Paracetamol, Metoclopramide

Paracetamol and Metoclopramide Hydrochloride combined medication is prescribed to help alleviate the symptoms of migraine attacks.

Generic Paramax

Paracetamol/ Metoclopramide



Cosme Pharma, Oaknet Healthcare


Paracetamol 500 mg / Metoclopramide 5 mg


Paracetamol, Metoclopramide

I. Introduction

Overview of Paracetamol and Metoclopramide:

Paracetamol, famous for its pain-relieving and fever-reducing qualities, and Metoclopramide, mainly known for preventing nausea, are two types of medications commonly used in medical situations. When included in treatment plans, they help with a range of symptoms, such as managing pain and addressing gastrointestinal movement issues.

Importance and relevance in medical treatment:

The practical benefits of these drugs go beyond treating symptoms as they greatly contribute to improving the quality of life for patients and enhancing treatment results in different areas of medicine.

II. Composition and Properties

Chemical composition of Paracetamol and Metoclopramide:

Paracetamol, also referred to as N acetyl p aminophenol and Metoclopramide, which is a derivative of benzamide, have unique molecular structures that define their pharmacological and pharmacokinetic properties.

Basic pharmacological properties:

While Paracetamol works to alleviate pain and reduce fever in the body, Metoclopramide helps promote movement by blocking dopamine receptors in the central nervous system and the upper gastrointestinal tract.

Acetaminophen vs Paracetamol

Acetaminophen and paracetamol are essentially the thing both referring to a chemical compound called para acetylaminophenol. In the United States they are commonly recognized by the brand name Tylenol.

Paracetamol vs ibuprofen

Paracetamol and ibuprofen have mechanisms of action, making paracetamol more effective than ibuprofen for certain types of pain. Paracetamol is typically recommended for pain conditions like headaches and stomach discomfort, while ibuprofen may be more suitable for managing period cramps or toothaches.

Aceclofenac paracetamol

This blend is commonly employed to alleviate pain and reduce inflammation in osteoarthritis, rheumatoid arthritis, and musculoskeletal disorders. Aceclofenac works to combat inflammation while Paracetamol aids in pain relief and lowering fever.

III. Uses of Paracetamol and Metoclopramide

IV. Off-label Uses of Paracetamol and Metoclopramide

Diving into known medical uses: Apart from their main purposes, Paracetamol is occasionally utilized to treat osteoarthritis, while Metoclopramide is used for alleviating migraine headaches.

Research studies have shown that Metoclopramide can effectively relieve migraines showcasing its versatility and potential, for treatment options.

Paracetamol for sore throat

If your throat feels scratchy there are things you can do to ease the discomfort. Taking some paracetamol can alleviate the pain. Trying a warm saltwater gargle might shorten the duration of the infection (though its not advisable, for children). Generally it's only necessary to consult your doctor if your sore throat persists beyond a week.

Paracetamol for tooth pain

For adults you can effectively manage pain by alternating between taking paracetamol and ibuprofen every 2 hours (ensuring each drug is taken every 4 hours). Typically paracetamol can be discontinued after 24 48 hours. Take Paracetamol in 500, mg tablets and Ibuprofen (Nurofen/Brufen) in 400mg tablets.

V. How Paracetamol and Metoclopramide Work

Mechanism of action of Paracetamol:

It primarily works by blocking cyclooxygenase enzymes in the brain, which play a role in producing prostaglandins that are important, for managing pain and regulating body temperature.

Mechanism of action of Metoclopramide:

It improves the system's movement by boosting the strength of stomach contractions, easing the pyloric sphincter, and promoting smooth muscle contractions in the upper part of the small intestine.

Synergistic effects when used together:

The pain relieving properties of Paracetamol when paired with the ability of Metoclopramide to aid digestion can greatly enhance the treatment of issues, like migraines and post operative healing.

VI. Dosage and Administration

The usual amount of Paracetamol given is between 500 mg to 1 g every four to six hours with a daily limit of 4 g. For Metoclopramide the typical dosage is 10 mg taken up to three times daily before meals and, before bedtime.

Methods of administration:

Both drugs can be taken orally rectally or through an IV, giving healthcare providers flexibility in how they administer treatment depending on the patient's needs and preferences.

Timing and frequency of dosage:

The usual practice for taking Paracetamol is to use it when needed whereas its recommended to take Metoclopramide 30 minutes before meals and, at bedtime to improve gut movement.

Can you give paracetamol to infants?

You may administer paracetamol to children who're at least 2 months old for pain or fever. Ibuprofen can be given to children who are 3 months or older and weigh over 5kg (11lb).

How much paracetamol can i take when pregnant?

During pregnancy, it is safe to use Paracetamol 500mg Tablets if needed. It is recommended to take the effective dose to alleviate pain or fever and only use it for a limited duration. If the pain or fever persists or if you find yourself needing to take the medication consult your healthcare provider or midwife.

Paracetamol or ibuprofen for headache

If you're just seeking a common pain reliever. Like for a headache. The standard advice, from doctors is to begin with paracetamol and switch to ibuprofen if it doesn't work.

VII. Side Effects and Management

Common side effects of Paracetamol:

Paracetamol is usually well tolerated. It can sometimes lead to side effects like nausea, allergic reactions, and, in rare cases, liver problems, especially when used for a long time or taken in excess.

Common side effects of Metoclopramide:

  • Patients might feel tired, sleepy and in cases could develop extrapyramidal symptoms like sudden muscle spasms especially in young adults and children.
  • Ways to handle side effects include checking liver enzyme levels when taking Paracetamol for a long time.
  • Keeping the Metoclopramide treatment duration short to lower the chances of experiencing tardive dyskinesia.
  • Seeking advice, from healthcare professionals promptly if any unexpected side effects arise.

VIII. Important Precautions and Warnings

Contraindications for use; It is advised to avoid using Paracetamol in patients with liver problems. Metoclopramide should not be used by individuals with pheochromocytoma due to the risk of causing severe high blood pressure.

Specific warnings for each medication: Paracetamol can lead to skin reactions like Stevens-Johnson syndrome. Metoclopramide has the potential to trigger malignant syndrome, a life threatening condition.

Precautions for populations;

Elderly; Both medications should be used cautiously with adjustments in dosage to minimize the risks related to kidney function.

Children; When prescribing Paracetamol in doses it is important to consider the risk of respiratory depression.

Pregnant women: Paracetamol is generally considered safe during pregnancy, while Metoclopramide should only be utilized when absolutely necessary and under medical supervision.

Paracetamol toxicity cats

Cats poisoned by paracetamol may experience oxygen deprivation due to compounds in their system. Symptoms may include a brown discoloration of their gums and tongue, increased heart rate, facial and paw swelling,

vomiting, dark urine, and breathing difficulties.

IX. Drug Interactions

Possible effects when combining medications: Paracetamol could heighten the impact of warfarin, potentially raising the risk of bleeding.

  • Metoclopramide might speed up the absorption of substances like diazepam and alcohol, enhancing their effects.
  • Regarding diet and actions to steer of; It's advisable to steer clear of alcohol while using both medications to avoid worsening their liver related and central nervous system effects individually.
  • When using Metoclopramide it's wise, to consumption of foods that could worsen stomach discomfort.

X. Special Considerations

  • Elderly individuals may need doses of both medications due to their reduced liver, kidney, and heart functions, which are commonly seen in this age group.
  • For women and nursing mothers, it is generally considered safer to use Paracetamol during pregnancy, while Metoclopramide should only be used in severe cases where the benefits outweigh the risks. Both drugs can be passed into breast milk, so nursing mothers should use them with caution.
  • When giving medication to children, it is crucial to use dosages and closely monitor them to prevent overdosing with Paracetamol and reduce the risk of dystonic reactions from Metoclopramide.

XI. Overdosage

XII. Handling and Storage

To ensure that both medications remain effective, it's important to store them in the right conditions. Keep Paracetamol in a dry place and protect Metoclopramide from freezing.

  • Store them at room temperature away from sunlight and moisture to prevent any degradation.
  • When handling the medications, make sure the packaging is intact to shield them from air exposure, which can lead to degradation.
  • Also be gentle, with liquid Metoclopramide formulations to prevent foam formation that could impact accuracy.

XIII. Careful Administration

Instructions for management: It is crucial to administer the correct dosage as per the prescription guidelines.

Pay attention to adjusting doses for at-risk groups like the elderly or individuals with kidney issues. Recommendations, for monitoring and follow up; Ensure check ups to evaluate effectiveness and identify any potential side effects early on.

In cases of prolonged Paracetamol use consider conducting liver function tests. For Metoclopramide, it is advisable to assess neurological function to watch out for extrapyramidal symptoms, especially during long-term usage.

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