Agomelatine is an anti depressant which is used for the treatment of depression. Agomelatine works to copy the action of melatonin in the brain where it is responsible to re-synchronize the body's circadian rhythms which then help to improve mood.

Valdoxan, Agomelatine


Agopose, Agroprex, Agosan, Noveltin


Mankind, Sun Pharma, Intas, Eisai Pharma


25 mg



1. Introduction to Agomelatine

1.1. Overview of Agomelatine

Agomelatine, a type of antidepressant, is noteworthy in medicine due to its distinct melatoninergic and serotonergic mechanisms. Unlike antidepressants, Agomelatine takes a multifaceted approach by addressing the disruption of circadian rhythm, which plays a crucial role in mood disorders.

1.2. Historical Development and Approval

Agomelatine, which was developed in the 2000s, signifies a groundbreaking change in the way we approach depression treatment. The path from its inception to its application in settings is evidence of our evolving comprehension of neurochemistry's role in mood disorders. Following clinical trials, Agomelatine obtained approval, representing a significant achievement in psychiatric pharmacotherapy.

1.3. Agomelatine in Modern Medicine

Agomelatine is highly praised for its ability to effectively improve symptoms of depression while minimizing the side effects commonly associated with antidepressants. Its impact on medicine goes beyond simply managing symptoms, as it provides a comprehensive approach to enhancing patients' overall well-being.

2. Composition of Agomelatine

2.1. Chemical Structure and Properties

Agomelatine possesses a pharmacological profile due to its chemical composition, which features a molecular structure based on naphthalene. This specific architecture enables penetration into the brain, essential for its therapeutic effects.

2.2. Active Ingredients and Excipients

Primary Component; Agomelatine, which is the key substance responsible for the therapeutic benefits. Additional Components; These inactive substances, like lactose and magnesium stearate play a role, in formulating the medication by improving its stability and how easily it can be absorbed by the body.

3. How Agomelatine Works

3.1. Mechanism of Action

Agomelatine works by stimulating receptors (MT1 and MT2) while blocking serotonin receptors known as 5 HT2C. This dual mechanism helps to balance the levels of melatonin and serotonin, which are essential neurotransmitters involved in regulating mood and sleep.

3.2. Pharmacodynamics and Pharmacokinetics

After taking Agomelatine it is quickly absorbed into the body. Undergoes significant metabolism in the first pass. The way this medication moves through the body is characterized by a short period of effectiveness which means it needs to be taken once a day to keep the proper levels of medication in the bloodstream.

3.3. Effects on the Brain and Neurotransmitters

Agomelatine has an impact, on neurochemistry that goes beyond adjusting serotonin and melatonin. It also possesses properties that can protect the brain, potentially reducing any damage caused by stress.

4. Uses of Agomelatine

4.1. Primary Indications: Depression and Anxiety Disorders

Agomelatine is a medication that is commonly prescribed to treat depressive disorder and various anxiety disorders. It helps improve mood, sleep and overall quality of life for individuals experiencing these conditions 1.


  1. The Psychiatrist, 37(11), 356-3581
  2. Nature Reviews Drug Discovery, 9(9), 628-6422

4.2. Agomelatine in Sleep Regulation

Agomelatines distinctive impact on receptors makes it a valuable tool for addressing sleep disorders linked to depression.

4.3. Agomelatine in Circadian Rhythm Disorders

Agomelatine has the potential to be used as a treatment for conditions such as Delayed Sleep Phase Syndrome due to its ability to regulate rhythms.

5. Off-Label Uses of Agomelatine

Although Agomelatine is not approved for use in Generalized Anxiety Disorder (GAD), recent network meta-analyses support the use of pharmacotherapy in patients with GAD. Agomelatine has been shown to have efficacy that is greater than placebo in patients with GAD, and to have a tolerability profile that compares favorably with that of escitalopram 2.

6. Dosage and Administration

The recommended amount of Agomelatine to take is 25 once a day usually at bedtime. The dosage can be changed depending on how the patient responds and their ability to tolerate it. It should not go beyond 50 mg per day.

6.2. Dose Adjustments in Special Populations

6.3. Administration Techniques and Timing

7. Side Effects of Agomelatine

7.1. Common Side Effects and Management

Some of the side effects of Agomelatine may include headaches, dizziness, and gastrointestinal issues. However, these side effects are usually mild and temporary. They tend to improve over time with treatment or slight adjustments in the dosage.

7.2. Serious Adverse Reactions

Serious though uncommon side effects may include damage, to the liver. It is essential for patients to be aware of the symptoms of liver injury and to promptly seek help if any such symptoms arise.

7.3. Long-term Side Effects

Long-term safety information about Agomelatine is still being developed. It is essential for healthcare providers to stay alert for side effects that may arise over time, especially with prolonged usage.

8. Interactions with Other Medications

8.1. Drug-Drug Interactions

The way Agomelatine is broken down in the body through CYP1A2 suggests that there could be interactions with medications that are also processed by this enzyme. It's essential to be cautious when using Agomelatine alongside substances that inhibit or induce CYP1A2.

8.2. Food and Lifestyle Interactions

Specific factors related to one's lifestyle, such as smoking and dietary choices, can have an impact on how effective and safe Agomelatine is. It is essential for patients to be advised about the importance of leading a lifestyle to achieve the best possible treatment results.

8.3. Agomelatine and Alcohol Interaction

It is recommended to refrain from drinking alcohol while undergoing Agomelatine therapy as it can increase the chances of liver damage and worsen symptoms of depression.

9. Contraindications and Warnings

9.1. Absolute Contraindications

Agomelatine should not be used in patients with a known allergy or sensitivity to the medication or its components. Moreover, it is not recommended for individuals with liver problems due to its potential to cause liver damage.

9.2. Warnings for Specific Populations

It is essential to be extra careful with groups of people, including those who have a history of bipolar disorder or manic episodes. This is because there is a risk of experiencing a switch to a state. Additionally, patients with existing liver conditions should undergo monitoring of their liver function.

9.3. Precautionary Measures

Healthcare professionals must be alert and watchful for any indications of thoughts, especially when patients are starting their treatment or when there are changes in medication dosage.

10. Special Considerations in Administration

10.1. Administration to the Elderly

Elderly individuals might experience heightened sensitivity, to Agomelatine, which necessitates dosing and frequent monitoring for potential adverse reactions.

10.2. Use in Pregnant Women and Nursing Mothers

Agomelatine can be considered for use during pregnancy and breastfeeding only if the benefits outweigh the potential risks to the baby. It has not yet been well determined how this medication might affect development or its presence in breast milk.

10.3. Pediatric Use: Safety and Efficacy

The safety and effectiveness of Agomelatine in children and adolescents have not been thoroughly researched, It is not recommended for use in pediatric populations.

11. Handling and Storage of Agomelatine

11.1. Storage Conditions and Shelf Life

Agomelatine should be kept at room temperature, away from direct light and moisture, in order to maintain its pharmacological effectiveness. When stored under these conditions, it typically remains potent for years.

11.2. Safe Handling Practices

Healthcare providers should follow pharmaceutical protocols when handling Agomelatine to prevent any potential cross-contamination with other medications.

11.3. Disposal of Unused Medication

You should dispose of any Agomelatine you haven't used or expired following the regulations. This is important to avoid any harm to the environment or accidental consumption.

12. Overdose and Management

12.1. Symptoms of Overdose

Excessive intake of Agomelatine may result in symptoms such as feeling tired, restlessness, and problems related to the digestive system. In some instances, it could potentially cause damage to the liver.

12.2. Immediate Steps and Antidotes

If an overdose occurs, it is vital to seek medical help. Although there is no antidote, it is essential to start symptomatic and supportive treatment.

12.3. Long-term Management of Overdose

After an overdose, it is essential to monitor the functioning of the liver and mental well-being while also making necessary changes to medication plans in the long run.

13. Important Precautions for Healthcare Providers

13.1. Monitoring Requirements

It is crucial to check liver enzyme levels, especially during the initial six months of treatment. Additionally, it is essential to conduct mental health evaluations to assess the effectiveness of the treatment and ensure patient safety.

13.2. Patient Education and Counseling

It is crucial to ensure that patients understand the significance of following their medication doses being aware of potential side effects and regularly attending medical checkups.

13.3. Reporting Adverse Events

Healthcare professionals have the task of informing regulatory authorities about any adverse incidents related to the use of Agomelatine. This is crucial, for ensuring monitoring and safety measures.

14. Future Research and Developments

14.1. Ongoing Clinical Trials

Researchers are currently investigating the range of healing possibilities Agomelatine offers, including its potential effectiveness, in treating seasonal affective disorder and chronic pain conditions.

14.2. Potential Future Indications

Researching the neuroprotective properties of Agomelatine could lead to new opportunities for treating neurodegenerative diseases and cognitive disorders.

14.3. Innovations in Agomelatine Therapy

Researchers are currently investigating ways to improve the effectiveness of Agomelatine and ensure that patients adhere to their treatment. They are exploring advancements in formulation and delivery, such as extended-release tablets or transdermal patches.

Rated: 4.0 / 5 based on 4.0 customer reviews.

Posted by Shirley on Jun 24, 2019 Verified Purchase

Deep Sleep

Helps you sleep better and arrives in about 10 days or so (in europe), didn't help much with my anxiety but definitely changes sleep architecture, gave it two weeks then realised it wasn't helping with my anxiety so switched to a MAOI.

Note: does not imply any medical claims from this review.
Posted by jody on Jul 15, 2017 Verified Purchase

facilitates better sleep

Taking at bedtime facilitates an easement to falling to sleep. It has kind of a neutralizing effect. The next day comes on like a clean slate. There is a subtle mood shift but more than that there is a forgetting any current day drama and kind of a resetting of the system.

Note: does not imply any medical claims from this review.
Posted by jody on Jul 12, 2017 Verified Purchase


Seems to function as a sleep aid and should kick in as a mood brightener in a few days.

Note: does not imply any medical claims from this review.

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