Indomethacin is a nonsteroidal anti-inflammatory drug prescribed to alleviate the symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It may also be prescribed to treat acute gouty arthritis, as well as shoulder pain that is due to bursitis or tendinitis.

Generic Indocin


Inocin, Microcid, Indocap, Inmecin, Artilup, Indoflam


Bombay Tablet Mfg, Micro Labs, EMP, Lupin, Recon, Jagsonpal Pharma, Sterkem Pharma, Zydus Cadila


75 mg, 50 mg, 25 mg



I. Introduction to Indomethacin

A. History and Development of Indomethacin

Indomethacin, created in the 1960s, is a non-steroidal anti-inflammatory medication (NSAID). Since its development, it quickly gained recognition within the community because of its remarkable effectiveness in addressing various inflammatory conditions. The introduction of Indomethacin marked an advancement in pharmacology, providing a better option than the existing anti-inflammatory and pain relief drugs.

B. General Overview of Indomethacin's Clinical Use

Throughout the years, Indomethacin has gained recognition as a versatile therapeutic agent. While its primary use is anti-inflammatory, it can also serve as an analgesic and antipyretic. However, it's essential to exercise caution when using Indomethacin due to its side effects. As a result, doctors usually prescribe this medication when other first-line NSAIDs have failed to produce the desired results.

II. Understanding How Indomethacin Works

A. Mechanism of Action

Indomethacin achieves its effects by blocking the action of cyclooxygenase (COX) enzymes, specifically COX 1 and COX 2. These enzymes produce prostaglandins, hormone-like substances responsible for causing pain, fever, and inflammation. Through inhibiting these enzymes, Indomethacin reduces the generation of prostaglandins leading to relief from the symptoms.

B. Impact on Inflammatory Responses

Indomethacin works by inhibiting the production of prostaglandins, which affects the inflammatory response. It reduces blood vessel dilation decreases the permeability of capillaries, and reduces the sensitivity of pain receptors. As a result, it significantly reduces the signs of inflammation, including

  • Pain
  • Redness
  • Heat
  • Swelling

III. Uses of Indomethacin

A. Primary Uses: Gout, Arthritis, and Other Inflammatory Conditions

Indomethacin is commonly prescribed to treat inflammatory disorders. These include:

  • Gouty Arthritis: Indomethacin's powerful anti-inflammatory properties effectively manage flares.
  • Rheumatoid Arthritis and Osteoarthritis: It significantly eases chronic symptoms leading to an improved quality of life for patients.
  • Ankylosing Spondylitis: Indomethacin provides substantial pain relief and reduces stiffness associated with this spinal condition.

B. Lesser-Known Uses: Other FDA Approved Indications

Besides its uses, Indomethacin has been approved by the FDA for other applications. This includes providing relief from pain and swelling caused by Bursitis and Tendinitis. It is also helpful in closing the heart vessel known as Patent Ductus Arteriosus in newborns.

C. Exploring Off-Label Uses of Indomethacin

Apart from its approved purposes, Indomethacin is also utilized in unapproved situations. These include treating conditions like Bartter syndrome, cluster headaches, and pericarditis. However, using it in cases requires a thorough understanding of the risks and benefits of the drug, as Indomethacin's strong pharmacological properties can lead to potential side effects.

IV. Dosage and Administration of Indomethacin

A. Standard Dosage Guidelines

The dosing of Indomethacin typically varies based on factors such as the patient's condition, age, and how they respond to treatment. However, there are dosage guidelines to follow. The initial recommended dose for adults is between 25 and 50 mg, taken two to three times a day. It's important not to exceed a daily dose of 200 mg.

B. Dosage Modifications for Specific Conditions

Certain medical conditions may require adjustments to the dosage. In the case of gouty arthritis, it is often suggested to start with an initial dose of 50 mg taken three times a day. To ensure a level of medication in the body for conditions like ankylosing spondylitis or rheumatoid arthritis, doctors may prescribe a sustained-release form of Indomethacin.

C. Dosage Adjustments for Specific Populations

Properly adjusting the dosage is essential when it comes to groups of people. For patients, it's important to prescribe the lowest effective dose because they are more likely to experience adverse effects. Regarding children, the dose is typically based on their body weight. It's necessary not to surpass the recommended dosage for adults.

V. Indomethacin Composition

Active Ingredient Analysis: Indomethacin

Indomethacin, derived from acetic acid, is a vital ingredient in the medication. Its distinctive composition enables it to effectively suppress prostaglandins' production, providing relief from inflammation and pain.

B. Overview of Excipients and Their Roles

Indomethacin capsules include not the active ingredient but also additional substances called excipients. These excipients include adding volume to the capsule with fillers, like lactose and cornstarch. Additionally, magnesium stearate is used as a lubricant to prevent clumping of the ingredients. Gelatin and titanium dioxide are employed in the creation of the capsule shell.

VI. Storage Guidelines for Indomethacin

A. Ideal Storage Conditions

Store indomethacin at room temperature, between 20°C to 25°C. Ensure you keep the medication away from light, moisture, and heat. Also, store it in its container and tightly close the lid.

B. Shelf Life and Expiration

The typical shelf life of Indomethacin is three years from the manufacturing date as long as it is stored according to the recommended conditions. Expired medication might lose its effectiveness. In rare cases could be potentially harmful. Hence, it is essential to correctly dispose of any medication that has exceeded its expiration date.

VII. Interaction of Indomethacin with Other Substances

A. Common Drug-Drug Interactions

How Indomethacin interacts with medications can significantly impact how well it works or increase the chances of experiencing unwanted side effects. Some crucial interactions to be aware of

  • Antihypertensives and Diuretics: Indomethacin may reduce their effectiveness, affecting blood pressure control.
  • Anticoagulants: Using Indomethacin at the time as an anticoagulant may increase the risk of bleeding.
  • Lithium and Methotrexate: Indomethacin can potentially raise the levels of these drugs in the bloodstream, making them more toxic.

    It's essential to be mindful of these interactions to ensure the effective use of Indomethacin.

B. Interactions with Food, Alcohol, and Herbal Supplements

The absorption of Indomethacin may be influenced by food and beverages.

  • Alcohol, for instance, can worsen the side effects of Indomethacin and increase the likelihood of ulcers or bleeding.
  • Consuming high-fat meals, on the hand, can slow down the absorption of Indomethacin, resulting in reduced effectiveness.
  • It's also important to be cautious when taking supplements, like Ginkgo Biloba alongside Indomethacin, as they could heighten the risk of bleeding.

VIII. Warnings and Contraindications for Indomethacin Use

A. Pre-existing Conditions and Indomethacin

Individuals with existing medical conditions need to be mindful when using Indomethacin. These conditions encompass:

  • Gastrointestinal Disorders: Indomethacin may worsen symptoms. Lead to ulcers, bleeding, or perforation.
  • Cardiovascular Diseases: Prolonged usage of Indomethacin could heighten the likelihood of events.
  • Renal or Hepatic Impairment: Such conditions may impact the way Indomethacin is processed and eliminated by the body, necessitating adjustments to the dosage.

B. Absolute Contraindications for Use

Indomethacin should not be used in the following situations: If you have a known sensitivity or allergy to Indomethacin or any ingredient in the medication. Suppose you have a history of asthma, hives, or allergic reactions after taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Treating pain after artery bypass graft (CABG) surgery is not recommended.

IX. Administering Indomethacin with Care

A. Necessary Precautions for Safe Use

When prescribing or using Indomethacin, it is essential to take precautions:

  • Regularly monitor your blood pressure if you are using it for a time.
  • Periodically assess the functions of your liver and kidneys.
  • Always be watchful for any signs of bleeding, particularly in older individuals.

B. Addressing Potential Risks and Side Effects

The chances of experiencing effects become more likely when using higher doses and for more extended periods. Some observed side effects include digestive system issues, such as gastrointestinal disorders, while others are related to the central nervous system, like dizziness and headaches. Additionally, dermatologic reactions may also occur. If any side effects persist or worsen, it is advisable to seek medical attention.

X. Specific Guidelines for Indomethacin Administration

A. Administration to Elderly Patients

To minimize the chances of experiencing effects, older patients should start treatment with the smallest adequate amount. Additionally, observing these individuals for any signs of gastrointestinal bleeding or kidney problems is essential.

B. Administration to Pregnant Women and Nursing Mothers

It is advisable to avoid using Indomethacin during the stages of pregnancy because it could potentially lead to the premature closing of the ductus arteriosus in the fetus. If you are a nursing mother, it's essential to exercise caution, as Indomethacin can be passed through breast milk.

C. Administration to Children

The use of Indomethacin in patients has not been proven safe and effective except for the treatment of patent ductus arteriosus in neonates. Therefore children need to receive supervision when using this medication.

XI. Understanding Overdosage of Indomethacin

A. Symptoms of Overdosage

Overdosing on Indomethacin can have consequences for one's health. Some common symptoms to watch out for include

  • Feeling nauseated and experiencing vomiting due to irritation in the stomach.
  • Intense headaches, dizziness, or confusion could indicate toxicity in the central nervous system.
  • Rare some serious effects might include seizures or even a coma.

If someone takes much Indomethacin, it is crucial to seek immediate medical help. The treatment methods mainly revolve around the steps:

  1. Performing gastric lavage right away reduces the absorption of the drug.
  2. Giving activated charcoal to bind the Indomethacin in the system.
  3. Providing symptomatic and supportive care to address specific symptoms.

XII. Handling Precautions for Indomethacin

A. Safe Handling and Disposal Procedures

To ensure the handling and proper disposal of Indomethacin, it is advisable to take the following steps:

  1. Use dry hands when handling the medication.
  2. Do not dispose of the medication in household waste. Pour it down the drain.
  3. Always adhere to regulations or seek guidance from a pharmacist regarding appropriate disposal methods.

B. Guidelines for Accidental Exposure

If there is an exposure, like a child consuming the medicine or if it spills onto the skin, it is essential to seek medical help right away. Make sure to rinse the skin thoroughly with water.

XIII. Side Effects of Indomethacin

A. Commonly Reported Side Effects

Although Indomethacin is usually well tolerated, there are some experienced side effects, including

  • Gastrointestinal issues, like feeling sick, throwing up, or experiencing stomach discomfort.
  • Headaches and dizziness.
  • Rash or itching sensation.

B. Less Common but Serious Side Effects

Although they are not as common, there can be some side effects that would require medical attention. These may include

  • Signs of bleeding, such as stools that are black or contain blood.
  • Symptoms related to liver diseases like the yellowing of the eyes or skin.
  • Unexplained weight gain or swelling in the hands and feet.

C. Managing Side Effects of Indomethacin

If you experience any side effects, the management strategies may include: Adjusting the dosage or temporarily stopping the medication. Providing care, like ensuring you stay hydrated if you feel nauseous or vomit. Considering switching to medication if the side effects continue or become worse.

XIV. Important Precautions When Using Indomethacin

A. Regular Monitoring and Follow-up

It is essential for individuals taking Indomethacin to schedule checkups to assess how they are responding to the treatment and to check for any possible side effects.

B. Awareness of Potential Allergic Reactions

It is essential to inform patients about the indications of a response to Indomethacin. These indications might consist of

  • Hives
  • Trouble with breathing
  • Swelling of the face, lips, tongue, or throat.

    If any of these symptoms appear, it is crucial to seek medical assistance.

C. Precautions for Long-Term Use

For individuals taking Indomethacin for some time, it is essential to monitor liver and kidney function through tests regularly. Additionally, it is crucial to inform patients about the signs of gastrointestinal bleeding. It would be wise to explore treatment options or additional therapies to minimize the need for high doses and prolonged use of Indomethacin.

Rated: 4.8 / 5 based on 4.8 customer reviews.

Posted by Bernal on Oct 29, 2021 Verified Purchase


Pain relief for Gout. Will be purchasing again

Note: does not imply any medical claims from this review.
Posted by th on Apr 12, 2020 Verified Purchase

excellent quality

perfect for halting severe headaches.  works better than any other NSAID or COX inhibitor I have tried.  effective against SARS-CoV-2 in vitro and against other coronaviruses in animal models.

Note: does not imply any medical claims from this review.
Posted by miller on Jul 9, 2019 Verified Purchase

great fit

good product will get more

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Posted by Terry on May 2, 2018 Verified Purchase


5 stars! Outstanding quality and price!

Note: does not imply any medical claims from this review.
Posted by Jones on Feb 18, 2018 Verified Purchase

As Expected Medications - Items Took 10 days to Arrive

Generic meds shipped to the US from India. First package arrived after 10 calendar days and still waiting for second package. Seems very reasonable and legit.

Note: does not imply any medical claims from this review.
Posted by Kidd on Jan 12, 2018 Verified Purchase


Great product! Fast delivery!

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Posted by Sandor on Aug 17, 2017 Verified Purchase


I have a painful middle finger joint that swells and becomes extremely tender from time to time. Two of these caps resolve the issue unlike other NSAIDS which require multiple doses. I experience no side affects from this tried and true medicine unlike newer prescription meds.

Note: does not imply any medical claims from this review.
Posted by Darren on May 5, 2017 Verified Purchase

Quick and efficient

Quick and efficient delivery. Pleaser to buy and easier than the normal way.

Note: does not imply any medical claims from this review.

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