Ivermectin is an anthelmintic that is prescribed for the treatment of certain parasitic roundworm infections, such as strongyloidiasis or onchocerciasis.

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I. Introduction

Ivermectin, a groundbreaking substance created in the 1970s, has emerged as a vital component in treating parasitic infections. Its remarkable discovery, which earned it a Nobel Prize, significantly changed how we handle these conditions. The medical importance of Ivermectin goes beyond its purpose; it now plays a crucial role in global health efforts, especially when it comes to fighting diseases in areas with limited resources.

II. Composition and Properties of Ivermectin

Ivermectin is classified as a lactone with a complex molecular structure granting it anti-parasitic solid capabilities. In terms of its properties, this compound demonstrates significant solubility in lipids. This characteristic allows it to cross membranes, which is crucial in its effectiveness effectively.

III. Therapeutic Uses of Ivermectin

Ivermectin is a medication that is commonly prescribed for the treatment of nematode infections, such as Onchocerciasis and Intestinal Strongyloidiasis. Its effectiveness in combating infections is attributed to its unique mechanism of action that disables the infective larvae, providing relief in cases of long-term infections1.

Here are some references that provide more information about Ivermectin:

IV. Off-Label Uses and Emerging Research

Although Ivermectin has not been approved for treating conditions beyond its approved uses, recent studies have explored its potential in clinical settings, including antiviral treatments and possible anti-cancer therapies2Ongoing studies and trials are exploring the range of pharmacological applications beyond its traditional use2.

Here are some references that provide more information about Ivermectin:

V. Mechanism of Action: How Ivermectin Works

Pharmacodynamics: Ivermectin enhances the release of chemicals in the system, causing parasite paralysis. Effect on Parasitic Organisms: This interruption in the functions of parasites results in their inability to move and eventually leads to their demise, effectively stopping the infection.

VI. Dosage and Administration Guidelines

The dosage of Ivermectin depends on the type of infection and the patient's weight. The standard way to administer it is orally, which can differ depending on clinical needs.

VII. Side Effects of Ivermectin

Although Ivermectin is usually well tolerated, it can sometimes cause side effects like dizziness, nausea, and, in rare instances, more severe reactions. To address these effects, doctors typically recommend symptomatic treatment and may occasionally advise discontinuing the therapy.

VIII. Drug Interactions and Contraindications

The use of Ivermectin alongside medications requires careful attention, especially when it comes to drugs that are processed by the liver. It is not recommended for groups of patients, such as those with hypersensitivity to any of its ingredients.

IX. Special Precautions and Warnings

It is essential to take care when giving Ivermectin to people who are more susceptible to risks, like elderly pregnant women or those with weakened immune systems. Being aware of allergic reactions is vital for the safety of patients.

X. Special Considerations in Administration

The administration of Ivermectin needs to be considered in certain demographic groups to ensure it is effective and safe. For patients, it is essential to be cautious as they may have a heightened sensitivity to Ivermectin. This may require adjusting the dosage and closely monitoring for any effects. Regarding women and nursing mothers, it is advisable to use Ivermectin only if the benefits outweigh the potential risks. We don't fully understand its impact on the development of nursing infants yet. When administering Ivermectin to children, precise calculations based on their body weight are necessary. Observing them for any signs of intolerance or unusual reactions to the medication is also essential.

XI. Managing Overdosage Situations

If someone takes much Ivermectin, it is essential to recognize the symptoms and take appropriate action quickly. Signs of an overdose may include nausea, dizziness, seizures, or difficulty breathing. It is crucial to seek medical attention in such cases. While there isn't an antidote for an Ivermectin overdose, providing supportive care and treating the symptoms can help minimize the impact.

XII. Storage and Handling Precautions

It is crucial to store and handle Ivermectin properly to maintain its effectiveness and reduce the risks of exposure or degradation of the medication. Ivermectin should be stored at room temperature, away from light and moisture to ensure its stability and potency. When handling this medication in clinical settings, it is essential to exercise caution to prevent accidental ingestion or contact. Such precautions are necessary to safeguard target populations from potential harm.

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