Generic Remeron, Mirtazapine

Mirtazapine is an antidepressant that is prescribed to help treat major depressive disorder.

Remeron, Zispin

Mirtazapine

Mirtaz, Mirnite

10

Sun Pharma, Actavis, Aurobindo Pharma, Intas Pharma

Tablet

7.5 mg, 15 mg, 30 mg, 45 mg

India

Mirtazapine

Uses
Mirtazapine is used for the treatment of depression
How it Works
Mirtazapine is an antidepressant which works by increasing the activity of serotonin and noradrenaline in the brain.Mirtazapine increases the amount of circulating serotonin available in your brain, Serotonin works to stimulate other neurons in the brain that stimulates mood and physical symptoms in depression. Mirtazapine works by potentiating the activity of serotonin in the brain which it achieves by inhibiting the reuptake of serotonin.Altering the balance of the chemicals in the brain can help with the symptoms of depression
Common Side effects
Patients who take Mirtazapine may suffer from such side effects; Vertigo, Vomiting, Sleepiness, Gaining body weight, Sleepy and drowsy feeling, Headache, A visible increase in appetite
Introduction
Mirtazapine is used for the treatment of major depression and mood disorders. It can be also used as an antiemetic, anxiolytic, hypnotic, and appetite stimulant. This drug is quite a sedative and is suitable for patients with insomnia. It works by restoring the balance of neurotransmitters in the brain.
Use
This drug is used mainly to help manage depression and mood disorders but it can also be given for generalized anxiety disorder, obsessive compulsive disorder, panic disorder, insomnia, post-traumatic stress disorder and migraine prophylaxis. It can be also used as an appetite stimulant for underweight patients.
Dosage and administration
The drug is available in 7.5 mg or 15 mg tablets in the market for patients suffering from depression. It is to be taken orally, preferably once daily at bed time but it can also be taken as two divided doses. An initial oral dose of 7.5 mg at bedtime is suitable for adults with mild to moderate depression. The initial dose of 15 mg daily may be given for those with major depression with a gradual increase in the dose up to 45 mg daily, depending on its clinical response. The changes in dose should be done at intervals of at least 1 to 2 weeks. The disintegrated tablet is also available, which has to stay in the mouth when taken or dissolved in a glass of water before taking it.
Warning
The overdose of this drug shows signs and symptoms of,Disorientation,Drowsiness,Impaired memory, andTachycardia.Taking MAO inhibitors with this drug may cause a serious and possibly fatal drug interaction thus it should be avoided.Alcohol and other CNS depressants taken along with it may cause potentiation of sedative effect.Special precaution should be taken in cases of patients with previos psychiatric disorders, previous suicide attempts, liver disease, renal disease, epilepsy, dyslipidemia, arrhythmia, recent MI and angina, stroke, dehydration, hypotension, and angle closer glaucoma.It should not be taken by the elderly, pregnant women, and breastfeeding mothers.
Side effects
The common side effects of this drug are:Increase in appetite and body weight,Oedema,Drowsiness or sedation,Dizziness,Headache,Jaundice with increased liver enzyme levels,Postural hypotension,Skin rash,Agitation,Tremor,Akathisia,Arthralgia,Myalgia,Restless legs syndrome,Nightmares,Hallucinations,Mania,Paraesthesia,Convulsions may also be evident with higher doses or prolonged therapy. It can also cause some serious side effects like myoclonus, reversible agranulocytosis, leucopenia, granulocytopenia, or hyponatremia.

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