Granisetron
  • Granisetron
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Granisetron

Granisetron is prescribed to prevent and treat nausea and vomiting associated with chemotherapy and radiation therapy.
US Brand Name Generic Kytril
Generic Name Granisetron
Other Brand Name Granicip, Graniset
Packing 4
Manufacturer Cipla
Form Tablet
Strength 1 mg, 2 mg
Country India

  • 4 tabs 1 mg $7.60
  • 4 tabs 2 mg $15.60
Available online
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  • Granicip, Generic  Kytril,  Granisetron Packaging
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Details

Granisetron

Uses

Granisetron works in the treatment of stopping the symptoms of nausea and vomitting

How it Works

Granisetron works by inhibiting the action of serotonin in the body is are responsible for nausea and vomiting. Granisetron action is similar to that of the chemical known as Ondansetron.

Common Side effects

Patients who take Granisetron may suffer from such side effects;

Pain in the stomach,
Loss of appetite,
Indigestion,
Flushing,
Insomnia,
Anxiety,
Fever,
Dizziness

Introduction

Granisetron is a drug that belongs to the medication class of anti-emetics. The drug helps prevent nausea and vomiting associated with repeated cancer chemotherapy and radiotherapy. The drug is a 5-HT3 receptor antagonist. It works by blocking a chemical called serotonin that can cause vomiting.

Use

The tablets have been indicated to help prevent:-

Nausea and vomiting associated with repeated courses of chemotherapy.
Nausea and vomiting associated with full body radiotherapy or fractionated abdominal radiotherapy.

Chemotherapeutic drugs provoke an emetic response due to the stimulation of 5-HT3 receptors located at the vagal nerve ends. This stimulation is through the serotonin release by the enterochromaffin cells of the mucosa. This drug works by preventing the stimulation of these 5-HT3 receptors by binding with them and thereby preventing nausea and vomiting.

Dosage and administration

Granisetron is available as tablets of 1 mg or 2 mg concentrations. The route of administration is oral.

For use with chemotherapy:

For adults, the recommended daily dose is the 2 mg tablet, once daily or the 1 mg tablets, twice daily. For the 2 mg tablet drug regime, the tablet is given at least 1 hour before chemotherapy. For the 1 mg tablets drug regime, the first 1 mg tablet is given at least 1 hour before chemotherapy and the second tablet is given 12 hours after the first.

For use with radiotherapy:

For adults, the recommended daily dose is the 2 mg tablet, once daily that is to be taken within 1 hour of radiotherapy.

Warning

Use of this drug masks gastric or ileus distension by preventing gastric and intestinal peristalsis.
Although not extensively studied, the drug has shown to increase the QT intervals therefore it should be used with caution in patients with cardiac problems.
Safety of this drug has not been established in pediatric patients.
Pregnant women and breast feeding mothers are to use this medication only if it has been prescribed by the doctor.
If you miss a dose, then do not take two doses to compensate for the forgotten dose. Your doctor would advise you on the proper use of this medication.
Some cases of 5-HT3 receptor antagonist usage have reported the development of serotonin syndrome. Symptoms of serotonin syndrome may include hallucinations, delirium, tachycardia, fluctuating blood pressure, hyperthermia, incoordination, tremors, or rigidity. In such a case, discontinue the use of the drug and consult your doctor immediately.
In case of any serious side effects such as anaphylactic reactions like urticaria, rash, angioedema, feeling short of breath, or pain and discomfort in the chest, discontinue the use of this medicine and seek medical care immediately.

Side effects

Prolonged weakness
Headaches
Constipation
Dyspepsia
Loss of appetite
Fever
Diarrhea
Insomnia
Dizziness
Anxiety