Mirtazapine
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Mirtazapine

Mirtazapine is an antidepressant that is prescribed to help treat major depressive disorder.
US Brand Name Remeron
Generic Name Mirtazapine
Other Brand Name Mirtaz, Mirnite
Packing 10
Manufacturer Sun Pharma, Actavis, Aurobindo Pharma, Intas Pharma
Form Tablet
Strength 7.5mg, 15mg, 30mg, 45mg
Country India

  • 28 tabs 15 mg $30.52
  • 28 tabs 30 mg $49.56
  • 30 tabs 7.5 mg $14.70
  • 28 tabs 45 mg $58.52
Available online
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Details

Mirtazapine

Uses

Mirtazapine is used for the treatment of depression

How it Works

Mirtazapine is an antidepressant which works by increasing the activity of serotonin and noradrenaline in the brain.Mirtazapine increases the amount of circulating serotonin available in your brain, Serotonin works to stimulate other neurons in the brain that stimulates mood and physical symptoms in depression. Mirtazapine works by potentiating the activity of serotonin in the brain which it achieves by inhibiting the reuptake of serotonin.Altering the balance of the chemicals in the brain can help with the symptoms of depression

Common Side effects

Patients who take Mirtazapine may suffer from such side effects;

Vertigo,
Vomiting,
Sleepiness,
Gaining body weight,
Sleepy and drowsy feeling,
Headache,
A visible increase in appetite

Introduction

Mirtazapine is used for the treatment of major depression and mood disorders. It can be also used as an antiemetic, anxiolytic, hypnotic, and appetite stimulant. This drug is quite a sedative and is suitable for patients with insomnia. It works by restoring the balance of neurotransmitters in the brain.

Use

This drug is used mainly to help manage depression and mood disorders but it can also be given for generalized anxiety disorder, obsessive compulsive disorder, panic disorder, insomnia, post-traumatic stress disorder and migraine prophylaxis. It can be also used as an appetite stimulant for underweight patients.

Dosage and administration

The drug is available in 7.5 mg or 15 mg tablets in the market for patients suffering from depression. It is to be taken orally, preferably once daily at bed time but it can also be taken as two divided doses. An initial oral dose of 7.5 mg at bedtime is suitable for adults with mild to moderate depression. The initial dose of 15 mg daily may be given for those with major depression with a gradual increase in the dose up to 45 mg daily, depending on its clinical response. The changes in dose should be done at intervals of at least 1 to 2 weeks. The disintegrated tablet is also available, which has to stay in the mouth when taken or dissolved in a glass of water before taking it.

Warning

The overdose of this drug shows signs and symptoms of,

Disorientation,
Drowsiness,
Impaired memory, and
Tachycardia.
Taking MAO inhibitors with this drug may cause a serious and possibly fatal drug interaction thus it should be avoided.
Alcohol and other CNS depressants taken along with it may cause potentiation of sedative effect.
Special precaution should be taken in cases of patients with previos psychiatric disorders, previous suicide attempts, liver disease, renal disease, epilepsy, dyslipidemia, arrhythmia, recent MI and angina, stroke, dehydration, hypotension, and angle closer glaucoma.
It should not be taken by the elderly, pregnant women, and breastfeeding mothers.

Side effects

The common side effects of this drug are:

Increase in appetite and body weight,
Oedema,
Drowsiness or sedation,
Dizziness,
Headache,
Jaundice with increased liver enzyme levels,
Postural hypotension,
Skin rash,
Agitation,
Tremor,
Akathisia,
Arthralgia,
Myalgia,
Restless legs syndrome,
Nightmares,
Hallucinations,
Mania,
Paraesthesia,
Convulsions may also be evident with higher doses or prolonged therapy.

It can also cause some serious side effects like myoclonus, reversible agranulocytosis, leucopenia, granulocytopenia, or hyponatremia.