Xyzal (Levocetirizine) is an antihistamine that helps alleviate allergy symptoms such as, tearing of the eyes, sneezing, itching, rash, etc.





UCB Pharma, Dr Reddy's Laboratories


5 mg




Xyzal, also referred to as levocetirizine, is an example in the field of modern pharmacology. It goes beyond being another component in the vast realm of modern medicine, as Xyzal proves its significance by effectively addressing a range of medical conditions.

With a historical background within the family of antihistamines, it serves as a highly effective remedy for allergic symptoms. Furthermore, it is widely recognized for its success in treating urticaria and rhinitis.

How it Works

When we delve further into the biochemistry of Xyzal we can understand its effectiveness by looking at how it works in the human body. This process is quite intricate. Can be broken down into three important parts that play a significant role.

Mechanism of Action in the Body

Xyzal primarily acts as a blocker for the H1 receptor in humans. In terms, it attaches to these receptors and prevents histamine, a molecule known for its involvement in allergic reactions, from interacting. As a result, it hinders the chain of events that lead to symptoms like inflammation and itching.

Target Receptors and Pathways

The main focus of Xyzal's action revolves around the H1 receptors. These receptors are widely found in the cells lining blood vessels and in the nervous system.

When interacting with the cells lining blood vessels, it prevents vasodilation. Reduces capillary permeability, which is typically associated with inflammation and swelling.

Its effects on the nervous system are nuanced, as it has a milder sedative effect compared to older antihistamines.

Onset and Duration of Action

The rapid onset of action of Levocetirizine is quite remarkable, often starting within an hour after taking it. This is particularly noteworthy when compared to medications in its class.

Once the drug takes effect, its benefits last for an amount of time, typically lasting for about 24 hours after taking it orally.

This extended effectiveness highlights the convenience of taking it once a day and showcases its powerful and long-lasting therapeutic properties.


When exploring the field of pharmacological treatments, it is crucial to clearly define the various purposes for which a drug can be used, whether they are officially approved or off-label.

This information is essential as it grants healthcare professionals, scientists, and individuals a comprehension of the drug's adaptability and possible uses.(1)

1. NCBI - Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies

Approved Medical Uses

The list of approved uses for a drug demonstrates how thoroughly it has been evaluated in clinical trials to ensure its effectiveness and safety. Some drugs have a range of applications,(1)

Chronic Idiopathic Urticaria is a condition where the cause is unknown. This drug provides relief to those struggling with this ailment, alleviating symptoms and improving their quality of life.(2)

Allergic Rhinitis(3) affects a portion of the population due to the presence of allergens everywhere. This drug acts as a defense against the symptoms, ensuring nasal passages and relief.(4)



3. National Library of Medicine - Allergic Rhinitis

4. Drugs - Xyzal

Idiopathic Urticaria

Idiopathic Urticaria

Symptoms and Conditions it Treats

The drug's effectiveness lies in its capability to address symptoms and underlying conditions. It not only targets the obvious manifestations but also addresses the root causes.

  • It relieves itching, which can be bothersome for people.
  • It eliminates redness and skin flare-ups, restoring the appearance of the skin.
  • It eases congestion, ensuring clear and unobstructed breathing passages.

Nasal Congestion

Duration and Efficacy of Treatment

Once the drug is taken, it quickly exhibits its abilities, typically showing its effects within the first hour. This acting nature is accompanied by a long-lasting impact that can endure for up to 24 hours.

This extended effectiveness eliminates the need for administration, making it crucial to managing chronic conditions that demand continuous relief.

Off-label Use

Often, the use of medications goes beyond what regulatory authorities have defined, uncovering possibilities for treatment. This departure from the usual called, off-label use highlights the flexibility and untapped capabilities of substances.

Definition and Importance of Off-label Use

Off-label use, at its core, refers to using agents in ways that are not officially approved by regulatory bodies. This involves adjusting the dosage considering the age groups of patients or treating conditions that are not typically associated with the drug.

The basis, for this approach lies in expertise real-world observations, and practical evidence. These unconventional applications become significant when traditional treatment methods fail to provide relief or when new research reveals unknown effectiveness.

Common Off-label Applications for Xyzal

Xyzal, also known as levocetirizine, is widely recognized in the field of antihistamines for its effectiveness in treating allergic conditions. However, it also has medical applications that extend beyond its primary use.

For instance, it has shown results in alleviating symptoms of atopic dermatitis, a recurring and irritating skin condition characterized by inflammation.

Furthermore, Xyzal has been observed to provide relief from asthma-related allergies, helping to reduce difficulties caused by allergens.

Research and Findings Supporting Off-label Uses

Although using medications for off-label purposes may appear daring, it is often based on scientific investigation. In the case of Xyzal, various research endeavors have played a role in uncovering its effectiveness beyond its intended use.

A study published in the Journal of Clinical Immunology provided insights into how Xyzal can alleviate symptoms in patients with atopic dermatitis, highlighting its inflammatory capabilities.

Additionally, a significant research study featured in the European Respiratory Journal praised Xyzal for its ability to alleviate allergy symptoms in individuals with asthma, offering a therapeutic option for many patients.

Side Effects

The field of pharmacology, although filled with treatment possibilities, does come with its share of challenges. It's important to have an understanding of the side effects that can occur as a result of medication use in order to provide comprehensive care to patients.

Definition and Categorization of Side Effects

Side effects, which are often referred to as drug reactions (ADRs) are the unintended and undesired effects of a medication that occur when it is used for prevention, diagnosis, or treatment purposes. These effects can be categorized as follows;

1. Common; Frequently encountered and generally mild in nature.

2. Severe; harmful and potentially life-threatening.

3. Rare: Occurring in a percentage of the population but requiring careful monitoring.

4. Idiosyncratic; Unrelated to the drug dosage or mechanism.

Factors Influencing the Occurrence of Side Effects

The appearance of side effects is an interaction of various factors;

1. Our individual genetic makeup, also known as pharmacogenomics, plays a role in determining how we respond to drugs.

2. The presence of medications can either enhance or reduce the effectiveness of the drug being taken.

3. Existing health conditions can increase our vulnerability to experiencing side effects.

4. Variations in liver and kidney function can impact how drugs are processed and eliminated from our bodies.

Common Side Effects

While there are side effects associated with the range of pharmacological treatments, some specific manifestations are more common and should be closely monitored by healthcare professionals.

List of Frequently Reported Side Effects

Occasional headaches that come and go on their own. Feeling sleepy or drowsy at times affects how alert you are. Experiencing issues, like feeling nauseous or having indigestion. Having a mouth, which may make you drink more fluids.

Management and Mitigation Measures

To reduce the side effects it is important to balance education and clinical interventions. If you experience drowsiness it may be helpful to take the medication at night.

Staying properly hydrated can help with mouth and headaches. Addressing any issues can be done through antacids or making changes, to your diet.

When to Seek Medical Attention

While most side effects are temporary and harmless, it is important to seek medical advice if you experience any severe lasting, or unusual symptoms. Symptoms, like a rash, difficulty breathing, or palpitations, should be seen as warning signs.

Dosage and Administration

The journey of therapy is based on the administration of the right amount aiming for the best results while minimizing any potential negative effects.

Adults usually find it helpful to take a 5mg dose a day. When it comes to dosing for children it often depends on their weight and age which requires adjusting the dosage, for each individual.

Frequency and Timing of Doses

For the results, taking the medication once a day, preferably in the evening, to reduce any drowsiness that may occur during daytime activities is recommended.

Dosage Modifications Based on Specific Conditions

Patients who have impaired kidney or liver function may require changes to their dosage. Regular tests to assess function can help determine the appropriate dosage for such individuals.

Additionally, older patients or those taking medications may find it beneficial to begin with a lower dose and exercise caution.


The core of any product lies in its formulation, which is a careful combination of active and inactive ingredients that provide both effectiveness and stability.

Active Ingredients and Their Proportions

Xyzal's therapeutic effectiveness lies in its components, particularly Levocetirizine dihydrochloride. Each tablet generally contains 5mg of this molecule, which gives the drug its properties.

Inactive Ingredients and Their Roles

Although they may not play a role in the therapeutic journey, the inactive components are crucial for maintaining the physical and chemical stability of the medication and its ability to be absorbed by the body. Here are some examples of these ingredients and their functions;

  • Lactose monohydrate: It's commonly used as a filler and binder in tablet formulations.
  • Magnesium stearate: This ingredient acts as a lubricant ensuring smooth tablet production.
  • Microcrystalline cellulose; It provides structure and strength to the tablet.

These inactive ingredients are essential for creating stable, easy-to-manufacture tablets and have the necessary structural integrity.

Available Formulations

Xyzal offers a range of options to meet the requirements of its customers. They have disintegrating tablets, which are convenient for those who dislike regular tablets. They also have a particularly suitable formulation for children or individuals who struggle with swallowing.


The effectiveness of a medication is closely tied to how it's stored so it's important to follow the recommended guidelines, for storage.

To ensure that Xyzal maintains its potency, it should be stored in a dry location away from direct sunlight. The recommended temperature range for storage is between 15°C to 30°C.

Stability and Shelf Life

When kept in storage conditions, Xyzal can remain effective for, up to 24 months. However, after this period, its therapeutic potency may be affected.

Safety Precautions in Storage

To ensure the safety of the drug, it's important to be cautious about risks. To prevent ingestion, make sure to keep it out of reach of children and pets. Additionally ensure that the container is tightly sealed to avoid any moisture or contaminants, from entering.


As Xyzal begins its journey, in the field of therapeutics it may come across medications, which makes it important to be aware of any potential interactions.

Drugs and Substances that May Interact with Xyzal

Taking substances at the same time as Xyzal could affect how it works in the body. Here are a couple of examples;

  • Alcohol; Drinking alcohol while taking Xyzal can make the sedative effects stronger.
  • Other antihistamines; Using antihistamines, alongside Xyzal may increase the chances of experiencing side effects.

It's important to be aware of these interactions to ensure the safe and effective use of Xyzal.

Potential Outcomes of These Interactions

Interactions, although they can have effects, can also have negative consequences. For example, taking this medication together with alcohol may cause increased drowsiness or sleepiness.

Additionally, there is a chance of experiencing adverse reactions such as dry mouth or difficulty urinating when combined with other antihistamines.

Safe Practices and Alternative Medications

To navigate the complexities of drug interactions it is important to inform your healthcare provider about any other medications you are taking at the same time.

It is advisable to seek advice from a physician before using over the counter antihistamines. Additionally exploring alternative treatment options, with mechanisms can help avoid potential risks associated with drug interactions.


In the world of medical treatments medications serve as both a remedy and a potential source of problems. As we explore the healing properties of Xyzal, it becomes crucial to understand when it should be used carefully and in situations.

Situations where Caution is Necessary

Although Xyzal is known for its effectiveness in treating allergies, there are situations where caution should be exercised. Avoid taking it with central nervous system depressants as they may enhance the sedative effects.

If you have a history of kidney problems, consult your doctor before using Xyzal. Be mindful when engaging in activities that require mental alertness, like driving or operating machinery.

Potential Risks and Hazards

Ignoring the warning to be cautious can lead to various negative consequences. It can cause increased sleepiness, which may result in accidents during tasks that require alertness. Additionally, it can potentially worsen kidney problems in people who're susceptible to them.

Monitoring and Follow-Up Requirements

To ensure the use of Xyzal it is important to regularly monitor renal function for individuals with compromised kidney function. Additionally, it is essential to watch out for any signs of drowsiness or difficulties, with thinking and cognition.


In the field of pharmacology, contraindications act as guidelines that define situations where the risks of a drug outweigh its potential benefits.

Conditions where Xyzal should not be Used

There are situations where the use of Xyzal is not recommended for patients who have a known allergy to levocetirizine or any of the ingredients used in Xyzal. Patients with end-stage renal disease or those who are undergoing dialysis.

Potential Risks of Ignoring Contraindications

Ignoring these guidelines can lead to a range of complications, such as severe allergic reactions in people who are hypersensitive. It is also important to consider that the drug may build up in patients, with kidney problems, which could potentially result in harmful effects.

Careful Administration

Beyond the realm of explicit contraindications, there are groups of people who require a personalized approach when it comes to administering Xyzal.

Special Populations Requiring Adjusted Administration

Certain groups of people require customized approaches. For instance, elderly patients with reduced kidney function need specific therapeutic strategies. Similarly, children have a need for age-appropriate dosages.

Pregnant or breastfeeding women must carefully consider the balance between risks and benefits in their treatment decisions.

Monitoring and Follow-Up in These Cases

To ensure the well-being of these groups it is crucial to prioritize vigilance and regular evaluations. It is important to assess renal function in elderly individuals.

Additionally, closely monitor children for any adverse reactions to ensure their safety. For mothers, antenatal visits should primarily focus on identifying any possible drug-related anomalies or complications that may arise.

Important Precautions

In the field of practice, being careful and knowledgeable about how medication is administered is important for both achieving the best results and avoiding any unexpected problems. Understanding precautions before starting a treatment journey with Xyzal can significantly impact the overall outcome of the treatment.

List of Precautions to Consider Before and During Treatment

Before starting or during therapy there are an important precautions to keep in mind;

1. Take a look at the medications the patient is currently taking to avoid any possible interactions with levocetirizine or related substances.

2. Check if the patient has any known allergies to levocetirizine or compounds.

3. Be cautious when treating patients with a history of kidney or liver problems.

4. Advise patients not to engage in activities that require mental focus like driving, especially during the initial stages of therapy as it may cause drowsiness.

These precautions are essential, for ensuring effective treatment.

Signs and Symptoms that Warrant Medical Attention

Although Xyzal is usually well tolerated, there are indications that requires prompt medical attention. These include any signs of a reaction such as a rash, swelling, or breathing difficulties.

If you experience nausea or gastrointestinal issues significant changes, in urinary frequency or volume, or unusual fatigue or palpitations it's important to consult a healthcare professional.

Administration to Elderly

Elderly patients who have changes in their body functions and take multiple medications require a careful approach to treatment when starting Xyzal.

Specific Considerations for Elderly Patients

As people age, they experience an interplay of changes. One of these changes is a decrease in clearance, which can affect how drugs are metabolized in the body.

Additionally older individuals may become more sensitive to the effects of medications. Another important factor to consider is that they are more likely to take medications increasing the potential, for drug drug interactions.

Dosage Adjustments and Monitoring

For the patients the administration of Xyzal requires personalized adjustments; Start with a lower dose and adjust it based on how well it works and how well it is tolerated. Regularly assess kidney function to determine the dose. Keep an eye out for any negative reactions especially when starting the treatment.

Administration to Pregnant Women and Nursing Mothers

The relationship between a mother and child is deep. The careful administration of medication is crucial for both of them. It requires attention to detail; It is of utmost importance.

Known Risks and Benefits During Pregnancy

Although the exact impact of drugs on fetal development is not fully understood we can identify some general patterns for Xyzal.

While studies on animals have not shown any negative effects there is still limited data available regarding its effects on humans.

It is important to consider that the potential benefits for the mother should be carefully weighed against any risks, to the fetus.

Transfer of Medication in Breast Milk

The effects of medication extend beyond the mother's body. Levocetirizine, although present in small amounts, can be found in human breast milk.

Therefore, nursing mothers should carefully consider the advantages of breastfeeding compared to any risks it may pose to their infants.

Recommendations and Precautions

For pregnant or breastfeeding individuals in this group, it is important to prioritize caution and seek professional guidance. It is advisable to consult experts before starting or continuing the use of Xyzal during pregnancy or while breastfeeding.

Additionally, it is recommended to monitor infants for any unexpected symptoms if the medication is being taken during the breastfeeding period.

Administration to Children

The unique characteristics of childrens bodies and their changing physiological traits require a customized approach, to their treatment.

Age-Based Dosage Recommendations

When it comes to giving medication to children it's important to adjust the dosage based on their age.

  • Kids between the ages of 6 and 12 usually receive a dose than adults and it's usually given once a day.
  • As, for children aged 2 to 6 a lower dose is given, taking into account that their metabolic pathways are still developing.

Pediatric Considerations and Safety Profile

Children are not just versions of adults. They may react differently to medications. Although most medications are safe for children some children may be more sensitive to effects.

It is crucial to monitor them for any negative reactions, especially at the beginning of treatment. Caregivers should be advised to stay alert and watch out for any changes, in behavior or physical symptoms.


In the world of pharmacotherapy although it is uncommon, accidentally taking too much medication can be a serious situation. Xyzal, known for its effectiveness in therapy, is also not exempt, from unintended incidents.

It is crucial to comprehend the consequences of occurrences and the available ways to resolve them.

Symptoms of Overdose

Exceeding the recommended dosage limits of Xyzal can lead to symptoms of;

  • Feeling extremely sleepy or tired, sometimes mixed with periods of restlessness.
  • Experiencing heartbeats or unusual cardiac rhythms.
  • Having trembling sensations or uncontrollable muscle movements. 
  • Facing difficulty in breathing or shallow breaths.

Immediate Actions to Take

If you suspect an overdose, it is crucial to act wisely. Stopping any medication intake is essential. It is important to seek medical help by contacting local emergency services or going to the nearest healthcare facility.

If possible, try to determine the amount of drug that was consumed so that healthcare professionals have an understanding and can intervene accordingly.

Treatment Options and Prognosis

When dealing with an overdose of Xyzal there are important steps to take. The main focus is providing care, which can involve things like helping with breathing or giving fluids through an IV.

Other options, like lavage or using activated charcoal may be considered, depending on how much time has passed since taking the medication.

It's important to monitor the person in a medical setting until they stabilize. With interventions, the outlook is generally positive.

However, it's crucial to remain vigilant and seek medical attention for the best possible outcomes.

Handling Precautions

Beyond the clinical realm, it is crucial to carefully manage Xyzal at every stage. Whether it's storing the medication or disposing of it properly, we must ensure that Xyzal continues to be a treatment rather than an unintended harm.

Safe Handling and Disposal of Xyzal

To create an environment for Xyzal, follow these steps;

1. Store it in its packaging away from direct sunlight or extreme temperatures.

2. Keep it out of the reach of children and pets in a locked cabinet or on a high shelf.

3. Dispose of any unused medication responsibly by either returning it to a pharmacy or following local guidelines, for pharmaceutical waste disposal.

Precautions to Prevent Accidental Ingestion or Exposure

To avoid accidents it is important to be cautious and careful.

  • Always remember not to transfer the medication into containers, without labels or mix it with medications.
  • Whenever possible use child-resistant packaging.
  • Also, make sure to keep the medication from food or drinks to prevent any accidental contamination.
  • If there is any spillage clean it up away and make sure there are no traces of the medication left behind in the area.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Daniel on Jan 12, 2015 Verified Purchase


Thank you so much for the excellent service and products :)

Note: does not imply any medical claims from this review.

Customers also bought

Popular Products

Similar Product