Sigmaxin, Digoxin

Sigmaxin is a cardiac glycoside, Sigmaxin works to slow down the heart rate while increasing the force of heart beats to allow it to pump sufficient blood to the whole body.





Aspen pharmacare Australia Pty Ltd


250 mcg




Sigmaxin is used for the treatment of certain heart problems such as arrhythmias which is also called atrial fibrillation and atrial flutter and heart failure.

How it Works

Sigmaxin works to strengthen the force of heartbeata, making Sigmaxin useful in heart failure. Heart failure is a condition in which your heart does not pump blood as strongly as it should. Sigmaxin also works by slowing down or normalizing the rate at which the heart beats. When heart rate is brought down to normal, heart becomes efficient again and the symptoms improve.

Common Side effects

Some of the potential side effects of Sigmaxin can include the symptoms below;

Skin rash,
Slow heart rate,
Visual disturbance,


Sigmaxin is prescribed to treat certain heart issues like congestive heart failure and irregular heartbeats (paroxysmal atrial tachycardia). Additionally, it helps lower the risk of having a heart attack.

This medicine is a cardiac glycoside that works by increasing the force of heart muscle contractions and decreasing oxygen consumption. Additionally, it acts as an effective vasodilator, decreasing the time it takes for your blood to reach your heart.

Additionally, it slows conduction in the atrioventricular bundle, creating a slower ventricular beat. In certain instances, this drug can help convert atrial fibrillation back to regular sinus rhythm.

This medication may cause an imbalance of natural minerals in your blood (calcium, magnesium and potassium). Your doctor can advise you if you should take dietary supplements or follow a special diet for proper care.

How it Works

Sigmaxin (Digoxin) is a medication that works by decreasing oxygen consumption of heart muscle. It's often prescribed to treat those suffering from heart failure or atrial fibrillation and combined with other medications for these conditions such as calcium channel blockers or beta blockers. Digoxin helps the heart pump more efficiently by increasing contraction force of its muscles and shortening time it takes for blood to fill up in the vessel.

Your doctor will determine the appropriate dose based on your condition, age and other factors. It is essential that you take this medicine exactly as prescribed to get the most benefit from it; additionally, avoid products which could reduce its effect such as antacids, kaolin-pectin, magnesia milk, metoclopramide sulfasalazine and aminosalicylic acid.

Dosage and administration

Sigmaxin (Digoxin) dosage is usually determined by your doctor based on individual needs. This medicine can be used for various reasons, such as flushing out waste products and toxins from the bloodstream or liver/kidneys. Taken regularly, this drug may help protect against certain health issues like heart disease and cancer, while keeping the brain healthy. It should be noted that taking this drug may be hazardous to those with impaired renal function if taken at higher doses for extended periods. Therefore, drink plenty of water while taking this medicine and consult your pharmacist before buying online.

Careful administration

Sigmaxin should be taken orally at the recommended dosage and frequency, as a treatment for hypertension and coronary artery disease. Additionally, it has been known to lower high cholesterol and triglycerides levels.

The appropriate dose for you depends on your age, gender, weight and medical history. As this medication can be taxing on the kidneys, it's essential to keep them functioning optimally. Taking it too often or at an inappropriate time may result in side effects like drowsiness or dizziness.

Take this medication as prescribed by your doctor, taking it at the correct time and dose. Be mindful that overdosing on this drug could have serious and even fatal side effects.


While several sigma receptor ligands have been developed for therapeutic use in CNS diseases, our understanding of their pharmacology remains incomplete.

Recent research in rodents demonstrated that S1R agonists (Cutamesine and SA4503) can reduce NIHS scale and sensorimotor function following stroke, as well as diminish membrane rafts in the peri-infarct area [85]. These findings suggest S1R activation during stroke may have neuroprotective effects.

SIGMAR1 is found throughout human tissues and cells throughout the central nervous system, with highest expression found in liver tissues and lower concentrations in brain tissue. Motor neurons associate SIGMAR1 with nuclear envelope proteins to form detergent-resistant complexes inside their nuclei. Mutations to SIGMAR1 have been linked to multiple motor neuron disorders such as ALS and spinocerebellar ataxia types 1-3.

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