Systane Eye Drop

Systane Ophthalmic Solution (Polyethylene Glycol and Propylene Glycol) is used to help alleviate burning or irritation due to dryness of the eye.

Systane Eye Drop, Systane Ultra Lubricant Eye Drops

Polyethylene Glycol/ Propylene Glycol

Systane Eye Drop, Systane Ultra Lubricant Eye Drops

10mL, 15mL

Alcon Laboratories

Eye Drop

Polyethylene Glycol 0.4% / Propylene Glycol 0.3%

India, Australia

Systane Eye Drop


History and development of Systane Eye Drops

Throughout the history of solutions, the development of Systane Eye Drops serves as a remarkable example of advancements in medical research. It all began with scientific investigations aimed at improving eye discomfort. Over time, Systane Eye Drops have undergone improvements, resulting in the effective formula we know today. This progress was driven by a relentless pursuit of excellence and a solid commitment to enhancing the lives of individuals suffering from eye conditions.

The primary purpose of the formulation

Systane Eye Drops offer advantages for various eye-related issues. The primary purpose of its development is to alleviate the symptoms caused by the eyes, a common problem affecting many people worldwide. Additionally, it aims to maintain and nourish the balance of the eye surface, resulting in improved vision and overall comfort.



Treating symptoms of dry eyes

Dryness of the eyes, which can occur due to reduced production or increased tear evaporation, often leads to various symptoms1 such as:

  • Stinging or burning sensations
  • Intermittent blurriness
  • Ocular fatigue
  • Sensitivity to light

Systane Eye Drops are highly recommended to alleviate these discomforts as they provide relief and long-lasting comfort.

Maintaining eye moisture

The health and proper functioning of the surface rely on maintaining an ideal moisture balance. Systane Eye Drops which contain elements that help create a moist environment by:

  • Increasing the water content of the tear film
  • Reducing stress on corneal cells caused by osmosis
  • Ensuring that the tear film spreads evenly across the ocular surface

Post-surgical eye care

It's essential to follow a post-operative care routine after undergoing eye surgery, whether for improving vision or treating cataracts. Systane Eye Drops can help with this by promoting healing, reducing complications from the surgery, and helping you recover your vision quickly.


How it Works

The science behind the active ingredients

The effectiveness of Systane primarily relies on its selected active ingredients. These ingredients, consisting of a combination of polyethylene glycol and propylene glycol, have an affinity for water. This helps them supplement the natural tears in the eyes and maintain a stable tear film. Some variations of Systane also include lipid components that mimic the meibum, further aiding in tear film stabilization and reducing evaporation.

Mechanism of action in the eye

Systane's way of working in the eye is imposing. When you apply it, its active ingredients quickly blend with the natural tear film. This blending enhances the film's three-layer structure, consisting of mucin, aqueous and lipid layers. The result is a tear film more resistant to disruption and evaporation. At the time, this solution reduces hyperosmolarity, which can cause damage to cells in dry eyes. This helps protect the conjunctival cells—systane protects against various environmental and physiological stresses.


Dosage and Administration

Pharmacology encompasses more than developing effective medications; it also involves ensuring proper use among different age groups. When it comes to a solution, determining the correct dosage is crucial. Here are the general guidelines:

  • For adults and seniors: Apply 1-2 drops to each affected eye up to 4 times daily.
  • For children and adolescents aged 12 and above: Apply one drop to each affected eye 2-3 times daily.
  • Please note that for children under 12, it is essential to consult with a professional to determine the appropriate dosage and suitability.

Proper method of administering the eye drops

Applying eye drops correctly2 is essential for results and minimizing potential issues. Here are the recommended steps:

  1. Start by washing your hands to remove any potential contaminants.
  2. Tilt your head back and pull down the lower eyelid to create a small pocket.
  3. Hold the dropper above your eye and carefully squeeze out the number of drops.
  4. After applying the drops, gently close your eyes and press near the corner (close to your nose) for about a minute. This helps prevent the solution from draining out.
  5. If you need to use eye medications, wait at least 5 minutes between each application. Following these steps should help ensure the administration of eye drops while minimizing any complications that may arise.



Active and inactive ingredients

Understanding the synergy of a formulation requires recognizing the difference between active and inactive ingredients. The active components are responsible for the effect, while the inactive ingredients enhance stability, absorption, and palatability. 

  • Active ingredients: glycol, Propylene glycol.
  • Inactive ingredients: acid, Calcium chloride, Hydroxypropyl guar, Magnesium chloride, Potassium chloride, Sodium chloride, Zinc chloride.

Role of each component in the formulation

Each active or inactive ingredient plays a role in the overall formulation.

  • Polyethylene glycol and Propylene glycol act as lubricants to relieve eye symptoms by moisturizing the eyes.
  • Boric acid helps stabilize the solution's pH level, ensuring compatibility with the environment of the eyes.
  • Calcium, Magnesium, Potassium, Sodium, and Zinc chlorides are agents that maintain the proper osmolarity of tears to prevent damage to cells.
  • Hydroxypropyl guar is an agent that enhances viscosity and improves how long the solution stays on the eyes' surface.


Side Effects

Potential short-term effects

Similar to any treatment, occasional short-term effects may occur, although they are rare. Some patients might feel burning or stinging when the medication is applied. It's also possible to experience periods of blurred vision or mild redness and irritation in the eyes. If any of these symptoms persist or worsen, it is essential to consult an ophthalmologist for guidance.

Possible long-term effects

Although it is uncommon for problems to arise from using this formulation, using it for an extended period without medical supervision may result in the following:

  • Changes to the surface of the eye, such as punctate keratitis.
  • There is a higher likelihood of developing eye infections due to bacteria entering the bottle.
  • Hypersensitivity reactions that manifest as redness, itching, or swelling. While rare, there may be long-term consequences.

This emphasizes the importance of checkups with an eye specialist and following prescribed treatment plans.

Common Side Effects

Frequency of occurrence

Although Systane is widely recognized for its effectiveness in lubricating the eye's surface, it's important to note that, like any medication, it may have some side effects. These effects can differ among individuals, with some experiencing them while others may share them more regularly. It's worth mentioning that many of these side effects are harmless and temporary. These include blurring of vision right after application, mild discomfort or stinging sensation in the eye, and slight redness or inflammation of the eye.

Managing common side effects

Although these side effects come and go, there are ways to reduce their impact or prevent them from happening in the first place. Ensure the dropper is kept clean to avoid introducing any irritants from the outside. You can apply the medication at times when having vision right away is not crucial, like before going to bed. If the side effects continue or worsen, seeking advice from an eye specialist without delay is essential.


Off-Label Use

Instances where Systane might be used outside its intended purpose

Although Systane is primarily designed for lubricating the eyes, its unique characteristics make it a possible option. However, it is essential to note that these alternative uses may not always have clinical evidence supporting them. Some of these uses include helping to remove foreign objects from the eye, alleviating symptoms of eye allergies, and serving as a supplement in dry environments or during long flights.

Precautions and guidelines

Considering and following safety guidelines is essential when deviating from the intended use. Always consult an eye specialist before using products or treatments for purposes other than what they are specifically designed for. Use them sparingly. Be cautious of any unexpected adverse reactions. Regular eye checkups are essential to maintain your health and safety.



Drugs and substances that may interfere with Systane

Ocular pharmacology can be complex. When multiple agents are used together, there can be unexpected interactions. Systane, for example, can potentially interact with antihistamines in a way that may worsen dry eye symptoms. Additionally, prescribed medicated eye drops might have their absorption affected when used alongside Systane. It's worth noting that some systemic medications, anticholinergics, can also contribute to dryness.

Advice on simultaneous use of other ophthalmic products

To protect the health of your eyes, it's essential to be cautious when using eye products simultaneously. Make sure to apply effects with a gap of at least 15 minutes between them. It's recommended to use drops before using lubricants, like Systane, to help them absorb better. Also, remember to maintain hygiene practices to prevent any potential contamination or infection.


Situations and conditions under which the use of Systane should be closely monitored

Although Systane is generally considered safe for use in the eyes, there are situations where it is essential to be cautious. Different individuals may have physiological responses, so we need to exercise prudence. If you have a history of eye surgeries, it is advisable to consult an ophthalmologist before using any over-the-counter eye solutions. For those diagnosed with eye conditions like glaucoma or macular degeneration, it is recommended to approach Systane with care. If you experience irritation after applying the product, it may indicate an unusual reaction. Sometimes, it's best to stop using Systane and seek guidance from a medical professional.



Conditions or factors that make the use of Systane inadvisable

Contraindications refer to situations where a treatment could potentially cause harm. When using Systane, understanding the conditions that make its use inappropriate is essential. Individuals with hypersensitivity to any Systane component should avoid using it. If someone already uses prescribed eye drops, they should consult a specialist before using Systane. Furthermore, if an ocular infection is present, postponing Systaneany's worsening condition is advisable.


Careful Administration

Cases that require special attention when using the drops

Eye drops, even though they may seem harmless, need to be applied in specific situations. If you wear contact lenses, it's essential to ensure that Systane is compatible with the material of your lenses. Individuals who have recently had eye surgery or are in the procedural stage should only use Systane under the guidance of a healthcare professional.

Monitoring and follow-ups

Regular checkups and oversight are essential to ensure you get the most out of your treatment and avoid any adverse effects. By seeing an eye doctor, you can ensure Systane provides the soothing relief you need. If you experience any symptoms or discomfort, you must consult an eye care professional immediately.

Important Precautions

Preventing contamination of the dropper

Although challenging, the eye's surface can be affected by infections and irritations caused by substances. Therefore, it is necessary to maintain the cleanliness of vision-relatedlated products. Do not let the dropper tip contact your eye eyelashes or surfaces. Avoid sharing the product with anyone, including family members, to prevent spreading contamination. Ensure to replace the bottle cap after each use as a protective measure against potential contaminants.

Signs that the product may no longer be safe to use

Like any other medical equipment, it's essential to stay alert and notice any signs that might indicate a product quality problem. Keep an eye out for changes in color, cloudiness, or any noticeable differences in how the solution looks. Also, watch for particles or sediment floating in the solution. If you notice any changes in consistency, like the product becoming too thick or too watery, that could be another indication of an issue.


Administration to Elderly

Age-specific considerations

Elderly individuals often have physical changes requiring careful consideration when considering any treatment. The natural decrease in production with age may require more frequent application. Other eye conditions like cataracts or glaucoma can also impact the product's effectiveness. Assessing potential interactions with other medications commonly prescribed for older adults is vital.

Dosage adjustments if necessary

While Systane is mainly used as a lubricant and is generally safe, adjusting its administration for adults may be essential. Since dry eyes are more common in older people, using them frequently could be helpful. However, it's important to avoid use to prevent any imbalances in the eyes, moisture, or overhydration of the ocular surface. If any changes are needed in the dosage, it should be done under the guidance of an ophthalmologist.


Administration to Pregnant Women and Nursing Mothers

Safety profile during pregnancy

During pregnancy, some changes occur in the body, so it becomes even more important to consider the safety of any treatment used during this time. Although there haven't been any reports of Systane causing harm to a developing baby, it's still important to use it only when necessary. The chances of any effects on the baby from Systane being absorbed into the bloodstream through the eyes are meager. However, it's always an idea to consult with a healthcare professional before starting or continuing to use Systane during pregnancy.

Implications for breastfeeding and lactation

The period after giving birth, which involves changes in the body and hormones, requires careful consideration when taking any medications, especially if you are breastfeeding. The amount of medicine absorbed into the bloodstream after applying it to the eyes is minimal, so the chances of it passing into breast milk are highly unlikely. However, since there isn't evidence available, using the product cautiously during breastfeeding is wise. It's always an idea to consult with a healthcare professional before using anything to ensure the safety of both mother and baby.

Administration to Children

Age limits and considerations

When providing treatment for kids, it's essential to be careful and consider their unique physical characteristics. This includes using solutions like Systane. While Systane can be used for children, it's crucial to follow the dosage based on age. Before using Systane on newborns and infants, consulting an ophthalmologist is necessary. Children tend to have a blink reflex, so holding their eyelids while applying the solution might be helpful.

Pediatric-specific side effects

Children may experience various side effects that differ from those experienced by adults. It is essential to monitor them after applying the treatment. They may experience discomfort in their eyes or feel something foreign is present. They might have hypersensitivity reactions such as excessive tearing or redness. If any side effect persists or worsens, it is crucial to stop using the treatment and consult with a professional.


Over Dosage

Identifying signs of overdose

Using many effective and harmless treatments can lead to unexpected outcomes. Identifying when an overdose occurs is crucial so prompt action can be taken. Although systemic overdose is rare, ocular side effects, like blurred vision, excessive tearing, or discomfort, may indicate excessive use. Taking a dose can dilute the natural proteins and enzymes on the eye's surface, affecting their proper functioning. Continuously or repeatedly overdosing may worsen existing conditions.

Immediate actions and remedies

It is crucial to take careful action to minimize the consequences of an overdose. The first step is to stop administering any more of the substance away. Use water to rinse the eyes and remove any excess product gently. If any unusual symptoms continue or worsen, seek medical help.



Optimal storage conditions

To ensure that Systane remains effective and lasts for a time, storing it properly away from any harmful external factors is essential. Keep it at room temperature. Avoid exposing it to extremely cold or hot temperatures. Also, protect the bottle from sunlight because ultraviolet radiation can change the properties of the solution. Lastly, avoid storing it in places with humidity, as it could affect the bottle's seal.

Shelf life and expiration

No matter how well-crafted a product is, it won't stay effective forever. It's crucial to follow expiration dates to ensure therapeutic results. Always check the expiration date before using any solution, as one that has passed its prime might not be ineffective but could pose a potential risk. After opening, it's ideal to use the product within a month to maintain its purity and effectiveness. When disposing of long-opened bottles, it's essential to do so responsibly while considering environmental impact.


Handling Precautions

Safety guidelines for users

Even over-the-counter eye drops like Systane require handling to avoid any possible complications. Ensure you wash your hands before applying the eye drops to prevent contaminants from getting into your eyes. If you wear contact lenses, remember to take them out before using the eye drops and wait a period before putting them back in. It's important to note that you may experience blurred vision after using the eye drops, so be cautious when engaging in activities that require a clear picture right away.

Ensuring product integrity

Systane's effectiveness depends on its components' purity;d maintaining this requires careful attention and following specific protocols. It is important not to tamper with the seal on the bottle before using it for the time. To avoid contamination, ensure the dropper does not touch your eye or any surface directly. If you notice any changes in the solution's texture, clarity, or color, it should raise concerns about its compromised quality and integrity.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Looney on Jan 17, 2018 Verified Purchase

Eye drops

Very effective for dry eye relief

Note: does not imply any medical claims from this review.

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