Amlodipine is prescribed to lower blood pressure in individuals suffering from hypertension.

Generic Norvasc

Amlodipine besylate

Amlip, Aginal, Amlodac, Aginal, Amlopres, Amlogard, Amleod and other generic brands


USV, Kopran, Zydus Medica, Cipla, Pfizer, U.S.V, Alembic Pharma, Sandoz, Knoll Pharma and others


2.5 mg, 5 mg, 10 mg



I. Introduction

A. Brief Overview of Amlodipine

Amlodipine is widely used in medicine as a calcium channel blocker serving a dual role in managing hypertension (high blood pressure) and angina, characterized by chest pain due to reduced blood flow to the heart.

B. Historical Background of Amlodipine

Amlodipine, a calcium channel blocker, was introduced in the late 1980s. It proved to be a significant advancement in this category of medication as it provided extended benefits and caused fewer side effects. Developed by Pfizer and marketed as Norvasc, Amlodipine gained widespread recognition and is currently an indispensable component of cardiovascular treatment globally.

C. Role of Amlodipine in Modern Medicine

Amlodipine is widely recognized as an effective therapeutic tool in modern medicine. Its ability to dilate blood vessels and enhance blood flow makes it essential in many treatment plans, particularly cardiovascular health-related ones.

II. Composition of Amlodipine

A. Chemical Composition and Characteristics

Amlodipine besylate, is the active ingredient. It is a white crystalline powder. It has some solubility in water and ethanol. Its structure is defined by a long aliphatic tail, which allows for its gradual and long-lasting effects. Each tablet of Amlodipine contains 2.5, 5, or 10 mg of Amlodipine (as the besylate salt). Additionally, it includes inactive ingredients such as microcrystalline cellulose, dibasic calcium phosphate anhydrous, and magnesium stearate.

B. Variations and Derivatives of Amlodipine

While Amlodipine is a highly regarded medication, it is also frequently used with other cardiovascular drugs like Atorvastatin or Valsartan. This strategy leverages the combined benefits of these medications to manage more intricate or progressive conditions effectively.

III. How Amlodipine Works

A. Mechanism of Action

Amlodipine is a highly effective calcium channel blocker known for its long-lasting effects. It works by preventing the entry of calcium ions into both cardiac muscle and vascular smooth muscle. Since these muscles rely on calcium for contraction, inhibiting its influx leads to the relaxation of blood vessels and reduced heart muscle contractility. Consequently, this mechanism causes the dilation of major coronary and systemic arteries. It results in a decrease in peripheral vascular resistance and blood pressure.

B. Impact on the Cardiovascular System

By directly acting on the cardiovascular system, Amlodipine brings forth good outcomes. It effectively lowers blood pressure and diminishes the heart's demand for oxygen. These impacts aid in controlling hypertension and alleviate angina symptoms by enhancing the oxygen supply to the heart muscle.

IV. Uses of Amlodipine

A. Treatment of Hypertension

Amlodipine holds great importance in the treatment of hypertension. It helps to widen peripheral arteries and decrease vascular resistance, effectively relieving strain on the cardiovascular system 1. These factors play a role in reducing both systolic and diastolic blood pressure and lowering the risk of stroke and heart attack 2. Furthermore, Amlodipine contributes to improving overall cardiovascular health 3.


B. Management of Coronary Artery Disease

Amlodipine has been proven to be highly effective in treating Coronary Artery Disease (CAD) by improving coronary vasodilation1. It enhances oxygen delivery to the heart, especially in individuals with vasospastic angina2. These qualities result in significant benefits, such as relieving symptoms of angina pectoris, reducing the frequency of angina attacks, and enhancing exercise tolerance among CAD patients3.


C. Other Medical Uses

Amlodipine, commonly used to treat hypertension and CAD, has additional applications in various medical situations. One such scenario is its use in Raynaud's disease, where it helps alleviate the spasms of arteries that lead to reduced blood flow1. It has also been utilized off-label for preventing migraine headaches2. Nevertheless, consulting a healthcare professional before considering these alternative uses is crucial.


V. Off-Label Uses of Amlodipine

A. Use in Migraine Prevention

Although not explicitly intended for it, Amlodipine has been found to help prevent migraine headaches. The vasodilatory effect of Amlodipine is believed to play a role in reducing the frequency and severity of migraines1. This can have a significant positive impact on the lives of individuals suffering from this incapacitating condition. However, it is essential to note that using Amlodipine for migraines should always be supervised by a healthcare provider2.


B. Potential Use in Raynaud's Phenomenon

Amlodipine is effective in managing Raynauds' phenomenon. This condition is characterized by spasms in the small vessels of the fingers and toes, which commonly occur in response to cold temperatures or stress1. Amlodipine promotes vasodilation, which helps increase blood flow to the extremities2. As a result, it reduces the frequency and severity of Raynauds' attacks, ultimately improving the overall well-being and daily functioning of patients3.


C. Exploring Other Off-Label Applications

Amlodipine's versatility in pharmacology has sparked interest in exploring potential off-label applications beyond its usual purpose. Amlodipine demonstrates its efficacy in treating select arrhythmias1 and managing certain kidney conditions2. Nonetheless, it is crucial to recognize that these uses are still experimental and should only be pursued under the direct supervision of a medical expert3. Reminder: when considering the off-label use of Amlodipine, or any other medication, it is imperative to rely on robust scientific evidence and obtain approval from a healthcare professional before proceeding.


VI. Dosage and Administration of Amlodipine

A. Standard Dosage Guidelines

Amlodipine is commonly taken once daily. It is typically prescribed for adults at an initial dose of 5mg per day, which can be adjusted to a maximum of 10mg per day depending on the individual's response and tolerance. Pediatric patients are generally recommended a daily dose of 2.5 to 5mg. However, it is crucial to note that these are just guidelines, and a healthcare provider should determine the precise dosage. It is worth mentioning that Amlodipine can be taken with or without food. Furthermore, it should be swallowed whole with a glass of water for best results. Consistency in taking it simultaneously daily is also vital for optimal therapeutic effectiveness.

B. Dosage Adjustments for Specific Conditions

Dosage adjustments become necessary due to patient-specific factors—patients with hepatic impairment. For example, it may require a reduction in dosage as the liver extensively metabolizes Amlodipine. Additionally, the elderly may need careful dosage adjustment due to potential sensitivity to the drug. A healthcare provider must supervise any dosage modifications.

VII. Careful Administration of Amlodipine

A. Factors Influencing Dosage Adjustments

Various factors can impact the requirement for dosage adjustments of Amlodipine, including age, liver function, renal function, and concomitant medications. It is important to note that geriatric patients may require lower initial dosages due to a higher chance of reduced hepatic, renal, or cardiac function. Additionally, it is advisable to exercise caution when administering Amlodipine to patients with severe hepatic impairment.

B. Monitoring Patient Response to Amlodipine

Monitoring blood pressure, heart rate and potential side effects is essential in evaluating the effectiveness and safety of Amlodipine. Additionally, continuous monitoring helps in determining if any adjustments to the dosage are necessary, ultimately promoting optimal therapeutic outcomes for patients.

VIII. Important Precautions While Taking Amlodipine

A. Warnings and Possible Complications

Although Amlodipine is generally regarded as a safe and well-tolerated medication, it is essential to acknowledge the possibility of potential complications. These can include symptoms such as edema, fatigue, palpitations, and dizziness, among others. While these side effects are uncommon there have been rare instances where more serious adverse effects like myocardial infarction or angina have occurred. It is crucial for patients to be adequately informed about these risks and advised to seek medical attention if they experience severe side effects promptly.

B. Handling Precautions to Avoid Adverse Effects

To minimize the chance of experiencing adverse effects, taking certain precautions when handling medication is essential. One such protection is never stopping medicines without consulting a healthcare provider. Additionally, it is necessary to schedule regular follow-up appointments to monitor the medication's effectiveness and potential side effects. Lastly, informing healthcare providers about any other medications you may be taking is crucial to prevent any possible interactions.

IX. Administration to Specific Populations

A. Amlodipine in Elderly Patients

As individuals age, their bodies change drug metabolism and excretion, making it essential to provide specialized care for elderly patients when administering medications. Specifically, when it comes to Amlodipine, it is crucial to exercise caution and adopt an individualized approach to dosage due to the potential heightened sensitivity experienced by this population. Vigilant monitoring for indications of drug intolerance and any adverse effects is of utmost importance in ensuring their well-being.

B. Amlodipine During Pregnancy and Lactation

Under FDA guidelines. Amlodipine falls into Category C of usage during pregnancy. This designation conveys that its safety has not been firmly determined and should only be employed if sufficient benefits outweigh any potential risks. The impact of Amlodipine on breastfeeding remains unknown—whether or not it can pass into breast milk. Thus. Considering its importance for the mother, a decision must be reached as to whether nursing should cease or discontinue this medication would suffice.

C. Use of Amlodipine in Pediatric Patients

Amlodipine is a medication that has been approved to treat hypertension in children between the ages of 6 and 17. However, it is essential to use caution and have professional supervision when administering this medication to pediatric patients. It is recommended to start with a lower dose and closely monitor these patients for their safety and effectiveness. Please note that the use of Amlodipine in children under six has not yet been established, so its safety and efficacy cannot be assured in this age group.

X. Potential Drug Interactions with Amlodipine

A. Common Drugs that Interact with Amlodipine

Amlodipine has the potential to interact with various medications, which can affect their effectiveness or increase the likelihood of side effects. Some notable examples of these interactions are:

1. Simvastatin: When co-administered with Amlodipine, it has been observed that the levels of Simvastatin in the body may increase. This elevation in Simvastatin levels can potentially raise the risk of liver damage.

2. Diltiazem: Diltiazem alongside Amlodipine can cause an elevation in plasma concentrations of Amlodipine. This increase in Amlodipine levels can lead to a higher possibility of experiencing adverse effects.

3. Other antihypertensive agents: Co administering Amlodipine with other antihypertensive agents have been known to produce an additive effect. This combination may lead to a more pronounced decrease in blood pressure. 

B. Managing Interactions and Contraindications

To effectively manage drug interactions, healthcare professionals must employ diligent monitoring, make necessary dose adjustments or opt for alternative medications. Given the uniqueness of each patient's case, these professionals need to evaluate potential drug interactions individually and subsequently adapt the treatment plan accordingly.

XI. Side Effects of Amlodipine

A. Common Side Effects

Although Amlodipine is generally well tolerated, it is essential to note that certain patients may potentially encounter common side effects, including edema, dizziness, and flushing.

B. Less Common but Severe Side Effects

On rare occasions, individuals may experience side effects that are both less frequent and more serious. It is essential to seek immediate medical attention if any symptoms manifest: severe dizziness or fainting, rapid pounding, or irregular heartbeat, and signs of liver problems like yellowing of the eyes/skin or dark urine.

XII. Overdose and its Management

A. Identifying Symptoms of Overdose

Taking too much Amlodipine can lead to excessive expansion of blood vessels in the outer areas of the body and potentially cause a significant drop in blood pressure. Signs that one may have taken too much of this medication include feeling lightheaded or about to pass out and experiencing an abnormally quick or slow heart rate and feeling extremely tired. If there is a suspicion of an overdose, it is crucial to seek immediate medical help.

B. Immediate Steps and Treatment Approaches

When an overdose occurs, preserving essential bodily functions is paramount. In some instances, implementing gastric lavage, also known as stomach pumping, may be beneficial. Additionally, other strategies for managing the situation may involve administering fluids intravenously utilizing vasopressor infusion, and providing ventilation support. It is crucial to closely observe and monitor the patient's condition until stability is achieved.

XIII. Contraindications of Amlodipine

A. Medical Conditions that Prohibit Use

Patients with a known sensitivity to dihydropyridine derivatives, Amlodipine, or any of the excipients in the formulation should avoid using Amlodipine. Please exercise caution in individuals with severe aortic stenosis when using this medication, as it may potentially worsen the condition.

B. Drugs that Should Not Be Taken with Amlodipine

It is important to note that certain medications should not be taken simultaneously as Amlodipine due to the possibility of adverse interactions. One example is potent CYP3A4 inhibitors, including certain antifungal and antiretroviral drugs. These inhibitors can potentially elevate Amlodipine levels in the body, which may result in an increased risk of experiencing side effects.

XIV. Storage of Amlodipine

A. Ideal Storage Conditions

Amlodipine is best stored at room temperature, protected from light and moisture. Keeping it out of the reach of children and pets is essential. Additionally, storing the medicine in a bathroom should be avoided, as the humidity in this area could impact its effectiveness.

B. Shelf Life and Disposal Methods

The shelf life of Amlodipine ranges typically from around five years following its production. The specific expiry information can usually be found on the packaging provided with the medicine. Users are strongly discouraged from utilizing this medication once it has exceeded its expiration date. Proper disposal procedures entail adhering to local regulations or returning unused or expired medicine to a pharmacy for appropriate and safe disposal.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Veronica on Jan 9, 2020 Verified Purchase

great product

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Note: does not imply any medical claims from this review.
Posted by Speece on Dec 12, 2019 Verified Purchase

I find them to be working as described.

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Note: does not imply any medical claims from this review.
Posted by Speece on Dec 12, 2019 Verified Purchase

I find them to be working as described.

Great, will use this Pharmacy for all my prescriptions. 

Note: does not imply any medical claims from this review.
Posted by UMAR on May 12, 2019 Verified Purchase


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Note: does not imply any medical claims from this review.
Posted by Swanson on Dec 17, 2018 Verified Purchase


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Posted by Jacobs on Aug 14, 2018 Verified Purchase

Quality product

I see no difference in this and the name brand I was purchasing. Same quality, better price. I will buy again.

Note: does not imply any medical claims from this review.
Posted by Jacobs on Aug 14, 2018 Verified Purchase

Quality product

I see no difference in this and the name brand I was purchasing. Same quality, better price. I will buy again.

Note: does not imply any medical claims from this review.
Posted by UMAR on Apr 30, 2018 Verified Purchase


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Note: does not imply any medical claims from this review.
Posted by John on Feb 10, 2015 Verified Purchase

Generic Norvasc

Work just like the branded Norvasc...have been using this product in a 5mg dose for years; it does a great job controlling my age-related hypertension with no side effects.

Note: does not imply any medical claims from this review.

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