Meniere’s syndrome
Mental illness such as schizophrenia
Short term anxiety disorder

Dosage and administration

For adults: - For nausea and vomiting - The recommended dose is the 5 mg or 10 mg tablets to be taken 3 to 4 times in a day. For non-psychotic anxiety and mild schizophrenia - The recommended dose is the 5 mg tablets to be taken 3 to 4 times in a day. Moderate to severe schizophrenia - The recommended dose is the 10 mg tablets to be taken 3 to 4 times in a day, till the symptoms are brought under control. For children: - For nausea and vomiting - The daily dose should be given according to their body weight: Between 20 to 29 pounds - not to exceed 7.5 mg a day. Between 30 to 39 pounds - not to exceed 10 mg a day. Between 40 to 85 pounds - not to exceed 15 mg a day. For schizophrenia; between the age of 2 to 5 years, the daily dose should not exceed 20 mg and between the age of 6 to 12 years, the daily dose should not exceed 25 mg.


Tell your doctor if you are allergic to this drug or to any other substances.
Tell your doctor if you have any history of kidney problems, liver disorders, cardiac disorders like irregular heartbeat, stroke, or a history of blood clotting problems.
Consult your doctor if you have any history of Parkinson’s disease, epilepsy, dementia, seizures, depression, signs of glaucoma, pheochromocytoma, Myasthenia Gravis, or any history of bone marrow suppression.
This drug is known to cause dizziness hence you are advised not to drive after taking the normal dose of this drug. Also, avoid alcoholic beverages.
This medication is not recommended for children under 2 years of age.
This drug will make your skin more sensitive to sunlight, hence avoid being in the sun for too long and take all necessary precautions when outdoors.
Pregnant women and breast feeding mothers are to use this medication only if it has been prescribed by the doctor.

Side effects

Feeling restless or agitated
Loss of menstrual periods
Breast enlargement in men
Increased skin sensitivity
Blurred vision
Dry mouth

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