Celsentri (Maraviroc) is prescribed along with other antiretroviral agents to help treat adults infected with only CCR5-tropic HIV-1 detectable virus, who have evidence of viral replication as well as HIV-1 strains resistant to multiple antiretroviral agents.





Viiv Healthcare


300 mg


Out of Stock.


I. Introduction to Celsentri

A. Overview of Celsentri (Maraviroc)

At the forefront of treatment, Celsentri, also known as Maraviroc, exemplifies the innovative efforts of pharmaceutical companies. This medication plays a role in combating Human Immunodeficiency Virus Type 1 (HIV 1), providing individuals affected by it with a ray of hope in effectively managing this previously unstoppable viral opponent.

B. The Importance of HIV-1 Entry Inhibitors in HIV Treatment

Entry inhibitors like Celsentri are essential in the strategy for HIV treatment. They play a role in preventing the virus from entering CD4 cells, which are vital for our immune system. This category of medications has significantly influenced the way we approach treatment and has paved the way for combination therapies that improve suppression.

C. Advancements in HIV Therapy with Celsentri

Celsentri has ushered in an era in the treatment of HIV. Its unique way of working adds a level of protection against the replication of the virus. When used alongside antiretrovirals, it can significantly improve the effectiveness of therapy, allowing people to live their lives without being weighed down by uncontrolled viral levels.

II. Composition of Celsentri

A. Active Ingredients

Maraviroc, known as Celsentri, is an engineered compound that targets the CCR5 receptor found on CD4 cells in humans. Its complex design enables it to strongly bind and interact with the receptor, making it a prime example of targeted therapy.

B. Pharmaceutical Formulation

The experts in pharmaceuticals have carefully designed the formulation of Celsentri to ensure the body quickly absorbs it. Has the desired effects over time. This formulation represents a result of combining medical knowledge with advanced pharmaceutical techniques.

C. Different Strengths and Variants

Celsentri comes in strengths and versions, allowing creating a personalized treatment plan that matches the specific pharmacodynamic and pharmacokinetic characteristics of each patient. This showcases the essence of medicine.

III. How Celsentri Works

A. Mechanism of Action against HIV-1

Celsentri works in a way to prevents HIV 1 from taking control of the host's CD4 cells. It does this by attaching itself to the CCR5 co-receptor, acting as a barrier at a molecular level.

B. Binding to CCR5 Co-Receptor

Maravirocs' strategic interaction with the CCR5 co-receptor can be compared to a lock and key mechanism preventing viral particles from accessing their cellular havens.

C. Blocking Viral Entry into CD4 Cells

Celsentri serves as the barrier to prevent the fusion of HIV 1 with CD4 cells, thus hindering the virus lifecycle from its very beginning and safeguarding the integrity of the immune system.

IV. Uses of Celsentri

A. Indications for HIV-1 Infection

Certainly, Celsentri is primarily used to treat HIV 1 infection. Its use depends on confirming the presence of CCR5 HIV 1 through a diagnostic test.

B. Treatment-Naïve vs. Treatment-Experienced Patients

Celsentri demonstrates therapeutic benefits, proving effective for individuals new to treatment and those with previous antiretroviral therapy experience. This distinction, in usage, highlights the drug's ability to adapt in clinical situations.

C. Use in Combination with Other Antiretrovirals

Celsentri doesn't work alone; it shows its therapeutic potential when used in combination with other antiretroviral drugs. These combined treatments have been proven to reduce the viral load and provide a strong defense against the advancement of HIV.

V. Off-Label Use of Celsentri

A. Exploring Off-Label Scenarios

The off-label usage of Celsentri, even though entities do not officially support it, has sparked interest among clinicians who are exploring its potential benefits that have not yet been fully explored.

B. Clinical Studies Supporting Off-Label Uses

Sometimes, new studies show that the drug might be effective in situations not originally approved for. This suggests that it could have more uses than initially thought, and it's worth investigating further.

C. Expert Opinions and Case Studies

Expert discussions and real-life examples often provide insights into these applications, although its important to note that such accounts cannot replace empirical verification.

VI. Dosage and Administration of Celsentri

A. Standard Dosage Guidelines

It is crucial to follow the recommended dosage instructions for Celsentri. These guidelines have been derived from clinical trials and real-life experiences to ensure effectiveness while minimizing potential negative impacts.

B. Adjustments for Renal and Hepatic Impairment

For individuals who have kidney or liver problems, it may be necessary to adjust the dosage of Celsentri to prevent any build-up and potential harm.

C. Administration Techniques and Recommendations

To ensure that Celsentri is absorbed effectively, it should be administered using the recommended techniques and in coordination with the patient's treatment plan. This will help ensure the patient follows the regimen and achieves successful therapeutic outcomes.

VII. Common Side Effects of Celsentri

A. Gastrointestinal Disturbances

Gastrointestinal issues, like feeling queasy and experiencing diarrhea, are some of the side effects of Celsentri. However, they usually don't last long. It can be easily managed.

B. Upper Respiratory Tract Infections

Patients may also experience infections in the upper airway, which demonstrates how the drug affects the complex balance of the immune system.

C. Other Frequent Adverse Reactions

Coughing, fever, and tiredness are also listed as side effects, which indicate that the drug affects the whole body.

VIII. Serious Side Effects and Adverse Reactions

A. Immune Reconstitution Syndrome

In individuals, the strengthening of the immune response caused by Celsentri can lead to immune reconstitution syndrome. This is a clinical phenomenon that requires careful monitoring.

B. Hepatotoxicity Concerns

Although hepatotoxicity is uncommon, it is still a concern. It is essential to assess liver function for individuals taking Celsentri regularly.

C. Cardiovascular Risks

Finally, there have been some cases where Celsentri has been linked to risks, such as myocardial infarction. However, it is essential to note that these instances are sporadic and only affect several patients. This highlights the importance of assessing cardiovascular risk before starting the treatment.

IX. Important Precautions While Taking Celsentri

A. Hypersensitivity Reactions

Patients should be aware of the possibility of experiencing hypersensitivity reactions while taking Celsentri. It is important to seek attention promptly if any unusual rash or hives occur, as these symptoms may indicate an allergic reaction.

B. Risk of Infection and Opportunistic Diseases

Celsentri helps strengthen the system against HIV 1, but it might make patients more vulnerable to other infections and diseases that take advantage of weakened immunity. Patients must undergo health checkups to identify and address these risks promptly.

C. Interaction with Other Medications

Celsentris's pharmacokinetic characteristics could be affected by medications, so it's important to carefully assess a patient's current medication regimen to avoid any potential adverse interactions.

X. Drug Interactions with Celsentri

A. Concomitant Use with Other Antiretrovirals

When using Celsentri alongside antiretrovirals, it is crucial to carefully consider the best approach for achieving optimal treatment results and reducing the chances of drug resistance.

B. Effects of Celsentri on Other Drugs

Celsentri, being an enzyme inhibitor, has the potential to increase the levels of other medications in the bloodstream. This may require adjustments in dosage and careful monitoring.

C. Celsentri Interactions with Over-the-Counter Medicines

It is essential to talk with healthcare professionals about all the medications, supplements, and herbal products you are taking because even over-the-counter remedies can potentially interact significantly with Celsentri.

XI. Warnings and Contraindications for Celsentri

A. Known Contraindications

Patients who have had reactions to any ingredient in Celsentri or who have the CXCR4 tropic or dual/mixed tropic HIV 1 variants should not receive this medication.

B. Warnings for Patients with Pre-existing Conditions

Individuals with existing liver conditions, cardiovascular ailments, or susceptibility to infections should exercise extra caution when commencing treatment with Celsentri.

C. Potential for Drug Abuse and Dependence

While Celsentri is not considered addictive, healthcare providers must stay alert due to its potential for misuse when combined with medications.

XII. Careful Administration of Celsentri

A. Dosing Considerations in Special Populations

Certain groups of people like those with kidney or liver problems, may require adjustments, to their medication doses in order to prevent side effects.

B. Management of Missed Doses

If you happen to miss a dose it is recommended that you take it as soon as you remember. However, be cautious not to take two doses if the time, for your dose is close.

C. Guidelines for Discontinuation

The cessation of Celsentri should not occur suddenly. Rather, it should be a carefully considered decision considering the potential risks of viral resurgence and the condition of the patient's immune system.

XIII. Administration of Celsentri to Special Populations

A. Administration to Elderly Patients

Older individuals may sometimes show a sensitivity, to Celsentri, so it's essential to approach the dosing with caution. This should be based on their response and ability to tolerate the medication.

B. Use in Pregnant Women and Nursing Mothers

Although the impact of Celsentri on development is still not fully understood, it is advisable to consider using it during pregnancy only if the advantages outweigh the potential risks to the unborn child.

C. Pediatric Use and Considerations

When considering the use of Celsentri in patients, it is crucial to assess their body weight and developmental status carefully. It is essential to adjust the doses to achieve effective plasma concentrations.

XIV. Overdose and Management

A. Symptoms of Overdose with Celsentri

Taking much Celsentri can lead to a worsening of its side effects, which requires immediate medical attention and intervention.

Treatment for an overdose mainly involves providing support to ensure bodily functions are maintained and facilitating the prompt removal of the drug from the body.

C. Long-Term Health Implications

Term adverse health effects may arise from excessive use of Celsentri, highlighting the crucial need to follow prescribed dosages diligently.

XV. Storage and Handling Precautions for Celsentri

Celsentri should be kept at room temperature and protected from light and moisture to ensure its effectiveness as a medication remains intact.

B. Safe Handling Practices

To ensure safety and prevent exposure, it is important to follow standard safety procedures when dealing with Celsentri tablets, especially around individuals who are not patients or children.

C. Disposal of Unused or Expired Medication

. Expired Celsentri should be disposed of following the guidelines for pharmaceutical disposal to prevent potential environmental contamination.

Popular Products

Similar Product