Cafergot is used for the treatment of migraine headaches. Cafergot works by narrowing the widened blood vessels in the head.


Ergotamin/ Caffeine




Tablet, Sugar coated tablet

Ergotamin 1 mg / Caffeine 100 mg

India, Turkey



Cafergot, a known pharmaceutical remedy, is highly regarded for its effectiveness in treating various headache disorders. It contains ingredients that make it a reliable solution for individuals with persistent head pain. This medication is particularly beneficial for managing episodes of throbbing pain, often on one side of the head. It is also known to relieve cluster headaches, notorious for their cyclical and excruciating nature. Additionally, Cafergot can help alleviate headaches that result from abnormalities in cranial blood vessels. It is crucial to emphasize the importance of obtaining Cafergot with a doctor's prescription and guidance. Consulting a physician ensures responsible and appropriate medication usage, reducing the risk of unintended consequences.

Uses of Cafergot

Cafergot is a combination medication that contains ergotamine and caffeine. It is used to treat or prevent certain types of headaches, including vascular headaches such as migraines and cluster headaches 1Ergotamine works by narrowing the widened blood vessels in the head, while caffeine increases the absorption of ergotamine and also narrows widened blood vessels 1. Cafergot is known for its effectiveness in combating migraines, and providing relief from the pain and associated symptoms. The combination of its components brings comfort to the suffering brain, making migraine episodes more manageable 1. Cafergot is highly regarded for its ability to interrupt the cycles of cluster headaches, offering moments of relief amidst the tormenting pain attacks. It works by narrowing the blood vessels in the head, preventing the onslaught of pain signals 1. Vascular headaches occur due to disturbances in the blood vessels in the brain. Cafergot, with its properties, helps regulate optimal blood flow to the brain, alleviating the debilitating symptoms of these headaches 1.

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Off-Label Uses of Cafergot

Cafergot is a combination medication that contains ergotamine and caffeine. It treats or prevents certain types of headaches, including vascular headaches such as migraines and cluster headaches 1Cafergot can be recommended by a doctor to help reduce the severity and frequency of menstrual migraines 1. Cafergot can also be used off-label as a remedy for Raynaud’s phenomenon, a condition that causes vasoconstriction in fingers and toes, resulting in paleness and pain. It helps ensure blood flow in such cases 12. Cafergot has shown promising results in alleviating symptoms of orthostatic tachycardia syndrome (POTS), a condition characterized by an increased heart rate when standing up. However, it is essential for healthcare professionals to closely monitor its usage in such cases 3.

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How Cafergot Works

Cafergots effectiveness stems from its way of working. Its dual action mechanism prevents blood vessels from swelling and blocks the transmission of pain signals. The medication contains two active ingredients: Ergotamine and Caffeine. Ergotamine constricts the blood vessels, while Caffeine helps it absorb better, making it more effective. Cafergot maintains a balance between the circulatory and nervous systems, reducing blood vessel dilation and calming down pain signals to promote a sense of tranquility in the brain.

Composition of Cafergot

Active Ingredients: The main components of Cafergot are Ergotamine and Caffeine. Ergotamine helps to combat headaches by constricting blood vessels, while Caffeine acts as a complementary element by improving the absorption of Ergotamine into the body. Inactive Ingredients: Apart from the components, Cafergot also contains other substances such as lactose, cellulose, and magnesium stearate. These inactive ingredients are crucial in ensuring the tablet remains stable and effective. Forms: Cafergot is available in various forms, like tablets and suppositories. The choice of form depends on factors such as the patient's condition and their physician's recommendation.

Dosage and Administration

It is typically recommended for adults to take one or two tablets when the symptoms of a headache start. Then, follow the instructions given by a healthcare professional for any additional doses. The dosage may differ from the standard recommendation in cases like cluster headaches. Therefore, it is crucial to adhere to your physician's guidance. While oral tablets are commonly prescribed, suppositories can be an option for individuals who experience gastrointestinal issues.

Administration to the Elderly

Dosage and Monitoring in Patients When it comes to older patients, it's essential to be cautious and adjust the dosage accordingly. Close monitoring is often necessary to prevent any effects on the cardiovascular system. Taking Precautions for Seniors For individuals, it's crucial to regularly monitor their kidney and liver functions as these organs metabolize and eliminate the medication.

Administration to Pregnant Women and Nursing Mothers

Risks and Recommendations: Considering the effects of Ergotamine, it is generally advised to avoid using Cafergot during pregnancy. Lactating mothers should also be cautious, as the medication can be passed through breast milk. Alternative Options: If you are pregnant or nursing, it may be worth exploring medications with a safer track record. It is crucial to consult with a healthcare professional in situations for proper guidance and advice.

Administration to Children

Can Cafergot be used for children? The use of Cafergot in populations is a complex topic with limited research on its safety and effectiveness in this age group. It is generally not recommended for children due to the lack of studies. However, in cases where Cafergot is deemed necessary, strict adherence to specific pediatric dosage guidelines is crucial. It should only be administered under the supervision of a qualified healthcare provider.

Side Effects of Cafergot

Common Side Effects: Nausea: A feeling of discomfort in the stomach. Vomiting: The expulsion of the contents of the stomach. Weakness: A general feeling of tiredness or reduced muscle strength. Uncommon and Severe Side Effects: Chest Pain: A distressing sensation in the chest area that could indicate issues with the heart. Difficulty Breathing: Experiencing trouble with breathing, which may require immediate medical attention. Severe Allergic Reactions: This includes anaphylaxis, a potentially life-threatening hypersensitive response.


Interactions between Drugs; When taking medications like antifungals, HIV protease inhibitors or other vasoconstrictors alongside Cafergot, it is essential to be aware that there can be an increase in effects. It is highly recommended to consult with a healthcare provider for an assessment of any potential interactions. Interactions between Drugs and Food; Consuming grapefruit or grapefruit juice while on Cafergot may interfere with the drug metabolism potentially worsening side effects. Interaction, with Alcohol and Other Substances; It is advisable to avoid alcohol while using this medication as it can enhance its effects. Additionally, other substances that depress the nervous system can also intensify the sedation caused by Cafergot.


Cautionary Alert: This medication includes a warning about the potential occurrence of serious cardiovascular events. Risks to the Heart: Due to its ability to constrict blood vessels, Cafergot carries notable risks to cardiovascular health. It is crucial to administer this medication in individuals with a history of heart conditions. Headaches, from Medication Overuse; Interestingly excessive use of Cafergot may actually worsen the frequency and severity of headaches. This phenomenon is known as "medication overuse headaches."


Who should avoid using Cafergot? People with artery disease, uncontrolled high blood pressure, and specific types of abnormal heart rhythms should refrain from taking this medication. If you have existing conditions such as liver or kidney dysfunction, it can significantly impact how Cafergot is processed in your body. In some cases, adjustments to the dosage or complete avoidance may be necessary.

Careful Administration and Important Precautions

Regularly monitoring blood levels may be necessary to watch for polycythemia, a condition marked by hematocrit levels. If you notice signs of insufficiency or an allergic reaction, stop using the product immediately and seek medical evaluation. Any adverse effects should be promptly reported to healthcare authorities following the pharmacovigilance protocols.


Taking an excessive amount of this medication can lead to various symptoms, such as numbness in the extremities, seizures, or even a coma. What you should do away It's crucial to seek immediate medical help without hesitation. Contact your poison control center or go to the emergency room immediately. Medical procedures for overdosing To address an overdose, healthcare professionals may use methods like activated charcoal and gastric lavage alongside managing symptoms.


It is best to store Cafergot in a dry place away from direct sunlight and out of reach of children. If the medication has expired, it should not be consumed. Please refer to the guidelines provided by pharmacologists for disposal methods.

Handling Precautions

It is essential to follow the recommended guidelines for handling and disposing of medication. This includes practicing hand hygiene and ensuring secure storage. To ensure safety in households, it is important to keep medications out of the reach of children and pets. It is also recommended that all users familiarize themselves with the accompanying literature to minimize any risks and maximize the effectiveness of the medication.

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