Salmeterol/ Fluticasone

Salmeterol/ Fluticasone Xinafoate inhaler is prescribed to patients with chronic obstructive pulmonary disease (COPD) and asthma.

Generic Advair

Salmeterol/ Fluticasone

Seroflo, Seretide Evohaler




Salmeterol 25 mcg / Fluticasone 125 mcg


Salmeterol/ Fluticasone

I. Introduction

Salmeterol/Fluticasone is an inhaler combo commonly used to manage asthma and other chronic respiratory issues. This medication combines the lasting effects of Salmeterol with the strong anti-inflammatory properties of Fluticasone, effectively controlling symptoms and enhancing lung function.

Significance in Respiratory Disease Treatment: Conditions like asthma and COPD can greatly impact one's quality of life.

This dual therapy plays a role in reducing flare-ups and maintaining overall respiratory well-being. 

II. Composition and Formulation

Key Ingredients and Their Functions: Salmeterol acts as a prolonged beta agonist (LABA), working to ease muscle tension around the air passages.

  • Fluticasone, a corticosteroid, reduces inflammation in the airways, decreasing their sensitivity to allergens and irritants.
  • Different versions and types of this medication are offered in strengths and forms, including dry powder inhalers and metered dose inhalers to meet various treatment requirements and patient preferences.


III. Mechanism of Action

Salmeterol operates as a bronchodilator by attaching to the beta 2 adrenoceptors in the lungs, maintaining airway expansion and promoting breathing for longer durations.

Fluticasone works to decrease inflammation by focusing on the pathways lessening the production and discharge of inflammatory mediators.

When combined these medications work together to prevent and manage flare ups ultimately decreasing hospital trips and enhancing patient outcomes.

IV. Uses and Indications

V. Off-Label Uses

Researchers are currently investigating how this medication can impact respiratory conditions beyond its approved uses, such as refractory asthma. While there is evidence from studies suggesting potential benefits for other obstructive airway diseases these treatments are not widely accepted yet. 


VI. Dosage and Administration

Dosage Guidelines for Different Age Groups: Dosage varies significantly across demographics, and it is tailored to the severity of the condition as well as patient age and responsiveness to treatment.

Instructions for Use: Patients are advised to follow a strict regimen, inhaling at consistent times each day to maximize the drug's efficacy and minimize potential side effects.

Adjustment in Dosage Based on Medical Condition: Dosage adjustments may be necessary based on the therapeutic response and any concurrent medication the patient may be taking.

Salmeterol/Fluticasone dosage

VII. Administration Special Cases

  • Elderly individuals might need doses because their liver or kidney function could be reduced.
  • For women and nursing mothers, using Salmeterol/Fluticasone during pregnancy or breastfeeding should only be done if the benefits outweigh the risks, as corticosteroids can pass into breast milk.
  • When administering to children, it's important to consider the dosage and potential long-term effects on their growth and development.

VIII. Side Effects

Common Side Effects and Management

When using Salmeterol/Fluticasone, you may experience side effects like headaches, throat irritation, and hoarseness. These issues usually improve with time. Regularly gargling and staying hydrated can help ease throat discomfort. If you have worsening symptoms, it's best to seek advice from your healthcare provider.

Serious Side Effects and Emergency Responses

Adverse reactions may involve allergic reactions, intense narrowing of the airways, and heart-related issues. It is crucial to seek medical assistance in such situations. Patients should stay alert for symptoms like heartbeat, chest discomfort, or worsening breathing and promptly seek medical attention if any of these signs manifest.

Long-term Side Effect Considerations

  • Extended use of medications can pose long term risks such as osteoporosis and growth issues, in children.
  • To address and reduce these dangers it's advisable to monitor bone density and undergo pediatric evaluations regularly.

IX. Important Precautions

Interactions with Other Medications

Using Salmeterol/Fluticasone, with beta blockers or MAO inhibitors may lead to harmful interactions. It is important for patients to disclose all their medications to ensure they can be used together.

Pre-existing Conditions and Contraindications

People who have had allergic reactions to milk proteins or any part of the inhaler should steer clear of this medication.

Patients, with existing heart conditions or serious liver problems need customized doses and careful supervision.

Lifestyle and Dietary Considerations

Maintaining a consumption of caffeine and steering clear of smoking can improve the effectiveness of treatments and lessen the likelihood of side effects. It is advisable to follow a rounded diet that includes ample calcium and vitamin D to counteract any possible negative impact, on bone health.

X. Handling and Storage

Proper Storage Conditions to Maintain Efficacy

To maintain its effectiveness, Store Salmeterol/Fluticasone at room temperature in a dry place away from sunlight. Proper storage will help it remain potent for the duration of its shelf life.

Handling Precautions to Ensure Safety

To keep the inhaler clean, always handle it with washed hands. Regularly inspect the mouthpiece, for cleanliness to avoid contamination and ensure safe use.

Disposal of Expired or Unused Medication

Unused or expired inhalers should be properly disposed of following the guidelines set by your authorities. Many pharmacies offer programs to help you safely get rid of them.

XI. Drug Interactions

Common and Significant Drug Interactions

Interactions to take note of may happen when using medications or anti-HIV drugs, which could change the levels of Fluticasone in the bloodstream. These interactions might result in increased effects of corticosteroids.

How to Manage Potential Interactions

Consistently informing healthcare professionals about any medications and keeping an eye out for signs such as heightened fatigue or hormonal changes can effectively handle these situations.

Interaction with Over-the-Counter Drugs

Over-the-counter medications, such as those used for treating cold and flu symptoms, might contain ingredients that could react with Salmeterol/Fluticasone. It's important to talk to a healthcare professional before beginning any new non-prescription medication.

XII. Overdosage

Symptoms of Overdosage

Taking too much can cause heart palpitations, feeling lightheaded, and a rise in blood pressure. In serious situations, it could result in low potassium levels and high blood sugar.

Immediate Actions and Antidotes

Stopping the medication away and providing symptomatic treatment, such as giving beta blockers for cardiovascular symptoms, are crucial steps to take in case of an overdose.

When to Seek Medical Attention

It is important to seek help quickly if the symptoms of an overdose are severe or if there is any uncertainty, about the health effects that the patient is experiencing.

XIII. Warnings and Contraindications

Specific Warnings Associated with Use

It's important for patients to understand the potential for a risk of asthma-related fatalities linked to LABA medications such as Salmeterol. It's crucial to use Salmeterol/Fluticasone under the guidance of a healthcare provider and in accordance with prescribed guidelines.

Absolute Contraindications for Use

This medicine should not be used by people with severe uncontrolled asthma or those who have had reactions to any of the active ingredients before.

Precautions During Surgery or Medical Procedures

Before any surgery, it is crucial to inform the team about using Salmeterol/Fluticasone as it can interact with anesthesia and other drugs given during the procedure, ensuring the safety of the patient.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by patrick on Oct 28, 2017 Verified Purchase

Works great easy to use

Have been using Cipla's Seroflo for years to control mild asthma and it works great.

Note: does not imply any medical claims from this review.

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