Tinidazole is an antibiotic which is prescribed to treat bacterial and parasitic infections.

Generic Tindamax, Fasigyn, Simplotan, Sporinex


Tiniba, Enidazol, Fasigyn


Zydus Cadila, East India Pharma, Pfizer

Tab, Tablet

300 mg, 500 mg, 1000 mg



I. Introduction to Tinidazole

A. Brief Overview of Tinidazole

Tinidazole is an antimicrobial drug mainly prescribed for treating specific infections caused by bacteria and protozoa. It has a structure to metronidazole, which is a widely recognized antibiotic. Tinidazole can enter cells and interfere with their genetic material, eliminating harmful pathogens.

B. Medical Classification and Significance

Tinidazole is a drug in medicine that falls under the category of antiprotozoal and antibacterial agents. It belongs to a group called nitroimidazole derivatives, which means it can fight against bacterial infections and protozoan infestations. Its significance is even more significant in settings as it is often chosen as a treatment option for conditions like trichomoniasis, giardiasis, and amebiasis.

II. Composition and Characteristics of Tinidazole

A. Active Ingredients and Their Role

Tinidazole, the active ingredient in this medication, is a powerful compound that plays a crucial role in its therapeutic effects. It works by entering the cells of microorganisms and causing damage to their DNA strands. This effectively hampers their ability to survive and reproduce.


B. Inactive Components and Their Importance

Apart from the active component, Tinidazole tablets contain various inactive ingredients known as excipients. These substances, such as microcrystalline cellulose, magnesium stearate, and corn starch, are not directly involved in the drug's effect but are vital for formulating the medication. The presence of these ingredients can affect the stability and bioavailability of the tablet as well as impact patients' overall experience in terms of taste, ease of swallowing, and tolerability.

III. Uses of Tinidazole

A. Approved Indications for Tinidazole

Tinidazole has been approved by health authorities for various purposes. These include treating trichomoniasis, giardiasis, amebiasis, and amebic liver abscesses.

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B. Conditions Treated by Tinidazole

Tinidazole is approved for treating various conditions. These conditions usually involve protozoan infections that don’t respond well to initial treatment options or when patients have allergies to other medications. It’s crucial to follow the advice of healthcare professionals and never use this medication without a prescription.

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IV. Off-Label Uses of Tinidazole

A. Overview of Off-Label Uses

Tinidazole has proven helpful in clinical scenarios that are not officially approved. These instances highlight the versatility of the medication and demonstrate the resourcefulness of healthcare professionals in enhancing patient care. Some examples of these off-label uses include treating Helicobacter pylori infections, which are responsible for causing peptic ulcer disease and preventing post-surgical infections, especially in colorectal surgeries.

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B. Scientific Evidence Supporting Off-Label Uses

Scientific research plays a role in supporting these unconventional uses. For example, multiple studies have indicated that Tinidazole is effective when used as part of a four-treatment to eliminate Helicobacter pylori. Moreover, its ability to prevent infections has been further reinforced by research highlighting its superiority over other medications in reducing complications after colorectal surgeries.

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V. How Tinidazole Works

A. Mechanism of Action Explained

Tinidazole falls under the category of nitroimidazole compounds. Exerts its powerful effects through a twofold mechanism. Firstly it is easily absorbed by organisms and protozoans, where it becomes activated within the cell's reduced environment. Once activated, Tinidazole generates a nitroso radical that works by causing damage to the DNA of microbes, hindering the synthesis of nucleic acids, ultimately resulting in cell death.

B. Interaction with Human Body Systems

After taking Tinidazole by mouth, it is quickly and fully absorbed by the body. It spreads throughout tissues, including the brain, and reaches adequate levels in cerebrospinal fluid, saliva, bones, liver, and kidneys. The liver processes it. It is eliminated from the body through urine and feces. It's important to mention that Tinidazole doesn't interact with human cells because it selectively targets and activates microbial cells.

VI. Dosage and Administration of Tinidazole

A. Standard Dosage Guidelines

The recommended Tinidazole dosage depends on the type and severity of the infection being treated. In the case of trichomoniasis, a single dose of 2g is usually prescribed. For giardiasis and amebiasis, the standard dosage is 2g per day for three days. It's essential to take all doses with food. Patients must carefully follow their healthcare provider's instructions to achieve therapeutic results.

B. Dosing Adjustments for Specific Populations

Special populations need to be taken into account. For example, patients with liver problems may need to adjust their dosage because their body clears the medication more slowly. Likewise, older patients might require a change in dosage due to changes in how their bodies process and eliminate drugs as they age. When it comes to children, the dosage usually depends on their weight. Pregnant and breastfeeding women should only use Tinidazole if the potential benefits outweigh the risks since we don't have assurance of its safety in these situations.

VII. Special Considerations in Administering Tinidazole

A. Administration to Elderly Patients

When dealing with individuals, it is essential to consider the potential effects of Tinidazole. As people age, their liver function, kidney function, and other bodily processes may decline. This can affect how the drug is metabolized and eliminated from the body. To prevent any side effects and ensure the treatment is effective healthcare professionals may need to adjust the dosage. The specific dosing regimen will be determined based on the patient's health condition by their healthcare provider.

B. Administration to Pregnant Women and Nursing Mothers

During pregnancy and breastfeeding, caution is essential when using any medication, including Tinidazole. Studies conducted on animals have indicated that Tinidazole may cause harm to the fetus. These effects were observed at much higher doses than recommended for humans. Therefore it is advisable to use Tinidazole during pregnancy if there are no safer alternatives available and if the potential benefits outweigh the potential risks. Nursing mothers should discontinue breastfeeding while undergoing treatment with Tinidazole and for three days after the last dose, as the medication can be passed into breast milk.

C. Administration to Pediatric Patients

Typically doctors prescribe Tinidazole to patients who are three years old or older. The dosage is usually determined based on the child's weight. Its recommended to take the medication with food for better absorption. Healthcare providers should be extra careful in monitoring for any side effects as younger patients may have difficulty expressing their symptoms accurately.

VIII. Common and Rare Side Effects of Tinidazole

A. Common Side Effects: Signs and Symptoms

Like any medication, Tinidazole can have side effects. Some common ones are nausea and vomiting a taste, mouth stomach cramps or discomfort, and diarrhea or constipation. Usually, these side effects go away on their own once the treatment is finished. However, if the symptoms persist or get worse, it's essential to seek medical attention.

B. Less Common Side Effects: What to Look Out For

Common but potentially significant adverse effects of Tinidazole may include; Unusual fatigue or weakness, Seizures or convulsions, Intense stomach or abdominal pain Indications of a severe allergic reaction such as rash, itching, swelling, severe dizziness, and difficulty breathing If you experience any of these symptoms it is crucial to seek immediate medical attention. Remember to inform your healthcare provider about any unusual or severe side effects.

IX. Interactions of Tinidazole with Other Drugs

A. Potential Drug-Drug Interactions

Tinidazole has the potential to interact with medications, which could affect how well it works or increase the chances of experiencing side effects. It's important to note that significant interactions can occur when taking drugs such as warfarin, lithium, or disulfiram alongside tinidazole. For example, using tinidazole at the time as disulfiram may lead to severe neurological disturbances. Additionally, combining it with warfarin can heighten its blood-thinning effects. Raise the risk of bleeding. Always provide your healthcare provider with a list of all the medications you currently use.

B. Effect on Efficacy and Side Effects

Drug interactions can influence the effectiveness of Tinidazole and the occurrence of side effects. Some medications may interfere with how Tinidazole's absorbed, distributed, metabolized, or excreted, which could decrease its therapeutic impact. On the hand, these interactions might also raise the concentration of Tinidazole in the body, increasing the risk of experiencing adverse effects. Therefore it is crucial to understand these interactions to optimize the benefits of treatment while minimizing any potential harm.

X. Warnings and Contraindications for Tinidazole Use

A. Medical Conditions that Preclude Tinidazole Use

There are medical conditions where it is advisable to avoid or be cautious when using Tinidazole. Patients with a known sensitivity to Tinidazole or other similar drugs should refrain from taking this medication. Moreover, it is not recommended for use during the trimester of pregnancy due to potential risks to the unborn baby and while breastfeeding because there might be excretion of the drug in breast milk. Individuals with neurological disorders or a history of blood disorders should exercise caution when using Tinidazole.

B. Situations Requiring Careful Administration

In some cases, it's essential to exercise caution when administering Tinidazole. For example, patients with liver disease may require dosage adjustments due to changes in how the body processes the drug. Additionally, it's advisable to avoid consuming alcohol while using Tinidazole, as this can result in symptoms such as nausea, vomiting, and headaches.

XI. Important Precautions when Using Tinidazole

A. Lifestyle Changes and Precautions

Patients who're prescribed Tinidazole must follow certain lifestyle precautions. As mentioned, it is essential to refrain from consuming alcohol while undergoing treatment and for at least three days afterward. It is also recommended to minimize exposure to sunlight since Tinidazole can increase skin sensitivity to UV radiation, which raises the risk of sunburn.

B. Precautions for Co-administration with Other Drugs

Patients need to exercise caution when taking Tinidazole alongside medications. To ensure safety and effectiveness, patients should inform their healthcare providers about all the medicines they are currently taking, including over-the-counter drugs and dietary supplements. Additionally, it is crucial to follow the prescribed dosage and administration instructions for this medication.

XII. What Happens in Case of Overdosage with Tinidazole

A. Symptoms of Tinidazole Overdosage

Taking an amount of Tinidazole can result in adverse effects, such as feeling nauseous, vomiting experiencing severe discomfort in the upper abdomen, or even having seizures. In some situations, individuals might feel dizzy or have momentary episodes of losing consciousness.

B. Immediate Steps and Treatments

If you suspect an overdose, it's crucial to seek medical assistance. Typically treatment involves providing care to address any symptoms that may appear. While there isn't an antidote for Tinidazole overdose, considering gastric lavage promptly if the overdose is identified can be an option. The critical approach in managing such a situation is to ensure hydration and relieve the symptoms experienced.

XIII. Safe Storage of Tinidazole

A. Ideal Conditions for Storing Tinidazole

It is essential to store the medication to ensure that Tinidazole remains effective and safe. Keep it at room temperature, between 20 to 25 degrees Celsius (68 to 77 degrees Fahrenheit). Avoid exposing it to light and moisture, and refrain from storing it in a bathroom or near a kitchen sink. Keep the medication out of children's reach and sight to prevent ingestion.

B. How Long Tinidazole Remains Usable

The expiration date on the packaging of Tinidazole indicates its shelf life compared to other medications. Tinidazole should not be used after this date as it may become less effective and unsafe.

XIV. Handling Precautions for Tinidazole

A. Safe Handling Practices

It's essential to handle Tinidazole. Ensure your hands are dry when taking the medication, and remember to wash your hands after. When using the form of Tinidazole, always use the measuring device provided to ensure you get the correct dose. If you're taking the tablet, don't crush or break it unless your healthcare provider tells you to.

B. Disposal of Unused or Expired Tinidazole

Disposing of any expired Tinidazole properly is essential to ensure safety and minimize environmental harm. You shouldn't flush the medication down the toilet. Pour it down the drain. The best thing to do is to participate in a take-back program if there's one. If not, you can safely throw away the medication in your household trash by mixing it with something undesirable, like coffee grounds or cat litter. Remember to remove all information from the prescription label before discarding the container.

Rated: 3.0 / 5 based on 3.0 customer reviews.

Posted by Angenent on Dec 20, 2019 Verified Purchase

Expensive, but worth it

Good quality tinidazole . This helps me so much with my Lyme disease! More expensive than metronidazole, but totally worth it. Package arrived about 2 weeks after ordering.  

Note: buy-pharma.md does not imply any medical claims from this review.
Posted by Walsh on Oct 15, 2018 Verified Purchase

Poor quality

I took this same medication and dosage supplied by a USA pharmacy and the side effects were much stronger. I suspect there is something wrong with the quality of this product.

Our response:
Dear Walsh, Thank you for your review, we apologize regarding this matter and for the inconvenience this has caused you. However we have sent you a full refund for this product as per requested on the 12th of October. We assure you The pharmaceutical products we supply are all genuine products. We source our products only from FDA approved manufacturer. We ship all our meds in their original manufacturer packaging.
Note: buy-pharma.md does not imply any medical claims from this review.

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