Hydroxyurea
  • Hydroxyurea
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Hydroxyurea

Hydroxyurea is prescribed for sickle cell anemia and certain types of cancers.
US Brand Name Generic Hydrea
Generic Name Hydroxyurea
Other Brand Name Cytodrox
Packing 10
Manufacturer Cipla
Form Cap
Strength 500 mg
Country India

  • 100 caps 500 mg $79.00
Available online

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Details

Hydroxyurea

Uses

Hydroxyurea is used in the treatment of chronic myeloid leukemia, ovarian cancer and also sickle cell anemia.

How it Works

Hydroxyurea is a S-phase specific medication. Hydroxyurea works by causing inhibition of DNA synthesis during the S-phase of cell division by acting as a ribonucleotide reductase inhibitor resulting to the cell death.

Common Side effects

Some of the potential side effects of Hydroxyurea can include the symptoms below;

Megaloblastic anemia,
Decreased white blood cell count,
Oligospermia (low sperm count),
Azoospermia (absence of sperms)

Introduction

Hydroxyurea is a drug which belongs to the class of antimetabolites. It is available in the form of capsules that are to be taken orally for diseases like sickle cell anemia, and for certain cancers like chronic leukemia (white blood cell cancer), Polycythemia Vera (red blood cell cancer), etc.

Use

It is used in the treatment of sickle cell anemia since it prevents the formation of red blood cells into the sickle cells. It is also an antineoplastic drug, used for the treatment of certain cancers like cancer of the head and neck, malignant melanoma, or cancer of the cervix and the ovary. It is also used in the treatment of chronic myelocytic leukemia, a type of cancer of the white blood cells.

Dosage and administration

It is available in the form of capsules that are to be taken orally. The dose depends on your weight and your response to the medication. Always take the medicine as directed by the doctor or as instructed on the prescription label. Usually, it is to be taken once a day, with or without food. For treating certain types of cancer, it can be taken every third day in the dose of 80 mg/kg body weight as intermittent therapy. As for continuous therapy, it is taken in the dose of 30 mg/kg body weight daily. Take the medicine at the same time of the day and keep to it. Do not take the medicine more than the prescribed dose, even if you miss a normal dose of the drug. Your doctor would advise you on the proper use of this medicine.

Warning

It must be kept out of reach of children. Use latex gloves while handling the medication. Wash your hands immediately after use.
Always tell your doctor if you are allergic to hydroxyurea or to any other substances. Also, inform the doctor if you have any history of chronic disease, bone marrow disorders such as neutropenia and thrombocytopenia, radiation therapy, chemotherapy, or any previous encounters with liver disease or kidney disease.
The drug is harmful for the fetus hence, it is contraindicated for pregnant women or nursing mothers. So, if you are a female and you are taking this drug, then do not plan to become pregnant and if you are a male who is taking this drug, always ensure the use of effective birth control measures.
In case of any serious side effects such as seizures, hallucinations, feeling short of breath, or pain and discomfort in the chest, discontinue the use of the medicine and consult your doctor immediately.

Side effects

Vomiting
Nausea
Constipation
Loss of appetite
Skin rash
Skin pigmentation
Hair loss
Headaches
Dizziness
Fever and chills